Pfam Domains mapped on to the structure: 1F8M

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00463	Isocitrate lyase family	PF00463	PF00463
2	A	PF00463	Isocitrate lyase family	PF00463	PF00463
3	A	PF13714	Phosphoenolpyruvate phosphomutase	PF13714	PF13714

Conserved Domain Database Superfamily Annotations: 1F8M

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1F8M	119341	cd06556	ICL_KPHMT -	cl00435
2	1F8M	212216	cl00435	ICL_KPHMT	superfamily - -

Structural Details of PDB entry 1F8M PDBid Chains Hinge Swapped Domain 1F8M A,D,C,B A:346-348,D:346-348,C:346-348,B:346-348 A:349-384,D:349-384,C:349-384,B:349-384 Swapped-domain interface residues and interactions: Chains Residues A 75, 76, 79, 80, 83, 84, 85, 320, 329, 330, 333, 349, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 365, 366, 369, 370, 371, 373, 374, 376, 377, 378, 379, 380, 381, 383, 388, 390, B 75, 76, 79, 80, 83, 84, 85, 320, 329, 330, 333, 349, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 365, 366, 369, 370, 371, 373, 374, 376, 377, 378, 379, 380, 381, 383, 388, 390, C 75, 76, 79, 80, 83, 84, 85, 320, 329, 330, 333, 349, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 365, 366, 369, 370, 371, 373, 374, 376, 377, 378, 379, 380, 381, 383, 388, 390, D 75, 76, 79, 80, 83, 84, 85, 320, 329, 330, 333, 349, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 365, 366, 369, 370, 371, 373, 374, 376, 377, 378, 379, 380, 381, 383, 390, Non-swapped-domain interface residues and interactions: Chains Residues A 1, 2, 4, 5, 29, 30, 34, 36, 37, 38, 40, 41, 42, 44, 45, 47, 48, 50, 51, 54, 55, 65, 67, 69, 73, 93, 97, 98, 101, 102, 103, 104, 105, 106, 107, 109, 110, 111, 113, 114, 115, 122, 123, 126, 129, 130, 132, 133, 136, 137, 144, 145, 147, 159, 160, 161, 162, 163, 165, 166, 169, 187, 188, 190, 193, 194, 195, 196, 207, 210, 211, 214, 236, 239, 240, 241, 253, 254, 255, 256, 257, 259, 287, 316, 317, 318, 319, 321, 322, 323, 346, 386, 393, 394, 396, 397, 399, 401, 402, 404, 405, 406, 408, 409, 410, 412, 413, 414, 415, 416, 417, 419, 420, 421, 422, 425, 426, 427, B 1, 2, 4, 5, 29, 30, 34, 36, 37, 38, 40, 41, 42, 44, 45, 47, 48, 50, 51, 54, 55, 58, 65, 67, 69, 73, 93, 97, 98, 101, 102, 103, 104, 105, 106, 107, 109, 110, 111, 113, 114, 115, 122, 123, 126, 127, 129, 130, 132, 133, 136, 137, 145, 147, 159, 160, 161, 162, 163, 165, 166, 169, 185, 187, 188, 190, 193, 194, 195, 196, 207, 210, 211, 214, 236, 239, 240, 241, 253, 254, 255, 256, 257, 259, 260, 287, 316, 317, 318, 319, 321, 322, 323, 346, 386, 393, 394, 396, 397, 399, 401, 402, 404, 405, 406, 408, 409, 410, 412, 414, 415, 416, 417, 419, 420, 421, 422, 425, 426, 427, C 1, 2, 4, 5, 29, 30, 34, 36, 37, 38, 40, 41, 42, 44, 45, 47, 48, 50, 51, 54, 55, 58, 65, 67, 69, 73, 93, 97, 98, 101, 102, 103, 104, 105, 106, 107, 109, 110, 111, 113, 114, 115, 122, 123, 126, 129, 130, 132, 133, 136, 137, 144, 145, 147, 159, 160, 161, 162, 163, 165, 166, 169, 170, 185, 187, 188, 190, 193, 194, 195, 196, 207, 210, 211, 214, 236, 239, 240, 241, 253, 254, 255, 256, 257, 259, 260, 287, 314, 316, 317, 318, 319, 321, 322, 323, 346, 386, 393, 394, 396, 397, 399, 401, 402, 404, 405, 406, 408, 409, 410, 412, 413, 414, 415, 416, 417, 419, 420, 421, 422, 425, 426, 427, D 1, 2, 4, 5, 29, 30, 34, 36, 37, 38, 40, 41, 42, 44, 45, 47, 48, 50, 51, 54, 55, 58, 65, 67, 69, 73, 93, 97, 98, 101, 102, 103, 104, 105, 106, 107, 109, 110, 111, 113, 114, 115, 122, 123, 126, 129, 130, 132, 133, 136, 137, 144, 145, 147, 159, 160, 161, 162, 163, 165, 166, 169, 187, 188, 190, 193, 194, 195, 196, 203, 207, 210, 211, 214, 236, 239, 240, 241, 253, 254, 255, 256, 257, 259, 260, 287, 316, 317, 318, 319, 321, 322, 323, 346, 386, 388, 393, 394, 396, 397, 399, 401, 402, 404, 405, 406, 408, 409, 410, 412, 413, 414, 415, 416, 417, 419, 420, 421, 422, 425, 426,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
D	No mutation	No mutation	No mutation	No mutation
C	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

D:1F8M

A:1F8M

B:1F8M

C:1F8M

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1F8M.ali
atm file:	1F8M.atm
cof file:	1F8M.cof
hbd file:	1F8M.hbd
pdb file:	1F8M.pdb
psa file:	1F8M.psa
sst file:	1F8M.sst