HEADER    OXIDOREDUCTASE                          
COMPND    MOL_ID: 1;                                                  
COMPND   2 MOLECULE: DIHYDROFOLATE REDUCTASE;                         
COMPND   3 CHAIN: A, B;                                               
COMPND   4 SYNONYM: DHFR;                                             
COMPND   5 EC: 1.5.1.3;                                               
COMPND   6 ENGINEERED: YES;                                           
COMPND   7 BIOLOGICAL_UNIT: ACTS AS A MONOMER WITH NADPH              
SOURCE    MOL_ID: 1;                                                  
SOURCE   2 ORGANISM_SCIENTIFIC: CANDIDA ALBICANS;                     
SOURCE   3 ORGANISM_COMMON: YEAST;                                    
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                       
SOURCE   5 EXPRESSION_SYSTEM_STRAIN: BL21 (DE3);                      
SOURCE   6 EXPRESSION_SYSTEM_CELLULAR_LOCATION: CYTOPLASM;            
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID                     
RESOLUTION  SOURCE               : ROTATING ANODE             
AUTHOR    M.WHITLOW,A.J.HOWARD,D.STEWART                              
RESOLUTION     : KONNERT,HENDRICKSON,FINZEL                   
EXPDTA    X-RAY DIFFRACTION                                           
JRNL        AUTH   M.WHITLOW,A.J.HOWARD,D.STEWART,K.D.HARDMAN,        
JRNL        AUTH 2 L.F.KUYPER,D.P.BACCANARI,M.E.FLING,R.L.TANSIK      
JRNL        TITL   X-RAY CRYSTALLOGRAPHIC STUDIES OF CANDIDA ALBICANS 
JRNL        TITL 2 DIHYDROFOLATE REDUCTASE. HIGH RESOLUTION STRUCTURES
JRNL        TITL 3 OF THE HOLOENZYME AND AN INHIBITED TERNARY COMPLEX 
JRNL        REF    J.BIOL.CHEM.                  V. 272 30289 1997    
JRNL        REFN   ASTM JBCHA3  US ISSN 0021-9258                 0071
RESOLUTION   1.60 ANGSTROMS.                                  



 Sequence in PIR format: 
>P1;1aoeA
 structureX:1aoeA:   1 :A: 192 :A:dihydrofolate reductase:candida albicans: 9.99: 9.99
 MLKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWESIPQKFRPLPDRLNI
 ILSRSYENEIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNELINNSLVSHLLITEIEHPSPESIEMDTFLK
 FPLESWTKQPKSELQKFVGDTVLEDDIKEGDFTYNYTLWTRK*




 View SSTRUC file for 1aoeA 
 Rasmol View of  1aoeA