8FAB

crystal structure of the fab fragment from the human myeloma immunoglobulin igg hil at 1.8 angstroms resolution

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 183
  • Norm. En. per Res.: -2.8925
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-21.4857	-25.5609	-374.99	-422.0366	166	9	10	15075	1	16	18
A-C	0.0	-20.5445	-22.9872	-43.5317	37	0	0	1176	0	4	2
B-C	0.0	0.0	-0.2969	-0.2969	10	0	0	92	0	0	0
C-D	-37.5986	-39.3334	-452.396	-529.328	183	9	12	17942	3	20	20

Interface residues

• A-B: ALA105B, ALA127A, ALA130A, ALA133B, ALA144B, ALA145B, ALA173A, ALA174A, ALA176B, ALA207A, ALA32A, ALA42A, ALA49B, ALA89A, ALA94A, ALA97B, ARG38B, ARG41A, ARG57B, ARG98B, ASN92A, ASP101B, ASP109B, ASP138A, ASP152B, ASP62B, ASP84A, ASP91A, ASP99B, CYS134A, CYS148B, CYS87A, CYS96B, GLN113B, GLN126A, GLN167A, GLN179B, GLN36A, GLN37A, GLN39B, GLN6A, GLN6B, GLN88A, GLU123A, GLU124A, GLU160A, GLU220B, GLU46B, GLY100A, GLY112B, GLY114B, GLY147B, GLY158A, GLY182B, GLY40A, GLY42B, GLY44B, GLY61B, GLY98A, GLY99A, HIS172B, HIS35B, ILE102B, ILE136A, ILE47A, ILE96A, LEU103B, LEU117A, LEU125A, LEU132A, LEU132B, LEU135A, LEU146B, LEU149B, LEU178A, LEU178B, LEU180A, LEU183B, LEU186B, LEU45B, LYS125B, LYS129A, LYS151B, LYS166A, LYS217B, LYS218B, LYS222B, LYS38A, LYS43B, LYS49A, MET45A, PHE106B, PHE108B, PHE118A, PHE130B, PHE139A, PHE174B, PHE97A, PRO100B, PRO119A, PRO120A, PRO131B, PRO134B, PRO164A, PRO175B, PRO208A, PRO41B, PRO43A, PRO54A, SER107B, SER121A, SER122A, SER128B, SER137A, SER165A, SER168A, SER175A, SER176A, SER179A, SER180B, SER181B, SER185B, SER187B, SER188B, SER93A, SER95A, THR104B, THR116A, THR131A, THR161A, THR162A, THR163A, THR173B, THR191B, TRP111B, TRP34A, TRP36B, TRP47B, TRP52B, TRP90A, TYR110B, TYR172A, TYR177A, TYR31A, TYR33A, TYR35A, TYR48A, TYR59B, TYR60B, TYR85A, TYR86A, TYR95B, VAL129B, VAL133A, VAL150B, VAL159A, VAL177B, VAL189B, VAL190B, VAL206A, VAL219B, VAL37B, VAL44A, VAL48B, VAL50B, VAL93B
• A-C: ALA18C, ALA79A, ARG19C, ARG41A, ARG60A, ASN169A, ASP81A, GLN108A, GLN16C, GLN194C, GLN78A, GLU198C, GLU80A, GLY107A, GLY15A, GLY199C, GLY67C, GLY76A, HIS197C, LEU106A, LYS171A, LYS38A, PRO109A, PRO58A, SER200C, SER66C, THR17C, THR196C, THR201C, THR21C, THR68C, THR69C, THR71C, THR73C, VAL10C, VAL12C, VAL77A
• B-C: ARG189C, ASP151C, PRO154C, PRO193B, SER152C, SER153C, SER169B, SER194B, SER195B, THR143B
• C-D: ALA105D, ALA127C, ALA130C, ALA133D, ALA144D, ALA145D, ALA173C, ALA174C, ALA176D, ALA207C, ALA32C, ALA40D, ALA42C, ALA49D, ALA89C, ALA94C, ALA97D, ARG38D, ARG41C, ARG57D, ARG98D, ASN169C, ASN29C, ASN92C, ASP101D, ASP109D, ASP138C, ASP152D, ASP62D, ASP84C, ASP91C, ASP99D, CYS134C, CYS148D, CYS87C, CYS96D, GLN113D, GLN126C, GLN167C, GLN179D, GLN30C, GLN36C, GLN37C, GLN39D, GLN6D, GLN88C, GLU123C, GLU124C, GLU160C, GLU220D, GLU46D, GLY100C, GLY112D, GLY114D, GLY147D, GLY158C, GLY182D, GLY40C, GLY42D, GLY44D, GLY61D, GLY98C, GLY99C, HIS172D, HIS35D, ILE102D, ILE136C, ILE47C, ILE96C, LEU103D, LEU117C, LEU125C, LEU132C, LEU132D, LEU135C, LEU146D, LEU149D, LEU178C, LEU178D, LEU180C, LEU183D, LEU186D, LEU45D, LYS129C, LYS137D, LYS151D, LYS166C, LYS171C, LYS204C, LYS217D, LYS218D, LYS222D, LYS38C, LYS43D, LYS49C, MET45C, PHE106D, PHE108D, PHE118C, PHE130D, PHE139C, PHE174D, PHE97C, PRO100D, PRO119C, PRO120C, PRO131D, PRO134D, PRO164C, PRO175D, PRO208C, PRO41D, PRO43C, PRO54C, SER107D, SER114C, SER121C, SER122C, SER128D, SER135D, SER136D, SER137C, SER138D, SER165C, SER168C, SER175C, SER176C, SER179C, SER180D, SER181D, SER185D, SER187D, SER188D, SER55C, SER93C, SER95C, THR104D, THR116C, THR131C, THR161C, THR162C, THR163C, THR173D, THR191D, THR205C, TRP111D, TRP162D, TRP185C, TRP34C, TRP36D, TRP47D, TRP52D, TRP90C, TYR110D, TYR172C, TYR177C, TYR184D, TYR31C, TYR33C, TYR35C, TYR48C, TYR59D, TYR60D, TYR85C, TYR86C, TYR95D, VAL115C, VAL129D, VAL133C, VAL150D, VAL159C, VAL177D, VAL189D, VAL190D, VAL206C, VAL215D, VAL219D, VAL37D, VAL44C, VAL46C, VAL48D, VAL50D, VAL93D