3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1JS0

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00074 Pancreatic ribonuclease PF00074 PF00074

Conserved Domain Database Superfamily Annotations: 1JS0

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1JS0 119387 cd06265 RNase_A_canonical - cl00128

2 1JS0 206850 cl00128 RNase_A superfamily - -

Structural Details of PDB entry 1JS0

Structural Details of PDB entry 1JS0

PDBid Chains Hinge Swapped Domain

1JS0 A,C,B A:112-115,C:112-115,B:112-115 A:116-124,C:116-124,B:116-124

Swapped-domain interface residues and interactions:

Chains Residues
A 4, 5, 8, 55, 58, 65, 66, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 116, 117, 118, 119, 120, 121, 122, 123, 124,

B 4, 5, 8, 55, 58, 66, 104, 105, 106, 107, 108, 109, 110, 111, 112, 116, 117, 118, 119, 120, 121, 122, 123, 124,

C 4, 5, 8, 55, 58, 66, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 116, 117, 118, 119, 120, 121, 122, 123,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 1, 12, 45, 52, 56, 59, 62, 67, 68, 69, 70, 71, 72, 73, 74, 81, 114, 115,

B 1, 12, 45, 47, 56, 59, 62, 67, 68, 69, 70, 72, 73, 74, 81, 83, 113, 114, 115,

C 1, 12, 45, 47, 56, 59, 62, 67, 68, 69, 70, 71, 72, 73, 74, 81, 114, 115,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

C No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1JS0 B:1JS0 C:1JS0

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1JS0.ali
atm file: 1JS0.atm
cof file: 1JS0.cof
hbd file: 1JS0.hbd
html file: 1JS0.html
pdb file: 1JS0.pdb
ps file: 1JS0.ps
psa file: 1JS0.psa
rtf file: 1JS0.rtf
sst file: 1JS0.sst
tem file: 1JS0.tem