3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1E5X

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00291 Pyridoxal-phosphate dependent enzyme PF00291 PF00291

Conserved Domain Database Superfamily Annotations: 1E5X

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1E5X 107206 cd01563 Thr-synth_1 - cl00342

2 1E5X 212605 cl00342 Trp-synth-beta_II superfamily - -

3 1E5X 212605 cl00342 Trp-synth-beta_II superfamily - -

Structural Details of PDB entry 1E5X

Structural Details of PDB entry 1E5X

PDBid Chains Hinge Swapped Domain

1E5X A,B A:448-461,B:448-461 A:462-486,B:462-479

Swapped-domain interface residues and interactions:

Chains Residues
A 234, 235, 236, 237, 238, 239, 247, 462, 463, 464, 465, 466, 468, 471, 474, 475, 476, 478, 479, 486,

B 234, 235, 236, 237, 238, 239, 247, 462, 463, 464, 465, 466, 468, 471, 474, 475, 476, 478,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 16, 17, 18, 19, 20, 21, 96, 97, 98, 99, 101, 126, 127, 132, 133, 134, 135, 137, 138, 141, 147, 148, 150, 156, 157, 158, 160, 185, 201, 204, 205, 206, 207, 209, 211, 219, 222, 225, 226, 228, 229, 230, 231, 232, 233, 250, 251, 254, 255, 281, 283, 395, 396, 397, 398, 400, 424, 426, 434, 436, 437, 439, 442, 443, 446, 459, 461,

B 17, 18, 19, 20, 21, 96, 97, 98, 99, 101, 126, 127, 132, 133, 134, 135, 137, 138, 141, 147, 148, 150, 156, 157, 158, 160, 185, 201, 204, 205, 206, 207, 209, 211, 219, 222, 225, 226, 228, 229, 230, 231, 232, 233, 250, 251, 254, 255, 281, 283, 395, 396, 397, 398, 400, 424, 434, 436, 437, 439, 442, 443, 446, 459, 461,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1E5X B:1E5X

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1E5X.ali
atm file: 1E5X.atm
cof file: 1E5X.cof
hbd file: 1E5X.hbd
html file: 1E5X.html
pdb file: 1E5X.pdb
ps file: 1E5X.ps
psa file: 1E5X.psa
rtf file: 1E5X.rtf
sst file: 1E5X.sst
tem file: 1E5X.tem