Table 1a: Dial0 Single Domain Problematic@ Cases


No

Code

Class

Fold

Protein Name

1

1ccr-

All alpha proteins

Cytochrome C

Cytochrome C

2

1ash-

All alpha proteins

Globin-like

Hemoglobin

3

1babB

All alpha proteins

Globin-like

Hemoglobin thionville

4

1bgeB

All alpha proteins

4-helical cytokines

Colonystimulatingfactor

5

1bcfA

All alpha proteins

Ferritin-like

Bacterioferin

6

1fha-

All alpha proteins

Ferritin-like

Ferritin

7

1aaj-

All beta proteins

Cupredoxins

Amicyanin

8

1cauA

All beta proteins

Double stranded beta helix

Canavalin

9

1dynA

All beta proteins

PH-domainlike

Dynamin

10

4rhv1

All beta proteins

Viral coat and capsid protein

Rhinovirus coat protein

11

1add-

Alpha and Beta (a/b)

TIM barrel

Adinosine deaminase

12

1ads-

Alpha and Beta (a/b)

TIM barrel

Aldose reductase

13

1tph1

Alpha and Beta (a/b)

TIM barrel

Triose phosphate isomerase

14

4xiaA

Alpha and Beta (a/b)

TIM barrel

Xylase isomerase

15

153l-

Alpha and Beta (a+b)

Lysozyme-like

Lysozyme

16

1ayaA

Alpha and Beta (a+b)

SH2-like

Tyrosine phosphate

17

1hjrA

Alpha and Beta (a+b)

Ribonuclease H-like motif

Resolvase

18

7rsa-

Alpha and Beta (a+b)

RNase A-like

Ribonuclease A

19

5fd1-

Alpha and Beta (a+b)

Ferrodoxin-like

Ferrodoxin

20

1bet-

Small proteins

Cystine-knot cytokines

Beta nerve growth factor

21

1ccf-

Small proteins

Knottins

Coagulation factor

22

1cdtA

Small proteins

Snake toxin-like

Cridio toxin

23

1colA

Membrane, cell surface proteins and peptides

Toxin membrane translocation domains

Colicin A



@Problematic cases are those where the number of domains identified by DIAL0 did not match with crystallographer's definition.