HEADER    OXIDOREDUCTASE                          
COMPND    MOL_ID: 1;                                                  
COMPND   2 MOLECULE: DIHYDROFOLATE REDUCTASE;                         
COMPND   3 CHAIN: NULL;                                               
COMPND   4 SYNONYM: DHFR;                                             
COMPND   5 EC: 1.5.1.3;                                               
COMPND   6 ENGINEERED: YES;                                           
COMPND   7 BIOLOGICAL_UNIT: MONOMER                                   
SOURCE    MOL_ID: 1;                                                  
SOURCE   2 ORGANISM_SCIENTIFIC: LACTOBACILLUS CASEI;                  
SOURCE   3 STRAIN: METHOTREXATE-RESISTANT;                            
SOURCE   4 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                       
SOURCE   5 EXPRESSION_SYSTEM_STRAIN: NF1;                             
SOURCE   6 EXPRESSION_SYSTEM_PLASMID: PMT702                          
AUTHOR    A.R.GARGARO,A.SOTERIOU,T.A.FRENKIEL,C.J.BAUER,B.BIRDSALL,   
AUTHOR   2 V.I.POLSHAKOV,I.L.BARSUKOV,G.C.K.ROBERTS,J.FEENEY          
RESOLUTION     : BRUNGER                                      
EXPDTA    NMR, 21 STRUCTURES                                          
JRNL        AUTH   A.R.GARGARO,A.SOTERIOU,T.A.FRENKIEL,C.J.BAUER,     
JRNL        AUTH 2 B.BIRDSALL,V.I.POLSHAKOV,I.L.BARSUKOV,             
JRNL        AUTH 3 G.C.K.ROBERTS,J.FEENEY                             
JRNL        TITL   THE SOLUTION STRUCTURE OF THE COMPLEX WITH         
JRNL        TITL 2 LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH   
JRNL        TITL 3 METHOTREXATE                                       
JRNL        REF    TO BE PUBLISHED                                    
JRNL        REFN                                                  0353
RESOLUTION   NOT APPLICABLE.                                  



 Sequence in PIR format: 
>P1;1ao8-
 structureX:1ao8-:   1 : : 162 : :dihydrofolate reductase:lactobacillus casei: 9.99: 9.99
 TAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVV
 VHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPA
 LTHTYEVWQKKA*




 View SSTRUC file for 1ao8- 
 Rasmol View of  1ao8-