Pfam Domains mapped on to the structure: 1CGS

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	H	PF13895	Immunoglobulin domain	PF13895	PF13895

Conserved Domain Database Superfamily Annotations: 1CGS

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	1CGS	143182	cd04981	IgV_H -	cl11960
2	1CGS	212623	cl11960	Ig	superfamily - -
3	1CGS	212623	cl11960	Ig	superfamily - -
4	1CGS	212623	cl11960	Ig	superfamily - -

Structural Details of PDB entry 1CGS PDBid Chains Hinge Swapped Domain 1CGS H,L H:42-46,L:46-50 H:1-41,L:1-45 Swapped-domain interface residues and interactions: Chains Residues H 35, 39, 102, L 1, 37, 39, 41, 43, Non-swapped-domain interface residues and interactions: Chains Residues H 44, 45, 47, 50, 59, 61, 95, 101, 103, 104, 105, 106, 107, 108, 125, 126, 127, 128, 129, 130, 131, 133, 134, 140, 144, 146, 165, 167, 168, 169, 170, 172, 174, 179, 181, 183, 211, L 48, 49, 51, 54, 55, 60, 92, 99, 100, 101, 102, 103, 121, 122, 123, 124, 126, 128, 129, 132, 136, 138, 140, 142, 143, 165, 166, 167, 168, 169, 179, 181, 183, 185, 212, 213, 219,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
H	No mutation	GLU(39)GLN, SER(102)PRO,	ASN(59)LYS, ARG(61)ASN, SER(101)ALA,	LEU(5)VAL, GLN(19)LYS, GLU(31)SER, VAL(37)ILE, GLU(39)GLN,
L	No mutation	HIS(39)TYR,	LEU(51)PRO,	SER(7)THR, PRO(25)SER, HIS(39)TYR,

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1CGS

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	1CGS.ali
atm file:	1CGS.atm
cof file:	1CGS.cof
hbd file:	1CGS.hbd
html file:	1CGS.html
pdb file:	1CGS.pdb
ps file:	1CGS.ps
psa file:	1CGS.psa
rtf file:	1CGS.rtf
sst file:	1CGS.sst
tem file:	1CGS.tem