Pfam Domains mapped on to the structure: 1HQS
No.
Chain ID
Pfam ID
Pfam Description
Linkout - Pfam
Linkout - CDD
1
A
PF00180
Isocitrate/isopropylmalate dehydrogenase
PF00180
PF00180
Conserved Domain Database Superfamily Annotations: 1HQS
Structural Details of PDB entry 1HQS
Structural Details of PDB entry 1HQS
PDBid Chains Hinge Swapped Domain
1HQS
A,B
A:150-155,B:150-155
A:1-149,B:1-149
Swapped-domain interface residues and interactions:
Chains Residues
A
96 , 97 , 98 , 99 , 100 , 101 , 103 , 104 , 111 , 114 , 130 , 131 , 132 , 133 , 147 , 148 , 180 , 185 , 222 , 223 , 226 , 227 , 230 , 294 , 295 , 308 , 345 ,
B
96 , 97 , 98 , 99 , 100 , 101 , 103 , 104 , 107 , 114 , 130 , 131 , 132 , 133 , 147 , 148 , 173 , 180 , 222 , 223 , 224 , 225 , 226 , 227 , 230 , 285 , 291 , 294 , 295 ,
Non-swapped-domain interface residues and interactions:
Chains Residues
A
150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 162 , 165 , 166 , 169 , 170 , 173 , 174 , 176 , 178 , 179 , 181 , 184 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 199 , 221 , 224 , 225 , 228 , 233 , 234 , 235 , 263 , 285 , 286 , 287 , 290 , 291 , 309 , 311 , 312 , 315 , 316 , 319 , 324 , 350 , 423 ,
B
150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 162 , 165 , 166 , 169 , 170 , 174 , 176 , 178 , 179 , 181 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 199 , 221 , 228 , 233 , 234 , 235 , 267 , 286 , 287 , 288 , 290 , 308 , 309 , 311 , 312 , 315 , 316 , 319 , 324 , 350 ,
Mutations in critical regions:
Chains
Hinge
Domain swapped interface Non-swapped interface Swapped Domain
A No mutation No mutation No mutation CME(118)CYS, B No mutation No mutation No mutation CME(118)CYS,
HIDE output:
JMOL Visualization:
2D-plot:
JOY Structural annotation for hinge hinge and swapped domain:
JOY output:
