HEADER OXIDOREDUCTASE COMPND MOL_ID: 1; COMPND 2 MOLECULE: DIHYDROFOLATE REDUCTASE; COMPND 3 CHAIN: A; COMPND 4 SYNONYM: DHFR; COMPND 5 EC: 1.5.1.3 SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: MYCOBACTERIUM TUBERCULOSIS REVDAT 2 28-JUN-00 1DF7 1 SOURCE HETATM DBREF RESOLUTION SOURCE : APS SBC 19ID AUTHOR R.LI,R.SIRAWARAPORN,P.CHITNUMSUB,W.SIRAWARAPORN,J.WOODEN, AUTHOR 2 F.ATHAPPILLY,S.TURLEY,W.G.HOL RESOLUTION : BRUNGER EXPDTA X-RAY DIFFRACTION JRNL AUTH R.LI,R.SIRAWARAPORN,P.CHITNUMSUB,W.SIRAWARAPORN, JRNL AUTH 2 J.WOODEN,F.ATHAPPILLY,S.TURLEY,W.G.HOL JRNL TITL THREE-DIMENSIONAL STRUCTURE OF M. TUBERCULOSIS JRNL TITL 2 DIHYDROFOLATE REDUCTASE REVEALS OPPORTUNITIES FOR JRNL TITL 3 THE DESIGN OF NOVEL TUBERCULOSIS DRUGS JRNL REF J.MOL.BIOL. V. 295 307 2000 JRNL REFN ASTM JMOBAK UK ISSN 0022-2836 RESOLUTION 1.70 ANGSTROMS.

Sequence in PIR format:

>P1;1df7A structureX:1df7A: 1 :A: 159 :A:dihydrofolate reductase:mycobacterium tuberculosis: 9.99: 9.99 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASG AEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLR YRLYSYHRS*

View SSTRUC file for 1df7A

Rasmol View of 1df7A