3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1CTS

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00285 Citrate synthase PF00285 PF00285

Conserved Domain Database Superfamily Annotations: 1CTS

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1CTS 99858 cd06105 ScCit1-2_like - cl00416

2 1CTS 199305 cl00416 CS_ACL-C_CCL superfamily - -

3 1CTS 199305 cl00416 CS_ACL-C_CCL superfamily - -

Structural Details of PDB entry 1CTS

Structural Details of PDB entry 1CTS

PDBid Chains Hinge Swapped Domain

1CTS A,B A:417-423,B:417-423 A:424-437,B:424-437

Swapped-domain interface residues and interactions:

Chains Residues
A 28, 31, 32, 33, 49, 50, 51, 52, 53, 54, 239, 241, 424, 425, 426, 427, 428, 430, 431, 433, 434, 435, 437,

B 28, 31, 32, 33, 49, 50, 51, 52, 53, 54, 239, 241, 424, 425, 426, 427, 428, 430, 431, 433, 434, 435,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 20, 21, 24, 25, 29, 30, 34, 35, 36, 37, 38, 39, 41, 42, 43, 44, 45, 46, 47, 48, 57, 123, 126, 127, 130, 131, 132, 134, 135, 139, 143, 146, 147, 149, 150, 158, 242, 243, 246, 247, 250, 251, 254, 255, 256, 260, 264, 267, 268, 270, 271, 272, 273, 276, 417, 418, 419, 420, 421, 422, 423,

B 20, 21, 24, 25, 29, 30, 34, 35, 36, 37, 38, 39, 41, 42, 43, 44, 45, 46, 47, 48, 57, 123, 126, 127, 130, 131, 132, 134, 135, 139, 143, 146, 147, 149, 150, 158, 242, 243, 246, 247, 250, 251, 254, 255, 256, 260, 264, 267, 268, 270, 271, 272, 273, 276, 417, 418, 419, 420, 421, 422, 423,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1CTS B:1CTS

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1CTS.ali
atm file: 1CTS.atm
cof file: 1CTS.cof
hbd file: 1CTS.hbd
html file: 1CTS.html
pdb file: 1CTS.pdb
ps file: 1CTS.ps
psa file: 1CTS.psa
rtf file: 1CTS.rtf
sst file: 1CTS.sst
tem file: 1CTS.tem