3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1EUW

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00692 dUTPase PF00692 PF00692

Gene Ontology Annotations: 1EUW

No. GO ID GO Description Linkout - AmiGO

1 GO:0046080 dUTP metabolic process GO:0046080

Conserved Domain Database Superfamily Annotations: 1EUW

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1EUW 143638 cd07557 trimeric_dUTPase - cl00493

2 1EUW 207077 cl00493 trimeric_dUTPase superfamily - -

Structural Details of PDB entry 1EUW

Structural Details of PDB entry 1EUW

PDBid Chains Hinge Swapped Domain

1EUW A,B A:125-129,B:125-129 A:130-136,B:130-136

Swapped-domain interface residues and interactions:

Chains Residues
A 130, 131, 132, 133, 134, 135, 136,

B 4, 5, 6, 7, 8, 130, 131, 132, 133, 134, 135, 136,

C 4, 5, 6, 7, 8,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 1, 2, 3, 4, 5, 6, 7, 8, 9, 21, 23, 25, 26, 27, 28, 29, 30, 31, 46, 48, 50, 56, 58, 62, 63, 64, 69, 70, 72, 75, 76, 81, 83, 84, 85, 86, 88, 90, 91, 92, 94, 100, 102, 104, 106, 119, 121, 122, 123, 124, 125, 126, 127, 128, 129,

B 1, 2, 3, 9, 21, 23, 25, 26, 27, 28, 29, 30, 31, 46, 48, 50, 56, 58, 62, 63, 64, 69, 70, 72, 75, 76, 81, 83, 84, 85, 86, 88, 90, 91, 92, 94, 100, 102, 104, 106, 119, 121, 122, 123, 124, 125, 126, 127, 128, 129,

C 1, 2, 3, 9, 21, 23, 25, 26, 27, 28, 29, 30, 31, 46, 48, 50, 56, 58, 62, 63, 64, 69, 70, 72, 75, 76, 81, 83, 84, 85, 86, 88, 90, 91, 92, 94, 100, 102, 104, 106, 119, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1EUW C:1EUW

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1EUW.ali
atm file: 1EUW.atm
cof file: 1EUW.cof
hbd file: 1EUW.hbd
html file: 1EUW.html
pdb file: 1EUW.pdb
ps file: 1EUW.ps
psa file: 1EUW.psa
rtf file: 1EUW.rtf
sst file: 1EUW.sst
tem file: 1EUW.tem