3ZTJ

structure of influenza a neutralizing antibody selected from cultures of single human plasma cells in complex with human h3 influenza haemagglutinin.

• Total interactions analyzed: 66
• Total true interactions: 34
• Strongest Interaction:
  • Chains: F-K
  • Int. Res.: 43
  • Norm. En. per Res.: -3.7072
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-186.9747	-104.1286	-103.072	-394.1753	217	34	24	30439	8	65	52
A-C	-8.1696	0.0	-97.9054	-106.075	58	10	0	4603	0	5	15
A-D	0.0	2.1852	-67.3268	-65.1416	38	4	0	2896	0	11	12
A-E	-7.5402	0.0	-102.379	-109.9192	60	7	0	4955	0	4	15
A-F	0.0	-37.4736	-39.1223	-76.596	42	1	2	2240	2	14	9
A-G	0.0	-8.4893	-22.5821	-31.0714	44	5	0	1807	0	8	6
A-J	0.0	0.0	-12.7503	-12.7503	16	1	0	503	0	4	2
B-C	-17.8659	-26.4867	-36.936	-81.2886	46	4	2	2158	2	15	9
B-D	-38.2358	-142.2101	-306.773	-487.2189	138	21	9	13810	14	79	66
B-E	0.0	0.8231	-58.081	-57.2579	39	3	0	2703	1	11	11
B-F	-29.8104	-95.0535	-290.465	-415.3289	144	17	7	13329	11	76	61
B-G	-17.656	3.9651	-128.488	-142.1789	45	13	4	5652	2	2	5
B-H	0.0	0.0	-30.2899	-30.2899	23	0	0	1431	0	5	2
B-J	0.0	0.0	-13.7134	-13.7134	12	2	1	420	0	0	0
C-D	-173.9678	-92.2949	-159.642	-425.9046	217	40	20	30074	6	60	51
C-E	0.0	-1.1773	-109.799	-110.9763	62	9	0	5143	0	6	14
C-F	0.0	-3.526	-60.842	-64.368	34	2	0	2747	0	10	11
C-I	0.0	-4.9106	-7.1705	-12.0811	29	0	0	658	0	5	3
C-L	0.0	0.0	-8.2032	-8.2032	9	0	0	382	0	3	1
D-E	-10.722	-42.8235	-47.0589	-100.6044	44	4	2	2267	3	15	9
D-F	-25.1728	-127.8625	-325.411	-478.4463	141	12	9	13617	15	75	62
D-I	-8.2196	1.1993	-125.98	-133.0003	43	21	4	5553	2	2	5
D-J	0.0	0.0	-27.3874	-27.3874	23	1	0	1188	0	5	2
D-L	-15.8678	0.0	-15.4889	-31.3567	12	1	0	437	0	0	0
E-F	-152.659	-81.6461	-65.3198	-299.6249	217	47	25	30605	5	67	54
E-G	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	2	0
E-H	0.0	0.0	-8.8884	-8.8884	11	0	0	419	0	4	2
E-K	0.0	-6.9084	-10.5066	-17.415	29	1	0	819	0	6	3
F-H	-8.503	0.0	-10.3535	-18.8565	12	1	0	360	0	0	0
F-K	-13.0157	2.6397	-149.032	-159.408	43	20	4	5869	2	2	5
F-L	0.0	0.0	-27.8627	-27.8627	25	2	0	1322	0	5	2
G-H	-18.3378	10.1322	-246.014	-254.2196	94	10	5	10013	0	12	8
I-J	-33.4045	-3.455	-413.589	-450.4484	188	22	13	18551	1	26	19
K-L	-38.0087	2.3442	-445.417	-481.0815	189	21	12	18943	0	27	20

Interface residues

• A-B: ALA101B, ALA106A, ALA113A, ALA11A, ALA130B, ALA166B, ALA19A, ALA304A, ALA317A, ALA35B, ALA36B, ALA39A, ALA44B, ALA5B, ALA7B, ALA96B, ARG109A, ARG123B, ARG153B, ARG170B, ARG25B, ARG269A, ARG321A, ARG54B, ASN104B, ASN116B, ASN129B, ASN12B, ASN135B, ASN169B, ASN22A, ASN28B, ASN290A, ASN296A, ASN298A, ASN322A, ASN38A, ASN49B, ASN53B, ASN60B, ASN95B, ASP109B, ASP112B, ASP145B, ASP19B, ASP291A, ASP31A, ASP32A, ASP37B, ASP86B, ASP90B, CYS137B, CYS144B, CYS148B, CYS14A, CYS281A, CYS305A, GLN105B, GLN125B, GLN27B, GLN295A, GLN311A, GLN34B, GLN65B, GLU103B, GLU114B, GLU11B, GLU120B, GLU131B, GLU132B, GLU15B, GLU165B, GLU280A, GLU30B, GLU325A, GLU35A, GLU41A, GLU57B, GLU61B, GLU67B, GLU69B, GLU72B, GLU74B, GLU81B, GLU85B, GLU97B, GLY136B, GLY13B, GLY16A, GLY16B, GLY1B, GLY20B, GLY23B, GLY263A, GLY303A, GLY319A, GLY33B, GLY8B, HIS106B, HIS142B, HIS17A, HIS18A, HIS26B, HIS64B, ILE108B, ILE10B, ILE140B, ILE149B, ILE152B, ILE18B, ILE267A, ILE29A, ILE300A, ILE34A, ILE45B, ILE48B, ILE56B, ILE66B, ILE6B, ILE77B, ILE89B, LEU102B, LEU110B, LEU111A, LEU118B, LEU126B, LEU13A, LEU15A, LEU25A, LEU2B, LEU314A, LEU316A, LEU42A, LEU52B, LEU91B, LEU98B, LEU99B, LYS117B, LYS121B, LYS139B, LYS143B, LYS264A, LYS27A, LYS292A, LYS299A, LYS307A, LYS310A, LYS315A, LYS326A, LYS51B, LYS58B, LYS62B, LYS68B, LYS82B, LYS88B, MET115B, MET133B, MET17B, MET268A, MET320A, PHE119B, PHE138B, PHE24B, PHE294A, PHE63B, PHE70B, PHE9B, PRO21A, PRO284A, PRO289A, PRO293A, PRO306A, PRO324A, SER110A, SER114A, SER115A, SER265A, SER266A, SER29B, SER40B, SER71B, SER93B, SER9A, THR107B, THR10A, THR111B, THR122B, THR12A, THR262A, THR28A, THR301A, THR30A, THR313A, THR318A, THR32B, THR37A, THR40A, THR41B, THR59B, THR87B, TRP14B, TRP21B, TRP92B, TYR105A, TYR141B, TYR22B, TYR302A, TYR308A, TYR94B, VAL100B, VAL20A, VAL26A, VAL309A, VAL323A, VAL36A, VAL43A, VAL55B
• A-C: ARG201C, ARG207C, ARG208C, ARG220A, ARG224A, ARG229A, ASN165C, ASN188A, ASN216A, ASN246C, ASN248C, ASP101A, ASP241C, GLN210C, GLN211C, GLY218A, HIS184A, ILE182A, ILE213C, ILE214A, ILE214C, ILE217A, ILE230A, ILE245C, LEU164C, LEU243C, LYS307C, LYS310A, PRO103A, PRO185A, PRO215A, PRO221A, PRO99A, SER186A, SER205C, SER209C, SER219A, SER227A, SER228A, SER231A, SER247C, THR167C, THR187A, THR203C, THR206C, THR212C, TRP222A, TYR100A, TYR233A, VAL102A, VAL163C, VAL166C, VAL202C, VAL204C, VAL223A, VAL237C, VAL242C, VAL244C
• A-D: ALA43D, ALA44D, ARG127D, ARG54D, ASN49D, ASN53D, ASN60D, ASP31A, ASP32A, ASP46D, GLN311A, GLN33A, GLN47D, GLU103D, GLU57D, GLU61D, GLY50D, HIS106D, ILE29A, ILE48D, LEU102D, LEU110D, LEU314A, LEU52D, LEU99D, LYS27A, LYS310A, LYS51D, LYS58D, LYS62D, THR107D, THR12A, THR28A, THR30A, THR59D, TRP92D, VAL26A, VAL55D
• A-E: ARG201A, ARG207A, ARG208A, ARG220E, ARG224E, ARG229E, ASN165A, ASN188E, ASN216E, ASN246A, ASN248A, ASP101E, ASP241A, GLN210A, GLN211A, GLY218E, HIS183E, HIS184E, ILE182E, ILE213A, ILE214A, ILE214E, ILE217E, ILE230E, ILE245A, ILE29E, LEU164A, LEU243A, LEU316A, LYS307A, LYS310E, PRO103E, PRO185E, PRO215E, PRO221E, PRO99E, SER186E, SER205A, SER209A, SER219E, SER227E, SER231E, SER247A, THR167A, THR187E, THR203A, THR206A, THR212A, TRP222E, TYR100E, TYR233E, VAL102E, VAL163A, VAL166A, VAL202A, VAL204A, VAL223E, VAL237A, VAL242A, VAL244A
• A-F: ALA106A, ALA113A, ARG109A, ARG208A, ARG261A, ARG76F, ASP104A, ASP175A, ASP79F, ASP90F, GLN78F, GLU72F, GLU74F, GLY75F, ILE236A, ILE77F, LEU108A, LEU111A, LEU177A, LEU91F, LYS238A, LYS299A, LYS307A, LYS82F, MET260A, PHE294A, PRO293A, SER107A, SER110A, SER114A, SER115A, SER209A, SER71F, THR262A, THR301A, THR87F, TRP234A, TYR105A, TYR83F, TYR94F, VAL112A, VAL73F
• A-G: ALA24G, ALA317A, ALA39A, ARG99G, ASN290A, ASN38A, ASN55G, ASN73G, ASN76G, ASP275A, ASP291A, ASP53G, CYS277A, CYS52A, GLU280A, GLY319A, HIS18A, ILE278A, LEU100G, LEU316A, LYS292A, LYS75G, MET320A, PHE100G, PHE29G, PRO289A, PRO293A, PRO55A, SER25G, SER279A, SER287A, SER30G, SER74G, THR276A, THR28G, THR318A, THR31G, THR37A, THR40A, THR48A, TYR100G, TYR52G, TYR56G, VAL20A
• A-J: ARG321A, ASN28J, ASN31J, ASN322A, ASP31A, GLN33A, GLU325A, GLY66J, HIS17A, ILE34A, LYS30J, LYS326A, PRO324A, SER67J, TYR29J, VAL323A
• B-C: ALA106C, ARG109C, ARG208C, ARG261C, ARG76B, ASP104C, ASP175C, ASP79B, ASP90B, GLN78B, GLU72B, GLU74B, GLY75B, ILE236C, ILE29C, ILE77B, LEU102B, LEU108C, LEU111C, LEU177C, LEU91B, LYS238C, LYS299C, LYS307C, LYS82B, MET260C, PHE294C, PHE70B, PRO293C, SER107C, SER110C, SER114C, SER115C, SER209C, SER71B, SER93B, THR262C, THR301C, THR87B, TRP234C, TYR105C, TYR308C, TYR83B, TYR94B, VAL112C, VAL73B
• B-D: ALA101B, ALA130B, ALA5B, ALA7B, ALA96D, ARG123B, ARG123D, ARG124D, ARG127D, ARG163D, ARG170B, ARG170D, ARG54D, ARG76B, ARG76D, ASN104B, ASN116B, ASN116D, ASN135B, ASN169B, ASN60D, ASN95B, ASN95D, ASP109B, ASP109D, ASP112B, ASP112D, ASP160D, ASP164D, ASP79B, ASP79D, ASP86B, ASP86D, ASP90B, CYS137B, GLN105B, GLN125D, GLN172B, GLN172D, GLN47D, GLN65D, GLN78B, GLN78D, GLU103D, GLU114D, GLU120B, GLU120D, GLU128B, GLU128D, GLU131B, GLU132B, GLU57D, GLU61D, GLU67D, GLU69D, GLU72D, GLU74D, GLU81B, GLU81D, GLU85B, GLU85D, GLU97B, GLU97D, GLY134B, GLY136B, GLY1B, GLY4B, GLY75B, GLY75D, GLY8B, HIS106B, HIS106D, HIS159D, HIS64D, ILE10B, ILE140B, ILE66D, ILE6B, ILE77B, ILE77D, ILE89B, ILE89D, LEU102B, LEU102D, LEU110D, LEU167D, LEU2B, LEU2D, LEU80B, LEU80D, LEU91B, LEU91D, LEU98B, LEU98D, LEU99B, LEU99D, LYS117D, LYS121D, LYS139B, LYS51D, LYS58D, LYS62D, LYS68D, LYS82B, LYS82D, LYS88B, LYS88D, MET133B, PHE119B, PHE138B, PHE171B, PHE171D, PHE3B, PHE3D, PHE63D, PHE70D, PHE9B, SER113B, SER113D, SER71D, SER93B, SER93D, THR111D, THR59D, THR87B, THR87D, TRP92B, TRP92D, TYR141B, TYR83B, TYR83D, TYR94B, TYR94D, VAL100B, VAL100D, VAL55D, VAL84B, VAL84D
• B-E: ARG127B, ARG321E, ARG54B, ASN49B, ASN53B, ASN60B, ASP31E, ASP32E, ASP46B, GLN311E, GLN33E, GLN47B, GLU103B, GLU57B, GLU61B, GLY50B, HIS106B, ILE29E, ILE48B, LEU102B, LEU110B, LEU314E, LEU52B, LEU99B, LYS117B, LYS27E, LYS310E, LYS51B, LYS58B, LYS62B, THR107B, THR10E, THR12E, THR28E, THR30E, THR59B, TRP92B, VAL26E, VAL55B
• B-F: ALA101F, ALA130F, ALA5F, ALA7F, ALA96B, ALA96F, ARG123B, ARG123F, ARG124B, ARG127B, ARG163B, ARG170B, ARG170F, ARG54B, ARG76B, ARG76F, ASN104F, ASN116B, ASN116F, ASN129B, ASN135F, ASN169F, ASN60B, ASN95B, ASN95F, ASP109B, ASP109F, ASP112B, ASP112F, ASP160B, ASP164B, ASP79B, ASP79F, ASP86B, ASP86F, ASP90B, ASP90F, CYS137F, GLN105B, GLN105F, GLN125B, GLN172B, GLN172F, GLN47B, GLN65B, GLN78B, GLN78F, GLU103B, GLU114B, GLU120B, GLU120F, GLU128B, GLU128F, GLU131F, GLU132F, GLU57B, GLU61B, GLU67B, GLU69B, GLU72B, GLU74B, GLU81B, GLU81F, GLU85B, GLU85F, GLU97B, GLU97F, GLY134F, GLY136F, GLY1F, GLY4F, GLY75B, GLY75F, GLY8F, HIS106B, HIS106F, HIS159B, HIS64B, ILE108B, ILE10F, ILE140F, ILE66B, ILE66F, ILE6F, ILE77B, ILE77F, ILE89B, ILE89F, LEU102B, LEU102F, LEU110B, LEU167B, LEU167F, LEU2B, LEU2F, LEU80B, LEU80F, LEU91B, LEU91F, LEU98B, LEU98F, LEU99B, LYS117B, LYS121B, LYS139F, LYS51B, LYS58B, LYS62B, LYS68B, LYS82B, LYS82F, LYS88B, LYS88F, MET133F, PHE119F, PHE138F, PHE171B, PHE171F, PHE3B, PHE3F, PHE63B, PHE70B, PHE9F, SER113B, SER113F, SER71B, SER93B, SER93F, THR111B, THR59B, THR87B, THR87F, TRP92B, TRP92F, TYR141F, TYR83B, TYR83F, TYR94B, TYR94F, VAL100B, VAL100F, VAL55B, VAL84B, VAL84F
• B-G: ALA36B, ALA43B, ALA44B, ARG54B, ARG99G, ASN49B, ASN53B, ASP19B, ASP37B, ASP46B, ASP53G, GLN100G, GLN42B, GLN47B, GLN97G, GLU100G, GLU57B, GLY20B, GLY50B, ILE18B, ILE45B, ILE48B, ILE56B, LEU100G, LEU38B, LEU52B, LEU98G, LYS39B, LYS51B, LYS58B, MET17B, PHE100G, SER100G, SER40B, THR31G, THR41B, THR59B, TRP100G, TRP21B, TYR100G, TYR22B, TYR32G, TYR52G, TYR56G, VAL55B
• B-H: ALA43B, ALA44B, ARG93H, ASN28H, ASP37B, ASP46B, GLN27H, GLN42B, GLN47B, GLU114B, HIS91H, ILE45B, LEU38B, LYS117B, LYS39B, PHE27H, SER27H, SER40B, THR27H, THR41B, THR94H, TYR32H, TYR92H
• B-J: ALA5B, ALA7B, ASN12B, ASN28J, GLU11B, GLY13B, GLY1B, GLY8B, ILE10B, ILE6B, PHE9B, TYR29J
• C-D: ALA101D, ALA106C, ALA113C, ALA11C, ALA130D, ALA166D, ALA19C, ALA304C, ALA317C, ALA35D, ALA36D, ALA39C, ALA44D, ALA5D, ALA7D, ALA96D, ARG109C, ARG123D, ARG153D, ARG170D, ARG25D, ARG269C, ARG321C, ARG54D, ASN104D, ASN116D, ASN129D, ASN12D, ASN135D, ASN169D, ASN22C, ASN28D, ASN290C, ASN296C, ASN298C, ASN322C, ASN38C, ASN49D, ASN53D, ASN60D, ASN95D, ASP104C, ASP109D, ASP112D, ASP145D, ASP19D, ASP291C, ASP31C, ASP32C, ASP37D, ASP86D, ASP90D, CYS137D, CYS144D, CYS14C, CYS281C, CYS305C, GLN105D, GLN125D, GLN27D, GLN295C, GLN311C, GLN34D, GLN65D, GLU103D, GLU114D, GLU11D, GLU120D, GLU131D, GLU150D, GLU15D, GLU165D, GLU280C, GLU30D, GLU35C, GLU41C, GLU57D, GLU61D, GLU67D, GLU69D, GLU72D, GLU74D, GLU81D, GLU85D, GLU89C, GLU97D, GLY136D, GLY13D, GLY16C, GLY16D, GLY1D, GLY20D, GLY23D, GLY263C, GLY303C, GLY319C, GLY33D, GLY8D, HIS106D, HIS142D, HIS17C, HIS18C, HIS26D, HIS64D, ILE108D, ILE10D, ILE140D, ILE149D, ILE152D, ILE18D, ILE267C, ILE29C, ILE300C, ILE34C, ILE45D, ILE48D, ILE56D, ILE66D, ILE6D, ILE77D, ILE89D, LEU102D, LEU110D, LEU111C, LEU118D, LEU126D, LEU13C, LEU15C, LEU25C, LEU314C, LEU316C, LEU42C, LEU52D, LEU91D, LEU98D, LEU99D, LYS121D, LYS139D, LYS143D, LYS264C, LYS27C, LYS292C, LYS299C, LYS307C, LYS310C, LYS315C, LYS51D, LYS58D, LYS62D, LYS68D, LYS82D, LYS88D, MET115D, MET133D, MET17D, MET268C, MET320C, PHE119D, PHE138D, PHE24D, PHE294C, PHE63D, PHE70D, PHE9D, PRO21C, PRO284C, PRO289C, PRO293C, PRO306C, PRO324C, SER107C, SER110C, SER114C, SER115C, SER265C, SER266C, SER270C, SER29D, SER40D, SER71D, SER93D, SER9C, THR107D, THR10C, THR111D, THR122D, THR12C, THR262C, THR28C, THR301C, THR30C, THR313C, THR318C, THR32D, THR37C, THR40C, THR41D, THR59D, THR87D, TRP14D, TRP21D, TRP92D, TYR105C, TYR141D, TYR22D, TYR302C, TYR308C, TYR94D, VAL100D, VAL112C, VAL20C, VAL26C, VAL309C, VAL323C, VAL36C, VAL43C, VAL55D
• C-E: ARG201E, ARG207E, ARG208E, ARG220C, ARG224C, ARG229C, ASN165E, ASN188C, ASN216C, ASN246E, ASN248E, ASP101C, ASP241E, GLN197E, GLN210E, GLN211E, GLY218C, HIS184C, ILE182C, ILE213E, ILE214C, ILE214E, ILE217C, ILE230C, ILE245E, ILE29C, LEU164E, LEU226C, LEU243E, LEU316E, LYS307E, LYS310C, MET168E, PRO103C, PRO185C, PRO215C, PRO221C, PRO99C, SER186C, SER205E, SER209E, SER219C, SER227C, SER228C, SER231C, SER247E, THR167E, THR187C, THR203E, THR206E, THR212E, TRP222C, TYR100C, TYR105C, TYR233C, VAL102C, VAL163E, VAL202E, VAL204E, VAL223C, VAL242E, VAL244E
• C-F: ARG54F, ASN104F, ASN49F, ASN53F, ASN60F, ASP31C, ASP32C, ASP46F, GLN311C, GLN33C, GLN47F, GLU103F, GLU61F, GLY50F, HIS106F, ILE29C, ILE48F, LEU102F, LEU110F, LEU314C, LEU52F, LEU99F, LYS27C, LYS310C, LYS51F, LYS58F, LYS62F, THR107F, THR28C, THR30C, THR59F, TRP92F, VAL26C, VAL55F
• C-I: ALA39C, ARG99I, ASN290C, ASN38C, ASN55I, ASN73I, ASN76I, ASP291C, ASP53I, CYS277C, GLY319C, HIS18C, ILE278C, LEU100I, LYS292C, LYS75I, MET320C, PHE100I, PRO293C, SER30I, SER74I, THR28I, THR318C, THR31I, THR37C, THR40C, TYR100I, TYR52I, TYR56I
• C-L: ARG321C, ASN28L, ASN322C, ASP31C, HIS17C, LYS30L, PRO324C, TYR29L, VAL323C
• D-E: ALA106E, ARG109E, ARG208E, ARG261E, ARG76D, ASP104E, ASP175E, ASP241E, ASP79D, ASP90D, GLN78D, GLU72D, GLU74D, GLY75D, ILE236E, ILE29E, ILE77D, LEU102D, LEU108E, LEU111E, LEU177E, LEU91D, LYS238E, LYS299E, LYS307E, LYS82D, MET260E, PHE294E, PHE70D, PRO293E, SER107E, SER110E, SER114E, SER115E, SER209E, SER71D, THR262E, THR87D, TRP234E, TYR105E, TYR83D, TYR94D, VAL112E, VAL73D
• D-F: ALA101D, ALA130D, ALA5D, ALA7D, ALA96F, ARG123D, ARG123F, ARG124D, ARG124F, ARG127F, ARG163F, ARG170D, ARG170F, ARG54F, ARG76D, ARG76F, ASN104D, ASN116D, ASN116F, ASN135D, ASN169D, ASN60F, ASN95D, ASN95F, ASP109D, ASP109F, ASP112D, ASP112F, ASP160F, ASP164F, ASP79D, ASP79F, ASP86D, ASP86F, ASP90D, CYS137D, GLN105D, GLN105F, GLN125F, GLN172D, GLN172F, GLN47F, GLN65F, GLN78D, GLN78F, GLU103F, GLU114F, GLU120D, GLU120F, GLU128D, GLU128F, GLU131D, GLU132D, GLU61F, GLU67F, GLU69F, GLU72F, GLU74F, GLU81D, GLU81F, GLU85D, GLU85F, GLU97D, GLU97F, GLY134D, GLY136D, GLY1D, GLY4D, GLY75D, GLY75F, GLY8D, HIS106D, HIS106F, HIS159F, HIS64F, ILE108F, ILE10D, ILE140D, ILE66D, ILE66F, ILE6D, ILE77D, ILE77F, ILE89D, ILE89F, LEU102D, LEU102F, LEU110F, LEU167F, LEU2D, LEU2F, LEU80D, LEU80F, LEU91D, LEU91F, LEU98D, LEU98F, LEU99F, LYS117F, LYS121F, LYS139D, LYS51F, LYS58F, LYS62F, LYS68F, LYS82D, LYS82F, LYS88D, LYS88F, MET133D, PHE119D, PHE138D, PHE171D, PHE171F, PHE3D, PHE3F, PHE63F, PHE70F, PHE9D, SER113D, SER113F, SER71F, SER93D, SER93F, THR107F, THR111F, THR59F, THR87D, THR87F, TRP92D, TRP92F, TYR141D, TYR83D, TYR83F, TYR94D, TYR94F, VAL100D, VAL100F, VAL55F, VAL84D, VAL84F
• D-I: ALA36D, ALA43D, ALA44D, ARG54D, ARG99I, ASN49D, ASN53D, ASP19D, ASP37D, ASP46D, ASP53I, GLN100I, GLN42D, GLN47D, GLN97I, GLU100I, GLU57D, GLY20D, GLY50D, ILE18D, ILE45D, ILE48D, ILE56D, LEU100I, LEU38D, LEU52D, LEU98I, LYS39D, LYS51D, LYS58D, MET17D, PHE100I, SER100I, SER40D, THR31I, THR41D, TRP100I, TRP21D, TYR100I, TYR22D, TYR32I, TYR52I, VAL55D
• D-J: ALA36D, ALA43D, ALA44D, ARG93J, ASN28J, ASP37D, ASP46D, GLN27J, GLN42D, GLN47D, GLU114D, HIS91J, ILE45D, LEU38D, LYS117D, LYS30J, LYS39D, PHE27J, SER40D, THR41D, THR94J, TYR32J, TYR92J
• D-L: ALA5D, ALA7D, ASN12D, ASN28L, GLU11D, GLY13D, GLY1D, GLY8D, ILE10D, ILE6D, PHE9D, TYR29L
• E-F: ALA101F, ALA106E, ALA113E, ALA11E, ALA130F, ALA166F, ALA19E, ALA304E, ALA317E, ALA35F, ALA36F, ALA39E, ALA44F, ALA5F, ALA7F, ALA96F, ARG109E, ARG123F, ARG153F, ARG170F, ARG25F, ARG269E, ARG321E, ARG54F, ASN104F, ASN116F, ASN129F, ASN12F, ASN135F, ASN169F, ASN22E, ASN285E, ASN28F, ASN290E, ASN296E, ASN298E, ASN322E, ASN38E, ASN49F, ASN53F, ASN60F, ASN95F, ASP104E, ASP109F, ASP112F, ASP145F, ASP19F, ASP291E, ASP31E, ASP32E, ASP37F, ASP86F, ASP90F, CYS137F, CYS144F, CYS148F, CYS14E, CYS281E, CYS305E, GLN105F, GLN125F, GLN27F, GLN295E, GLN311E, GLN34F, GLN65F, GLU103F, GLU114F, GLU11F, GLU120F, GLU131F, GLU132F, GLU15F, GLU165F, GLU280E, GLU30F, GLU325E, GLU35E, GLU41E, GLU57F, GLU61F, GLU67F, GLU69F, GLU72F, GLU74F, GLU81F, GLU85F, GLU89E, GLU97F, GLY134F, GLY136F, GLY13F, GLY16E, GLY16F, GLY1F, GLY20F, GLY23F, GLY263E, GLY303E, GLY319E, GLY33F, GLY4F, GLY8F, HIS106F, HIS142F, HIS17E, HIS18E, HIS26F, HIS64F, ILE108F, ILE10F, ILE140F, ILE149F, ILE152F, ILE18F, ILE267E, ILE29E, ILE300E, ILE34E, ILE45F, ILE48F, ILE56F, ILE66F, ILE6F, ILE77F, ILE89F, LEU102F, LEU110F, LEU111E, LEU118F, LEU126F, LEU13E, LEU15E, LEU25E, LEU2F, LEU314E, LEU316E, LEU42E, LEU52F, LEU91F, LEU98F, LEU99F, LYS121F, LYS139F, LYS143F, LYS264E, LYS27E, LYS292E, LYS299E, LYS307E, LYS310E, LYS315E, LYS326E, LYS51F, LYS58F, LYS62F, LYS68F, LYS82F, LYS88F, MET115F, MET133F, MET17F, MET268E, MET320E, PHE119F, PHE138F, PHE24F, PHE294E, PHE63F, PHE70F, PHE9F, PRO21E, PRO284E, PRO293E, PRO306E, PRO324E, SER107E, SER110E, SER114E, SER265E, SER266E, SER29F, SER40F, SER71F, SER93F, SER9E, THR107F, THR10E, THR111F, THR122F, THR12E, THR28E, THR301E, THR30E, THR313E, THR318E, THR37E, THR40E, THR41F, THR59F, TRP14F, TRP21F, TRP92F, TYR141F, TYR22F, TYR302E, TYR308E, TYR94F, VAL100F, VAL112E, VAL20E, VAL26E, VAL309E, VAL323E, VAL36E, VAL43E, VAL55F
• E-G: ASP32E, LEU98G
• E-H: ARG321E, ASN28H, ASP31E, GLU325E, HIS17E, ILE34E, LYS326E, PRO324E, SER67H, TYR29H, VAL323E
• E-K: ALA317E, ALA39E, ARG99K, ASN290E, ASN38E, ASN73K, ASN76K, ASP291E, ASP53K, CYS277E, GLY319E, HIS18E, ILE278E, LEU100K, LYS292E, LYS75K, MET320E, PHE100K, PRO293E, SER30K, SER74K, THR28K, THR318E, THR31K, THR37E, THR40E, TYR100K, TYR52K, TYR56K
• F-H: ALA5F, ALA7F, ASN12F, ASN28H, GLU11F, GLY13F, GLY1F, GLY8F, ILE10F, ILE6F, PHE9F, TYR29H
• F-K: ALA36F, ALA43F, ALA44F, ARG54F, ARG99K, ASN49F, ASN53F, ASP19F, ASP37F, ASP46F, ASP53K, GLN100K, GLN42F, GLN47F, GLN97K, GLU100K, GLU57F, GLY20F, GLY50F, ILE18F, ILE45F, ILE48F, ILE56F, LEU100K, LEU38F, LEU52F, LEU98K, LYS39F, LYS51F, LYS58F, MET17F, PHE100K, SER100K, SER40F, THR31K, THR41F, TRP100K, TRP21F, TYR100K, TYR22F, TYR52K, TYR56K, VAL55F
• F-L: ALA43F, ALA44F, ARG93L, ASN154F, ASN28L, ASP37F, ASP46F, GLN27L, GLN42F, GLN47F, GLU114F, HIS91L, ILE45F, LEU38F, LYS117F, LYS30L, LYS39F, PHE27L, SER27L, SER40F, THR27L, THR41F, THR94L, TYR32L, TYR92L
• G-H: ALA34H, ALA40G, ALA49G, ALA51H, ALA60G, ALA93G, ARG38G, ARG54H, ARG93H, ASN31H, ASP101G, ASP1H, ASP61G, ASP95G, CYS88H, CYS92G, GLN100G, GLN100H, GLN105G, GLN1G, GLN37H, GLN38H, GLN39G, GLN42H, GLN6H, GLN89H, GLN90H, GLN97G, GLU100G, GLU46G, GLU55H, GLU6G, GLY100G, GLY101H, GLY104G, GLY106G, GLY41H, GLY42G, GLY44G, GLY57H, GLY99H, HIS35G, HIS91H, ILE48H, LEU100G, LEU33H, LEU45G, LEU46H, LEU47H, LEU98G, LYS43G, LYS45H, LYS57G, LYS94G, PHE100G, PHE27H, PHE98H, PRO40H, PRO41G, PRO43H, PRO44H, PRO95H, PRO96H, SER100G, SER56H, SER62G, SER96G, THR107G, THR53H, THR94H, THR97H, TRP100G, TRP103G, TRP35H, TRP36G, TRP47G, TRP50H, TYR100G, TYR102G, TYR32H, TYR36H, TYR49H, TYR58G, TYR59G, TYR86H, TYR87H, TYR90G, TYR91G, TYR92H, VAL37G, VAL48G, VAL50G, VAL85H, VAL89G
• I-J: ALA125I, ALA130J, ALA132I, ALA133I, ALA164I, ALA34J, ALA40I, ALA49I, ALA51J, ALA60I, ALA93I, ARG142J, ARG206I, ARG38I, ARG93J, ASN137J, ASN138J, ASN31J, ASP101I, ASP122J, ASP140I, ASP167J, ASP170J, ASP1J, ASP61I, ASP95I, CYS134J, CYS136I, CYS88J, CYS92I, GLN100I, GLN100J, GLN105I, GLN124J, GLN160J, GLN167I, GLN1I, GLN37J, GLN38J, GLN39I, GLN42J, GLN89J, GLN90J, GLN97I, GLU100I, GLU123J, GLU161J, GLU165J, GLU208I, GLU46I, GLU55J, GLU6I, GLY100I, GLY101J, GLY104I, GLY106I, GLY129I, GLY130I, GLY135I, GLY158I, GLY41J, GLY42I, GLY44I, GLY57J, GLY99J, HIS160I, HIS35I, HIS91J, ILE117J, ILE48J, LEU100I, LEU124I, LEU125J, LEU134I, LEU135J, LEU136J, LEU137I, LEU166I, LEU171I, LEU174I, LEU175J, LEU179J, LEU181J, LEU33J, LEU45I, LEU46J, LEU47J, LEU4I, LEU98I, LYS126J, LYS139I, LYS169J, LYS205I, LYS207J, LYS210I, LYS30J, LYS43I, LYS45J, LYS94I, PHE100I, PHE116J, PHE118J, PHE122I, PHE139J, PHE162I, PHE209J, PHE27J, PHE98J, PRO119J, PRO120J, PRO123I, PRO126I, PRO163I, PRO40J, PRO43J, PRO44J, PRO95J, PRO96J, SER100I, SER114J, SER120I, SER121J, SER127I, SER127J, SER128I, SER131J, SER157I, SER162J, SER168I, SER168J, SER169I, SER173I, SER174J, SER175I, SER176I, SER176J, SER177J, SER208J, SER56J, SER62I, SER96I, THR107I, THR129J, THR131I, THR161I, THR164J, THR172J, THR178J, THR179I, THR180J, THR53J, THR94J, THR97J, TRP100I, TRP103I, TRP35J, TRP36I, TRP47I, TRP50J, TYR100I, TYR102I, TYR172I, TYR173J, TYR32J, TYR36J, TYR49J, TYR58I, TYR59I, TYR86J, TYR87J, TYR91I, TYR92J, VAL115J, VAL121I, VAL132J, VAL133J, VAL159I, VAL163J, VAL165I, VAL177I, VAL178I, VAL180I, VAL207I, VAL37I, VAL48I, VAL50I, VAL85J, VAL89I
• K-L: ALA125K, ALA130L, ALA132K, ALA133K, ALA164K, ALA34L, ALA49K, ALA51L, ALA60K, ALA93K, ARG142L, ARG206K, ARG38K, ARG54L, ARG93L, ASN137L, ASN138L, ASN158L, ASN31L, ASP101K, ASP122L, ASP140K, ASP167L, ASP170L, ASP1L, ASP61K, ASP95K, CYS134L, CYS136K, CYS88L, CYS92K, GLN100K, GLN100L, GLN105K, GLN124L, GLN160L, GLN166L, GLN167K, GLN1K, GLN37L, GLN38L, GLN39K, GLN42L, GLN89L, GLN90L, GLN97K, GLU100K, GLU123L, GLU161L, GLU165L, GLU46K, GLU55L, GLU6K, GLY100K, GLY101L, GLY104K, GLY106K, GLY130K, GLY135K, GLY158K, GLY170K, GLY41L, GLY42K, GLY44K, GLY57L, GLY99L, HIS160K, HIS35K, HIS91L, ILE117L, ILE48L, LEU100K, LEU124K, LEU125L, LEU134K, LEU135L, LEU136L, LEU137K, LEU166K, LEU171K, LEU174K, LEU175L, LEU179L, LEU181L, LEU33L, LEU45K, LEU46L, LEU47L, LEU98K, LYS126L, LYS139K, LYS169L, LYS205K, LYS210K, LYS30L, LYS43K, LYS45L, LYS57K, LYS64K, LYS94K, PHE100K, PHE116L, PHE118L, PHE122K, PHE139L, PHE162K, PHE209L, PHE27L, PHE98L, PRO119L, PRO120L, PRO123K, PRO126K, PRO163K, PRO40L, PRO43L, PRO44L, PRO95L, PRO96L, SER100K, SER114L, SER120K, SER121L, SER127K, SER127L, SER131L, SER159L, SER162L, SER168K, SER169K, SER173K, SER174L, SER175K, SER176K, SER176L, SER177L, SER182K, SER208L, SER56L, SER62K, SER96K, THR129L, THR131K, THR161K, THR164L, THR172L, THR178L, THR179K, THR180L, THR53L, THR94L, THR97L, TRP100K, TRP103K, TRP35L, TRP36K, TRP47K, TRP50L, TYR100K, TYR102K, TYR172K, TYR173L, TYR32L, TYR36L, TYR49L, TYR58K, TYR59K, TYR86L, TYR87L, TYR91K, TYR92L, VAL115L, VAL121K, VAL132L, VAL133L, VAL138K, VAL159K, VAL163L, VAL165K, VAL177K, VAL178K, VAL180K, VAL207K, VAL2K, VAL37K, VAL48K, VAL50K, VAL85L, VAL89K