4A73

single point mutant of thermus thermophilus lactate dehydrogenase

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 162
  • Norm. En. per Res.: -4.4676
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-77.5106	-65.5631	-511.117	-654.1907	166	20	26	20264	5	38	53
A-C	0.0	-8.3581	-7.5993	-15.9574	26	0	0	736	0	10	13
A-D	-39.3473	-7.2797	-220.253	-266.88	108	12	12	10353	1	12	21
B-C	-42.1198	-52.9192	-226.401	-321.44	103	21	12	10457	4	13	19
B-D	0.0	0.0	-2.2402	-2.2402	20	0	0	400	0	8	8
C-D	-94.0806	-60.7772	-568.893	-723.7508	162	24	25	20848	7	39	51

Interface residues

• A-B: ALA170A, ALA170B, ALA174A, ALA174B, ALA183A, ALA235A, ALA235B, ALA236A, ALA236B, ALA245A, ALA245B, ALA252A, ALA252B, ALA255A, ALA255B, ALA35A, ALA35B, ALA37A, ALA37B, ALA39A, ALA39B, ALA41A, ALA41B, ALA59A, ALA59B, ALA61A, ALA61B, ALA63A, ALA63B, ALA69A, ALA69B, ALA73A, ALA73B, ARG171A, ARG171B, ARG173A, ARG173B, ARG234A, ARG234B, ARG238A, ARG238B, ARG256A, ARG256B, ARG259A, ARG259B, ARG56A, ARG56B, ASP168A, ASP168B, ASP55A, ASP55B, ASP65A, ASP65B, GLN185A, GLN185B, GLN60A, GLN60B, GLU178A, GLU178B, GLU241A, GLU241B, GLU64A, GLU64B, GLY231A, GLY231B, GLY242A, GLY242B, GLY244A, GLY244B, GLY249A, GLY249B, GLY251A, GLY251B, GLY253A, GLY253B, GLY30A, GLY30B, GLY33A, GLY33B, GLY44A, GLY44B, HIS62A, HIS62B, HIS68A, HIS68B, HIS74A, HIS74B, ILE166A, ILE166B, ILE239A, ILE239B, ILE240A, ILE240B, ILE250A, ILE250B, ILE66A, ILE66B, LEU167A, LEU167B, LEU175A, LEU175B, LEU254A, LEU254B, LEU257A, LEU257B, LEU40A, LEU40B, LEU42A, LEU42B, LEU43A, LEU43B, LEU51A, LEU51B, LEU58A, LEU58B, LEU67A, LEU67B, LYS243A, LYS243B, LYS57A, LYS57B, MET31A, MET31B, PHE172B, PHE72A, PHE72B, PRO184A, PRO184B, PRO71A, PRO71B, PRO75A, PRO75B, SER29A, SER29B, SER34A, SER34B, THR165A, THR165B, THR169A, THR169B, THR246A, THR246B, THR270A, THR270B, THR36A, THR36B, THR70A, THR70B, TRP77A, TRP77B, TYR237A, TYR237B, TYR247A, TYR247B, TYR248A, TYR248B, TYR269A, TYR269B, TYR38A, TYR38B, VAL232A, VAL232B, VAL32A, VAL32B, VAL45A, VAL78A
• A-C: ALA260A, ALA46C, ALA73C, ARG256A, ARG259A, ARG259C, ARG47A, ARG47C, ARG92A, ARG92C, ASP264A, ASP264C, GLU265A, GLU265C, HIS74A, HIS74C, LEU262A, LEU262C, LYS266A, MET22A, MET22C, PRO75A, PRO75C, THR263A, THR263C, VAL45C
• A-D: ALA177A, ALA177D, ALA183A, ALA183D, ALA189A, ALA189D, ALA206A, ALA206D, ALA215A, ALA215D, ALA260A, ALA260D, ARG173A, ARG173D, ARG181A, ARG181D, ARG216A, ARG216D, ARG256A, ARG256D, ARG259A, ARG259D, ARG291A, ARG291D, ASP264A, ASP264D, GLN185A, GLN185D, GLN207A, GLN207D, GLU178A, GLU178D, GLU211A, GLU211D, GLU265A, GLU265D, GLU299A, GLU299D, GLY209A, GLY209D, GLY267A, GLY267D, GLY294A, GLY294D, GLY301A, GLY301D, HIS188A, HIS188D, ILE292A, ILE292D, LEU180A, LEU180D, LEU192A, LEU192D, LEU210A, LEU210D, LEU289A, LEU293A, LEU293D, LEU307A, LEU307D, LYS266A, LYS266D, PHE212A, PHE212D, PRO184A, PRO184D, PRO209A, PRO209D, PRO290A, PRO290D, PRO305A, PRO305D, SER186A, SER186D, SER204A, SER204D, SER205A, SER205D, SER306A, SER306D, THR263A, THR270A, THR270D, THR302A, THR302D, TYR190A, TYR190D, TYR269A, TYR269D, TYR304A, TYR304D, VAL182A, VAL182D, VAL187A, VAL187D, VAL202A, VAL202D, VAL208A, VAL208D, VAL209A, VAL209D, VAL268A, VAL268D, VAL298A, VAL298D, VAL303A, VAL303D
• B-C: ALA177B, ALA177C, ALA183B, ALA183C, ALA189B, ALA189C, ALA206B, ALA206C, ALA215B, ALA215C, ALA260B, ALA260C, ARG173B, ARG173C, ARG181B, ARG181C, ARG216B, ARG216C, ARG256B, ARG256C, ARG259B, ARG259C, ARG291B, ARG291C, ASP264B, ASP264C, GLN185B, GLN185C, GLN207B, GLN207C, GLU178B, GLU178C, GLU211B, GLU211C, GLU214B, GLU265B, GLU265C, GLU299B, GLU299C, GLY209B, GLY209C, GLY267B, GLY267C, GLY294B, GLY294C, GLY301B, GLY301C, HIS188B, HIS188C, HIS74B, HIS74C, ILE292B, ILE292C, LEU180B, LEU180C, LEU192B, LEU210B, LEU293B, LEU293C, LEU307B, LYS266B, LYS266C, PHE212B, PHE212C, PRO184B, PRO184C, PRO209B, PRO209C, PRO290B, PRO290C, PRO305B, PRO305C, SER186B, SER186C, SER205B, SER205C, SER306B, SER306C, THR263C, THR302B, THR302C, TYR190B, TYR190C, TYR269B, TYR269C, TYR304B, TYR304C, VAL182B, VAL182C, VAL187B, VAL187C, VAL202B, VAL202C, VAL208B, VAL208C, VAL209B, VAL209C, VAL268B, VAL268C, VAL298B, VAL298C, VAL303B, VAL303C
• B-D: ALA73B, ALA73D, ARG256D, ARG259B, ARG259D, ARG47B, ARG47D, ARG92D, ASP264B, GLU265B, GLU265D, HIS74B, HIS74D, LEU262D, MET22B, MET22D, PRO75B, PRO75D, THR263B, THR263D
• C-D: ALA170C, ALA170D, ALA174C, ALA174D, ALA183D, ALA235C, ALA235D, ALA236C, ALA236D, ALA245C, ALA245D, ALA252C, ALA252D, ALA255C, ALA255D, ALA35C, ALA35D, ALA37C, ALA37D, ALA39C, ALA39D, ALA41C, ALA41D, ALA59C, ALA59D, ALA61C, ALA61D, ALA63C, ALA63D, ALA69C, ALA69D, ALA73C, ALA73D, ARG171C, ARG171D, ARG173C, ARG173D, ARG234C, ARG234D, ARG238C, ARG238D, ARG256C, ARG256D, ARG259C, ARG259D, ARG47C, ARG56C, ARG56D, ASP168C, ASP168D, ASP55C, ASP55D, ASP65C, ASP65D, GLN185C, GLN185D, GLN60C, GLN60D, GLU241C, GLU241D, GLU64C, GLU64D, GLY231C, GLY231D, GLY242C, GLY242D, GLY244C, GLY244D, GLY249C, GLY249D, GLY251C, GLY251D, GLY253C, GLY253D, GLY30C, GLY30D, GLY33C, GLY33D, GLY44C, GLY44D, HIS62C, HIS62D, HIS68C, HIS68D, HIS74C, HIS74D, ILE166C, ILE166D, ILE239C, ILE239D, ILE240C, ILE240D, ILE250C, ILE250D, ILE66C, ILE66D, LEU167C, LEU167D, LEU175C, LEU175D, LEU254C, LEU254D, LEU257C, LEU257D, LEU40C, LEU40D, LEU42C, LEU42D, LEU43C, LEU43D, LEU51C, LEU51D, LEU58C, LEU58D, LEU67C, LEU67D, LYS243C, LYS243D, LYS57C, LYS57D, MET31C, MET31D, PHE72C, PHE72D, PRO184C, PRO184D, PRO71C, PRO71D, PRO75C, PRO75D, SER29C, SER29D, SER34C, SER34D, THR165C, THR165D, THR169C, THR169D, THR246C, THR246D, THR270C, THR270D, THR36C, THR36D, THR70C, THR70D, TYR237C, TYR237D, TYR247C, TYR247D, TYR248C, TYR248D, TYR269C, TYR269D, TYR38C, TYR38D, VAL232C, VAL32C, VAL32D, VAL45C, VAL78C, VAL78D