Pfam Domains mapped on to the structure: 1LI4

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF05221	S-adenosyl-L-homocysteine hydrolase	PF05221	PF05221
2	A	PF00670	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	PF00670	PF00670
3	A	PF07991	Acetohydroxy acid isomeroreductase, catalytic domain	PF07991	PF07991

Gene Ontology Annotations: 1LI4

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0006730	one-carbon metabolic process	GO:0006730

Conserved Domain Database Superfamily Annotations: 1LI4

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1LI4	29522	cd00401	AdoHcyase -	cl09931
2	1LI4	212616	cl09931	NADB_Rossmann	superfamily - -
3	1LI4	212616	cl09931	NADB_Rossmann	superfamily - -

Structural Details of PDB entry 1LI4 PDBid Chains Hinge Swapped Domain 1LI4 A,B A:402-410,B:402-410 A:411-432,B:411-432 Swapped-domain interface residues and interactions: Chains Residues A 245, 278, 279, 412, 413, 416, 417, 419, 425, 426, 427, 428, 429, 430, 431, B 245, 278, 279, 412, 413, 416, 417, 419, 425, 426, 427, 428, 429, 430, 431, Non-swapped-domain interface residues and interactions: Chains Residues A 162, 165, 182, 184, 188, 189, 193, 196, 222, 223, 226, 243, 244, 246, 247, 248, 249, 250, 251, 253, 254, 255, 259, 260, 261, 264, 277, 280, 304, 356, 360, 385, 392, 395, 399, 402, 404, 405, 406, 407, 409, B 162, 165, 182, 184, 188, 189, 193, 196, 222, 223, 226, 243, 244, 246, 247, 248, 249, 250, 251, 253, 254, 255, 259, 260, 261, 264, 277, 280, 304, 356, 360, 385, 392, 395, 399, 402, 404, 405, 406, 407, 409,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1LI4

B:1LI4

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1LI4.ali
atm file:	1LI4.atm
cof file:	1LI4.cof
hbd file:	1LI4.hbd
html file:	1LI4.html
pdb file:	1LI4.pdb
ps file:	1LI4.ps
psa file:	1LI4.psa
rtf file:	1LI4.rtf
sst file:	1LI4.sst
tem file:	1LI4.tem