HEADER AMINE/CARBOXYLATE LIGASE COMPND MOL_ID: 1; COMPND 2 MOLECULE: GLUTATHIONE SYNTHETASE; COMPND 3 CHAIN: A; COMPND 4 EC: 6.3.2.3; COMPND 5 ENGINEERED: YES; COMPND 6 BIOLOGICAL_UNIT: HOMODIMER SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGAN: BRAIN; SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 6 EXPRESSION_SYSTEM_STRAIN: TG1; SOURCE 7 EXPRESSION_SYSTEM_PLASMID: PRG1; SOURCE 8 OTHER_DETAILS: CDNA RESOLUTION SOURCE : APS AUTHOR G.POLEKHINA,P.BOARD,J.ROSSJOHN,M.W.PARKER RESOLUTION : MURSHUDOV,VAGIN,DODSON EXPDTA X-RAY DIFFRACTION JRNL AUTH G.POLEKHINA,P.G.BOARD,R.R.GALI,J.ROSSJOHN, JRNL AUTH 2 M.W.PARKER JRNL TITL MOLECULAR BASIS OF GLUTATHIONE SYNTHETASE JRNL TITL 2 DEFICIENCY AND A RARE GENE PERMUTATION EVENT JRNL REF EMBO J. V. 18 3204 1999 JRNL REFN ASTM EMJODG UK ISSN 0261-4189 0897 RESOLUTION 2.10 ANGSTROMS.

Sequence in PIR format:

>P1;2hgsA structureX:2hgsA: 3 :A: 474 :A:glutathione synthetase:homo sapiens: 9.99: 9.99 TNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVD AVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASF GGLASRTPAVHRHVLSVLSKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENEL LARNIHVIRRTFEDISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQLA GTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGE EMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTK AIEHADGGVAAGVAVLDNPYPV*

View SSTRUC file for 2hgsA

Rasmol View of 2hgsA