4A9G

symmetrized cryo-em reconstruction of e. coli degq 24-mer in complex with beta-casein

• Total interactions analyzed: 276
• Total true interactions: 48
• Strongest Interaction:
  • Chains: B-J
  • Int. Res.: 43
  • Norm. En. per Res.: -0.1123
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-E	0.0	0.0	1.4633	1.4633	50	5	0	632	0	0	0
A-I	0.0	0.0	-4.6919	-4.6919	42	0	0	647	0	0	0
A-O	0.0	0.0	4.2853	4.2853	45	9	0	1226	0	0	0
A-P	0.0	0.0	14.9352	14.9352	39	14	0	1189	0	0	0
B-F	0.0	0.0	-1.5083	-1.5083	50	3	0	620	0	0	0
B-J	0.0	0.0	-4.8291	-4.8291	43	0	0	630	0	0	0
B-O	0.0	0.0	12.1035	12.1035	39	14	0	1175	0	0	0
B-P	0.0	0.0	3.9739	3.9739	43	10	0	1234	0	0	0
C-G	0.0	0.0	-0.0718	-0.0718	50	4	0	651	0	0	0
C-K	0.0	0.0	-4.6962	-4.6962	43	0	0	627	0	0	0
C-M	0.0	0.0	4.7206	4.7206	45	10	0	1239	0	0	0
C-N	0.0	0.0	13.4166	13.4166	40	14	0	1162	0	0	0
D-H	0.0	0.0	-1.5526	-1.5526	51	3	0	627	0	0	0
D-L	0.0	0.0	-4.682	-4.682	43	0	0	639	0	0	0
D-M	0.0	0.0	9.7077	9.7077	39	14	0	1167	0	0	0
D-N	0.0	0.0	4.3782	4.3782	44	10	0	1230	0	0	0
E-I	0.0	0.0	-2.3483	-2.3483	50	5	0	654	0	0	0
E-R	0.0	0.0	1.9296	1.9296	44	10	0	1234	0	0	0
E-T	0.0	0.0	15.5041	15.5041	39	14	0	1169	0	0	0
F-J	0.0	0.0	-0.0333	-0.0333	50	6	0	641	0	0	0
F-Q	0.0	0.0	5.0399	5.0399	44	10	0	1240	0	0	0
F-S	0.0	0.0	17.165	17.165	41	14	0	1171	0	0	0
G-K	0.0	0.0	-1.9654	-1.9654	52	5	0	642	0	0	0
G-R	0.0	0.0	13.9575	13.9575	40	14	0	1180	0	0	0
G-T	0.0	0.0	4.6185	4.6185	45	9	0	1231	0	0	0
H-L	0.0	0.0	-0.3939	-0.3939	52	6	0	643	0	0	0
H-Q	0.0	0.0	13.3379	13.3379	41	14	0	1167	0	0	0
H-S	0.0	0.0	3.6146	3.6146	44	10	0	1242	0	0	0
I-V	0.0	0.0	12.454	12.454	45	11	0	1255	0	0	0
I-W	0.0	0.0	16.3822	16.3822	45	11	0	1267	0	0	0
J-U	0.0	0.0	8.9557	8.9557	46	9	0	1263	0	0	0
J-Y	0.0	0.0	8.9003	8.9003	44	8	0	1260	0	0	0
K-U	0.0	0.0	18.7251	18.7251	44	10	0	1272	0	0	0
K-Y	0.0	0.0	8.0475	8.0475	47	9	0	1273	0	0	0
L-V	0.0	0.0	14.8325	14.8325	45	11	0	1267	0	0	0
L-W	0.0	0.0	7.9275	7.9275	46	8	0	1269	0	0	0
M-Q	0.0	0.0	-5.2327	-5.2327	50	0	0	643	0	0	0
M-U	0.0	0.0	-0.0841	-0.0841	51	5	0	615	0	0	0
N-R	0.0	0.0	-0.7394	-0.7394	51	3	0	630	0	0	0
N-V	0.0	0.0	-0.858	-0.858	50	5	0	628	0	0	0
O-S	0.0	0.0	1.0776	1.0776	50	4	0	626	0	0	0
O-W	0.0	0.0	-1.2095	-1.2095	52	5	0	643	0	0	0
P-T	0.0	0.0	1.2943	1.2943	51	3	0	622	0	0	0
P-Y	0.0	0.0	-0.7953	-0.7953	51	5	0	635	0	0	0
Q-U	0.0	0.0	-4.3149	-4.3149	43	1	0	642	0	0	0
R-V	0.0	0.0	-3.9074	-3.9074	42	1	0	622	0	0	0
S-W	0.0	0.0	-4.6436	-4.6436	43	0	0	638	0	0	0
T-Y	0.0	0.0	-4.1731	-4.1731	43	1	0	641	0	0	0

Interface residues

• A-E: ALA154A, ALA161E, ALA16A, ALA180E, ARG164E, ARG98A, ASN258E, ASP139E, ASP179E, ASP260E, GLN152A, GLU99A, GLY138E, GLY149A, GLY151A, GLY157E, GLY163E, GLY166E, GLY209E, GLY210A, GLY210E, GLY211A, GLY211E, GLY214E, GLY97A, ILE158E, LEU12A, LEU12E, LEU150A, LEU15A, LEU162E, LEU167E, LYS255E, PHE100A, PHE140E, PHE148A, PRO11A, PRO11E, SER14A, SER156A, SER160E, SER165E, SER181A, SER212A, SER212E, THR153A, THR155A, VAL159E, VAL213E, VAL261E
• A-I: ALA154I, ALA161A, ARG164A, ARG98I, ASN258A, ASP179A, ASP260A, GLN152I, GLU99I, GLY138A, GLY149I, GLY151I, GLY157A, GLY210A, GLY210I, GLY211A, GLY211I, GLY214A, GLY97I, ILE158A, LEU12A, LEU12I, LEU150I, LEU259A, LYS255A, PHE140A, PHE148I, PRO11A, PRO11I, PRO13I, SER14I, SER156I, SER160A, SER165A, SER181I, SER212A, SER212I, THR153I, THR155I, VAL159A, VAL213A, VAL261A
• A-O: ALA283A, ALA376O, ALA377O, ALA379O, ARG320A, ARG418O, ASN321A, ASN420O, ASP285A, ASP385O, GLN378O, GLN382O, GLU248A, GLU269A, GLU421O, GLY246A, GLY284A, GLY322A, GLY380O, GLY419O, ILE244A, ILE253A, ILE286A, ILE416O, ILE423O, LEU319A, LEU381O, LEU425O, LEU426O, LYS245A, LYS282A, LYS323A, LYS372O, LYS383O, MET249A, PHE266A, SER250A, SER268A, SER422O, THR247A, TYR424O, VAL267A, VAL270A, VAL370O, VAL417O
• A-P: ALA283P, ALA377A, ALA379A, ARG320P, ARG418A, ASN321P, ASN420A, ASP285P, ASP385A, GLN378A, GLN382A, GLU269P, GLU421A, GLY246P, GLY284P, GLY322P, GLY380A, GLY419A, ILE253P, ILE286P, ILE416A, ILE423A, LEU381A, LEU425A, LEU426A, LYS245P, LYS282P, LYS323P, LYS372A, LYS383A, PHE266P, SER250P, SER268P, SER422A, THR247P, TYR424A, VAL267P, VAL270P, VAL417A
• B-F: ALA154B, ALA161F, ALA16B, ALA180F, ARG164F, ARG98B, ASN258F, ASP139F, ASP179F, ASP260F, GLN152B, GLU99B, GLY138F, GLY149B, GLY151B, GLY157F, GLY163F, GLY166F, GLY209F, GLY210B, GLY210F, GLY211B, GLY211F, GLY214F, GLY97B, ILE158F, LEU12B, LEU12F, LEU150B, LEU15B, LEU162F, LEU167F, LYS255F, PHE100B, PHE140F, PHE148B, PRO11B, PRO11F, SER14B, SER156B, SER160F, SER165F, SER181B, SER212B, SER212F, THR153B, THR155B, VAL159F, VAL213F, VAL261F
• B-J: ALA154J, ALA161B, ARG164B, ARG98J, ASN258B, ASP179B, ASP260B, GLN152J, GLU99J, GLY138B, GLY149J, GLY151J, GLY157B, GLY209B, GLY210B, GLY210J, GLY211B, GLY211J, GLY214B, GLY97J, ILE158B, LEU12B, LEU12J, LEU150J, LEU259B, LYS255B, PHE140B, PHE148J, PRO11B, PRO11J, PRO13J, SER14J, SER156J, SER160B, SER165B, SER181J, SER212B, SER212J, THR153J, THR155J, VAL159B, VAL213B, VAL261B
• B-O: ALA283O, ALA377B, ALA379B, ARG320O, ARG418B, ASN321O, ASN420B, ASP285O, ASP385B, GLN378B, GLN382B, GLU269O, GLU421B, GLY246O, GLY284O, GLY322O, GLY380B, GLY419B, ILE253O, ILE286O, ILE416B, ILE423B, LEU381B, LEU425B, LEU426B, LYS245O, LYS282O, LYS323O, LYS372B, LYS383B, PHE266O, SER250O, SER268O, SER422B, THR247O, TYR424B, VAL267O, VAL270O, VAL417B
• B-P: ALA283B, ALA376P, ALA377P, ALA379P, ARG320B, ARG418P, ASN321B, ASN420P, ASP285B, ASP385P, GLN378P, GLN382P, GLU248B, GLU269B, GLU421P, GLY246B, GLY284B, GLY322B, GLY380P, GLY419P, ILE253B, ILE286B, ILE416P, ILE423P, LEU319B, LEU381P, LEU425P, LEU426P, LYS245B, LYS282B, LYS323B, LYS383P, MET249B, PHE266B, SER250B, SER268B, SER422P, THR247B, TYR424P, VAL267B, VAL270B, VAL370P, VAL417P
• C-G: ALA154C, ALA161G, ALA16C, ALA180G, ARG164G, ARG98C, ASN258G, ASP139G, ASP179G, ASP260G, GLN152C, GLU99C, GLY138G, GLY149C, GLY151C, GLY157G, GLY163G, GLY210C, GLY210G, GLY211C, GLY211G, GLY214G, GLY97C, ILE158G, LEU12C, LEU12G, LEU150C, LEU15C, LEU162G, LEU167G, LYS255G, PHE100C, PHE140G, PHE148C, PRO11C, PRO11G, PRO13G, PRO208C, SER14C, SER156C, SER160G, SER165G, SER181C, SER212C, SER212G, THR153C, THR155C, VAL159G, VAL213G, VAL261G
• C-K: ALA154K, ALA161C, ARG164C, ARG98K, ASN258C, ASP179C, ASP260C, GLN152K, GLU99K, GLY138C, GLY149K, GLY151K, GLY157C, GLY209C, GLY210C, GLY210K, GLY211C, GLY211K, GLY214C, GLY97K, ILE158C, LEU12C, LEU12K, LEU150K, LEU259C, LYS255C, PHE140C, PHE148K, PRO11C, PRO11K, PRO13K, SER14K, SER156K, SER160C, SER165C, SER181K, SER212C, SER212K, THR153K, THR155K, VAL159C, VAL213C, VAL261C
• C-M: ALA283C, ALA376M, ALA377M, ALA379M, ARG320C, ARG418M, ASN321C, ASN420M, ASP285C, ASP385M, GLN378M, GLN382M, GLU248C, GLU269C, GLU421M, GLY246C, GLY284C, GLY322C, GLY380M, GLY419M, ILE244C, ILE253C, ILE286C, ILE416M, ILE423M, LEU319C, LEU381M, LEU425M, LEU426M, LYS245C, LYS282C, LYS323C, LYS372M, LYS383M, MET249C, PHE266C, SER250C, SER268C, SER422M, THR247C, TYR424M, VAL267C, VAL270C, VAL370M, VAL417M
• C-N: ALA283N, ALA377C, ALA379C, ARG320N, ARG418C, ASN321N, ASN420C, ASP285N, ASP385C, GLN378C, GLN382C, GLU269N, GLU421C, GLY246N, GLY284N, GLY322N, GLY380C, GLY419C, ILE253N, ILE286N, ILE416C, ILE423C, LEU381C, LEU425C, LEU426C, LYS245N, LYS282N, LYS323N, LYS372C, LYS383C, PHE257N, PHE266N, SER250N, SER268N, SER422C, THR247N, TYR424C, VAL267N, VAL270N, VAL417C
• D-H: ALA154D, ALA161H, ALA16D, ALA180H, ARG164H, ARG98D, ASN258H, ASP139H, ASP179H, ASP260H, GLN152D, GLU99D, GLY138H, GLY149D, GLY151D, GLY157H, GLY163H, GLY166H, GLY209H, GLY210D, GLY210H, GLY211D, GLY211H, GLY214H, GLY97D, ILE158H, LEU12D, LEU12H, LEU150D, LEU15D, LEU162H, LEU167H, LEU259H, LYS255H, PHE100D, PHE140H, PHE148D, PRO11D, PRO11H, SER14D, SER156D, SER160H, SER165H, SER181D, SER212D, SER212H, THR153D, THR155D, VAL159H, VAL213H, VAL261H
• D-L: ALA154L, ALA161D, ARG164D, ARG98L, ASN258D, ASP179D, ASP260D, GLN152L, GLU99L, GLY138D, GLY149L, GLY151L, GLY157D, GLY209D, GLY210D, GLY210L, GLY211D, GLY211L, GLY214D, GLY97L, ILE158D, LEU12D, LEU12L, LEU150L, LEU259D, LYS255D, PHE140D, PHE148L, PRO11D, PRO11L, PRO13L, SER14L, SER156L, SER160D, SER165D, SER181L, SER212D, SER212L, THR153L, THR155L, VAL159D, VAL213D, VAL261D
• D-M: ALA283M, ALA377D, ALA379D, ARG320M, ARG418D, ASN321M, ASN420D, ASP285M, GLN378D, GLN382D, GLU269M, GLU421D, GLY246M, GLY284M, GLY322M, GLY380D, GLY419D, ILE253M, ILE286M, ILE416D, ILE423D, LEU319M, LEU381D, LEU425D, LEU426D, LYS245M, LYS282M, LYS323M, LYS372D, LYS383D, PHE266M, SER250M, SER268M, SER422D, THR247M, TYR424D, VAL267M, VAL270M, VAL417D
• D-N: ALA283D, ALA376N, ALA377N, ALA379N, ARG320D, ARG418N, ASN321D, ASN420N, ASP285D, ASP385N, GLN378N, GLN382N, GLU248D, GLU269D, GLU421N, GLY246D, GLY284D, GLY322D, GLY380N, GLY419N, ILE253D, ILE286D, ILE416N, ILE423N, LEU319D, LEU381N, LEU425N, LEU426N, LYS245D, LYS282D, LYS323D, LYS372N, LYS383N, MET249D, PHE266D, SER250D, SER268D, SER422N, THR247D, TYR424N, VAL267D, VAL270D, VAL370N, VAL417N
• E-I: ALA154E, ALA161I, ALA16E, ALA180I, ARG164I, ARG98E, ASN258I, ASP139I, ASP179I, ASP260I, GLN152E, GLU99E, GLY138I, GLY149E, GLY151E, GLY157I, GLY163I, GLY166I, GLY210E, GLY210I, GLY211E, GLY211I, GLY214I, GLY97E, ILE158I, LEU12E, LEU12I, LEU150E, LEU15E, LEU162I, LEU167I, LYS255I, PHE100E, PHE140I, PHE148E, PRO11E, PRO11I, PRO13E, SER14E, SER156E, SER160I, SER165I, SER181E, SER212E, SER212I, THR153E, THR155E, VAL159I, VAL213I, VAL261I
• E-R: ALA283R, ALA376E, ALA377E, ALA379E, ARG320R, ARG418E, ASN321R, ASN420E, ASP285R, ASP385E, GLN378E, GLN382E, GLU248R, GLU269R, GLU421E, GLY246R, GLY284R, GLY322R, GLY380E, GLY419E, ILE253R, ILE286R, ILE416E, ILE423E, LEU319R, LEU381E, LEU425E, LEU426E, LYS245R, LYS282R, LYS323R, LYS372E, LYS383E, MET249R, PHE266R, SER250R, SER268R, SER422E, THR247R, TYR424E, VAL267R, VAL270R, VAL370E, VAL417E
• E-T: ALA283E, ALA377T, ALA379T, ARG320E, ARG418T, ASN321E, ASN420T, ASP285E, ASP385T, GLN378T, GLN382T, GLU269E, GLU421T, GLY246E, GLY284E, GLY322E, GLY380T, GLY419T, ILE253E, ILE416T, ILE423T, LEU319E, LEU381T, LEU425T, LEU426T, LYS245E, LYS282E, LYS323E, LYS372T, LYS383T, PHE266E, SER250E, SER268E, SER422T, THR247E, TYR424T, VAL267E, VAL270E, VAL417T
• F-J: ALA154F, ALA161J, ALA16F, ARG164J, ARG98F, ASN258J, ASP139J, ASP179J, ASP260J, GLN152F, GLU99F, GLY138J, GLY149F, GLY151F, GLY157J, GLY163J, GLY166J, GLY209J, GLY210F, GLY210J, GLY211F, GLY211J, GLY214J, GLY97F, ILE158J, LEU12F, LEU12J, LEU150F, LEU15F, LEU162J, LEU167J, LYS255J, PHE100F, PHE140J, PHE148F, PRO11F, PRO11J, PRO13F, SER14F, SER156F, SER160J, SER165J, SER181F, SER212F, SER212J, THR153F, THR155F, VAL159J, VAL213J, VAL261J
• F-Q: ALA283Q, ALA376F, ALA377F, ALA379F, ARG320Q, ARG418F, ASN321Q, ASN420F, ASP285Q, ASP385F, GLN378F, GLN382F, GLU248Q, GLU269Q, GLU421F, GLY246Q, GLY284Q, GLY322Q, GLY380F, GLY419F, ILE244Q, ILE253Q, ILE286Q, ILE416F, ILE423F, LEU319Q, LEU381F, LEU425F, LEU426F, LYS245Q, LYS282Q, LYS323Q, LYS383F, MET249Q, PHE266Q, SER250Q, SER268Q, SER422F, THR247Q, TYR424F, VAL267Q, VAL270Q, VAL370F, VAL417F
• F-S: ALA283F, ALA377S, ALA379S, ARG320F, ARG418S, ASN321F, ASN420S, ASP285F, ASP385S, GLN378S, GLN382S, GLU269F, GLU421S, GLY246F, GLY284F, GLY322F, GLY380S, GLY419S, ILE253F, ILE286F, ILE416S, ILE423S, LEU319F, LEU381S, LEU425S, LEU426S, LYS245F, LYS282F, LYS323F, LYS372S, LYS383S, PHE257F, PHE266F, SER250F, SER268F, SER422S, THR247F, TYR424S, VAL267F, VAL270F, VAL417S
• G-K: ALA154G, ALA161K, ALA16G, ALA180K, ARG164K, ARG98G, ASN258K, ASP139K, ASP179K, ASP260K, GLN152G, GLU99G, GLY138K, GLY149G, GLY151G, GLY157K, GLY163K, GLY166K, GLY209K, GLY210G, GLY210K, GLY211G, GLY211K, GLY214K, GLY97G, ILE158K, LEU12G, LEU12K, LEU150G, LEU15G, LEU162K, LEU167K, LYS255K, PHE100G, PHE140K, PHE148G, PRO11G, PRO11K, PRO13G, PRO13K, SER14G, SER156G, SER160K, SER165K, SER181G, SER212G, SER212K, THR153G, THR155G, VAL159K, VAL213K, VAL261K
• G-R: ALA283G, ALA377R, ALA379R, ARG320G, ARG418R, ASN321G, ASN420R, ASP285G, ASP385R, GLN378R, GLN382R, GLU269G, GLU421R, GLY246G, GLY284G, GLY322G, GLY380R, GLY419R, ILE253G, ILE286G, ILE416R, ILE423R, LEU381R, LEU425R, LEU426R, LYS245G, LYS282G, LYS323G, LYS372R, LYS383R, PHE257G, PHE266G, SER250G, SER268G, SER422R, THR247G, TYR424R, VAL267G, VAL270G, VAL417R
• G-T: ALA283T, ALA376G, ALA377G, ALA379G, ARG320T, ARG418G, ASN321T, ASN420G, ASP285T, ASP385G, GLN378G, GLN382G, GLU248T, GLU269T, GLU421G, GLY246T, GLY284T, GLY322T, GLY380G, GLY419G, ILE244T, ILE253T, ILE286T, ILE416G, ILE423G, LEU319T, LEU381G, LEU425G, LEU426G, LYS245T, LYS282T, LYS323T, LYS372G, LYS383G, MET249T, PHE266T, SER250T, SER268T, SER422G, THR247T, TYR424G, VAL267T, VAL270T, VAL370G, VAL417G
• H-L: ALA154H, ALA161L, ALA16H, ALA180L, ARG164L, ARG98H, ASN258L, ASP139L, ASP179L, ASP260L, GLN152H, GLU99H, GLY138L, GLY149H, GLY151H, GLY157L, GLY163L, GLY166L, GLY209L, GLY210H, GLY210L, GLY211H, GLY211L, GLY214L, GLY97H, ILE158L, LEU12H, LEU12L, LEU150H, LEU15H, LEU162L, LEU167L, LYS255L, PHE100H, PHE140L, PHE148H, PRO11H, PRO11L, PRO13H, PRO13L, SER14H, SER156H, SER160L, SER165L, SER181H, SER212H, SER212L, THR153H, THR155H, VAL159L, VAL213L, VAL261L
• H-Q: ALA283H, ALA377Q, ALA379Q, ARG320H, ARG418Q, ASN321H, ASN420Q, ASP285H, ASP385Q, GLN378Q, GLN382Q, GLU269H, GLU421Q, GLY246H, GLY284H, GLY322H, GLY380Q, GLY419Q, ILE253H, ILE286H, ILE416Q, ILE423Q, LEU319H, LEU381Q, LEU425Q, LEU426Q, LYS245H, LYS282H, LYS323H, LYS372Q, LYS383Q, PHE257H, PHE266H, SER250H, SER268H, SER422Q, THR247H, TYR424Q, VAL267H, VAL270H, VAL417Q
• H-S: ALA283S, ALA376H, ALA377H, ALA379H, ARG320S, ARG418H, ASN321S, ASN420H, ASP285S, ASP385H, GLN378H, GLN382H, GLU248S, GLU269S, GLU421H, GLY246S, GLY284S, GLY322S, GLY380H, GLY419H, ILE253S, ILE286S, ILE416H, ILE423H, LEU319S, LEU381H, LEU425H, LEU426H, LYS245S, LYS282S, LYS323S, LYS372H, LYS383H, MET249S, PHE266S, SER250S, SER268S, SER422H, THR247S, TYR424H, VAL267S, VAL270S, VAL370H, VAL417H
• I-V: ALA283I, ALA376V, ALA377V, ALA379V, ARG320I, ARG418V, ASN321I, ASN420V, ASP285I, ASP385V, GLN378V, GLN382V, GLU248I, GLU269I, GLU421V, GLY246I, GLY284I, GLY322I, GLY380V, GLY419V, ILE244I, ILE253I, ILE286I, ILE416V, ILE423V, LEU319I, LEU381V, LEU425V, LEU426V, LYS245I, LYS282I, LYS323I, LYS372V, LYS383V, MET249I, PHE266I, SER250I, SER268I, SER422V, THR247I, TYR424V, VAL267I, VAL270I, VAL370V, VAL417V
• I-W: ALA283W, ALA376I, ALA377I, ALA379I, ARG320W, ARG418I, ASN321W, ASN420I, ASP285W, ASP385I, GLN378I, GLN382I, GLU248W, GLU269W, GLU421I, GLY246W, GLY284W, GLY322W, GLY380I, GLY419I, ILE253W, ILE286W, ILE416I, ILE423I, LEU319W, LEU381I, LEU425I, LEU426I, LYS245W, LYS282W, LYS323W, LYS372I, LYS383I, MET249W, PHE257W, PHE266W, SER250W, SER268W, SER422I, THR247W, TYR424I, VAL267W, VAL270W, VAL370I, VAL417I
• J-U: ALA283J, ALA376U, ALA377U, ALA379U, ARG320J, ARG418U, ASN321J, ASN420U, ASP285J, ASP385U, GLN378U, GLN382U, GLU248J, GLU269J, GLU421U, GLY246J, GLY284J, GLY322J, GLY380U, GLY419U, ILE244J, ILE253J, ILE286J, ILE416U, ILE423U, LEU319J, LEU381U, LEU425U, LEU426U, LYS245J, LYS282J, LYS323J, LYS372U, LYS383U, MET249J, PHE257J, PHE266J, SER250J, SER268J, SER422U, THR247J, TYR424U, VAL267J, VAL270J, VAL370U, VAL417U
• J-Y: ALA283Y, ALA376J, ALA377J, ALA379J, ARG320Y, ARG418J, ASN321Y, ASN420J, ASP285Y, ASP385J, GLN378J, GLN382J, GLU248Y, GLU269Y, GLU421J, GLY246Y, GLY284Y, GLY322Y, GLY380J, GLY419J, ILE253Y, ILE286Y, ILE416J, ILE423J, LEU319Y, LEU381J, LEU425J, LEU426J, LYS245Y, LYS282Y, LYS323Y, LYS372J, LYS383J, MET249Y, PHE266Y, SER250Y, SER268Y, SER422J, THR247Y, TYR424J, VAL267Y, VAL270Y, VAL370J, VAL417J
• K-U: ALA283U, ALA376K, ALA377K, ALA379K, ARG320U, ARG418K, ASN321U, ASN420K, ASP285U, ASP385K, GLN378K, GLN382K, GLU248U, GLU269U, GLU421K, GLY246U, GLY284U, GLY322U, GLY380K, GLY419K, ILE253U, ILE286U, ILE416K, ILE423K, LEU319U, LEU381K, LEU425K, LEU426K, LYS245U, LYS282U, LYS323U, LYS372K, LYS383K, MET249U, PHE266U, SER250U, SER268U, SER422K, THR247U, TYR424K, VAL267U, VAL270U, VAL370K, VAL417K
• K-Y: ALA283K, ALA376Y, ALA377Y, ALA379Y, ALA413Y, ARG320K, ARG418Y, ASN321K, ASN420Y, ASP252K, ASP285K, ASP385Y, GLN378Y, GLN382Y, GLU248K, GLU269K, GLU421Y, GLY246K, GLY284K, GLY322K, GLY380Y, GLY419Y, ILE253K, ILE286K, ILE416Y, ILE423Y, LEU319K, LEU381Y, LEU425Y, LEU426Y, LYS245K, LYS282K, LYS323K, LYS372Y, LYS383Y, MET249K, PHE257K, PHE266K, SER250K, SER268K, SER422Y, THR247K, TYR424Y, VAL267K, VAL270K, VAL370Y, VAL417Y
• L-V: ALA283V, ALA376L, ALA377L, ALA379L, ARG320V, ARG418L, ASN321V, ASN420L, ASP285V, ASP385L, GLN378L, GLN382L, GLU248V, GLU269V, GLU421L, GLY246V, GLY284V, GLY322V, GLY380L, GLY419L, ILE244V, ILE253V, ILE286V, ILE416L, ILE423L, LEU319V, LEU381L, LEU425L, LEU426L, LYS245V, LYS282V, LYS323V, LYS372L, LYS383L, MET249V, PHE266V, SER250V, SER268V, SER422L, THR247V, TYR424L, VAL267V, VAL270V, VAL370L, VAL417L
• L-W: ALA283L, ALA376W, ALA377W, ALA379W, ARG320L, ARG418W, ASN321L, ASN420W, ASP285L, ASP385W, GLN378W, GLN382W, GLU248L, GLU269L, GLU421W, GLY246L, GLY284L, GLY322L, GLY380W, GLY419W, ILE244L, ILE253L, ILE286L, ILE416W, ILE423W, LEU319L, LEU381W, LEU425W, LEU426W, LYS245L, LYS282L, LYS323L, LYS372W, LYS383W, MET249L, PHE257L, PHE266L, SER250L, SER268L, SER422W, THR247L, TYR424W, VAL267L, VAL270L, VAL370W, VAL417W
• M-Q: ALA154Q, ALA161M, ALA16Q, ALA180M, ARG164M, ARG98Q, ASN258M, ASP139M, ASP179M, ASP260M, GLN152Q, GLU99Q, GLY138M, GLY149Q, GLY151Q, GLY157M, GLY163M, GLY166M, GLY210M, GLY210Q, GLY211M, GLY211Q, GLY214M, GLY97Q, ILE158M, LEU12M, LEU12Q, LEU150Q, LEU15Q, LEU162M, LEU167M, LYS255M, PHE100Q, PHE140M, PHE148Q, PRO11M, PRO11Q, PRO208Q, SER14Q, SER156Q, SER160M, SER165M, SER181Q, SER212M, SER212Q, THR153Q, THR155Q, VAL159M, VAL213M, VAL261M
• M-U: ALA154M, ALA161U, ALA16M, ALA180U, ARG164U, ARG98M, ASN258U, ASP139U, ASP179U, ASP260U, GLN152M, GLU99M, GLY138U, GLY149M, GLY151M, GLY157U, GLY163U, GLY166U, GLY209U, GLY210M, GLY210U, GLY211M, GLY211U, GLY214U, GLY97M, ILE158U, LEU12M, LEU12U, LEU150M, LEU15M, LEU162U, LEU167U, LYS255U, PHE100M, PHE140U, PHE148M, PRO11M, PRO11U, PRO13M, SER14M, SER156M, SER160U, SER165U, SER181M, SER212M, SER212U, THR153M, THR155M, VAL159U, VAL213U, VAL261U
• N-R: ALA154R, ALA161N, ALA16R, ALA180N, ARG164N, ARG98R, ASN258N, ASP139N, ASP179N, ASP260N, GLN152R, GLU99R, GLY138N, GLY149R, GLY151R, GLY157N, GLY163N, GLY166N, GLY209N, GLY210N, GLY210R, GLY211N, GLY211R, GLY214N, GLY97R, ILE158N, LEU12N, LEU12R, LEU150R, LEU15R, LEU162N, LEU167N, LEU259N, LYS255N, PHE100R, PHE140N, PHE148R, PRO11N, PRO11R, SER14R, SER156R, SER160N, SER165N, SER181R, SER212N, SER212R, THR153R, THR155R, VAL159N, VAL213N, VAL261N
• N-V: ALA154N, ALA161V, ALA16N, ALA180V, ARG164V, ARG98N, ASN258V, ASP139V, ASP179V, ASP260V, GLN152N, GLU99N, GLY138V, GLY149N, GLY151N, GLY157V, GLY163V, GLY166V, GLY210N, GLY210V, GLY211N, GLY211V, GLY214V, GLY97N, ILE158V, LEU12N, LEU12V, LEU150N, LEU15N, LEU162V, LEU167V, LYS255V, PHE100N, PHE140V, PHE148N, PRO11N, PRO11V, PRO13N, SER14N, SER156N, SER160V, SER165V, SER181N, SER212N, SER212V, THR153N, THR155N, VAL159V, VAL213V, VAL261V
• O-S: ALA154S, ALA161O, ALA16S, ALA180O, ARG164O, ARG98S, ASN258O, ASP139O, ASP179O, ASP260O, GLN152S, GLU99S, GLY138O, GLY149S, GLY151S, GLY157O, GLY163O, GLY166O, GLY209O, GLY210O, GLY210S, GLY211O, GLY211S, GLY214O, GLY97S, ILE158O, LEU12O, LEU12S, LEU150S, LEU15S, LEU162O, LEU167O, LYS255O, PHE100S, PHE140O, PHE148S, PRO11O, PRO11S, SER14S, SER156S, SER160O, SER165O, SER181S, SER212O, SER212S, THR153S, THR155S, VAL159O, VAL213O, VAL261O
• O-W: ALA154O, ALA161W, ALA16O, ALA180W, ARG164W, ARG98O, ASN258W, ASP139W, ASP179W, ASP260W, GLN152O, GLU99O, GLY138W, GLY149O, GLY151O, GLY157W, GLY163W, GLY166W, GLY209W, GLY210O, GLY210W, GLY211O, GLY211W, GLY214W, GLY97O, ILE158W, LEU12O, LEU12W, LEU150O, LEU15O, LEU162W, LEU167W, LYS255W, PHE100O, PHE140W, PHE148O, PRO11O, PRO11W, PRO13O, PRO13W, SER14O, SER156O, SER160W, SER165W, SER181O, SER212O, SER212W, THR153O, THR155O, VAL159W, VAL213W, VAL261W
• P-T: ALA154T, ALA161P, ALA16T, ALA180P, ARG164P, ARG98T, ASN258P, ASP139P, ASP179P, ASP260P, GLN152T, GLU99T, GLY138P, GLY149T, GLY151T, GLY157P, GLY163P, GLY166P, GLY209P, GLY210P, GLY210T, GLY211P, GLY211T, GLY214P, GLY97T, ILE158P, LEU12P, LEU12T, LEU150T, LEU15T, LEU162P, LEU167P, LEU259P, LYS255P, PHE100T, PHE140P, PHE148T, PRO11P, PRO11T, SER14T, SER156T, SER160P, SER165P, SER181T, SER212P, SER212T, THR153T, THR155T, VAL159P, VAL213P, VAL261P
• P-Y: ALA154P, ALA161Y, ALA16P, ALA180Y, ARG164Y, ARG98P, ASN258Y, ASP139Y, ASP179Y, ASP260Y, GLN152P, GLU99P, GLY138Y, GLY149P, GLY151P, GLY157Y, GLY163Y, GLY166Y, GLY209Y, GLY210P, GLY210Y, GLY211P, GLY211Y, GLY214Y, GLY97P, ILE158Y, LEU12P, LEU12Y, LEU150P, LEU15P, LEU162Y, LEU167Y, LYS255Y, PHE100P, PHE140Y, PHE148P, PRO11P, PRO11Y, PRO13P, SER14P, SER156P, SER160Y, SER165Y, SER181P, SER212P, SER212Y, THR153P, THR155P, VAL159Y, VAL213Y, VAL261Y
• Q-U: ALA154U, ALA161Q, ARG164Q, ARG98U, ASN258Q, ASP179Q, ASP260Q, GLN152U, GLU99U, GLY138Q, GLY149U, GLY151U, GLY157Q, GLY209Q, GLY210Q, GLY210U, GLY211Q, GLY211U, GLY214Q, GLY97U, ILE158Q, LEU12Q, LEU12U, LEU150U, LEU259Q, LYS255Q, PHE140Q, PHE148U, PRO11Q, PRO11U, PRO13U, SER14U, SER156U, SER160Q, SER165Q, SER181U, SER212Q, SER212U, THR153U, THR155U, VAL159Q, VAL213Q, VAL261Q
• R-V: ALA154V, ALA161R, ARG164R, ARG98V, ASN258R, ASP179R, ASP260R, GLN152V, GLU99V, GLY138R, GLY149V, GLY151V, GLY157R, GLY209R, GLY210R, GLY210V, GLY211R, GLY211V, GLY214R, GLY97V, ILE158R, LEU12R, LEU12V, LEU150V, LYS255R, PHE140R, PHE148V, PRO11R, PRO11V, PRO13V, SER14V, SER156V, SER160R, SER165R, SER181V, SER212R, SER212V, THR153V, THR155V, VAL159R, VAL213R, VAL261R
• S-W: ALA154W, ALA161S, ARG164S, ARG98W, ASN258S, ASP179S, ASP260S, GLN152W, GLU99W, GLY138S, GLY149W, GLY151W, GLY157S, GLY209S, GLY210S, GLY210W, GLY211S, GLY211W, GLY214S, GLY97W, ILE158S, LEU12S, LEU12W, LEU150W, LEU259S, LYS255S, PHE140S, PHE148W, PRO11S, PRO11W, PRO13W, SER14W, SER156W, SER160S, SER165S, SER181W, SER212S, SER212W, THR153W, THR155W, VAL159S, VAL213S, VAL261S
• T-Y: ALA154Y, ALA161T, ARG164T, ARG98Y, ASN258T, ASP179T, ASP260T, GLN152Y, GLU99Y, GLY138T, GLY149Y, GLY151Y, GLY157T, GLY209T, GLY210T, GLY210Y, GLY211T, GLY211Y, GLY214T, GLY97Y, ILE158T, LEU12T, LEU12Y, LEU150Y, LEU259T, LYS255T, PHE140T, PHE148Y, PRO11T, PRO11Y, PRO13Y, SER14Y, SER156Y, SER160T, SER165T, SER181Y, SER212T, SER212Y, THR153Y, THR155Y, VAL159T, VAL213T, VAL261T