HEADER    OXIDO-REDUCTASE                         
COMPND    MOL_ID: 1;                                                  
COMPND   2 MOLECULE: DIHYDROFOLATE REDUCTASE;                         
COMPND   3 CHAIN: NULL;                                               
COMPND   4 EC: 1.5.1.3;                                               
COMPND   5 ENGINEERED: YES;                                           
COMPND   6 HETEROGEN: TRIMETHOPRIM;                                   
COMPND   7 HETEROGEN: NADPH                                           
SOURCE    MOL_ID: 1;                                                  
SOURCE   2 ORGANISM_SCIENTIFIC: PNEUMOCYSTIS CARINII;                 
SOURCE   3 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                       
SOURCE   4 EXPRESSION_SYSTEM_PLASMID: PT7-7;                          
SOURCE   5 EXPRESSION_SYSTEM_GENE: C-DNA P.CARINII DHFR;              
SOURCE   6 OTHER_DETAILS: RAT-DERIVED                                 
AUTHOR    J.N.CHAMPNESS,A.ACHARI,S.P.BALLANTINE,P.K.BRYANT,           
AUTHOR   2 C.J.DELVES,D.K.STAMMERS                                    
RESOLUTION                    KONNERT,HENDRICKSON,FINZEL      
EXPDTA    X-RAY DIFFRACTION                                           
JRNL        AUTH   J.N.CHAMPNESS,A.ACHARI,S.P.BALLANTINE,P.K.BRYANT,  
JRNL        AUTH 2 C.J.DELVES,D.K.STAMMERS                            
JRNL        TITL   THE STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE
JRNL        TITL 2 REDUCTASE TO 1.9 ANGSTROMS RESOLUTION              
JRNL        REF    STRUCTURE (LONDON)            V.   2   915 1994    
JRNL        REFN   ASTM STRUE6  UK ISSN 0969-2126                 2005
RESOLUTION   1.86 ANGSTROMS.                                  



 Sequence in PIR format: 
>P1;1dyr-
 structureX:1dyr-:   2 : : 206 : :dihydrofolate reductase:pneumocystis carinii: 9.99: 9.99
 NQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRI
 NVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIH
 CDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL*




 View SSTRUC file for 1dyr- 
 Rasmol View of  1dyr-