3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1IGW

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00463 Isocitrate lyase family PF00463 PF00463

2 A PF00463 Isocitrate lyase family PF00463 PF00463

3 A PF13714 Phosphoenolpyruvate phosphomutase PF13714 PF13714

Conserved Domain Database Superfamily Annotations: 1IGW

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1IGW 119340 cd00377 ICL_PEPM - cl00435

2 1IGW 212216 cl00435 ICL_KPHMT superfamily - -

Structural Details of PDB entry 1IGW

Structural Details of PDB entry 1IGW

PDBid Chains Hinge Swapped Domain

1IGW A,B A:351-353,B:351-353 A:354-417,B:354-417

Swapped-domain interface residues and interactions:

Chains Residues
A 354, 356, 357, 358, 359, 360, 361, 362, 363, 365, 366, 367, 369, 370, 371, 372, 373, 374, 375, 376, 378, 379, 382, 383, 385, 386, 387, 389, 392, 394, 396, 399, 400, 403, 405, 407, 408, 410, 411, 412, 414, 415, 416, 417,

B 354, 356, 357, 358, 359, 360, 361, 362, 363, 365, 366, 367, 369, 370, 371, 372, 373, 374, 375, 376, 378, 379, 382, 383, 384, 385, 386, 387, 389, 392, 394, 396, 399, 400, 403, 405, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417,

C 27, 75, 76, 79, 80, 83, 84, 85, 97, 105, 106, 107, 195, 211, 214, 215, 333, 334, 337, 354, 357, 358, 360, 361, 362, 382, 386,

D 27, 75, 76, 79, 80, 83, 84, 85, 97, 105, 106, 107, 166, 211, 214, 215, 333, 334, 337, 357, 358, 360, 361, 362, 363, 382, 386,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 4, 7, 26, 27, 31, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 44, 45, 48, 63, 67, 69, 73, 74, 75, 76, 78, 79, 80, 83, 84, 85, 93, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 109, 110, 111, 113, 114, 115, 122, 123, 126, 127, 129, 130, 132, 133, 136, 137, 139, 141, 142, 151, 163, 164, 165, 166, 167, 169, 170, 173, 177, 191, 192, 193, 194, 195, 211, 214, 215, 218, 243, 244, 245, 257, 260, 261, 293, 318, 335, 336, 337, 350, 352, 353,

B 3, 4, 7, 26, 27, 31, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 44, 45, 48, 63, 67, 69, 73, 74, 75, 76, 78, 79, 80, 83, 84, 85, 93, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 109, 110, 111, 113, 114, 115, 122, 123, 126, 127, 129, 130, 132, 133, 136, 137, 139, 141, 142, 151, 163, 164, 165, 166, 167, 169, 170, 173, 177, 191, 194, 211, 214, 215, 218, 243, 244, 245, 257, 259, 260, 261, 318, 319, 320, 322, 323, 324, 325, 333, 334, 336, 337, 350, 352, 353,

C 4, 7, 26, 31, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 44, 45, 48, 62, 63, 67, 69, 73, 74, 78, 93, 98, 99, 100, 101, 102, 103, 104, 109, 110, 111, 113, 114, 115, 122, 123, 126, 127, 129, 130, 132, 133, 136, 137, 139, 141, 142, 151, 163, 164, 165, 166, 167, 169, 170, 173, 177, 191, 192, 193, 218, 243, 244, 245, 257, 259, 260, 261, 320, 321, 322, 323, 324, 325, 350, 352, 353, 356, 359, 363, 365, 366, 367, 369, 370, 371, 372, 373, 374, 375, 376, 378, 379, 383, 385, 387, 389, 392, 394, 396, 397, 398, 399, 400, 403, 405, 407, 408, 409, 410, 411, 412, 414, 415, 416, 417,

D 4, 7, 26, 31, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 44, 45, 48, 63, 67, 69, 73, 74, 78, 93, 98, 99, 100, 101, 102, 103, 104, 109, 110, 111, 113, 114, 115, 122, 123, 126, 127, 129, 130, 132, 133, 136, 137, 139, 141, 142, 151, 163, 164, 165, 167, 169, 170, 173, 177, 191, 218, 243, 244, 245, 257, 259, 260, 261, 320, 321, 323, 324, 350, 352, 353, 354, 356, 359, 365, 366, 367, 369, 370, 371, 372, 373, 374, 375, 378, 385, 389, 392, 394, 396, 399, 400, 403, 405, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1IGW D:1IGW

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1IGW.ali
atm file: 1IGW.atm
cof file: 1IGW.cof
hbd file: 1IGW.hbd
html file: 1IGW.html
pdb file: 1IGW.pdb
ps file: 1IGW.ps
psa file: 1IGW.psa
rtf file: 1IGW.rtf
sst file: 1IGW.sst
tem file: 1IGW.tem