HEADER NUCLEAR RECEPTOR COMPND MOL_ID: 1; COMPND 2 MOLECULE: ESTROGEN RECEPTOR ALPHA; COMPND 3 CHAIN: A; COMPND 4 FRAGMENT: LIGAND-BINDING DOMAIN; COMPND 5 SYNONYM: OESTROGEN RECEPTOR, ER LBD; COMPND 6 ENGINEERED: YES; COMPND 7 BIOLOGICAL_UNIT: HOMODIMER; COMPND 8 OTHER_DETAILS: COMPLEXED WITH 4-HYDROXYTAMOXIFEN SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 GENE: ESTROGEN RECEPTOR ALPHA; SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 6 EXPRESSION_SYSTEM_STRAIN: BL21(DE3)PLYSS; SOURCE 7 EXPRESSION_SYSTEM_CELLULAR_LOCATION: CYTOPLASM; SOURCE 8 EXPRESSION_SYSTEM_PLASMID: PET23D RESOLUTION SOURCE : SSRL AUTHOR A.K.SHIAU,D.BARSTAD,P.M.LORIA,L.CHENG,P.J.KUSHNER,D.A.AGARD, AUTHOR 2 G.L.GREENE RESOLUTION : BRUNGER EXPDTA X-RAY DIFFRACTION JRNL AUTH A.K.SHIAU,D.BARSTAD,P.M.LORIA,L.CHENG,P.J.KUSHNER, JRNL AUTH 2 D.A.AGARD,G.L.GREENE JRNL TITL THE STRUCTURAL BASIS OF ESTROGEN JRNL TITL 2 RECEPTOR/COACTIVATOR RECOGNITION AND THE JRNL TITL 3 ANTAGONISM OF THIS INTERACTION BY TAMOXIFEN JRNL REF CELL (CAMBRIDGE,MASS.) V. 95 927 1998 JRNL REFN ASTM CELLB5 US ISSN 0092-8674 0998 RESOLUTION 1.90 ANGSTROMS.

Sequence in PIR format:

>P1;3ertA structureX:3ertA: 306 :A: 552 :A:estrogen receptor alpha:homo sapiens: 9.99: 9.99 LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLE CAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN SGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKC KNVVPLYDLLLEMLDAHRLHAP*

View SSTRUC file for 3ertA

Rasmol View of 3ertA