HEADER COMPLEX (INHIBITOR PROTEIN/KINASE) COMPND MOL_ID: 1; COMPND 2 MOLECULE: CYCLIN-DEPENDENT KINASE 6; COMPND 3 CHAIN: A; COMPND 4 ENGINEERED: YES; COMPND 5 MOL_ID: 2; COMPND 6 MOLECULE: P19INK4D; COMPND 7 CHAIN: B; COMPND 8 ENGINEERED: YES; REVDAT 3 04-AUG-99 1BLX 1 COMPND REVDAT 2 08-JUN-99 1BLX 1 COMPND SOURCE MOL_ID: 1; SOURCE 1 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 2 ORGANISM_COMMON: HUMAN; SOURCE 3 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA INSECT CELLS; SOURCE 4 EXPRESSION_SYSTEM_CELL_LINE: SF9; SOURCE 5 EXPRESSION_SYSTEM_VECTOR: GST-CDK6 BACULOVIRUS SOURCE 6 MOL_ID: 2; SOURCE 7 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 8 ORGANISM_COMMON: MOUSE; SOURCE 9 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 10 EXPRESSION_SYSTEM_STRAIN: BL21 (DE3); SOURCE 11 EXPRESSION_SYSTEM_PLASMID: GST FUSION PLASMID; RESOLUTION SOURCE : ESRF AUTHOR D.H.BROTHERTON,V.DHANARAJ,S.WICK,L.BRIZUELA,P.J.DOMAILLE, AUTHOR 2 E.VOLYANIK,X.XU,E.PARISINI,B.O.SMITH,S.J.ARCHER,M.SERRANO, AUTHOR 3 S.L.BRENNER,T.L.BLUNDELL,E.D.LAUE RESOLUTION : MURSHUDOV,VAGIN,DODSON EXPDTA X-RAY DIFFRACTION JRNL AUTH D.H.BROTHERTON,V.DHANARAJ,S.WICK,L.BRIZUELA, JRNL AUTH 2 P.J.DOMAILLE,E.VOLYANIK,X.XU,E.PARISINI,B.O.SMITH, JRNL AUTH 3 S.J.ARCHER,M.SERRANO,S.L.BRENNER,T.L.BLUNDELL, JRNL AUTH 4 E.D.LAUE JRNL TITL CRYSTAL STRUCTURE OF THE COMPLEX OF THE CYCLIN JRNL TITL 2 D-DEPENDENT KINASE CDK6 BOUND TO THE CELL-CYCLE JRNL TITL 3 INHIBITOR P19INK4D JRNL REF NATURE V. 395 244 1998 JRNL REFN ASTM NATUAS UK ISSN 0028-0836 0006 RESOLUTION 1.9 ANGSTROMS.

Sequence in PIR format:

>P1;1blxA structureX:1blxA: 5 :A: 309 :A:p19ink4d:mus musculus: 9.99: 9.99 GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRL FDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT SSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLG KILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE RCKEN*

View SSTRUC file for 1blxA

Rasmol View of 1blxA