6RLX

x-ray structure of human relaxin at 1.5 angstroms. comparison to insulin and implications for receptor binding determinants

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 20
  • Norm. En. per Res.: -4.0065
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-66.6529	-11.0778	450.785	373.0543	46	17	4	7585	2	8	5
A-C	0.0	0.0	-38.4884	-38.4884	24	1	3	1636	0	0	0
A-D	-6.8945	0.0	-47.7081	-54.6026	20	3	3	1879	0	1	3
B-C	-23.8119	2.653	-58.9717	-80.1306	20	4	3	2131	0	1	3
B-D	0.0	0.0	-32.9759	-32.9759	22	3	1	1622	0	0	0
C-D	-61.7244	-12.2107	1289.95	1216.0149	44	23	3	7496	1	9	5

Interface residues

• A-B: ALA14B, ALA17A, ALA17B, ALA3A, ARG13B, ARG14A, ARG18A, ASN4A, CYS11A, CYS19B, CYS20A, CYS6A, CYS7A, CYS7B, GLN15B, GLU10B, GLU1B, GLU2B, GLY10A, GLY20B, GLY8B, HIS8A, ILE16B, ILE18B, ILE4B, LEU11B, LEU16A, LEU2A, LEU6B, LYS13A, LYS5A, LYS5B, MET0B, MET21B, PHE19A, SER-2B, SER0A, SER15A, SER22B, THR12A, THR23B, TRP-1B, TYR-1A, VAL12B, VAL3B, VAL9A
• A-C: ALA1A, ALA1C, ALA3A, ALA3C, ASN4A, ASN4C, CYS6A, CYS6C, CYS7A, CYS7C, HIS8A, HIS8C, LEU-2A, LEU-2C, LEU16A, LEU16C, LEU2A, LEU2C, LYS5A, LYS5C, SER0A, SER0C, TYR-1A, TYR-1C
• A-D: ALA17A, ALA3A, ARG13D, ARG18A, ARG9D, CYS20A, CYS7D, GLN15D, GLU10D, GLY8D, ILE16D, LEU-2A, LEU11D, LEU16A, LEU2A, LEU6D, PHE19A, SER0A, TYR-1A, VAL12D
• B-C: ALA17C, ALA3C, ARG13B, ARG18C, ARG9B, CYS20C, CYS7B, GLN15B, GLU10B, GLY8B, ILE16B, LEU-2C, LEU11B, LEU16C, LEU2C, LEU6B, PHE19C, SER0C, TYR-1C, VAL12B
• B-D: ALA17B, ALA17D, ARG13B, ARG13D, ARG9B, ARG9D, CYS19B, CYS19D, GLN15B, GLN15D, GLY20B, GLY20D, ILE16B, ILE16D, ILE18B, ILE18D, LEU11B, LEU11D, SER22B, THR23B, VAL12B, VAL12D
• C-D: ALA14D, ALA17C, ALA17D, ALA3C, ARG14C, ARG18C, ASN4C, CYS11C, CYS19D, CYS20C, CYS6C, CYS7C, CYS7D, GLN15D, GLU10D, GLU1D, GLU2D, GLY10C, GLY20D, GLY8D, HIS8C, ILE16D, ILE18D, ILE4D, LEU11D, LEU16C, LEU2C, LEU6D, LYS13C, LYS5C, LYS5D, MET0D, MET21D, PHE19C, SER-2D, SER0C, SER15C, SER22D, THR12C, TRP-1D, TYR-1C, VAL12D, VAL3D, VAL9C