HEADER    IMMUNE SYSTEM                           
COMPND    MOL_ID: 1;                                                  
COMPND   2 MOLECULE: CHIMERIC DECARBOXYLASE ANTIBODY 21D8;            
COMPND   3 CHAIN: L;                                                  
COMPND   4 FRAGMENT: FAB;                                             
COMPND   5 ENGINEERED: YES;                                           
COMPND   6 OTHER_DETAILS: THE CONSTANT DOMAIN (RESIDUES 103-214) IS   
COMPND   7 FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1-102)
COMPND   8 IS FROM MURINE SOURCE;                                     
COMPND   9 MOL_ID: 2;                                                 
COMPND  10 MOLECULE: CHIMERIC DECARBOXYLASE ANTIBODY 21D8;            
COMPND  11 CHAIN: H;                                                  
COMPND  12 FRAGMENT: FAB;                                             
COMPND  13 ENGINEERED: YES;                                           
COMPND  14 OTHER_DETAILS: THE CONSTANT DOMAIN (RESIDUES 109-230) IS   
COMPND  15 FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1-108)
COMPND  16 IS FROM MURINE SOURCE                                      
COMPND   7 FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1-102)
COMPND   8 IS FROM MURINE SOURCE;                                     
COMPND  15 FROM HUMAN SOURCE, AND THE VARIABLE DOMAIN (RESIDUES 1-108)
COMPND  16 IS FROM MURINE SOURCE                                      
SOURCE    MOL_ID: 1;                                                  
SOURCE   2 ORGANISM_SCIENTIFIC: MUS MUSCULUS + HOMO SAPIENS;          
SOURCE   3 ORGANISM_COMMON: HOUSE MOUSE + HUMAN;                      
SOURCE   4 STRAIN: BALB/C;                                            
SOURCE   5 CELL_LINE: 21D8;                                           
SOURCE   6 ORGAN: SPLEEN;                                             
SOURCE   7 CELL: B-LYMPHOCYTE;                                        
SOURCE   8 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                       
SOURCE   9 EXPRESSION_SYSTEM_COMMON: BACTERIA;                        
SOURCE  10 EXPRESSION_SYSTEM_STRAIN: TOPP2;                           
SOURCE  11 EXPRESSION_SYSTEM_CELLULAR_LOCATION: PERIPLASM;            
SOURCE  12 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                    
SOURCE  13 EXPRESSION_SYSTEM_PLASMID: P4XH-M13;                       
SOURCE  14 MOL_ID: 2;                                                 
SOURCE  15 ORGANISM_SCIENTIFIC: MUS MUSCULUS + HOMO SAPIENS;          
SOURCE  16 ORGANISM_COMMON: HOUSE MOUSE + HUMAN;                      
SOURCE  17 STRAIN: BALB/C;                                            
SOURCE  18 CELL_LINE: 21D8;                                           
SOURCE  19 ORGAN: SPLEEN;                                             
SOURCE  20 CELL: B-LYMPHOCYTE;                                        
SOURCE  21 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                       
SOURCE  22 EXPRESSION_SYSTEM_COMMON: BACTERIA;                        
SOURCE  23 EXPRESSION_SYSTEM_STRAIN: TOPP2;                           
SOURCE  24 EXPRESSION_SYSTEM_CELLULAR_LOCATION: PERIPLASM;            
SOURCE  25 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                    
SOURCE  26 EXPRESSION_SYSTEM_PLASMID: P4XH-M13                        
RESOLUTION  SOURCE               : SSRL                       
AUTHOR    K.HOTTA,I.A.WILSON                                          
RESOLUTION     : G.M.SHELDRICK                                
RESOLUTION  ON METHOD: AUTHOR-DETERMINED                      
EXPDTA    X-RAY DIFFRACTION                                           
JRNL        AUTH   K.HOTTA,D.TANTILLO,H.LANGE,K.N.HOUK,D.HILVERT,     
JRNL        AUTH 2 I.A.WILSON                                         
JRNL        TITL   CATALYSIS OF DECARBOXYLATION BY A PREORGANIZED     
JRNL        TITL 2 HETEROGENEOUS MICROENVIRONMENT: CRYSTAL STRUCTURES 
JRNL        TITL 3 OF ABZYME 21D8                                     
JRNL        REF    J.MOL.BIOL.                   V. 302  1213 2000    
JRNL        REFN   ASTM JMOBAK  UK ISSN 0022-2836                     
RESOLUTION   1.61 ANGSTROMS.                                  



 Sequence in PIR format: 
>P1;1c5cH
 structureX:1c5cH:   1 :H: 230 :H:chimeric decarboxylase antibody 21d8:mus musculus + homo sapiens: 9.99: 9.99
 QVQLLEPGTELVKPGASVKLSCRASGYSFTSYWMHWVKQRPGQGLEWIGLIDPSNGRTNFNDKFKSRATLTVDTS
 SSTAYMQLSSLTSEDSAVYYCVRIAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT
 VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC*




 View SSTRUC file for 1c5cH 
 Rasmol View of  1c5cH