3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1DFB

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 L PF13895 Immunoglobulin domain PF13895 PF13895

2 L PF13895 Immunoglobulin domain PF13895 PF13895

3 L PF13927 Immunoglobulin domain PF13927 PF13927

4 L PF13927 Immunoglobulin domain PF13927 PF13927

5 H PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 1DFB

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1DFB 143182 cd04981 IgV_H - cl11960

2 1DFB 212623 cl11960 Ig superfamily - -

3 1DFB 143186 cd04985 IgC_CH1 - cl11960

4 1DFB 212623 cl11960 Ig superfamily - -

5 1DFB 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 1DFB

Structural Details of PDB entry 1DFB

PDBid Chains Hinge Swapped Domain

1DFB H,L H:179-182,L:160-163 H:183-229,L:164-212

Swapped-domain interface residues and interactions:

Chains Residues
H 184, 190, 192, 194, 196, 222, 228,

L 165, 172, 174, 176, 178, 205, 212,

Non-swapped-domain interface residues and interactions:

Chains Residues
H 35, 39, 44, 45, 47, 95, 100, 103, 105, 109, 110, 111, 112, 113, 114, 116, 117, 118, 135, 136, 137, 138, 140, 141, 142, 145, 146, 150, 154, 156, 177, 178, 179, 180, 182,

L 32, 36, 38, 43, 44, 46, 49, 50, 55, 87, 89, 91, 93, 94, 96, 112, 114, 115, 116, 119, 121, 122, 125, 127, 129, 131, 133, 135, 136, 158, 160, 161, 162,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

H No mutation No mutation No mutation No mutation

L No mutation No mutation VAL(43)ALA, TYR(87)PHE, SER(93)PRO, TYR(94)TRP, No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1DFB

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1DFB.ali
atm file: 1DFB.atm
cof file: 1DFB.cof
hbd file: 1DFB.hbd
html file: 1DFB.html
pdb file: 1DFB.pdb
ps file: 1DFB.ps
psa file: 1DFB.psa
rtf file: 1DFB.rtf
sst file: 1DFB.sst
tem file: 1DFB.tem