3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1KU2

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00140 Sigma-70 factor, region 1.2 PF00140 PF00140

2 A PF04542 Sigma-70 region 2 PF04542 PF04542

3 A PF04539 Sigma-70 region 3 PF04539 PF04539

Gene Ontology Annotations: 1KU2

No. GO ID GO Description Linkout - AmiGO

1 GO:0006355 regulation of transcription, DNA-dependent GO:0006355

Conserved Domain Database Superfamily Annotations: 1KU2

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1KU2 146937 cl08419 Sigma70_r2 superfamily - -

2 1KU2 146934 Sigma70_r3 superfamily C -

3 1KU2 201030 cl02812 Sigma70_r1_2 superfamily - -

Structural Details of PDB entry 1KU2

Structural Details of PDB entry 1KU2

PDBid Chains Hinge Swapped Domain

1KU2 A,B A:267-275,B:267-275 A:276-332,B:276-332

Swapped-domain interface residues and interactions:

Chains Residues
A 208, 209, 212, 213, 288, 291, 292, 294, 295, 296, 297, 298, 299, 300, 327, 328, 332,

B 108, 208, 209, 212, 213, 288, 290, 291, 292, 294, 295, 296, 297, 298, 299, 300, 327, 328,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 108, 109, 110, 111, 112, 114, 216, 237, 241, 243, 246, 247, 248, 249, 251, 252, 253, 255, 256, 257, 259, 260, 263, 264,

B 109, 110, 111, 112, 114, 216, 237, 241, 243, 246, 247, 248, 249, 251, 252, 253, 255, 256, 257, 259, 260, 263, 264,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1KU2 B:1KU2

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1KU2.ali
atm file: 1KU2.atm
cof file: 1KU2.cof
hbd file: 1KU2.hbd
html file: 1KU2.html
pdb file: 1KU2.pdb
ps file: 1KU2.ps
psa file: 1KU2.psa
rtf file: 1KU2.rtf
sst file: 1KU2.sst
tem file: 1KU2.tem