3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1DUB

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00378 Enoyl-CoA hydratase/isomerase family PF00378 PF00378

Gene Ontology Annotations: 1DUB

No. GO ID GO Description Linkout - AmiGO

1 GO:0008152 metabolic process GO:0008152

Conserved Domain Database Superfamily Annotations: 1DUB

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1DUB 119339 cd06558 crotonase-like - cl15762

2 1DUB 210162 cl15762 crotonase-like superfamily - -

3 1DUB 210162 cl15762 crotonase-like superfamily - -

Structural Details of PDB entry 1DUB

Structural Details of PDB entry 1DUB

PDBid Chains Hinge Swapped Domain

1DUB A,C,B A:249-253,C:249-253,B:249-253 A:254-290,C:254-290,B:254-290

Swapped-domain interface residues and interactions:

Chains Residues
A 100, 101, 104, 107, 108, 111, 112, 166, 167, 168, 169, 170, 171, 172, 173, 174, 177, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 272, 275, 276, 277, 279, 280, 287, 290,

B 100, 101, 104, 107, 108, 111, 112, 166, 167, 168, 169, 170, 171, 172, 173, 174, 177, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 272, 273, 275, 276, 277, 279, 280, 287, 290,

C 100, 101, 104, 106, 107, 108, 111, 112, 166, 167, 168, 169, 170, 171, 172, 173, 174, 177, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 272, 273, 275, 276, 277, 279, 280, 287, 290,

D 109, 258, 265, 268,

E 109, 258, 265, 268,

F 109, 249, 258, 265, 268,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 77, 103, 105, 106, 109, 113, 115, 116, 117, 121, 125, 127, 129, 147, 149, 150, 151, 165, 176, 178, 180, 181, 182, 183, 184, 185, 186, 187, 189, 190, 192, 193, 194, 196, 205, 207, 208, 210, 211, 225, 228, 229, 232, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 249, 250, 251, 252, 253,

B 77, 103, 105, 106, 109, 113, 115, 116, 117, 118, 119, 125, 127, 129, 147, 149, 150, 151, 165, 176, 178, 180, 181, 182, 183, 184, 185, 186, 187, 189, 190, 192, 193, 194, 196, 202, 204, 205, 207, 210, 211, 225, 228, 229, 232, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 249, 250, 251, 252, 253,

C 77, 103, 109, 113, 115, 116, 117, 121, 125, 127, 147, 149, 150, 151, 165, 176, 178, 180, 181, 182, 183, 184, 185, 186, 187, 189, 190, 192, 193, 194, 196, 204, 205, 207, 210, 211, 225, 228, 229, 232, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 249, 250, 251, 252, 253,

D 77, 100, 101, 103, 104, 105, 106, 107, 108, 111, 112, 113, 115, 116, 117, 121, 125, 127, 129, 147, 149, 150, 151, 165, 166, 167, 168, 169, 170, 172, 173, 174, 176, 177, 178, 180, 181, 182, 183, 184, 185, 186, 187, 189, 190, 192, 193, 194, 196, 204, 205, 207, 208, 210, 211, 225, 228, 229, 232, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 259, 260, 261, 262, 263, 264, 266, 267, 272, 275, 276, 277, 279, 280, 287, 290,

E 77, 100, 101, 103, 104, 105, 106, 107, 108, 111, 112, 113, 115, 116, 117, 125, 127, 129, 147, 149, 150, 151, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 176, 177, 178, 180, 181, 182, 183, 184, 185, 186, 187, 189, 190, 192, 193, 194, 196, 205, 207, 210, 211, 225, 228, 229, 232, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 259, 260, 261, 262, 263, 264, 266, 267, 272, 273, 275, 276, 277, 279, 280, 287,

F 77, 100, 101, 103, 104, 106, 108, 111, 112, 113, 115, 116, 117, 125, 127, 129, 147, 149, 150, 151, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 176, 177, 178, 180, 181, 182, 183, 184, 185, 186, 187, 189, 190, 192, 193, 194, 196, 204, 205, 207, 210, 211, 225, 228, 229, 232, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 250, 251, 252, 253, 254, 255, 256, 257, 259, 260, 261, 262, 263, 264, 266, 267, 272, 273, 275, 276, 277, 279, 280, 287, 290,

Swapped domains are represented using trasperent spheres.
Non-swapped part is reprented using light color and cartoon reprentation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

C No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

3:1DUB A:1DUB E:1DUB

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1DUB.ali
atm file: 1DUB.atm
cof file: 1DUB.cof
hbd file: 1DUB.hbd
html file: 1DUB.html
pdb file: 1DUB.pdb
ps file: 1DUB.ps
psa file: 1DUB.psa
rtf file: 1DUB.rtf
sst file: 1DUB.sst
tem file: 1DUB.tem