Pfam Domains mapped on to the structure: 1CKS
No.
Chain ID
Pfam ID
Pfam Description
Linkout - Pfam
Linkout - CDD
1
A
PF01111
Cyclin-dependent kinase regulatory subunit
PF01111
PF01111
Conserved Domain Database Superfamily Annotations: 1CKS
Structural Details of PDB entry 1CKS
Structural Details of PDB entry 1CKS
PDBid
Chains
Hinge
Swapped Domain
1CKS
A,C,B
A:61-65,C:61-65,B:61-65
A:66-75,C:66-79,B:66-79
Swapped-domain interface residues and interactions:
Chains
Residues
A
66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 75 ,
B
66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 78 , 79 ,
C
66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 78 , 79 ,
D
16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ,
E
15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ,
F
15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ,
Non-swapped-domain interface residues and interactions:
Chains
Residues
A
5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 29 , 32 , 34 , 35 , 37 , 38 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ,
B
2 , 3 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 29 , 30 , 32 , 34 , 35 , 37 , 38 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ,
C
2 , 3 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 29 , 32 , 34 , 35 , 36 , 37 , 38 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ,
D
2 , 3 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 25 , 26 , 29 , 30 , 32 , 34 , 35 , 37 , 38 , 48 , 49 , 50 , 51 , 52 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 78 , 79 ,
E
2 , 3 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 25 , 26 , 29 , 32 , 34 , 35 , 36 , 37 , 38 , 48 , 50 , 51 , 52 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 78 , 79 ,
F
5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 25 , 26 , 29 , 32 , 34 , 35 , 37 , 38 , 49 , 50 , 51 , 52 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ,
Swapped domains are represented using trasperent spheres.
Non-swapped part is reprented using light color and cartoon reprentation.
Hinge region is shown in yellow color.
Mutations in critical regions:
Chains
Hinge
Domain swapped interface
Non-swapped interface
Swapped Domain
A No mutation No mutation No mutation No mutation
C No mutation No mutation No mutation No mutation
B No mutation No mutation No mutation No mutation
HIDE output:
JMOL Visualization:
2D-plot:
JOY Structural annotation for hinge hinge and swapped domain:
JOY output: