4A0C

structure of the cand1-cul4b-rbx1 complex

• Total interactions analyzed: 15
• Total true interactions: 10
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 194
  • Norm. En. per Res.: -5.1525
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	0.0	-17.8831	-45.6167	-63.4998	41	4	0	2317	0	14	13
A-E	-46.8583	-99.5671	-642.332	-788.7573	414	30	7	29734	13	230	195
A-F	-19.0295	18.3211	-46.8123	-47.5207	28	3	0	2083	3	14	13
B-C	-22.7862	-158.6521	-533.764	-715.2023	392	24	4	26162	14	217	194
B-D	-10.2229	13.5404	-48.7903	-45.4728	29	1	0	1956	1	16	13
B-E	0.0	11.0257	-12.716	-1.6903	18	0	0	635	1	11	10
C-D	-206.365	-67.5863	-725.624	-999.5753	194	34	19	27853	5	64	58
C-E	0.0	10.909	-6.1895	4.7195	18	0	0	351	0	19	20
C-F	0.0	0.0	-0.0027	-0.0027	4	0	0	3	0	1	0
E-F	-151.2514	-63.7588	-709.606	-924.6162	191	32	17	26595	1	61	55

Interface residues

• A-D: ALA579A, ALA58D, ALA61D, ARG46D, ARG618A, ARG625A, ARG660A, ASN41D, ASN47D, ASN59D, ASN610A, ASN621A, ASP51D, CYS42D, CYS45D, CYS53D, CYS56D, GLN57D, GLN60D, GLN613A, GLU617A, GLU622A, GLU650A, GLU696A, GLY649A, GLY651A, HIS48D, ILE54D, ILE614A, ILE654A, LEU52D, LEU616A, LEU666A, LYS577A, LYS620A, LYS661A, PHE658A, PRO653A, SER657A, VAL38D, VAL39D
• A-E: ALA1084A, ALA1159A, ALA190A, ALA223E, ALA226E, ALA239A, ALA240A, ALA26A, ALA278A, ALA352A, ALA362E, ALA398E, ALA399E, ALA425E, ALA455E, ALA500E, ALA578E, ALA625E, ALA639E, ALA640E, ALA665A, ALA68A, ALA852E, ALA853E, ALA875A, ALA876A, ALA943A, ARG1024A, ARG103A, ARG1129A, ARG1174A, ARG1178A, ARG164A, ARG188A, ARG194A, ARG23A, ARG243A, ARG276E, ARG284A, ARG285A, ARG291E, ARG298E, ARG304E, ARG312E, ARG351A, ARG356E, ARG365E, ARG369E, ARG388E, ARG395E, ARG406A, ARG427E, ARG469E, ARG664A, ARG856E, ARG861E, ARG905A, ARG948A, ASN1021A, ASN1031A, ASN1036A, ASN10A, ASN1160A, ASN229E, ASN236E, ASN28A, ASN295E, ASN344E, ASN359E, ASN389A, ASN394E, ASN463A, ASN468E, ASN492A, ASN508E, ASN61A, ASN66A, ASN875E, ASN949A, ASP104A, ASP1080A, ASP1118A, ASP156A, ASP160A, ASP19A, ASP21A, ASP278E, ASP281E, ASP29A, ASP311E, ASP326E, ASP344A, ASP348E, ASP364E, ASP377E, ASP426E, ASP433E, ASP472E, ASP512E, ASP530A, ASP580E, ASP582A, ASP588E, ASP624E, ASP705A, ASP832A, ASP851E, ASP995A, CYS237A, CYS297E, CYS637E, GLN101A, GLN1164A, GLN1216A, GLN228E, GLN236A, GLN244A, GLN277A, GLN294E, GLN299E, GLN340E, GLN379E, GLN402E, GLN406E, GLN409A, GLN434E, GLN437E, GLN447E, GLN452A, GLN458E, GLN471E, GLN517E, GLN65A, GLN663A, GLN710A, GLN748A, GLN794A, GLN849E, GLN876E, GLN906A, GLU100A, GLU1067A, GLU1087A, GLU1165A, GLU1167A, GLU1171A, GLU153A, GLU222E, GLU238E, GLU239E, GLU270A, GLU273A, GLU277E, GLU357E, GLU361E, GLU391E, GLU392E, GLU400E, GLU407E, GLU412E, GLU460A, GLU467E, GLU510E, GLU518E, GLU577E, GLU581E, GLU582E, GLU584A, GLU584E, GLU636E, GLU63A, GLU646E, GLU653E, GLU703A, GLU870A, GLU871A, GLU872E, GLU944A, GLU945A, GLU953A, GLY1069A, GLY109A, GLY115A, GLY360E, GLY401E, GLY62A, GLY638E, GLY73A, GLY750A, GLY946A, HIS1035A, HIS1073A, HIS1116A, HIS201A, HIS296E, HIS415E, HIS452E, HIS528E, HIS635E, HIS707A, HIS7A, HIS911A, ILE105A, ILE108A, ILE1119A, ILE114A, ILE1215A, ILE196A, ILE197A, ILE227E, ILE233E, ILE241A, ILE301E, ILE303E, ILE306E, ILE324E, ILE363E, ILE429E, ILE495A, ILE505E, ILE507E, ILE532E, ILE535A, ILE854E, ILE857E, LEU1079A, LEU1122A, LEU1125A, LEU1172A, LEU11A, LEU152A, LEU189A, LEU220E, LEU237E, LEU240E, LEU280E, LEU284E, LEU308E, LEU329E, LEU367E, LEU368E, LEU396E, LEU428E, LEU432E, LEU493A, LEU57A, LEU583E, LEU587E, LEU630E, LEU633E, LEU668A, LEU67A, LEU746A, LEU747A, LEU818E, LEU864E, LEU877E, LEU908A, LYS1072A, LYS1083A, LYS111A, LYS1120A, LYS1158A, LYS1163A, LYS1168A, LYS14A, LYS193A, LYS20A, LYS234E, LYS287E, LYS288E, LYS341E, LYS345E, LYS348A, LYS355A, LYS403A, LYS403E, LYS446A, LYS449A, LYS459E, LYS511E, LYS513E, LYS534A, LYS570E, LYS585E, LYS600E, LYS60A, LYS627E, LYS632E, LYS634E, LYS644E, LYS650E, LYS70A, LYS789E, LYS793A, LYS859E, LYS862E, LYS873A, LYS878E, LYS904A, LYS914A, LYS990A, MET1068A, MET1121A, MET25A, MET300E, MET302E, MET31A, MET345A, MET374E, MET405E, MET515E, MET629E, MET706A, MET711A, MET858E, MET860E, PHE1071A, PHE1124A, PHE1166A, PHE22A, PHE24A, PHE307E, PHE501E, PHE532A, PHE641E, PHE649E, PHE991A, PRO1070A, PRO411E, PRO509E, PRO531A, PRO745A, PRO868A, PRO903A, SER1032A, SER107A, SER1161A, SER1175A, SER1214A, SER149A, SER17A, SER230E, SER232E, SER279E, SER282E, SER305E, SER323E, SER366E, SER370E, SER373E, SER376E, SER488A, SER489A, SER490A, SER491A, SER503E, SER622E, SER628E, SER631E, SER643E, SER702A, SER704A, SER709A, SER744A, SER867A, SER869A, SER874A, SER877A, THR1074A, THR1091A, THR1123A, THR112A, THR231E, THR233A, THR32A, THR430E, THR504E, THR514E, THR579E, THR642E, THR947A, TRP293E, TRP325E, TRP347A, TYR1090A, TYR1117A, TYR235E, TYR241E, TYR274A, TYR431E, TYR533A, TYR907A, TYR911E, VAL1028A, VAL1066A, VAL1075A, VAL1128A, VAL113A, VAL1162A, VAL148A, VAL191A, VAL224E, VAL283E, VAL342E, VAL408A, VAL448A, VAL623E, VAL64A, VAL69A, VAL708A, VAL855E, VAL872A, VAL950A
• A-F: ARG23A, ARG91F, ARG99F, ASN61A, ASP19A, ASP21A, ASP59A, GLN92F, GLU100F, GLU102F, GLU63A, GLY62A, ILE84F, LEU88F, LYS20A, LYS60A, LYS89F, PHE103F, PHE22A, PHE81F, SER17A, SER18A, SER85F, TRP101F, TYR106F, VAL64A, VAL74F, VAL93F
• B-C: ALA1159B, ALA190B, ALA223C, ALA226C, ALA239B, ALA240B, ALA26B, ALA362C, ALA398C, ALA399C, ALA425C, ALA455C, ALA500C, ALA625C, ALA639C, ALA640C, ALA665B, ALA751B, ALA852C, ALA853C, ARG1024B, ARG103B, ARG1064B, ARG1129B, ARG1174B, ARG1178B, ARG188B, ARG192B, ARG194B, ARG23B, ARG243B, ARG276C, ARG291C, ARG298C, ARG304C, ARG312C, ARG351B, ARG356C, ARG365C, ARG369C, ARG388C, ARG395C, ARG406B, ARG469C, ARG595C, ARG664B, ARG856C, ARG861C, ARG905B, ARG948B, ASN1031B, ASN1036B, ASN10B, ASN1160B, ASN229C, ASN236C, ASN28B, ASN295C, ASN344C, ASN359C, ASN389B, ASN394C, ASN468C, ASN492B, ASN508C, ASN575C, ASN61B, ASN66B, ASN875C, ASN949B, ASP104B, ASP1080B, ASP1118B, ASP156B, ASP160B, ASP19B, ASP21B, ASP278C, ASP281C, ASP290C, ASP29B, ASP311C, ASP326C, ASP344B, ASP348C, ASP364C, ASP377C, ASP426C, ASP433C, ASP512C, ASP530B, ASP580C, ASP582B, ASP588C, ASP59B, ASP624C, ASP705B, ASP995B, CYS237B, CYS297C, CYS637C, GLN101B, GLN1164B, GLN1216B, GLN228C, GLN236B, GLN244B, GLN274C, GLN277B, GLN294C, GLN299C, GLN379C, GLN402C, GLN406C, GLN434C, GLN437C, GLN447C, GLN452B, GLN458C, GLN517C, GLN65B, GLN663B, GLN710B, GLN748B, GLN794B, GLN849C, GLN876C, GLN906B, GLU100B, GLU1065B, GLU1067B, GLU1087B, GLU1165B, GLU1167B, GLU1171B, GLU153B, GLU225C, GLU270B, GLU273B, GLU277C, GLU33B, GLU355C, GLU357C, GLU361C, GLU387B, GLU391C, GLU400C, GLU407C, GLU422C, GLU467C, GLU510C, GLU518C, GLU538C, GLU581C, GLU582C, GLU584B, GLU584C, GLU636C, GLU63B, GLU646C, GLU653C, GLU703B, GLU870B, GLU871B, GLU872C, GLU944B, GLU945B, GLU953B, GLY109B, GLY115B, GLY360C, GLY401C, GLY62B, GLY638C, GLY749B, GLY750B, GLY946B, HIS1035B, HIS1073B, HIS1116B, HIS201B, HIS452C, HIS635C, HIS707B, HIS792B, HIS7B, HIS911B, HIS996B, ILE105B, ILE108B, ILE1119B, ILE1215B, ILE196B, ILE197B, ILE227C, ILE233C, ILE301C, ILE303C, ILE306C, ILE324C, ILE363C, ILE429C, ILE495B, ILE505C, ILE507C, ILE535B, ILE857C, ILE993B, LEU110B, LEU1122B, LEU1125B, LEU1172B, LEU11B, LEU152B, LEU189B, LEU237C, LEU280C, LEU284C, LEU308C, LEU329C, LEU351C, LEU367C, LEU371C, LEU372C, LEU378C, LEU396C, LEU428C, LEU432C, LEU493B, LEU57B, LEU583C, LEU630C, LEU633C, LEU668B, LEU67B, LEU746B, LEU747B, LEU864C, LEU877C, LEU908B, LYS1072B, LYS1083B, LYS111B, LYS1120B, LYS1158B, LYS1163B, LYS1168B, LYS14B, LYS193B, LYS20B, LYS234C, LYS287C, LYS341C, LYS345C, LYS348B, LYS355B, LYS403B, LYS403C, LYS446B, LYS449B, LYS487B, LYS511C, LYS513C, LYS534B, LYS536C, LYS585C, LYS627C, LYS632C, LYS634C, LYS650C, LYS70B, LYS789C, LYS793B, LYS817C, LYS859C, LYS862C, LYS873B, LYS878C, LYS904B, LYS914B, LYS990B, MET1068B, MET1121B, MET204B, MET25B, MET300C, MET302C, MET345B, MET374C, MET405C, MET591C, MET629C, MET706B, MET711B, MET858C, MET860C, PHE1166B, PHE22B, PHE24B, PHE275C, PHE285C, PHE307C, PHE309C, PHE501C, PHE532B, PHE641C, PHE865B, PHE991B, PRO119B, PRO509C, PRO531B, PRO745B, PRO868B, PRO903B, SER1032B, SER106B, SER107B, SER1161B, SER1175B, SER1214B, SER149B, SER17B, SER230C, SER232C, SER279C, SER282C, SER305C, SER323C, SER366C, SER370C, SER373C, SER376C, SER488B, SER489B, SER490B, SER491B, SER503C, SER622C, SER628C, SER631C, SER643C, SER702B, SER704B, SER709B, SER744B, SER866B, SER867B, SER869B, SER874B, SER994B, THR1074B, THR1091B, THR112B, THR195B, THR231C, THR233B, THR32B, THR430C, THR504C, THR514C, THR579C, THR642C, THR947B, TRP293C, TRP325C, TRP347B, TYR1090B, TYR1117B, TYR235C, TYR241C, TYR274B, TYR307B, TYR397C, TYR431C, TYR533B, TYR907B, TYR911C, VAL1028B, VAL1066B, VAL1075B, VAL1128B, VAL113B, VAL1162B, VAL148B, VAL191B, VAL283C, VAL448B, VAL64B, VAL69B, VAL708B, VAL855C, VAL950B
• B-D: ARG23B, ARG99D, ASN61B, ASN98D, ASP19B, ASP21B, ASP59B, GLN65B, GLN92D, GLU100D, GLU102D, GLU63B, GLY62B, ILE84D, LEU88D, LYS20B, LYS60B, LYS89D, PHE103D, PHE22B, PHE81D, SER17B, SER18B, SER85D, TRP101D, TYR106D, VAL64B, VAL74D, VAL93D
• B-E: ALA526B, ALA578B, ARG575B, ARG901E, ASN905E, ASN910E, ASP530B, ASP580B, ASP902E, GLU904E, GLY529B, ILE581B, LYS574B, LYS903E, PHE532B, PRO531B, THR536B, VAL528B
• C-D: ALA29D, ALA31D, ALA34D, ALA612C, ALA61D, ALA639C, ALA63D, ALA640C, ALA71D, ALA734C, ALA78D, ALA852C, ALA853C, ALA913C, ARG21D, ARG719C, ARG791C, ARG820C, ARG841C, ARG846C, ARG856C, ARG86D, ARG889C, ARG896C, ARG91D, ASN28D, ASN41D, ASN674C, ASN680C, ASN757C, ASN76D, ASN811C, ASN824C, ASP36D, ASP40D, ASP651C, ASP812C, ASP845C, ASP851C, ASP895C, ASP897C, CYS68D, CYS730C, CYS75D, CYS810C, CYS83D, GLN104D, GLN705C, GLN722C, GLN724C, GLN744C, GLN844C, GLN847C, GLN849C, GLN92D, GLU102D, GLU23D, GLU55D, GLU646C, GLU66D, GLU676C, GLU67D, GLU700C, GLU706C, GLU735C, GLU742C, GLU758C, GLU760C, GLU761C, GLU891C, GLY107D, GLY618C, GLY647C, GLY685C, GLY718C, GLY728C, GLY73D, GLY759C, HIS108D, HIS716C, HIS729C, HIS77D, HIS82D, ILE37D, ILE49D, ILE658C, ILE675C, ILE681C, ILE707C, ILE809C, ILE823C, ILE84D, ILE850C, ILE894C, ILE912C, LEU32D, LEU616C, LEU645C, LEU654C, LEU677C, LEU682C, LEU697C, LEU704C, LEU713C, LEU721C, LEU727C, LEU732C, LEU743C, LEU747C, LEU751C, LEU753C, LEU754C, LEU785C, LEU793C, LEU88D, LEU893C, LYS105D, LYS20D, LYS25D, LYS26D, LYS608C, LYS644C, LYS703C, LYS709C, LYS720C, LYS733C, LYS741C, LYS859C, LYS888C, LYS89D, MET648C, MET652C, MET659C, MET684C, MET701C, MET755C, MET899C, PHE103D, PHE22D, PHE708C, PHE736C, PHE756C, PHE762C, PHE81D, PRO688C, PRO692C, PRO698C, SER62D, SER643C, SER655C, SER717C, SER725C, SER746C, SER85D, SER892C, THR642C, THR64D, THR678C, THR683C, THR689C, THR69D, THR726C, THR750C, THR90D, TRP27D, TRP33D, TRP35D, TRP687C, TRP723C, TRP72D, TRP87D, TYR106D, TYR686C, TYR690C, TYR712C, TYR848C, TYR898C, TYR911C, VAL24D, VAL30D, VAL38D, VAL39D, VAL617C, VAL679C, VAL691C, VAL695C, VAL702C, VAL70D, VAL731C, VAL745C, VAL74D, VAL792C, VAL842C, VAL855C
• C-E: ALA836E, ARG779C, ARG889E, ASP801C, ASP804C, ASP806C, GLN844E, GLN847E, GLU765C, GLU803C, GLU840E, GLY805C, ILE802C, LYS882E, LYS888E, PHE843E, PRO797C, SER837E
• C-F: CYS68F, GLU803C, LEU52F, LYS798C
• E-F: ALA29F, ALA31F, ALA34F, ALA605E, ALA640E, ALA71F, ALA734E, ALA78F, ALA852E, ALA913E, ARG21F, ARG719E, ARG820E, ARG841E, ARG846E, ARG856E, ARG86F, ARG889E, ARG896E, ARG99F, ASN28F, ASN41F, ASN680E, ASN757E, ASN76F, ASN811E, ASN824E, ASP36F, ASP40F, ASP651E, ASP812E, ASP845E, ASP851E, ASP895E, ASP897E, CYS56F, CYS68F, CYS730E, CYS75F, CYS810E, CYS83F, GLN104F, GLN705E, GLN722E, GLN724E, GLN744E, GLN827E, GLN844E, GLN847E, GLN849E, GLN92F, GLU102F, GLU23F, GLU55F, GLU604E, GLU676E, GLU700E, GLU706E, GLU735E, GLU742E, GLU758E, GLU760E, GLU761E, GLY107F, GLY618E, GLY647E, GLY685E, GLY718E, GLY728E, GLY73F, GLY759E, HIS108F, HIS716E, HIS729E, HIS77F, HIS80F, HIS82F, ILE37F, ILE49F, ILE675E, ILE681E, ILE707E, ILE809E, ILE823E, ILE84F, ILE850E, ILE912E, LEU32F, LEU616E, LEU645E, LEU654E, LEU677E, LEU682E, LEU697E, LEU704E, LEU713E, LEU721E, LEU727E, LEU732E, LEU743E, LEU747E, LEU751E, LEU753E, LEU754E, LEU785E, LEU793E, LEU88F, LEU893E, LYS105F, LYS19F, LYS20F, LYS25F, LYS26F, LYS608E, LYS609E, LYS644E, LYS650E, LYS703E, LYS709E, LYS720E, LYS733E, LYS737E, LYS740E, LYS741E, LYS859E, LYS89F, MET50F, MET648E, MET659E, MET684E, MET701E, MET755E, MET858E, MET899E, PHE103F, PHE22F, PHE708E, PHE736E, PHE756E, PHE762E, PHE814E, PHE819E, PHE81F, PRO688E, PRO692E, PRO698E, SER643E, SER655E, SER717E, SER725E, SER746E, SER85F, SER892E, THR678E, THR683E, THR689E, THR69F, THR726E, THR750E, THR90F, TRP27F, TRP33F, TRP35F, TRP687E, TRP723E, TRP72F, TRP87F, TYR106F, TYR686E, TYR690E, TYR712E, TYR848E, TYR898E, TYR911E, VAL24F, VAL30F, VAL38F, VAL39F, VAL617E, VAL679E, VAL691E, VAL695E, VAL702E, VAL70F, VAL731E, VAL745E, VAL74F, VAL752E, VAL792E, VAL842E, VAL855E