3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1A59

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00285 Citrate synthase PF00285 PF00285

Conserved Domain Database Superfamily Annotations: 1A59

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1A59 99864 cd06111 DsCS_like - cl00416

2 1A59 199305 cl00416 CS_ACL-C_CCL superfamily - -

3 1A59 199305 cl00416 CS_ACL-C_CCL superfamily - -

Structural Details of PDB entry 1A59

Structural Details of PDB entry 1A59

PDBid Chains Hinge Swapped Domain

1A59 A,B A:360-372,B:360-372 A:373-378,B:373-378

Swapped-domain interface residues and interactions:

Chains Residues
A 33, 34, 38, 374, 375, 376, 377, 378,

B 33, 34, 38, 374, 375, 376, 377,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 20, 21, 30, 32, 35, 42, 43, 55, 56, 57, 79, 82, 83, 86, 87, 88, 91, 92, 95, 98, 99, 102, 103, 105, 106, 107, 111, 112, 187, 188, 189, 190, 193, 194, 197, 198, 201, 202, 203, 204, 207, 210, 211, 214, 215, 217, 218, 219, 220, 221, 270, 271, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372,

B 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 20, 21, 30, 32, 35, 42, 43, 55, 56, 57, 79, 82, 83, 86, 87, 88, 91, 92, 95, 98, 99, 102, 103, 105, 106, 107, 111, 112, 187, 188, 189, 190, 193, 194, 197, 198, 201, 202, 203, 204, 207, 210, 211, 214, 215, 217, 218, 219, 220, 221, 270, 271, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation No mutation No mutation No mutation

B No mutation No mutation No mutation No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1A59 B:1A59

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1A59.ali
atm file: 1A59.atm
cof file: 1A59.cof
hbd file: 1A59.hbd
html file: 1A59.html
pdb file: 1A59.pdb
ps file: 1A59.ps
psa file: 1A59.psa
rtf file: 1A59.rtf
sst file: 1A59.sst
tem file: 1A59.tem