3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1IIP

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PF00160 PF00160

2 A PF13414 TPR repeat PF13414 PF13414

3 A PF13414 TPR repeat PF13414 PF13414

4 A PF07719 Tetratricopeptide repeat PF07719 PF07719

5 A PF00515 Tetratricopeptide repeat PF00515 PF00515

6 A PF00515 Tetratricopeptide repeat PF00515 PF00515

Gene Ontology Annotations: 1IIP

No. GO ID GO Description Linkout - AmiGO

1 GO:0005515 protein binding GO:0005515

Conserved Domain Database Superfamily Annotations: 1IIP

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1IIP 29397 cd01926 cyclophilin_ABH_like - cl00197

2 1IIP 206894 cl00197 cyclophilin superfamily - -

3 1IIP 29151 cd00189 TPR - cl02429

4 1IIP 207591 cl02429 TPR superfamily - -

5 1IIP 207591 cl02429 TPR superfamily - -

Structural Details of PDB entry 1IIP

Structural Details of PDB entry 1IIP

PDBid Chains Hinge Swapped Domain

1IIP A,B A:259-262,B:259-262 A:263-298,B:263-300

Swapped-domain interface residues and interactions:

Chains Residues
A 263, 264, 267, 268, 269, 271, 272, 274, 275, 276, 278, 279, 281, 282, 283, 285, 286, 298,

D 216, 220, 239, 243, 246, 250, 253,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 212, 214, 215, 216, 217, 219, 220, 223, 227, 234, 239, 240, 243, 246, 247, 249, 250, 253, 256, 257, 260,

D 212, 214, 215, 217, 219, 223, 227, 234, 240, 247, 249, 256, 257, 260, 263, 264, 267, 268, 269, 271, 272, 274, 275, 276, 278, 279, 281, 282, 283, 285, 286,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

B:1IIP A:1IIP D:1IIP

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1IIP.ali
atm file: 1IIP.atm
cof file: 1IIP.cof
hbd file: 1IIP.hbd
html file: 1IIP.html
pdb file: 1IIP.pdb
ps file: 1IIP.ps
psa file: 1IIP.psa
rtf file: 1IIP.rtf
sst file: 1IIP.sst
tem file: 1IIP.tem