3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1JYU

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00017 SH2 domain PF00017 PF00017

Gene Ontology Annotations: 1JYU

No. GO ID GO Description Linkout - AmiGO

1 GO:0005515 protein binding GO:0005515

Conserved Domain Database Superfamily Annotations: 1JYU

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1JYU 199828 cd09941 SH2_Grb2_like - cl15255

2 1JYU 210054 cl15255 SH2 superfamily - -

Structural Details of PDB entry 1JYU

Structural Details of PDB entry 1JYU

PDBid Chains Hinge Swapped Domain

1JYU F,A,E,B,H,C,D,G F:121-123,A:121-123,E:121-123,B:121-123,H:121-123,C:121-123,D:121-123,G:121-123 F:124-151,A:124-151,E:124-151,B:124-151,H:124-151,C:124-151,D:124-151,G:124-151

Swapped-domain interface residues and interactions:

Chains Residues
A 81, 82, 83, 117, 118, 119, 120, 124, 125, 126, 127, 128, 129, 131, 132, 135, 138, 139, 140, 141, 142, 144, 145, 146, 147, 148, 149, 150, 151,

E 81, 82, 83, 117, 118, 119, 120, 124, 125, 126, 127, 128, 129, 131, 132, 135, 138, 139, 140, 141, 142, 144, 145, 146, 147, 148, 149, 150,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 58, 59, 60, 62, 77, 79, 80, 85, 95, 97, 99, 101, 106, 108, 110, 113, 121, 122, 123,

E 58, 59, 60, 62, 77, 79, 80, 85, 95, 97, 99, 101, 106, 108, 110, 113, 121, 122, 123,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

F No mutation No mutation No mutation No mutation

A No mutation No mutation No mutation No mutation

E No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

H No mutation No mutation No mutation No mutation

C No mutation No mutation No mutation No mutation

D No mutation No mutation No mutation No mutation

G No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

D:1JYU E:1JYU F:1JYU G:1JYU H:1JYU A:1JYU B:1JYU C:1JYU

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1JYU.ali
atm file: 1JYU.atm
cof file: 1JYU.cof
hbd file: 1JYU.hbd
html file: 1JYU.html
pdb file: 1JYU.pdb
ps file: 1JYU.ps
psa file: 1JYU.psa
rtf file: 1JYU.rtf
sst file: 1JYU.sst
tem file: 1JYU.tem