3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1B4J

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 L PF13927 Immunoglobulin domain PF13927 PF13927

2 L PF13927 Immunoglobulin domain PF13927 PF13927

3 L PF13895 Immunoglobulin domain PF13895 PF13895

4 L PF13895 Immunoglobulin domain PF13895 PF13895

5 L PF00047 Immunoglobulin domain PF00047 PF00047

6 H PF13927 Immunoglobulin domain PF13927 PF13927

Conserved Domain Database Superfamily Annotations: 1B4J

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1B4J 143182 cd04981 IgV_H - cl11960

2 1B4J 212623 cl11960 Ig superfamily - -

3 1B4J 143186 cd04985 IgC_CH1 - cl11960

4 1B4J 212623 cl11960 Ig superfamily - -

5 1B4J 212623 cl11960 Ig superfamily - -

Structural Details of PDB entry 1B4J

Structural Details of PDB entry 1B4J

PDBid Chains Hinge Swapped Domain

1B4J H,L H:42-47,L:41-46 H:2-41,L:1-40

Swapped-domain interface residues and interactions:

Chains Residues
H 39,

L 32, 34, 36, 38,

Non-swapped-domain interface residues and interactions:

Chains Residues
H 44, 45, 47, 50, 59, 61, 62, 95, 102, 103, 104, 105, 107, 109, 126, 127, 128, 129, 131, 133, 134, 135, 139, 141, 145, 147, 168, 170, 171, 173, 174, 175, 183, 185, 187, 213,

L 41, 43, 44, 46, 49, 50, 55, 87, 91, 94, 95, 96, 98, 100, 116, 117, 118, 119, 121, 123, 124, 131, 133, 135, 137, 138, 160, 162, 163, 164, 167, 174, 176, 178, 180, 207, 212, 214,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

H No mutation No mutation No mutation No mutation

L GLU(41)GLY, GLN(42)LYS, SER(43)ALA, SER(34)ASN, GLU(41)GLY, SER(43)ALA, GLY(50)ALA, TYR(55)GLN, HIS(87)TYR, TYR(94)THR, PHE(96)TYR, SER(100)GLN, LYS(9)SER, MET(11)LEU, TYR(12)SER, VAL(13)ALA, SER(14)PHE, ILE(15)VAL, GLU(17)ASP, LEU(21)ILE, SER(22)THR, LYS(24)ARG, GLU(27)GLN, ASN(28)SER, VAL(29)ILE, ASP(30)SER, THR(31)SER, VAL(33)LEU, SER(34)ASN,

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

H:1B4J

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1B4J.ali
atm file: 1B4J.atm
cof file: 1B4J.cof
hbd file: 1B4J.hbd
pdb file: 1B4J.pdb
psa file: 1B4J.psa
sst file: 1B4J.sst