4RUB

a crystal form of ribulose-1,5-bisphosphate carboxylase(slash) oxygenase from nicotiana tabacum in the activated state

• Total interactions analyzed: 28
• Total true interactions: 19
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 406
  • Norm. En. per Res.: -4.3426
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-S	-126.246	-37.0359	-461.105	-624.3869	160	31	7	18857	7	54	53
A-B	-40.148	-36.5316	-95.5184	-172.198	59	6	1	4157	7	25	31
A-T	-66.292	-40.4079	-187.872	-294.5719	90	15	3	8465	3	27	24
A-D	-304.5144	-42.0532	-640.253	-986.8206	407	74	29	57383	17	83	85
A-V	0.0	0.0	-0.1664	-0.1664	3	0	0	29	0	0	0
S-T	0.0	-2.6328	-72.2268	-74.8596	44	4	0	3351	0	6	6
S-D	0.0	0.0	-0.1518	-0.1518	2	0	0	28	0	0	0
B-T	-113.918	-31.3631	-461.114	-606.3951	158	30	7	18795	5	54	53
B-C	-308.3808	-44.4809	-1410.24	-1763.1017	406	80	30	57129	16	84	87
B-U	0.0	0.0	-0.1311	-0.1311	3	0	0	27	0	0	0
B-D	-11.1399	-14.4297	-80.7364	-106.306	58	1	5	4275	2	32	17
B-V	0.0	0.0	-83.0832	-83.0832	39	15	7	4259	0	3	3
T-C	0.0	0.0	-0.1663	-0.1663	3	0	0	30	0	0	0
T-D	0.0	0.0	-83.279	-83.279	40	17	6	4240	0	3	3
C-U	-119.2387	-27.7595	-478.165	-625.1632	162	28	7	18903	7	54	55
C-D	-49.1717	-34.3168	-97.6436	-181.1321	60	12	1	4201	9	24	31
C-V	-77.2397	-39.889	-189.992	-307.1207	90	20	3	8405	3	26	24
U-V	0.0	-2.7576	-65.3596	-68.1172	44	10	0	3320	0	6	6
D-V	-141.4551	-24.1121	-463.008	-628.5752	161	29	6	18805	7	54	55

Interface residues

• A-S: ALA228A, ALA230A, ALA254A, ALA257A, ALA414A, ALA417A, ALA419A, ALA423A, ALA426A, ALA430A, ALA448A, ALA457A, ARG100S, ARG108S, ARG159A, ARG167A, ARG194A, ARG258A, ARG350A, ARG421A, ARG431A, ARG53S, ARG65S, ASN163A, ASN287A, ASN36S, ASN413A, ASN420A, ASN432A, ASN56S, ASN8S, ASP160A, ASP198A, ASP351A, ASP352A, ASP396A, ASP397A, ASP63S, CYS112S, CYS284A, CYS427A, GLN109S, GLN111S, GLN156A, GLN229A, GLN25S, GLN2S, GLU13S, GLU191A, GLU231A, GLU234A, GLU24S, GLU259A, GLU29S, GLU31S, GLU425A, GLU433A, GLU43S, GLU454A, GLY103S, GLY166A, GLY195A, GLY196A, GLY233A, GLY237A, GLY261A, GLY288A, GLY412A, GLY416A, GLY434A, GLY49S, GLY60S, GLY64S, HIS153A, HIS409A, ILE101S, ILE102S, ILE113S, ILE155A, ILE235A, ILE264A, ILE7S, LEU15S, LEU162A, LEU169A, LEU170A, LEU18S, LEU193A, LEU197A, LEU21S, LEU225A, LEU260A, LEU26S, LEU27S, LEU289A, LEU290A, LEU33S, LEU375A, LEU424A, LEU455A, LYS10S, LYS11S, LYS161A, LYS164A, LYS227A, LYS236A, LYS35S, LYS429A, LYS57S, LYS9S, MET1S, PHE104S, PHE115S, PHE199A, PHE256A, PHE50S, PRO168A, PRO19S, PRO263A, PRO410A, PRO415A, PRO453A, PRO59S, PRO5S, PRO6S, SER114S, SER16S, SER22S, SER28S, SER452A, SER58S, THR14S, THR232A, TRP38S, TRP411A, TRP451A, TRP4S, TRP67S, TYR12S, TYR165A, TYR17S, TYR190A, TYR226A, TYR283A, TYR32S, TYR52S, TYR61S, TYR62S, TYR66S, VAL110S, VAL157A, VAL255A, VAL262A, VAL265A, VAL30S, VAL3S, VAL418A, VAL422A, VAL428A, VAL51S
• A-B: ALA182A, ARG159B, ARG187A, ARG213A, ARG215A, ARG217A, ARG253A, ARG258B, ARG285B, ASN163B, ASN184A, ASN287B, ASP160B, ASP216A, ASP286B, CYS284B, GLN149B, GLN156B, GLN209A, GLU158B, GLU223A, GLU249A, GLU259A, GLY150B, GLY288B, HIS153B, HIS282B, ILE235B, LEU162B, LEU180A, LEU219A, LEU260A, LEU289B, LEU371B, LYS146B, LYS161B, LYS164B, LYS183A, LYS252A, MET212A, PHE148B, PHE211A, PHE220A, PHE256A, PRO151B, PRO152B, PRO210A, PRO372B, SER181A, SER208A, SER370B, TRP214A, TRP368B, TYR165B, TYR185A, TYR283B, VAL157B, VAL255A, VAL369B
• A-T: ALA182A, ALA188A, ALA222A, ALA224A, ALA228A, ALA230A, ALA414A, ARG100T, ARG108T, ARG187A, ARG194A, ARG215A, ARG217A, ARG53T, ARG65T, ASN106T, ASN184A, ASN413A, ASN55T, ASN56T, ASP216A, ASP63T, CYS221A, CYS41T, GLN109T, GLN111T, GLN229A, GLU191A, GLU223A, GLU231A, GLU259A, GLU43T, GLU45T, GLU47T, GLU54T, GLY179A, GLY186A, GLY261A, GLY408A, GLY412A, GLY416A, GLY60T, GLY64T, HIS409A, HIS48T, ILE102T, LEU178A, LEU180A, LEU219A, LEU225A, LEU260A, LEU407A, LEU42T, LEU72T, LYS183A, LYS227A, LYS57T, LYS71T, MET212A, MET69T, PHE104T, PHE211A, PHE218A, PHE220A, PHE256A, PHE44T, PRO176A, PRO410A, PRO415A, PRO59T, PRO73T, SER181A, SER58T, THR46T, THR68T, TRP411A, TRP67T, TRP70T, TYR185A, TYR190A, TYR226A, TYR52T, TYR61T, TYR62T, TYR66T, TYR94T, VAL110T, VAL189A, VAL262A, VAL51T
• A-D: ALA129A, ALA129D, ALA132A, ALA132D, ALA15A, ALA15D, ALA188A, ALA188D, ALA242A, ALA242D, ALA244A, ALA244D, ALA276A, ALA276D, ALA281A, ALA281D, ALA296A, ALA296D, ALA299A, ALA299D, ALA414A, ALA414D, ALA457A, ALA457D, ALA458A, ALA458D, ALA470A, ALA470D, ALA471A, ALA471D, ALA56A, ALA56D, ALA58A, ALA58D, ALA59A, ALA59D, ARG131A, ARG131D, ARG134A, ARG134D, ARG187A, ARG187D, ARG213A, ARG213D, ARG217A, ARG217D, ARG253A, ARG253D, ARG295A, ARG295D, ARG303A, ARG303D, ARG79A, ARG79D, ASN115A, ASN115D, ASN123A, ASN123D, ASN184A, ASN184D, ASN205A, ASN205D, ASN207A, ASN207D, ASN241A, ASN241D, ASN277A, ASN277D, ASN306A, ASN306D, ASN413A, ASN413D, ASN420A, ASN420D, ASN468A, ASN468D, ASP106A, ASP106D, ASP203A, ASP203D, ASP268A, ASP268D, ASP302A, ASP302D, ASP72A, ASP72D, CYS192A, CYS192D, CYS247A, CYS247D, GLN209A, GLN209D, GLN304A, GLN304D, GLN401D, GLN45A, GLN45D, GLU109A, GLU109D, GLU110A, GLU110D, GLU191A, GLU191D, GLU204A, GLU204D, GLU248A, GLU248D, GLU249A, GLU249D, GLU336A, GLU336D, GLU338A, GLU338D, GLU464A, GLU464D, GLU52A, GLU52D, GLU60A, GLU60D, GLY111A, GLY111D, GLY122A, GLY122D, GLY126A, GLY126D, GLY16A, GLY16D, GLY179A, GLY179D, GLY245A, GLY245D, GLY272A, GLY272D, GLY273A, GLY273D, GLY308A, GLY308D, GLY333A, GLY333D, GLY337A, GLY337D, GLY380A, GLY380D, GLY381A, GLY381D, GLY403A, GLY403D, GLY404A, GLY404D, GLY405A, GLY405D, GLY408A, GLY408D, GLY412A, GLY412D, GLY47A, GLY47D, GLY64A, GLY64D, GLY73A, GLY73D, GLY82A, GLY82D, HIS267A, HIS267D, HIS282A, HIS282D, HIS294A, HIS294D, HIS298A, HIS298D, HIS307A, HIS307D, HIS310A, HIS310D, HIS327A, HIS327D, HIS383A, HIS383D, HIS386A, HIS386D, HIS409A, HIS409D, ILE120A, ILE120D, ILE174A, ILE174D, ILE251A, ILE251D, ILE301A, ILE301D, ILE309A, ILE309D, ILE382A, ILE382D, ILE465A, ILE465D, LEU105A, LEU105D, LEU107A, LEU107D, LEU130A, LEU130D, LEU133A, LEU133D, LEU135A, LEU135D, LEU178A, LEU178D, LEU180A, LEU180D, LEU270A, LEU270D, LEU280A, LEU280D, LEU314A, LEU314D, LEU335A, LEU335D, LEU407A, LEU407D, LEU74A, LEU74D, LEU77A, LEU77D, LYS128A, LYS128D, LYS14A, LYS14D, LYS175A, LYS175D, LYS177A, LYS177D, LYS183A, LYS18A, LYS18D, LYS201A, LYS201D, LYS334A, LYS334D, LYS81A, LYS81D, MET116A, MET116D, MET212A, MET212D, MET250A, MET250D, MET266A, MET266D, MET297A, MET297D, PHE108A, PHE108D, PHE117A, PHE117D, PHE125A, PHE125D, PHE127A, PHE127D, PHE13A, PHE13D, PHE148A, PHE148D, PHE211A, PHE211D, PHE274A, PHE274D, PHE402A, PHE402D, PHE40A, PHE40D, PHE467A, PHE467D, PHE469A, PHE469D, PRO104A, PRO104D, PRO176A, PRO176D, PRO210A, PRO210D, PRO410A, PRO410D, PRO415A, PRO415D, PRO44A, PRO44D, PRO46A, PRO46D, PRO49A, PRO49D, SER112A, SER112D, SER119A, SER119D, SER181A, SER181D, SER208A, SER208D, SER279A, SER279D, SER321A, SER321D, SER379A, SER379D, SER61A, SER61D, SER62A, SER62D, SER76A, SER76D, THR114A, THR114D, THR118A, THR118D, THR147A, THR147D, THR173A, THR173D, THR243A, THR243D, THR246A, THR246D, THR271A, THR271D, THR275A, THR275D, THR278A, THR278D, THR330A, THR330D, THR406A, THR406D, THR43A, THR43D, THR63A, THR63D, THR65A, THR65D, THR67A, THR67D, THR68A, THR68D, THR71A, THR71D, THR75A, THR75D, TRP214A, TRP214D, TRP385A, TRP385D, TRP411A, TRP411D, TRP462A, TRP462D, TRP66A, TRP66D, TRP70A, TRP70D, TYR103A, TYR103D, TYR144A, TYR144D, TYR185A, TYR185D, TYR20A, TYR20D, TYR24A, TYR24D, TYR269A, TYR269D, TYR283A, TYR283D, TYR80A, TYR80D, VAL113A, VAL113D, VAL121A, VAL121D, VAL124A, VAL124D, VAL17A, VAL17D, VAL189A, VAL189D, VAL206A, VAL206D, VAL300A, VAL300D, VAL331A, VAL331D, VAL332A, VAL332D, VAL384A, VAL384D, VAL461A, VAL461D, VAL466A, VAL466D, VAL472A, VAL472D, VAL48A, VAL48D, VAL57A, VAL69A, VAL69D
• A-V: MET1V, PHE13A, TRP70A
• S-T: ALA90T, ALA93T, ALA97T, ARG53S, ARG53T, ASN55T, ASN56T, ASN8S, GLN2S, GLN96T, GLU43T, GLU45T, GLU47T, GLU54S, GLU54T, GLU86T, GLU89T, ILE7S, LEU42T, LEU72T, LYS10S, LYS57S, LYS57T, LYS71T, LYS92T, LYS9S, MET1S, MET69T, MET74T, PHE44T, PHE75T, PRO5S, PRO6S, PRO73T, PRO95T, THR46T, THR68T, TRP4S, TRP67T, TRP70T, TYR52S, TYR62S, TYR94T, VAL3S
• S-D: MET1S, PHE13D
• B-T: ALA228B, ALA230B, ALA254B, ALA257B, ALA414B, ALA417B, ALA419B, ALA423B, ALA426B, ALA430B, ALA448B, ALA457B, ARG100T, ARG108T, ARG159B, ARG167B, ARG194B, ARG258B, ARG350B, ARG421B, ARG431B, ARG53T, ARG65T, ASN163B, ASN287B, ASN36T, ASN413B, ASN420B, ASN432B, ASN56T, ASN8T, ASP160B, ASP198B, ASP351B, ASP352B, ASP396B, ASP397B, ASP63T, CYS112T, CYS284B, CYS427B, GLN109T, GLN111T, GLN156B, GLN229B, GLN25T, GLN2T, GLU13T, GLU191B, GLU231B, GLU234B, GLU24T, GLU259B, GLU29T, GLU31T, GLU425B, GLU433B, GLU43T, GLU454B, GLY103T, GLY166B, GLY195B, GLY196B, GLY233B, GLY237B, GLY261B, GLY288B, GLY412B, GLY416B, GLY434B, GLY49T, GLY60T, GLY64T, HIS153B, HIS409B, ILE101T, ILE102T, ILE113T, ILE155B, ILE235B, ILE264B, ILE7T, LEU15T, LEU162B, LEU169B, LEU18T, LEU193B, LEU197B, LEU21T, LEU225B, LEU260B, LEU26T, LEU27T, LEU289B, LEU290B, LEU33T, LEU375B, LEU424B, LEU455B, LYS10T, LYS11T, LYS161B, LYS164B, LYS227B, LYS236B, LYS35T, LYS429B, LYS57T, LYS9T, MET1T, PHE104T, PHE115T, PHE256B, PHE50T, PRO168B, PRO19T, PRO263B, PRO410B, PRO415B, PRO453B, PRO59T, PRO5T, PRO6T, SER114T, SER16T, SER22T, SER28T, SER452B, SER58T, THR14T, THR232B, TRP38T, TRP411B, TRP451B, TRP4T, TRP67T, TYR12T, TYR165B, TYR17T, TYR190B, TYR226B, TYR283B, TYR32T, TYR52T, TYR61T, TYR62T, TYR66T, VAL110T, VAL157B, VAL255B, VAL262B, VAL265B, VAL30T, VAL3T, VAL418B, VAL422B, VAL428B, VAL51T
• B-C: ALA129B, ALA129C, ALA132B, ALA132C, ALA15B, ALA15C, ALA188B, ALA188C, ALA242B, ALA242C, ALA244B, ALA244C, ALA276B, ALA276C, ALA281B, ALA281C, ALA296B, ALA296C, ALA299B, ALA299C, ALA414B, ALA414C, ALA457B, ALA457C, ALA458B, ALA458C, ALA470B, ALA470C, ALA471B, ALA471C, ALA56B, ALA56C, ALA58B, ALA58C, ALA59B, ALA59C, ARG131B, ARG131C, ARG134B, ARG134C, ARG187B, ARG187C, ARG213B, ARG213C, ARG217B, ARG217C, ARG253B, ARG253C, ARG295B, ARG295C, ARG303B, ARG303C, ARG79B, ARG79C, ASN115B, ASN115C, ASN123B, ASN123C, ASN184B, ASN184C, ASN205B, ASN205C, ASN207B, ASN207C, ASN241B, ASN241C, ASN277B, ASN277C, ASN306B, ASN306C, ASN413B, ASN413C, ASN420B, ASN420C, ASN468B, ASN468C, ASP106B, ASP106C, ASP203B, ASP203C, ASP268B, ASP268C, ASP302B, ASP302C, ASP72B, ASP72C, CYS192B, CYS192C, CYS247B, CYS247C, GLN209B, GLN209C, GLN304B, GLN304C, GLN401C, GLN45B, GLN45C, GLU109B, GLU109C, GLU110B, GLU110C, GLU191B, GLU191C, GLU204B, GLU204C, GLU248B, GLU248C, GLU249B, GLU249C, GLU336B, GLU336C, GLU338B, GLU338C, GLU464B, GLU464C, GLU52B, GLU52C, GLU60B, GLU60C, GLY111B, GLY111C, GLY122B, GLY122C, GLY126B, GLY126C, GLY16B, GLY16C, GLY179B, GLY179C, GLY245B, GLY245C, GLY272B, GLY272C, GLY273B, GLY273C, GLY308B, GLY308C, GLY333B, GLY333C, GLY337B, GLY337C, GLY380B, GLY380C, GLY381B, GLY381C, GLY403B, GLY403C, GLY404B, GLY404C, GLY405B, GLY405C, GLY408B, GLY408C, GLY412B, GLY412C, GLY47B, GLY47C, GLY64B, GLY64C, GLY73B, GLY73C, GLY82B, GLY82C, HIS267B, HIS267C, HIS282B, HIS282C, HIS294B, HIS294C, HIS298B, HIS298C, HIS307B, HIS307C, HIS310B, HIS310C, HIS327B, HIS327C, HIS383B, HIS383C, HIS386B, HIS386C, HIS409B, HIS409C, ILE120B, ILE120C, ILE174B, ILE174C, ILE251B, ILE251C, ILE301B, ILE301C, ILE309B, ILE309C, ILE382B, ILE382C, ILE465B, ILE465C, LEU105B, LEU105C, LEU107B, LEU107C, LEU130B, LEU130C, LEU133B, LEU133C, LEU135B, LEU135C, LEU178B, LEU178C, LEU180B, LEU180C, LEU270B, LEU270C, LEU280B, LEU280C, LEU314B, LEU314C, LEU335B, LEU335C, LEU407B, LEU407C, LEU74B, LEU74C, LEU77B, LEU77C, LYS128B, LYS128C, LYS14B, LYS14C, LYS175B, LYS175C, LYS177B, LYS177C, LYS183C, LYS18B, LYS18C, LYS201B, LYS201C, LYS334B, LYS334C, LYS81B, LYS81C, MET116B, MET116C, MET212B, MET212C, MET250B, MET250C, MET266B, MET266C, MET297B, MET297C, PHE108B, PHE108C, PHE117B, PHE117C, PHE125B, PHE125C, PHE127B, PHE127C, PHE13B, PHE13C, PHE148B, PHE148C, PHE211B, PHE211C, PHE274B, PHE274C, PHE402B, PHE402C, PHE40B, PHE40C, PHE467B, PHE467C, PHE469B, PHE469C, PRO104B, PRO104C, PRO176B, PRO176C, PRO210B, PRO210C, PRO410B, PRO410C, PRO415B, PRO415C, PRO44B, PRO46B, PRO46C, PRO49B, PRO49C, SER112B, SER112C, SER119B, SER119C, SER181B, SER181C, SER208B, SER208C, SER279B, SER279C, SER321B, SER321C, SER379B, SER379C, SER61B, SER61C, SER62B, SER62C, SER76B, SER76C, THR114B, THR114C, THR118B, THR118C, THR147B, THR147C, THR173B, THR173C, THR243B, THR243C, THR246B, THR246C, THR271B, THR271C, THR275B, THR275C, THR278B, THR278C, THR330B, THR330C, THR406B, THR406C, THR43B, THR43C, THR63B, THR63C, THR65B, THR65C, THR67B, THR67C, THR68B, THR68C, THR71B, THR71C, THR75B, THR75C, TRP214B, TRP214C, TRP385B, TRP385C, TRP411B, TRP411C, TRP462B, TRP462C, TRP66B, TRP66C, TRP70B, TRP70C, TYR103B, TYR103C, TYR144B, TYR144C, TYR185B, TYR185C, TYR20B, TYR20C, TYR24B, TYR24C, TYR269B, TYR269C, TYR283B, TYR283C, TYR80B, TYR80C, VAL113B, VAL113C, VAL121B, VAL121C, VAL124B, VAL124C, VAL17B, VAL17C, VAL189B, VAL189C, VAL206B, VAL206C, VAL300B, VAL300C, VAL331B, VAL331C, VAL332B, VAL332C, VAL384B, VAL384C, VAL461B, VAL461C, VAL466B, VAL466C, VAL472B, VAL472C, VAL48B, VAL48C, VAL57B, VAL69B, VAL69C
• B-U: MET1U, PHE13B, TRP70B
• B-D: ALA143B, ALA143D, ARG285B, ARG285D, ARG79B, ARG79D, ASP106B, ASP106D, ASP33B, ASP33D, ASP352B, ASP352D, ASP367B, ASP367D, GLN149B, GLN149D, GLU109B, GLU109D, GLU110B, GLU110D, GLY111B, GLY111D, ILE36B, ILE36D, LEU105B, LEU105D, LEU107B, LEU107D, LEU371B, LEU371D, LYS146B, LYS146D, LYS32B, LYS32D, PHE108B, PHE108D, PHE148B, PHE148D, PRO141B, PRO141D, PRO142B, PRO142D, PRO372B, SER370B, SER370D, THR147B, THR147D, THR34B, THR34D, TRP368B, TYR144B, TYR144D, TYR80B, TYR80D, VAL145B, VAL145D, VAL369B, VAL369D
• B-V: ALA9B, ARG108V, ARG79B, ASN106V, ASP105V, ASP72B, ASP78B, CYS41V, CYS77V, GLN109V, GLY12B, GLY37V, GLY73B, GLY76V, ILE102V, LEU72V, LEU74B, LEU77B, LYS14B, LYS71V, MET69V, MET74V, PHE104V, PHE13B, PHE75V, PRO40V, PRO73V, SER10B, SER76B, THR71B, THR75B, TRP38V, TRP70B, TYR80B, VAL107V, VAL110V, VAL11B, VAL39V, VAL69B
• T-C: MET1T, PHE13C, TRP70C
• T-D: ALA15D, ALA9D, ARG108T, ARG79D, ASN106T, ASP105T, ASP72D, ASP78D, CYS41T, CYS77T, GLN109T, GLY12D, GLY37T, GLY73D, GLY76T, ILE102T, LEU72T, LEU74D, LEU77D, LYS14D, LYS71T, MET69T, MET74T, PHE104T, PHE13D, PHE75T, PRO40T, PRO73T, SER10D, SER76D, THR71D, THR75D, TRP38T, TRP70D, TYR80D, VAL107T, VAL110T, VAL11D, VAL39T, VAL69D
• C-U: ALA228C, ALA230C, ALA254C, ALA257C, ALA414C, ALA417C, ALA419C, ALA423C, ALA426C, ALA430C, ALA448C, ALA457C, ARG100U, ARG108U, ARG159C, ARG167C, ARG194C, ARG258C, ARG350C, ARG421C, ARG431C, ARG53U, ARG65U, ASN163C, ASN287C, ASN36U, ASN413C, ASN420C, ASN432C, ASN56U, ASN8U, ASP160C, ASP198C, ASP351C, ASP352C, ASP396C, ASP397C, ASP63U, CYS112U, CYS192C, CYS284C, CYS427C, GLN109U, GLN111U, GLN156C, GLN229C, GLN25U, GLN2U, GLU13U, GLU158C, GLU191C, GLU231C, GLU234C, GLU24U, GLU259C, GLU29U, GLU31U, GLU425C, GLU433C, GLU43U, GLU454C, GLY103U, GLY166C, GLY195C, GLY196C, GLY233C, GLY237C, GLY261C, GLY288C, GLY412C, GLY416C, GLY434C, GLY49U, GLY60U, GLY64U, HIS153C, HIS409C, ILE101U, ILE102U, ILE113U, ILE155C, ILE235C, ILE264C, ILE7U, LEU15U, LEU162C, LEU169C, LEU18U, LEU193C, LEU197C, LEU21U, LEU225C, LEU260C, LEU26U, LEU27U, LEU289C, LEU290C, LEU33U, LEU375C, LEU424C, LEU437C, LEU455C, LYS10U, LYS11U, LYS161C, LYS164C, LYS227C, LYS236C, LYS35U, LYS429C, LYS57U, LYS9U, MET1U, PHE104U, PHE115U, PHE199C, PHE256C, PHE50U, PRO168C, PRO19U, PRO263C, PRO410C, PRO415C, PRO453C, PRO59U, PRO5U, PRO6U, SER114U, SER16U, SER22U, SER28U, SER452C, SER58U, THR14U, THR232C, TRP38U, TRP411C, TRP451C, TRP4U, TRP67U, TYR12U, TYR165C, TYR17U, TYR190C, TYR226C, TYR283C, TYR32U, TYR52U, TYR61U, TYR62U, TYR66U, VAL110U, VAL157C, VAL255C, VAL262C, VAL265C, VAL30U, VAL3U, VAL418C, VAL422C, VAL428C, VAL51U
• C-D: ALA182C, ARG159D, ARG187C, ARG213C, ARG215C, ARG217C, ARG253C, ARG258D, ARG285D, ASN163D, ASN184C, ASN287D, ASP160D, ASP216C, ASP286D, CYS284D, GLN149D, GLN156D, GLN209C, GLU158D, GLU223C, GLU249C, GLU259C, GLY150D, GLY288D, HIS153D, HIS282D, ILE235D, LEU162D, LEU180C, LEU219C, LEU260C, LEU289D, LEU290D, LEU371D, LYS146D, LYS161D, LYS164D, LYS183C, LYS252C, MET212C, PHE148D, PHE211C, PHE220C, PHE256C, PRO151D, PRO152D, PRO210C, PRO372D, SER181C, SER208C, SER370D, TRP214C, TRP368D, TYR165D, TYR185C, TYR283D, VAL157D, VAL255C, VAL369D
• C-V: ALA182C, ALA188C, ALA222C, ALA224C, ALA228C, ALA230C, ALA414C, ARG100V, ARG108V, ARG187C, ARG194C, ARG215C, ARG217C, ARG53V, ARG65V, ASN106V, ASN184C, ASN413C, ASN55V, ASN56V, ASP105V, ASP216C, ASP63V, CYS221C, CYS41V, GLN109V, GLN111V, GLN229C, GLU191C, GLU223C, GLU231C, GLU259C, GLU43V, GLU45V, GLU47V, GLU54V, GLY179C, GLY186C, GLY261C, GLY412C, GLY416C, GLY60V, GLY64V, HIS409C, HIS48V, ILE102V, LEU178C, LEU180C, LEU219C, LEU225C, LEU260C, LEU407C, LEU42V, LEU72V, LYS183C, LYS227C, LYS57V, LYS71V, MET212C, MET69V, PHE104V, PHE211C, PHE218C, PHE220C, PHE256C, PHE44V, PRO176C, PRO410C, PRO415C, PRO59V, PRO73V, SER181C, SER58V, THR46V, THR68V, TRP411C, TRP67V, TRP70V, TYR185C, TYR190C, TYR226C, TYR52V, TYR61V, TYR62V, TYR66V, TYR94V, VAL110V, VAL189C, VAL262C, VAL51V
• U-V: ALA90V, ALA93V, ALA97V, ARG53U, ARG53V, ASN55V, ASN56V, ASN8U, GLN2U, GLN96V, GLU45V, GLU47V, GLU54U, GLU54V, GLU86V, GLU89V, HIS48V, ILE7U, LEU42V, LEU72V, LYS10U, LYS57U, LYS57V, LYS71V, LYS92V, LYS9U, MET1U, MET69V, MET74V, PHE44V, PHE75V, PRO5U, PRO6U, PRO73V, PRO95V, THR46V, THR68V, TRP4U, TRP67V, TRP70V, TYR52U, TYR62U, TYR94V, VAL3U
• D-V: ALA222D, ALA228D, ALA230D, ALA254D, ALA257D, ALA414D, ALA417D, ALA419D, ALA423D, ALA426D, ALA430D, ALA448D, ALA457D, ARG100V, ARG108V, ARG159D, ARG167D, ARG194D, ARG258D, ARG350D, ARG421D, ARG431D, ARG53V, ARG65V, ASN163D, ASN287D, ASN36V, ASN413D, ASN420D, ASN432D, ASN56V, ASN8V, ASP160D, ASP198D, ASP286D, ASP351D, ASP352D, ASP396D, ASP397D, ASP63V, CYS112V, CYS284D, CYS427D, GLN109V, GLN111V, GLN156D, GLN229D, GLN25V, GLN2V, GLU13V, GLU191D, GLU231D, GLU234D, GLU24V, GLU259D, GLU29V, GLU31V, GLU425D, GLU433D, GLU43V, GLU454D, GLY103V, GLY166D, GLY195D, GLY196D, GLY233D, GLY237D, GLY261D, GLY288D, GLY412D, GLY416D, GLY434D, GLY49V, GLY60V, GLY64V, HIS153D, HIS409D, ILE101V, ILE102V, ILE113V, ILE155D, ILE235D, ILE264D, ILE7V, LEU15V, LEU162D, LEU169D, LEU170D, LEU18V, LEU193D, LEU197D, LEU21V, LEU225D, LEU260D, LEU26V, LEU27V, LEU289D, LEU290D, LEU33V, LEU375D, LEU424D, LEU455D, LYS10V, LYS11V, LYS161D, LYS164D, LYS227D, LYS236D, LYS35V, LYS429D, LYS57V, LYS9V, MET1V, PHE104V, PHE115V, PHE256D, PHE50V, PRO168D, PRO19V, PRO263D, PRO410D, PRO415D, PRO453D, PRO59V, PRO5V, PRO6V, SER114V, SER16V, SER22V, SER28V, SER452D, SER58V, THR14V, THR232D, TRP38V, TRP411D, TRP451D, TRP4V, TRP67V, TYR12V, TYR165D, TYR17V, TYR190D, TYR226D, TYR283D, TYR32V, TYR52V, TYR61V, TYR62V, TYR66V, VAL110V, VAL157D, VAL255D, VAL262D, VAL265D, VAL30V, VAL3V, VAL418D, VAL422D, VAL428D, VAL51V