3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1CW1

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00180 Isocitrate/isopropylmalate dehydrogenase PF00180 PF00180

Conserved Domain Database Superfamily Annotations: 1CW1

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1CW1 212218 cl00445 Iso_dh superfamily - -

2 1CW1 212218 cl00445 Iso_dh superfamily - -

Structural Details of PDB entry 1CW1

Structural Details of PDB entry 1CW1

PDBid Chains Hinge Swapped Domain

1CW1 A,B A:187-201,B:187-201 A:2-186,B:2-186

Swapped-domain interface residues and interactions:

Chains Residues
A 110, 111, 112, 113, 120, 123, 139, 140, 141, 142, 156, 157, 159, 160, 161, 162, 163, 164, 165, 166, 167, 171, 174, 175, 178, 179, 182, 183, 185, 187, 189, 233, 234, 236, 290, 291,

B 110, 111, 112, 113, 120, 123, 139, 140, 141, 142, 156, 157, 159, 160, 161, 162, 163, 164, 165, 166, 167, 171, 174, 175, 178, 179, 182, 183, 185, 187, 189, 233, 234, 236, 290, 291,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 188, 190, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 208, 230, 232, 235, 237, 244, 282, 283, 286, 287, 304, 305, 307, 308, 311, 312, 315, 316, 320, 416,

B 188, 190, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 208, 230, 232, 235, 237, 244, 282, 283, 286, 287, 304, 305, 307, 308, 311, 312, 315, 316, 320,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1CW1 B:1CW1

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1CW1.ali
atm file: 1CW1.atm
cof file: 1CW1.cof
hbd file: 1CW1.hbd
html file: 1CW1.html
pdb file: 1CW1.pdb
ps file: 1CW1.ps
psa file: 1CW1.psa
rtf file: 1CW1.rtf
sst file: 1CW1.sst
tem file: 1CW1.tem