HEADER    TRANSFERASE                             
COMPND    MOL_ID: 1;                                                  
COMPND   2 MOLECULE: PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT;       
COMPND   3 CHAIN: A;                                                  
COMPND   4 SYNONYM: CAAX FARNESYLTRANSFERASE ALPHA SUBUNIT, RAS       
COMPND   5 PROTEINS PRENYLTRANSFERASE ALPHA, FTASE-ALPHA;             
COMPND   6 EC: 2.5.1.-;                                               
COMPND   7 ENGINEERED: YES;                                           
COMPND   8 MOL_ID: 2;                                                 
COMPND   9 MOLECULE: PROTEIN FARNESYLTRANSFERASE BETA SUBUNIT;        
COMPND  10 CHAIN: B;                                                  
COMPND  11 SYNONYM: CAAX FARNESYLTRANSFERASE BETA SUBUNIT, RAS        
COMPND  12 PROTEINS PRENYLTRANSFERASE BETA, FTASE-BETA;               
COMPND  13 EC: 2.5.1.-;                                               
COMPND  14 ENGINEERED: YES                                            
SOURCE    MOL_ID: 1;                                                  
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                         
SOURCE   3 ORGANISM_COMMON: HUMAN;                                    
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                       
SOURCE   5 EXPRESSION_SYSTEM_COMMON: BACTERIA;                        
SOURCE   6 MOL_ID: 2;                                                 
SOURCE   7 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                         
SOURCE   8 ORGANISM_COMMON: HUMAN;                                    
SOURCE   9 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                       
SOURCE  10 EXPRESSION_SYSTEM_COMMON: BACTERIA                         
RESOLUTION  SOURCE               : ROTATING ANODE             
AUTHOR    J.S.TAYLOR,K.L.TERRY,L.S.BEESE                              
RESOLUTION     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-      
EXPDTA    X-RAY DIFFRACTION                                           
JRNL        AUTH   I.M.BELL,S.N.GALLICCHIO,M.ABRAMS,L.S.BEESE,        
JRNL        AUTH 2 D.C.BESHORE,H.BHIMNATHWALA,M.J.BOGUSKY,C.A.BUSER,  
JRNL        AUTH 3 J.C.CULBERSON,J.DAVIDE,M.ELLIS-HUTCHINGS,          
JRNL        AUTH 4 C.FERNANDES,J.B.GIBBS,S.L.GRAHAM,K.A.HAMILTON,     
JRNL        AUTH 5 G.D.HARTMAN,D.C.HEIMBROOK,C.F.HOMNICK,H.E.HUBER,   
JRNL        AUTH 6 J.R.HUFF,K.KASSAHUN,K.S.KOBLAN,N.E.KOHL,R.B.LOBELL,
JRNL        AUTH 7 J.J.LYNCH JR.,R.ROBINSON,A.D.RODRIGUES,J.S.TAYLOR, 
JRNL        AUTH 8 E.S.WALSH,T.M.WILLIAMS,C.B.ZARTMAN                 
JRNL        TITL   3-AMINOPYRROLIDINONE FARNESYLTRANSFERASE           
JRNL        TITL 2 INHIBITORS: DESIGN OF MACROCYCLIC COMPOUNDS WITH   
JRNL        TITL 3 IMPROVED PHARMACOKINETICS AND EXCELLENT CELL       
JRNL        TITL 4 POTENCY                                            
JRNL        REF    J.MED.CHEM.                   V.  45  2388 2002    
JRNL        REFN   ASTM JMCMAR  US ISSN 0022-2623                     
RESOLUTION   1.80 ANGSTROMS.                                  



 Sequence in PIR format: 
>P1;1ld8B
 structureX:1ld8B: 517 :B: 923 :B:protein farnesyltransferase beta subunit:homo sapiens: 9.99: 9.99
 PVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTD
 AYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTE
 EAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGG
 VPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALH
 AQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPE
 NALQPTHPVYNIGPDKVIQATTYFLQKPVPGF*




 View SSTRUC file for 1ld8B 
 Rasmol View of  1ld8B