HEADER LYASE/DNA COMPND MOL_ID: 1; COMPND 2 MOLECULE: 8-OXOGUANINE DNA GLYCOSYLASE; COMPND 3 CHAIN: A; COMPND 4 FRAGMENT: CORE FRAGMENT (RESIDUES 12 TO 325); COMPND 5 SYNONYM: AP LYASE; COMPND 6 ENGINEERED: YES; COMPND 7 MUTATION: YES; COMPND 8 MOL_ID: 2; COMPND 9 MOLECULE: DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(OXO) COMPND 10 GP*GP*TP*CP*TP*AP*CP*C)-3'); COMPND 11 CHAIN: C; COMPND 12 ENGINEERED: YES; COMPND 13 MOL_ID: 3; COMPND 14 MOLECULE: DNA (5'- COMPND 15 D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'); COMPND 16 CHAIN: D; COMPND 17 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 4 EXPRESSION_SYSTEM_COMMON: BACTERIA; SOURCE 5 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 6 EXPRESSION_SYSTEM_PLASMID: PET30A-HOGG1; SOURCE 7 MOL_ID: 2; SOURCE 8 SYNTHETIC: YES; SOURCE 9 MOL_ID: 3; SOURCE 10 SYNTHETIC: YES RESOLUTION SOURCE : CHESS AUTHOR S.D.BRUNER,D.P.NORMAN,G.L.VERDINE RESOLUTION : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE- EXPDTA X-RAY DIFFRACTION JRNL AUTH S.D.BRUNER,D.P.NORMAN,G.L.VERDINE JRNL TITL STRUCTURAL BASIS FOR RECOGNITION AND REPAIR OF THE JRNL TITL 2 ENDOGENOUS MUTAGEN 8-OXOGUANINE IN DNA JRNL REF NATURE V. 403 859 2000 JRNL REFN ASTM NATUAS UK ISSN 0028-0836 RESOLUTION 2.10 ANGSTROMS.

Sequence in PIR format:

>P1;1ebmA structureX:1ebmA: 9 :A: 325 :A:dna (5'-:homo sapiens: 9.99: 9.99 GSEGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYR/SQA SRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVE RLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEE AHKALCILPGVGTQVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPY AGWAQAVLFSADLRQ*

View SSTRUC file for 1ebmA

Rasmol View of 1ebmA