4HMG

refinement of the influenza virus hemagglutinin by simulated annealing

• Total interactions analyzed: 15
• Total true interactions: 15
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 234
  • Norm. En. per Res.: -5.1725
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-267.2828	-79.434	-86.4203	-433.1371	237	60	25	33266	7	74	65
A-C	-4.7294	0.0	-121.952	-126.6814	63	6	0	5258	0	7	12
A-D	-9.9959	13.5216	-58.2126	-54.6869	33	4	0	2748	1	9	10
A-E	-6.2867	0.0	-123.917	-130.2037	63	7	0	5306	0	7	13
A-F	-20.1511	-9.8448	-62.7731	-92.769	53	4	2	2872	1	16	9
B-C	-22.481	-13.3452	-64.3451	-100.1713	51	6	2	2897	1	16	9
B-D	-73.432	-181.8472	-332.804	-588.0832	148	21	10	13784	23	76	62
B-E	-9.2563	13.5961	-62.6259	-58.286	33	5	0	2817	1	11	11
B-F	-91.3704	-180.3948	-344.289	-616.0542	150	27	10	14069	23	78	63
C-D	-264.8974	-112.0044	-833.455	-1210.3568	234	55	25	33155	9	74	64
C-E	-11.5338	0.0	-125.475	-137.0088	63	8	0	5407	0	7	13
C-F	-8.946	13.1857	-60.0136	-55.7739	33	4	0	2728	1	10	11
D-E	-27.0481	-11.5515	-64.7082	-103.3078	55	7	2	3109	1	16	9
D-F	-72.8719	-180.3006	-334.655	-587.8275	148	21	10	13888	23	76	64
E-F	-259.5889	-94.0514	-864.872	-1218.5123	239	58	25	33751	8	74	66

Interface residues

• A-B: ALA101B, ALA106A, ALA113A, ALA11A, ALA130B, ALA166B, ALA19A, ALA304A, ALA317A, ALA35B, ALA36B, ALA39A, ALA44B, ALA5B, ALA7B, ALA96B, ARG109A, ARG123B, ARG153B, ARG170B, ARG25B, ARG269A, ARG321A, ARG54B, ASN104B, ASN116B, ASN129B, ASN12B, ASN135B, ASN168B, ASN169B, ASN22A, ASN28B, ASN290A, ASN298A, ASN322A, ASN38A, ASN49B, ASN53B, ASN60B, ASN8A, ASN95B, ASP104A, ASP109B, ASP112B, ASP145B, ASP164B, ASP19B, ASP291A, ASP2A, ASP31A, ASP32A, ASP37B, ASP7A, ASP85A, ASP86B, ASP90B, CYS137B, CYS144B, CYS148B, CYS14A, CYS281A, CYS305A, GLN105B, GLN125B, GLN172B, GLN1A, GLN27B, GLN295A, GLN311A, GLN327A, GLN34B, GLN65B, GLU103B, GLU114B, GLU11B, GLU120B, GLU131B, GLU132B, GLU150B, GLU15B, GLU165B, GLU280A, GLU325A, GLU35A, GLU41A, GLU57B, GLU61B, GLU67B, GLU69B, GLU74B, GLU81B, GLU85B, GLU97B, GLY136B, GLY13B, GLY16A, GLY16B, GLY1B, GLY20B, GLY23B, GLY263A, GLY303A, GLY319A, GLY31B, GLY33B, GLY5A, GLY8B, HIS106B, HIS142B, HIS17A, HIS18A, HIS26B, HIS56A, HIS64B, ILE108B, ILE10B, ILE140B, ILE149B, ILE152B, ILE18B, ILE267A, ILE282A, ILE29A, ILE300A, ILE34A, ILE45B, ILE48B, ILE56B, ILE66B, ILE6B, ILE77B, ILE89B, LEU102B, LEU110B, LEU111A, LEU118B, LEU126B, LEU13A, LEU15A, LEU25A, LEU314A, LEU316A, LEU3A, LEU42A, LEU52B, LEU66A, LEU86A, LEU91B, LEU98B, LEU99B, LYS117B, LYS121B, LYS139B, LYS143B, LYS264A, LYS27A, LYS292A, LYS299A, LYS307A, LYS310A, LYS315A, LYS326A, LYS51B, LYS58B, LYS62B, LYS68B, LYS82B, LYS88B, MET115B, MET133B, MET17B, MET268A, MET320A, PHE119B, PHE138B, PHE24B, PHE294A, PHE63B, PHE70B, PHE9B, PRO21A, PRO284A, PRO289A, PRO293A, PRO306A, PRO324A, PRO4A, PRO55A, SER107A, SER110A, SER114A, SER115A, SER265A, SER266A, SER270A, SER29B, SER40B, SER71B, SER93B, SER9A, THR107B, THR10A, THR111B, THR122B, THR12A, THR28A, THR301A, THR30A, THR313A, THR318A, THR328A, THR32B, THR37A, THR40A, THR41B, THR59B, THR87B, TRP14B, TRP21B, TRP92B, TYR141B, TYR157B, TYR22B, TYR302A, TYR308A, TYR94B, VAL100B, VAL112A, VAL161B, VAL20A, VAL26A, VAL309A, VAL323A, VAL36A, VAL43A, VAL55B
• A-C: ARG201C, ARG207C, ARG208C, ARG220A, ARG224A, ARG229A, ASN165C, ASN188A, ASN216A, ASN246C, ASN248C, ASP101A, ASP241C, GLN210C, GLN211C, GLN226A, GLY218A, HIS183A, HIS184A, ILE182A, ILE213A, ILE213C, ILE214A, ILE214C, ILE217A, ILE230A, ILE232A, ILE245C, LEU164C, LEU243C, LYS307C, LYS310A, MET168C, PRO103A, PRO185A, PRO215A, PRO221A, PRO99A, SER186A, SER205C, SER209C, SER219A, SER227A, SER228A, SER231A, SER247C, THR167C, THR187A, THR203C, THR206C, THR212C, TRP222A, TYR100A, TYR233A, VAL102A, VAL163C, VAL166C, VAL202C, VAL204C, VAL223A, VAL237C, VAL242C, VAL244C
• A-D: ALA44D, ARG54D, ASN49D, ASN53D, ASN60D, ASP31A, ASP32A, ASP46D, GLN311A, GLN33A, GLN47D, GLU103D, GLU57D, GLU61D, GLY50D, HIS106D, ILE29A, ILE48D, LEU102D, LEU110D, LEU314A, LEU52D, LEU99D, LYS27A, LYS310A, LYS51D, LYS62D, THR107D, THR28A, THR30A, TRP92D, VAL26A, VAL55D
• A-E: ARG201A, ARG207A, ARG208A, ARG220E, ARG224E, ARG229E, ASN165A, ASN188E, ASN216E, ASN246A, ASN248A, ASP101E, ASP241A, GLN210A, GLN211A, GLN226E, GLY218E, HIS183E, HIS184E, ILE182E, ILE213A, ILE213E, ILE214A, ILE214E, ILE217E, ILE230E, ILE232E, ILE245A, LEU164A, LEU243A, LYS307A, LYS310E, MET168A, PRO103E, PRO185E, PRO215E, PRO221E, PRO99E, SER186E, SER205A, SER209A, SER219E, SER227E, SER228E, SER231E, SER247A, THR167A, THR187E, THR203A, THR206A, THR212A, TRP222E, TYR100E, TYR233E, VAL102E, VAL163A, VAL166A, VAL202A, VAL204A, VAL223E, VAL237A, VAL242A, VAL244A
• A-F: ALA106A, ARG109A, ARG208A, ARG261A, ARG76F, ASP104A, ASP175A, ASP2A, ASP79F, ASP90F, GLN1A, GLN78F, GLU72F, GLU74F, GLY175F, GLY75F, ILE236A, ILE29A, ILE300A, ILE77F, LEU102F, LEU108A, LEU111A, LEU177A, LEU3A, LEU91F, LYS174F, LYS238A, LYS299A, LYS307A, LYS82F, MET260A, PHE294A, PRO239A, PRO293A, PRO4A, SER107A, SER110A, SER114A, SER115A, SER209A, SER71F, SER93F, THR235A, THR262A, THR301A, TRP234A, TYR105A, TYR83F, TYR94F, VAL112A, VAL237A, VAL73F
• B-C: ALA106C, ARG109C, ARG208C, ARG261C, ARG76B, ASP104C, ASP175C, ASP2C, ASP79B, ASP90B, GLN1C, GLN78B, GLU72B, GLU74B, GLY175B, GLY75B, ILE173B, ILE236C, ILE300C, ILE77B, LEU108C, LEU111C, LEU177C, LEU3C, LEU91B, LYS174B, LYS238C, LYS299C, LYS307C, LYS82B, MET260C, PHE294C, PRO239C, PRO293C, PRO4C, SER107C, SER110C, SER114C, SER115C, SER209C, SER71B, THR235C, THR262C, THR301C, TRP234C, TYR105C, TYR83B, TYR94B, VAL112C, VAL237C, VAL73B
• B-D: ALA101B, ALA130B, ALA166D, ALA5B, ALA7B, ALA96B, ALA96D, ARG123B, ARG123D, ARG124D, ARG127D, ARG163D, ARG170B, ARG170D, ARG54D, ARG76B, ARG76D, ASN104B, ASN116B, ASN116D, ASN135B, ASN168D, ASN169B, ASN169D, ASN60D, ASN95B, ASN95D, ASP109B, ASP109D, ASP112B, ASP112D, ASP160D, ASP164D, ASP79B, ASP79D, ASP86B, ASP86D, ASP90B, ASP90D, CYS137B, GLN105B, GLN125D, GLN172B, GLN172D, GLN47D, GLN65D, GLN78B, GLN78D, GLU103D, GLU114D, GLU120B, GLU120D, GLU128B, GLU128D, GLU131B, GLU132B, GLU165D, GLU57D, GLU61D, GLU67D, GLU69D, GLU72D, GLU74D, GLU81B, GLU81D, GLU85B, GLU85D, GLU97B, GLY134B, GLY136B, GLY175B, GLY1B, GLY4B, GLY75B, GLY75D, GLY8B, HIS106B, HIS106D, HIS159D, HIS64D, ILE108D, ILE10B, ILE173B, ILE66B, ILE66D, ILE6B, ILE77B, ILE77D, ILE89B, ILE89D, LEU102B, LEU102D, LEU110D, LEU167B, LEU167D, LEU2B, LEU2D, LEU80B, LEU80D, LEU91B, LEU91D, LEU98B, LEU98D, LEU99B, LEU99D, LYS117D, LYS121D, LYS139B, LYS174B, LYS51D, LYS62D, LYS68D, LYS82B, LYS82D, LYS88B, LYS88D, MET133B, PHE119B, PHE138B, PHE171B, PHE171D, PHE3B, PHE3D, PHE63D, PHE70D, PHE9B, SER113B, SER113D, SER93B, SER93D, THR107D, THR111D, THR87B, THR87D, TRP92B, TRP92D, TYR141B, TYR162D, TYR83B, TYR83D, TYR94B, TYR94D, VAL100B, VAL100D, VAL161D, VAL55D, VAL84B, VAL84D
• B-E: ALA44B, ARG54B, ASN49B, ASN53B, ASN60B, ASP31E, ASP32E, ASP46B, GLN311E, GLN33E, GLN47B, GLU103B, GLU57B, GLU61B, GLY50B, HIS106B, ILE29E, ILE48B, LEU102B, LEU110B, LEU314E, LEU52B, LEU99B, LYS27E, LYS310E, LYS51B, LYS62B, THR107B, THR28E, THR30E, TRP92B, VAL26E, VAL55B
• B-F: ALA101F, ALA130F, ALA166B, ALA5F, ALA7F, ALA96B, ALA96F, ARG123B, ARG123F, ARG124B, ARG127B, ARG163B, ARG170B, ARG170F, ARG54B, ARG76B, ARG76F, ASN104F, ASN116B, ASN116F, ASN135F, ASN168B, ASN169B, ASN169F, ASN60B, ASN95B, ASN95F, ASP109B, ASP109F, ASP112B, ASP112F, ASP160B, ASP164B, ASP79B, ASP79F, ASP86B, ASP86F, ASP90B, ASP90F, CYS137F, GLN105F, GLN125B, GLN172B, GLN172F, GLN47B, GLN65B, GLN78B, GLN78F, GLU103B, GLU114B, GLU120B, GLU120F, GLU128B, GLU128F, GLU131F, GLU132F, GLU165B, GLU57B, GLU61B, GLU67B, GLU69B, GLU72B, GLU74B, GLU81B, GLU81F, GLU85B, GLU85F, GLU97B, GLU97F, GLY134F, GLY136F, GLY175F, GLY1F, GLY4F, GLY75B, GLY75F, GLY8F, HIS106B, HIS106F, HIS159B, HIS64B, ILE108B, ILE10F, ILE173F, ILE66B, ILE66F, ILE6F, ILE77B, ILE77F, ILE89B, ILE89F, LEU102B, LEU102F, LEU110B, LEU167B, LEU167F, LEU2B, LEU2F, LEU80B, LEU80F, LEU91B, LEU91F, LEU98B, LEU98F, LEU99B, LEU99F, LYS117B, LYS121B, LYS139F, LYS174F, LYS51B, LYS62B, LYS68B, LYS82B, LYS82F, LYS88B, LYS88F, MET133F, PHE119F, PHE138F, PHE171B, PHE171F, PHE3B, PHE3F, PHE63B, PHE70B, PHE9F, SER113B, SER113F, SER71B, SER93B, SER93F, THR107B, THR111B, THR87B, THR87F, TRP92B, TRP92F, TYR141F, TYR162B, TYR83B, TYR83F, TYR94B, TYR94F, VAL100B, VAL100F, VAL161B, VAL55B, VAL84B, VAL84F
• C-D: ALA101D, ALA106C, ALA113C, ALA11C, ALA130D, ALA166D, ALA19C, ALA304C, ALA317C, ALA35D, ALA36D, ALA39C, ALA44D, ALA5D, ALA7D, ALA96D, ARG109C, ARG123D, ARG153D, ARG170D, ARG25D, ARG269C, ARG321C, ARG54D, ASN104D, ASN116D, ASN129D, ASN12D, ASN135D, ASN168D, ASN169D, ASN22C, ASN28D, ASN290C, ASN298C, ASN322C, ASN38C, ASN49D, ASN53D, ASN60D, ASN8C, ASN95D, ASP104C, ASP109D, ASP112D, ASP145D, ASP164D, ASP19D, ASP291C, ASP31C, ASP32C, ASP37D, ASP7C, ASP85C, ASP86D, ASP90D, CYS137D, CYS144D, CYS148D, CYS14C, CYS281C, CYS305C, GLN105D, GLN125D, GLN172D, GLN1C, GLN27D, GLN295C, GLN311C, GLN327C, GLN34D, GLN65D, GLU103D, GLU114D, GLU11D, GLU120D, GLU131D, GLU132D, GLU150D, GLU15D, GLU165D, GLU280C, GLU325C, GLU35C, GLU41C, GLU57D, GLU61D, GLU67D, GLU69D, GLU74D, GLU81D, GLU85D, GLU97D, GLY136D, GLY13D, GLY16C, GLY16D, GLY1D, GLY20D, GLY23D, GLY263C, GLY303C, GLY319C, GLY31D, GLY33D, GLY5C, GLY8D, HIS106D, HIS142D, HIS17C, HIS18C, HIS26D, HIS56C, HIS64D, ILE108D, ILE10D, ILE140D, ILE149D, ILE152D, ILE18D, ILE267C, ILE282C, ILE29C, ILE300C, ILE34C, ILE45D, ILE48D, ILE56D, ILE66D, ILE6D, ILE77D, ILE89D, LEU102D, LEU110D, LEU111C, LEU118D, LEU126D, LEU13C, LEU15C, LEU25C, LEU314C, LEU316C, LEU42C, LEU52D, LEU66C, LEU86C, LEU91D, LEU98D, LEU99D, LYS117D, LYS121D, LYS139D, LYS143D, LYS264C, LYS27C, LYS292C, LYS299C, LYS307C, LYS310C, LYS315C, LYS326C, LYS51D, LYS58D, LYS62D, LYS68D, LYS82D, LYS88D, MET115D, MET133D, MET17D, MET268C, MET320C, PHE119D, PHE138D, PHE24D, PHE294C, PHE63D, PHE70D, PHE9D, PRO21C, PRO284C, PRO289C, PRO293C, PRO306C, PRO324C, PRO4C, PRO55C, SER107C, SER110C, SER114C, SER115C, SER265C, SER266C, SER270C, SER29D, SER40D, SER71D, SER93D, SER9C, THR107D, THR10C, THR111D, THR122D, THR12C, THR28C, THR301C, THR30C, THR313C, THR318C, THR328C, THR32D, THR37C, THR40C, THR41D, THR59D, THR87D, TRP14D, TRP21D, TRP92D, TYR141D, TYR22D, TYR302C, TYR308C, TYR94D, VAL100D, VAL112C, VAL161D, VAL20C, VAL26C, VAL309C, VAL323C, VAL36C, VAL43C, VAL55D
• C-E: ARG201E, ARG207E, ARG208E, ARG220C, ARG224C, ARG229C, ASN165E, ASN188C, ASN216C, ASN246E, ASN248E, ASP101C, ASP241E, GLN210E, GLN211E, GLN226C, GLY218C, HIS183C, HIS184C, ILE182C, ILE213C, ILE213E, ILE214C, ILE214E, ILE217C, ILE230C, ILE232C, ILE245E, LEU164E, LEU243E, LYS307E, LYS310C, MET168E, PRO103C, PRO185C, PRO215C, PRO221C, PRO99C, SER186C, SER205E, SER209E, SER219C, SER227C, SER228C, SER231C, SER247E, THR167E, THR187C, THR203E, THR206E, THR212E, TRP222C, TYR100C, TYR233C, VAL102C, VAL163E, VAL166E, VAL202E, VAL204E, VAL223C, VAL237E, VAL242E, VAL244E
• C-F: ALA44F, ARG54F, ASN49F, ASN53F, ASN60F, ASP31C, ASP32C, ASP46F, GLN311C, GLN33C, GLN47F, GLU103F, GLU57F, GLU61F, GLY50F, HIS106F, ILE29C, ILE48F, LEU102F, LEU110F, LEU314C, LEU52F, LEU99F, LYS27C, LYS310C, LYS51F, LYS62F, THR107F, THR28C, THR30C, TRP92F, VAL26C, VAL55F
• D-E: ALA106E, ARG109E, ARG208E, ARG261E, ARG76D, ASP104E, ASP175E, ASP2E, ASP79D, ASP90D, GLN1E, GLN78D, GLU72D, GLU74D, GLY175D, GLY75D, ILE173D, ILE236E, ILE29E, ILE300E, ILE77D, LEU102D, LEU108E, LEU111E, LEU177E, LEU3E, LEU91D, LYS174D, LYS238E, LYS299E, LYS307E, LYS82D, MET260E, PHE294E, PRO239E, PRO293E, PRO4E, SER107E, SER110E, SER114E, SER115E, SER209E, SER71D, SER93D, THR235E, THR262E, THR301E, TRP234E, TYR105E, TYR308E, TYR83D, TYR94D, VAL112E, VAL237E, VAL73D
• D-F: ALA101D, ALA130D, ALA166F, ALA5D, ALA7D, ALA96D, ALA96F, ARG123D, ARG123F, ARG124F, ARG127F, ARG163F, ARG170D, ARG170F, ARG54F, ARG76D, ARG76F, ASN104D, ASN116D, ASN116F, ASN135D, ASN168F, ASN169D, ASN169F, ASN60F, ASN95D, ASN95F, ASP109D, ASP109F, ASP112D, ASP112F, ASP160F, ASP164F, ASP79D, ASP79F, ASP86D, ASP86F, ASP90D, ASP90F, CYS137D, GLN105D, GLN125F, GLN172D, GLN47F, GLN65F, GLN78D, GLN78F, GLU103F, GLU114F, GLU120D, GLU120F, GLU128D, GLU128F, GLU131D, GLU132D, GLU165F, GLU57F, GLU61F, GLU67F, GLU69F, GLU72F, GLU74F, GLU81D, GLU81F, GLU85D, GLU85F, GLU97D, GLY134D, GLY136D, GLY175D, GLY1D, GLY4D, GLY75D, GLY75F, GLY8D, HIS106D, HIS106F, HIS159F, HIS64F, ILE108F, ILE10D, ILE173D, ILE66D, ILE66F, ILE6D, ILE77D, ILE77F, ILE89D, ILE89F, LEU102D, LEU102F, LEU110F, LEU167D, LEU167F, LEU2D, LEU2F, LEU80D, LEU80F, LEU91D, LEU91F, LEU98D, LEU98F, LEU99D, LEU99F, LYS117F, LYS121F, LYS139D, LYS174D, LYS51F, LYS62F, LYS68F, LYS82D, LYS82F, LYS88D, LYS88F, MET133D, PHE119D, PHE138D, PHE171D, PHE171F, PHE3D, PHE3F, PHE63F, PHE70F, PHE9D, SER113D, SER113F, SER71F, SER93D, SER93F, THR107F, THR111F, THR87D, THR87F, TRP92D, TRP92F, TYR141D, TYR162F, TYR83D, TYR83F, TYR94D, TYR94F, VAL100D, VAL100F, VAL161F, VAL55F, VAL84D, VAL84F
• E-F: ALA101F, ALA106E, ALA113E, ALA11E, ALA130F, ALA166F, ALA19E, ALA304E, ALA317E, ALA35F, ALA36F, ALA39E, ALA44F, ALA5F, ALA7F, ALA96F, ARG109E, ARG123F, ARG153F, ARG163F, ARG170F, ARG25F, ARG269E, ARG321E, ARG54F, ASN104F, ASN116F, ASN129F, ASN12F, ASN135F, ASN168F, ASN169F, ASN22E, ASN28F, ASN290E, ASN296E, ASN298E, ASN322E, ASN38E, ASN49F, ASN53F, ASN60F, ASN8E, ASN95F, ASP104E, ASP109F, ASP112F, ASP145F, ASP160F, ASP164F, ASP19F, ASP291E, ASP2E, ASP31E, ASP32E, ASP37F, ASP7E, ASP85E, ASP86F, ASP90F, CYS137F, CYS144F, CYS148F, CYS14E, CYS281E, CYS305E, GLN105F, GLN125F, GLN172F, GLN1E, GLN27F, GLN295E, GLN311E, GLN327E, GLN34F, GLN65F, GLU103F, GLU114F, GLU11F, GLU120F, GLU131F, GLU132F, GLU150F, GLU15F, GLU165F, GLU280E, GLU30F, GLU325E, GLU35E, GLU41E, GLU57F, GLU61F, GLU67F, GLU69F, GLU74F, GLU81F, GLU85F, GLU97F, GLY136F, GLY13F, GLY16E, GLY16F, GLY1F, GLY20F, GLY23F, GLY263E, GLY303E, GLY319E, GLY31F, GLY33F, GLY5E, GLY8F, HIS106F, HIS142F, HIS17E, HIS18E, HIS26F, HIS56E, HIS64F, ILE108F, ILE10F, ILE140F, ILE149F, ILE152F, ILE18F, ILE267E, ILE282E, ILE29E, ILE300E, ILE34E, ILE45F, ILE48F, ILE56F, ILE66F, ILE6F, ILE77F, ILE89F, LEU102F, LEU110F, LEU111E, LEU118F, LEU126F, LEU13E, LEU15E, LEU25E, LEU314E, LEU316E, LEU3E, LEU42E, LEU52F, LEU66E, LEU86E, LEU91F, LEU98F, LEU99F, LYS117F, LYS121F, LYS139F, LYS143F, LYS264E, LYS27E, LYS292E, LYS299E, LYS307E, LYS310E, LYS315E, LYS326E, LYS51F, LYS58F, LYS62F, LYS68F, LYS82F, LYS88F, MET115F, MET133F, MET17F, MET268E, MET320E, PHE119F, PHE138F, PHE24F, PHE294E, PHE63F, PHE70F, PHE9F, PRO21E, PRO284E, PRO289E, PRO293E, PRO306E, PRO324E, PRO4E, PRO55E, SER107E, SER110E, SER114E, SER115E, SER265E, SER266E, SER29F, SER40F, SER71F, SER93F, SER9E, THR107F, THR10E, THR111F, THR122F, THR12E, THR28E, THR301E, THR30E, THR313E, THR318E, THR32F, THR37E, THR40E, THR41F, THR59F, THR87F, TRP14F, TRP21F, TRP92F, TYR141F, TYR162F, TYR22F, TYR302E, TYR308E, TYR94F, VAL100F, VAL112E, VAL161F, VAL20E, VAL26E, VAL309E, VAL323E, VAL36E, VAL43E, VAL55F