HEADER IMMUNOGLOBULIN COMPND MOL_ID: 1; COMPND 2 MOLECULE: MONOCLONAL ANTIBODY C219; COMPND 3 CHAIN: A, B, C, D; COMPND 4 FRAGMENT: FV; COMPND 5 SYNONYM: VARIABLE DOMAIN; COMPND 6 ENGINEERED: YES; COMPND 7 OTHER_DETAILS: LIGHT AND HEAVY CHAINS LINKED WITH A COMPND 8 SYNTHETIC (GGGGS)3 LINKER SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: MUS MUSCULUS; SOURCE 3 ORGANISM_COMMON: MOUSE; SOURCE 4 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 5 EXPRESSION_SYSTEM_STRAIN: TG1; SOURCE 6 EXPRESSION_SYSTEM_CELLULAR_LOCATION: PERIPLASMIC; SOURCE 7 EXPRESSION_SYSTEM_PLASMID: PSJF2 RESOLUTION SOURCE : ROTATING ANODE AUTHOR P.J.HOEDEMAEKER,D.R.ROSE RESOLUTION : BRUNGER EXPDTA X-RAY DIFFRACTION JRNL AUTH F.J.HOEDEMAEKER,T.SIGNORELLI,K.JOHNS,D.A.KUNTZ, JRNL AUTH 2 D.R.ROSE JRNL TITL A SINGLE CHAIN FV FRAGMENT OF JRNL TITL 2 P-GLYCOPROTEIN-SPECIFIC MONOCLONAL ANTIBODY C219. JRNL TITL 3 DESIGN, EXPRESSION, AND CRYSTAL STRUCTURE AT 2.4 A JRNL TITL 4 RESOLUTION JRNL REF J.BIOL.CHEM. V. 272 29784 1997 JRNL REFN ASTM JBCHA3 US ISSN 0021-9258 0071 RESOLUTION 2.4 ANGSTROMS.
Sequence in PIR format:
>P1;1ap2B structureX:1ap2B: 1 :B: 120 :B:monoclonal antibody c219:mus musculus: 9.99: 9.99 EVQLQQSGAELVRPGASVKLSCTASGFNIKDDFMHWVKQRPEQGLEWIGRIDPANDNTKYAPKFQDKATIIADTS SNTAYLQLSSLTSEDTAVYYCARREVYSYYSPLDVWGAGTTVTVP*
View SSTRUC file for 1ap2B
Rasmol View of 1ap2B