3ZVP

crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3

• Total interactions analyzed: 528
• Total true interactions: 29
• Strongest Interaction:
  • Chains: O-T
  • Int. Res.: 80
  • Norm. En. per Res.: -3.2103
• Hub Node: E(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
0-8	0.0	0.0	-0.055	-0.055	5	0	0	27	0	2	1
0-Q	0.0	-2.7458	-62.7896	-65.5354	29	7	1	3015	0	3	14
0-S	0.0	-7.3785	-3.3325	-10.711	17	0	0	314	0	8	10
2-X	-16.0658	-5.162	-102.608	-123.8359	47	14	1	4700	0	9	9
4-G	0.0	-6.6069	-80.4737	-87.0806	74	17	3	5924	0	19	19
5-R	0.0	23.1034	-47.2298	-24.1264	33	4	3	2414	0	7	14
5-U	0.0	0.0	-5.2556	-5.2556	10	2	0	447	0	0	8
5-W	0.0	-0.4633	-91.8756	-92.3389	56	30	3	5279	0	14	20
6-8	0.0	0.0	-20.4928	-20.4928	21	3	0	1143	0	3	2
7-F	0.0	0.0	-0.0035	-0.0035	2	0	0	3	0	0	0
7-W	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
7-X	0.0	0.0	-2.1698	-2.1698	9	0	0	204	0	1	6
8-P	-21.3189	37.5337	-149.256	-133.0412	61	40	0	7399	0	19	60
9-Q	0.0	0.0	-0.1895	-0.1895	3	0	0	55	0	1	2
E-N	0.0	0.0	-30.5126	-30.5126	13	1	0	1238	0	0	0
E-O	0.0	2.779	-20.0996	-17.3206	15	0	0	882	0	8	9
E-R	0.0	4.0395	-29.0786	-25.0391	17	3	0	1644	0	1	11
E-T	-11.0574	-18.1528	-77.5279	-106.738	76	5	3	5945	1	19	18
F-P	0.0	17.0278	-80.9305	-63.9027	42	6	0	3893	0	16	20
F-U	0.0	0.0	-2.6728	-2.6728	12	0	0	397	0	0	2
J-K	0.0	0.0	-0.0487	-0.0487	7	0	0	19	0	0	0
K-Z	0.0	0.0	-2.8732	-2.8732	9	0	0	266	0	0	0
N-U	-7.7635	-10.201	-53.3956	-71.3601	46	18	1	4934	0	8	25
N-V	0.0	2.9152	-16.451	-13.5358	14	4	0	832	0	1	4
O-T	-20.6974	-54.0878	-182.038	-256.8232	80	35	4	9029	4	40	41
P-V	-2.9563	16.1164	-18.1187	-4.9585	15	1	0	853	0	0	6
Q-Z	-12.4488	33.7873	-186.221	-164.8826	114	64	6	11187	4	56	55
R-W	0.0	-16.0342	-18.7012	-34.7354	19	4	1	1029	0	5	10
U-V	-20.7411	-13.9311	-133.178	-167.8502	89	55	7	8947	0	17	37

Interface residues

• 0-8: ARG550, GLN358, GLU408, LYS398, SER378
• 0-Q: 5198CB9.6822, 9197CB6.9412, ALA20, ARG10Q, ARG110, ARG82Q, ASN120, ASN89Q, GLU80Q, GLY60, GLY80, GLY84Q, GLY86Q, HIS30, HIS309, LEU70, LEU79Q, LYS11Q, LYS40, LYS50, LYS77Q, LYS85Q, LYS87Q, MET83Q, PRO78Q, SER90, THR100, TYR9Q, VAL81Q
• 0-S: ARG15S, ARG23S, ARG720, ARG820, ASN500, ASP42S, GLU43S, GLY22S, ILE18S, LEU620, LEU750, LYS44S, LYS460, LYS490, PRO830, THR21S, TYR780
• 2-X: ALA10X, ALA392, ALA42X, ALA46X, ALA4X, ALA91X, ARG262, ARG302, ARG362, ASP6X, GLN382, GLN432, GLU222, GLU272, GLU312, GLU342, GLU44X, GLY422, HIS31X, ILE412, ILE572, ILE89X, ILE8X, LEU13X, LEU322, LEU612, LEU92X, LEU9X, LYS282, LYS292, LYS48X, MET332, PHE28X, PHE372, PHE47X, PRO11X, SER402, THR3X, THR45X, TRP29X, TYR18X, TYR5X, VAL12X, VAL252, VAL30X, VAL43X, VAL7X
• 4-G: ALA110G, ALA124, ALA61G, ALA6G, ARG113G, ARG118G, ARG181G, ARG98G, ARG9G, ASN108G, ASN204, ASP4G, ASP97G, CYS164, CYS364, CYS394, GLN58G, GLN66G, GLU104G, GLU143G, GLU234, GLU344, GLY119G, GLY177G, GLY44, GLY65G, HIS404, HIS64, ILE101G, ILE140G, ILE144, ILE144G, ILE224, ILE314, ILE54, ILE63G, LEU107G, LEU111G, LEU3G, LEU60G, LEU62G, LEU7G, LEU94, LYS105G, LYS284, LYS384, LYS67G, LYS84, PHE102G, PHE117G, PHE141G, PHE424, PRO112G, PRO114, PRO142G, PRO179G, PRO2G, PRO68G, PRO74, SER264, SER374, THR145G, THR244, THR274, THR64G, TYR146G, TYR254, TYR324, VAL104, VAL109G, VAL334, VAL354, VAL5G, VAL92G
• 5-R: ALA101R, ALA112R, ALA535, ARG103R, ARG105R, ARG33R, ARG555, ARG96R, CYS465, GLU102R, GLU115R, GLU485, GLY545, HIS435, LEU100R, LEU111R, LEU113R, LEU305, LEU98R, LYS405, LYS565, LYS99R, PRO285, PRO415, PRO425, PRO475, THR35R, THR445, TYR515, TYR525, VAL455, VAL575, VAL97R
• 5-U: ALA145, ARG155, ARG165, GLY26U, LEU27U, LYS105, LYS135, LYS30U, SER125, TRP25U
• 5-W: ALA245, ALA25, ALA32W, ALA385, ALA44W, ARG15W, ARG165, ARG18W, ARG195, ARG205, ARG33W, ARG37W, ARG90W, ARG92W, ASN34W, ASN40W, ASP175, ASP22W, ASP67W, CYS335, CYS465, GLU30W, GLU31W, GLU485, HIS225, HIS235, ILE24W, ILE35W, LEU19W, LEU23W, LEU255, LEU305, LEU36W, LYS16W, LYS27W, LYS35, LYS375, LYS405, LYS41W, MET395, PRO275, PRO285, PRO325, PRO415, PRO425, PRO475, THR265, THR295, THR39W, THR445, TYR38W, VAL17W, VAL20W, VAL21W, VAL315, VAL455
• 6-8: ALA226, ARG428, ASN338, GLN358, GLU126, GLU246, GLY388, ILE418, LEU106, LEU116, LEU328, LEU96, LYS256, LYS368, LYS86, SER378, THR236, TRP348, TRP426, TYR396, VAL56
• 7-F: ALA58F, LYS377
• 7-W: ARG37, ARG90W
• 7-X: ARG477, ARG60X, ARG68X, ARG97, ASP75X, LYS487, LYS63X, LYS72X, TRP407
• 8-P: ALA108, ALA248, ALA558, ARG138, ARG308, ARG468, ARG49P, ARG50P, ARG55P, ARG578, ARG61P, ARG65P, ASP47P, GLN68P, GLU52P, GLU548, GLU568, GLU74P, GLY288, GLY458, GLY66P, GLY69P, GLY98, HIS318, HIS78, ILE168, ILE588, LEU328, LEU59P, LEU608, LEU618, LEU62P, LYS118, LYS128, LYS158, LYS268, LYS298, LYS448, LYS478, LYS528, LYS58, LYS598, LYS64P, LYS88, MET258, MET48, MET60P, MET67P, PHE51P, PRO48P, PRO538, PRO63P, SER56P, THR278, THR57P, THR58P, THR68, VAL148, VAL228, VAL238, VAL498
• 9-Q: ARG119Q, HIS123Q, LYS89
• E-N: ARG149E, GLY153E, GLY77N, GLY80N, LYS152E, LYS154E, PRO147E, PRO79N, SER76N, TYR151E, TYR75N, TYR78N, VAL150E
• E-O: ALA20E, ARG13E, ARG19E, ARG71O, ASP17E, ASP18E, ASP73O, GLY74O, ILE14E, LYS70O, PHE15E, PRO22E, PRO72O, SER75O, VAL21E
• E-R: ALA114E, ALA162E, ARG111E, ARG2R, GLY110E, GLY112E, GLY115E, GLY161E, HIS159E, HIS3R, LYS109E, LYS118E, LYS5R, PHE113E, PRO191E, SER108E, TYR160E
• E-T: ALA20E, ALA5T, ARG13E, ARG13T, ARG16E, ARG16T, ARG19E, ARG39T, ARG3T, ARG53T, ARG76E, ASN180E, ASN192E, ASN2T, ASN55T, ASN58T, ASP174E, ASP17E, ASP18E, GLN54E, GLU11T, GLU178E, GLU179E, GLY10E, GLY193E, GLY194E, GLY29E, GLY4T, GLY56T, GLY6E, HIS79T, ILE14E, ILE176E, ILE26E, ILE75T, ILE7T, LEU181E, LEU182E, LEU183E, LEU195E, LEU27E, LEU52E, LEU6T, LEU78T, LEU82T, LEU9T, LYS8E, LYS8T, MET11E, MET1T, PHE15E, PHE51E, PHE57T, PHE76T, PRO22E, PRO53E, PRO77T, PRO81T, SER12T, SER80T, THR12E, THR24E, THR59T, THR60T, TYR14T, TYR32T, VAL10T, VAL15T, VAL173E, VAL196E, VAL23E, VAL25E, VAL34T, VAL75E, VAL7E, VAL9E
• F-P: ALA113F, ALA12P, ARG117F, ARG119F, ARG15P, ARG16P, ARG188F, ARG18P, ARG38F, ARG7P, ARG95F, ASN13P, ASN29F, ASN9P, ASP116F, ASP185F, ASP5P, GLN40F, GLU120F, GLU190F, GLU35F, GLY11P, HIS31F, ILE186F, ILE28F, LEU32F, LEU33F, LEU41F, LEU6P, LYS122F, LYS14P, MET112F, PRO10P, PRO30F, PRO8P, SER153F, THR189F, TRP34F, TYR184F, VAL183F, VAL187F, VAL37F
• F-U: ALA49F, ARG3U, ARG45F, GLY47F, GLY91F, PRO2U, PRO92F, SER50F, THR48F, THR51F, TYR97F, VAL88F
• J-K: UNK116K, UNK117K, UNK118K, UNK2K, UNK34J, UNK49J, UNK50J
• K-Z: ARG112Z, UNK133K, UNK88K, UNK89K, UNK90K, UNK91K, UNK92K, UNK94K, UNK95K
• N-U: ALA67U, ALA68U, ALA96U, ALA99U, ARG101U, ARG35N, ARG39N, ARG59U, ARG64U, ARG70U, ARG92U, ASN45N, ASN66U, ASN94U, ASP41N, ASP56U, ASP97U, CYS69U, GLN71U, GLY36N, HIS38N, ILE65U, LEU60U, LEU95U, LEU98U, LYS2N, LYS37N, LYS7N, LYS93U, MET1N, MET48N, PHE106U, PHE57U, PRO103U, PRO40N, PRO44N, PRO6N, THR32N, THR3N, THR43N, TRP42N, TRP61U, TYR4N, VAL100U, VAL5N, VAL63U
• N-V: ALA3V, ARG13V, ARG21V, GLN11V, ILE4V, LEU20V, LYS10V, LYS19V, LYS2N, MET1N, PHE2V, TYR12V, VAL14V, VAL5V
• O-T: ALA103O, ALA118O, ALA11O, ALA76O, ALA83O, ARG103T, ARG104O, ARG107O, ARG41T, ARG51T, ARG64O, ARG64T, ARG71O, ARG74T, ARG78O, ASN104T, ASN38T, ASN82O, ASP44T, ASP73O, ASP80O, ASP81O, GLN43T, GLU105O, GLU108O, GLU120O, GLU36T, GLU46T, GLU68O, GLU73T, GLU9O, GLY100O, GLY37T, GLY69T, GLY71T, GLY74O, HIS79T, ILE50T, ILE69O, ILE75T, ILE77O, LEU122O, LEU82T, LYS33T, LYS35T, LYS65T, LYS66O, LYS70O, MET112O, PHE45T, PHE61T, PHE76T, PHE79O, PHE99O, PRO101O, PRO119O, PRO72O, PRO77T, PRO81T, SER106T, SER31T, SER67T, SER75O, SER80T, THR60T, THR62T, THR65O, TYR100T, TYR32T, TYR68T, VAL102O, VAL115O, VAL121O, VAL34T, VAL63O, VAL63T, VAL66T, VAL70T, VAL72T, VAL98O
• P-V: ALA31P, ARG82V, ARG83V, GLN80V, GLY26P, GLY28P, HIS27P, LYS76V, LYS84V, PHE75V, SER25P, THR30P, THR32P, TYR81V, VAL79V
• Q-Z: ALA107Q, ALA113Z, ALA136Q, ALA140Q, ALA173Z, ALA20Q, ALA28Q, ALA36Q, ALA51Z, ARG101Q, ARG112Z, ARG122Z, ARG133Q, ARG134Q, ARG49Z, ARG51Q, ARG56Q, ARG59Q, ARG60Q, ARG72Z, ARG79Z, ARG80Z, ARG81Z, ARG82Z, ASN75Z, ASP123Z, ASP135Q, ASP138Q, ASP25Q, ASP31Q, ASP45Z, ASP77Z, ASP87Z, GLN118Z, GLN141Q, GLN73Z, GLU105Q, GLU119Z, GLU139Q, GLU178Z, GLU38Q, GLU84Z, GLU97Z, GLY100Q, GLY108Q, GLY114Z, GLY115Z, GLY19Q, GLY23Q, GLY24Q, GLY30Q, GLY61Q, GLY62Q, HIS121Z, HIS54Z, HIS55Z, ILE120Z, ILE124Z, ILE131Q, ILE53Z, ILE57Z, ILE64Q, LEU102Z, LEU117Z, LEU125Z, LEU37Q, LEU70Z, LEU76Z, LYS128Q, LYS130Q, LYS18Q, LYS22Q, LYS63Q, LYS78Z, LYS98Q, MET54Q, MET98Z, PHE104Z, PHE29Q, PHE48Z, PHE58Q, PHE65Q, PHE89Z, PRO101Z, PRO176Z, PRO177Z, PRO39Q, PRO83Z, PRO99Q, SER52Z, THR129Q, THR21Q, TYR137Q, TYR26Q, TYR29Z, TYR32Q, TYR99Z, VAL100Z, VAL102Q, VAL106Q, VAL109Q, VAL111Z, VAL116Z, VAL126Z, VAL132Q, VAL174Z, VAL175Z, VAL27Q, VAL35Q, VAL52Q, VAL55Q, VAL71Z, VAL74Z, VAL96Z
• R-W: ALA101R, ALA109R, ALA44W, ARG103R, ARG104R, ARG105R, ARG37W, ARG42W, ASN40W, ASP107R, GLU102R, GLY106R, GLY108R, LEU100R, LYS41W, PRO110R, THR39W, TYR38W, TYR45W
• U-V: ALA107U, ALA3V, ALA41U, ALA42U, ALA46U, ALA48U, ALA77V, ALA86U, ALA96U, ARG101U, ARG112U, ARG13V, ARG36U, ARG50U, ARG53U, ARG82V, ARG83V, ARG92U, ASN44U, ASN94U, ASP91U, ASP97U, GLN104U, GLN11V, GLU102U, GLU108U, GLU15V, GLU37U, GLU43V, GLU89U, GLY41V, GLY42V, GLY43U, GLY48V, GLY86V, GLY87U, GLY8V, GLY9V, HIS87V, ILE17U, ILE4V, ILE70V, ILE88U, LEU109U, LEU20U, LEU38V, LEU39U, LEU39V, LEU40V, LEU71V, LEU83U, LEU95U, LEU98U, LYS10V, LYS16U, LYS44V, LYS51U, LYS54U, LYS69V, LYS6V, LYS74V, LYS76V, LYS84V, LYS85U, LYS85V, LYS93U, MET1V, PHE106U, PHE2V, PHE40U, PHE75V, PRO50V, SER73V, THR45V, THR49V, THR7V, TRP61U, TYR12V, TYR45U, TYR47U, TYR81V, VAL105U, VAL14V, VAL46V, VAL47V, VAL51V, VAL5V, VAL72V, VAL90U