3ZQP

crystal structure of the small terminase oligomerization domain from a spp1-like bacteriophage

• Total interactions analyzed: 36
• Total true interactions: 18
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 141
  • Norm. En. per Res.: -5.5063
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-204.9823	-39.0773	-532.332	-776.3916	141	34	23	22127	6	55	61
A-C	0.0	-3.3668	-0.8546	-4.2215	34	0	0	261	0	8	12
A-H	0.0	-4.1344	-0.9783	-5.1127	36	0	0	290	0	8	13
A-I	-195.9271	-32.0082	-526.428	-754.3632	141	35	23	22006	6	54	62
B-C	-173.5482	-39.3796	-522.895	-735.8228	144	35	23	22391	6	56	64
B-D	0.0	-4.0183	-0.88	-4.8983	34	0	0	267	0	8	12
B-I	0.0	-4.0685	-0.9195	-4.988	34	0	0	277	0	8	11
C-D	-188.1839	-30.1664	-543.801	-762.1514	142	34	24	22293	6	54	61
C-E	0.0	-4.1975	-0.8664	-5.064	33	0	0	267	0	8	12
D-E	-181.9547	-48.5263	-528.336	-758.817	140	33	22	21764	5	56	63
D-F	0.0	-3.2557	-0.6228	-3.8786	30	0	0	234	0	8	11
E-F	-178.7638	-12.0351	-517.396	-708.1949	140	32	24	21776	6	54	62
E-G	0.0	-4.1578	-0.6116	-4.7694	33	0	0	244	0	8	12
F-G	-177.2941	-47.9717	-494.684	-719.9498	139	36	23	21424	6	54	61
F-H	0.0	-3.1212	-0.7309	-3.852	32	0	0	248	0	7	11
G-H	-195.8552	-31.4317	-555.872	-783.1588	143	35	23	22837	6	57	64
G-I	0.0	-4.0752	-1.2361	-5.3113	33	0	0	306	0	8	12
H-I	-192.6329	-36.5502	-546.562	-775.745	143	32	23	22567	6	56	64

Interface residues

• A-B: ALA107A, ALA113A, ALA113B, ALA120A, ALA120B, ALA122A, ALA122B, ALA70A, ALA70B, ALA81A, ALA81B, ALA97A, ALA97B, ARG110A, ARG110B, ARG79A, ARG79B, ASN133A, ASN133B, ASN71A, ASN71B, ASP109A, ASP109B, ASP126A, ASP126B, ASP139A, ASP139B, ASP140A, GLN128A, GLN128B, GLN134A, GLN134B, GLN69A, GLN69B, GLN84A, GLN88B, GLU104A, GLU104B, GLU115A, GLU115B, GLU131A, GLU131B, GLU72A, GLU72B, GLU75A, GLU75B, GLU85A, GLU85B, GLU87A, GLU87B, GLU98A, GLU98B, GLY118A, GLY118B, GLY83A, GLY92A, GLY92B, GLY94A, GLY94B, GLY96A, GLY96B, HIS102A, HIS102B, HIS121A, HIS121B, HIS76A, HIS76B, ILE111A, ILE111B, ILE136A, ILE136B, ILE137A, ILE137B, ILE67B, ILE80A, ILE80B, ILE93A, ILE93B, LEU114A, LEU114B, LEU116A, LEU116B, LEU117A, LEU117B, LEU68B, LEU74A, LEU74B, LEU77A, LEU77B, LEU82A, LEU90A, LEU90B, LYS100A, LYS100B, LYS108A, LYS108B, LYS112A, LYS112B, LYS119A, LYS119B, LYS127A, LYS127B, LYS129A, LYS129B, LYS66B, LYS86A, LYS86B, LYS95A, LYS95B, MET91A, MET91B, PHE124A, PHE124B, SER106A, SER106B, THR101A, THR101B, THR125A, THR125B, THR132A, THR132B, THR78A, THR78B, THR99A, THR99B, VAL103A, VAL103B, VAL105A, VAL105B, VAL123A, VAL123B, VAL130A, VAL130B, VAL135A, VAL135B, VAL138A, VAL138B, VAL73A, VAL73B, VAL89A, VAL89B
• A-C: ALA120C, ALA122C, ASN133A, ASP126A, ASP126C, ASP139A, ASP140A, GLN128A, GLN128C, GLN134A, GLN134C, GLU131A, HIS121C, ILE136A, ILE136C, ILE137A, ILE67C, LYS108A, LYS108C, LYS119C, LYS127A, LYS127C, LYS129A, LYS95A, LYS95C, PHE124C, THR125C, THR132A, THR132C, VAL123A, VAL130A, VAL130C, VAL135A, VAL138A
• A-H: ALA120A, ALA122A, ASN133A, ASN133H, ASP126A, ASP126H, ASP139H, GLN128A, GLN128H, GLN134A, GLN134H, GLU131A, GLU131H, HIS121A, ILE136A, ILE136H, ILE137A, ILE137H, ILE67A, LYS108A, LYS108H, LYS119A, LYS127A, LYS127H, LYS129H, PHE124A, SER141H, THR125A, THR132A, THR132H, VAL123H, VAL130A, VAL130H, VAL135A, VAL135H, VAL138H
• A-I: ALA107I, ALA113A, ALA113I, ALA120A, ALA120I, ALA122A, ALA122I, ALA70A, ALA70I, ALA81A, ALA81I, ALA97A, ALA97I, ARG110A, ARG110I, ARG79A, ARG79I, ASN133A, ASN133I, ASN71A, ASN71I, ASP109A, ASP109I, ASP126A, ASP126I, ASP139A, ASP139I, ASP140A, ASP140I, GLN128A, GLN128I, GLN134A, GLN134I, GLN69A, GLN84I, GLN88A, GLU104A, GLU104I, GLU115A, GLU115I, GLU131A, GLU131I, GLU72A, GLU72I, GLU75A, GLU75I, GLU85A, GLU85I, GLU87A, GLU87I, GLU98A, GLU98I, GLY118A, GLY118I, GLY83I, GLY92A, GLY92I, GLY94A, GLY94I, GLY96A, GLY96I, HIS102A, HIS102I, HIS121A, HIS121I, HIS76A, HIS76I, ILE111A, ILE111I, ILE136A, ILE136I, ILE137A, ILE137I, ILE67A, ILE80A, ILE80I, ILE93A, ILE93I, LEU114A, LEU114I, LEU116A, LEU116I, LEU117A, LEU117I, LEU68A, LEU74A, LEU74I, LEU77A, LEU77I, LEU82I, LEU90A, LEU90I, LYS100A, LYS100I, LYS108A, LYS108I, LYS112A, LYS112I, LYS119A, LYS119I, LYS127A, LYS127I, LYS129A, LYS129I, LYS66A, LYS86A, LYS86I, LYS95A, LYS95I, MET91A, MET91I, PHE124A, PHE124I, SER106A, SER106I, THR101A, THR101I, THR125A, THR125I, THR132A, THR132I, THR78A, THR78I, THR99A, THR99I, VAL103A, VAL103I, VAL105A, VAL105I, VAL123A, VAL123I, VAL130A, VAL130I, VAL135A, VAL135I, VAL138A, VAL138I, VAL73A, VAL73I, VAL89A, VAL89I
• B-C: ALA107B, ALA113B, ALA113C, ALA120B, ALA120C, ALA122B, ALA122C, ALA70B, ALA70C, ALA81B, ALA81C, ALA97B, ALA97C, ARG110B, ARG110C, ARG79B, ARG79C, ASN133B, ASN133C, ASN71B, ASN71C, ASP109B, ASP109C, ASP126B, ASP126C, ASP139B, ASP139C, ASP140B, ASP140C, GLN128B, GLN128C, GLN134B, GLN134C, GLN69C, GLN84B, GLN88C, GLU104B, GLU104C, GLU115B, GLU115C, GLU131B, GLU131C, GLU72B, GLU72C, GLU75B, GLU75C, GLU85B, GLU85C, GLU87B, GLU87C, GLU98B, GLU98C, GLY118B, GLY118C, GLY83B, GLY92B, GLY92C, GLY94B, GLY94C, GLY96B, GLY96C, HIS102B, HIS102C, HIS121B, HIS121C, HIS76B, HIS76C, ILE111B, ILE111C, ILE136B, ILE136C, ILE137B, ILE137C, ILE67C, ILE80B, ILE80C, ILE93B, ILE93C, LEU114B, LEU114C, LEU116B, LEU116C, LEU117B, LEU117C, LEU68C, LEU74B, LEU74C, LEU77B, LEU77C, LEU82B, LEU90B, LEU90C, LYS100B, LYS100C, LYS108B, LYS108C, LYS112B, LYS112C, LYS119B, LYS119C, LYS127B, LYS127C, LYS129B, LYS129C, LYS65C, LYS66C, LYS86B, LYS86C, LYS95B, LYS95C, MET91B, MET91C, PHE124B, PHE124C, SER106B, SER106C, SER141B, SER141C, THR101B, THR101C, THR125B, THR125C, THR132B, THR132C, THR78B, THR78C, THR99B, THR99C, VAL103B, VAL103C, VAL105B, VAL105C, VAL123B, VAL123C, VAL130B, VAL130C, VAL135B, VAL135C, VAL138B, VAL138C, VAL73B, VAL73C, VAL89B, VAL89C
• B-D: ALA120D, ALA122D, ASN133B, ASP126B, ASP126D, ASP139B, ASP140B, GLN128B, GLN128D, GLN134B, GLN134D, GLU131B, HIS121D, ILE136B, ILE136D, ILE137B, ILE67D, LYS108B, LYS108D, LYS119D, LYS127B, LYS127D, LYS129B, PHE124D, SER141B, THR125D, THR132B, THR132D, VAL123B, VAL130B, VAL130D, VAL135B, VAL135D, VAL138B
• B-I: ALA120B, ALA122B, ASN133B, ASN133I, ASP126B, ASP126I, ASP139I, GLN128B, GLN128I, GLN134B, GLN134I, GLU131B, GLU131I, HIS121B, ILE136B, ILE136I, ILE137I, ILE67B, LYS108B, LYS108I, LYS119B, LYS127B, LYS127I, LYS129I, PHE124B, THR125B, THR132B, THR132I, VAL123I, VAL130B, VAL130I, VAL135B, VAL135I, VAL138I
• C-D: ALA107C, ALA113C, ALA113D, ALA120C, ALA120D, ALA122C, ALA122D, ALA70C, ALA70D, ALA81C, ALA81D, ALA97C, ALA97D, ARG110C, ARG110D, ARG79C, ARG79D, ASN133C, ASN133D, ASN71C, ASN71D, ASP109C, ASP109D, ASP126C, ASP126D, ASP139C, ASP139D, ASP140C, ASP140D, GLN128C, GLN128D, GLN134C, GLN134D, GLN69D, GLN84C, GLN88D, GLU104C, GLU104D, GLU115C, GLU115D, GLU131C, GLU131D, GLU72C, GLU72D, GLU75C, GLU75D, GLU85C, GLU85D, GLU87C, GLU87D, GLU98C, GLU98D, GLY118C, GLY118D, GLY83C, GLY92C, GLY92D, GLY94C, GLY94D, GLY96C, GLY96D, HIS102C, HIS102D, HIS121C, HIS121D, HIS76C, HIS76D, ILE111C, ILE111D, ILE136C, ILE136D, ILE137C, ILE137D, ILE67D, ILE80C, ILE80D, ILE93C, ILE93D, LEU114C, LEU114D, LEU116C, LEU116D, LEU117C, LEU117D, LEU68D, LEU74C, LEU74D, LEU77C, LEU77D, LEU82C, LEU90C, LEU90D, LYS100C, LYS100D, LYS108C, LYS108D, LYS112C, LYS112D, LYS119C, LYS119D, LYS127C, LYS127D, LYS129C, LYS129D, LYS66D, LYS86C, LYS86D, LYS95C, LYS95D, MET91C, MET91D, PHE124C, PHE124D, SER106C, SER106D, SER141C, THR101C, THR101D, THR125C, THR125D, THR132C, THR132D, THR78C, THR78D, THR99C, THR99D, VAL103C, VAL103D, VAL105C, VAL105D, VAL123C, VAL123D, VAL130C, VAL130D, VAL135C, VAL135D, VAL138C, VAL138D, VAL73C, VAL73D, VAL89C, VAL89D
• C-E: ALA120E, ALA122E, ASN133C, ASN133E, ASP126C, ASP126E, ASP139C, GLN128C, GLN128E, GLN134C, GLN134E, GLU131C, GLU131E, HIS121E, ILE136C, ILE136E, ILE137C, ILE67E, LYS108C, LYS108E, LYS119E, LYS127C, LYS127E, LYS129C, PHE124E, THR125E, THR132C, THR132E, VAL123C, VAL130C, VAL130E, VAL135C, VAL138C
• D-E: ALA107D, ALA113D, ALA113E, ALA120D, ALA120E, ALA122D, ALA122E, ALA70D, ALA70E, ALA81D, ALA81E, ALA97D, ALA97E, ARG110D, ARG110E, ARG79D, ARG79E, ASN133D, ASN133E, ASN71D, ASN71E, ASP109D, ASP109E, ASP126D, ASP126E, ASP139D, ASP140D, GLN128D, GLN128E, GLN134D, GLN134E, GLN69E, GLN84D, GLN88E, GLU104D, GLU104E, GLU115D, GLU115E, GLU131D, GLU131E, GLU72D, GLU72E, GLU75D, GLU75E, GLU85D, GLU85E, GLU87D, GLU87E, GLU98D, GLU98E, GLY118D, GLY118E, GLY83D, GLY92D, GLY92E, GLY94D, GLY94E, GLY96D, GLY96E, HIS102D, HIS102E, HIS121D, HIS121E, HIS76D, HIS76E, ILE111D, ILE111E, ILE136D, ILE136E, ILE137D, ILE137E, ILE67E, ILE80D, ILE80E, ILE93D, ILE93E, LEU114D, LEU114E, LEU116D, LEU116E, LEU117D, LEU117E, LEU68E, LEU74D, LEU74E, LEU77D, LEU77E, LEU82D, LEU90D, LEU90E, LYS100D, LYS100E, LYS108D, LYS108E, LYS112D, LYS112E, LYS119D, LYS119E, LYS127D, LYS127E, LYS129D, LYS129E, LYS65E, LYS66E, LYS86D, LYS86E, LYS95D, LYS95E, MET91D, MET91E, PHE124D, PHE124E, SER106D, SER106E, THR101D, THR101E, THR125D, THR125E, THR132D, THR132E, THR78D, THR78E, THR99D, THR99E, VAL103D, VAL103E, VAL105D, VAL105E, VAL123D, VAL123E, VAL130D, VAL130E, VAL135D, VAL135E, VAL138D, VAL138E, VAL73D, VAL73E, VAL89D, VAL89E
• D-F: ALA120F, ALA122F, ASN133D, ASP126D, ASP126F, GLN128D, GLN128F, GLN134D, GLN134F, GLU131D, GLU131F, ILE136D, ILE136F, ILE137D, ILE67F, LYS108D, LYS108F, LYS119F, LYS127D, LYS127F, LYS129D, PHE124F, THR125F, THR132D, THR132F, VAL123D, VAL130D, VAL130F, VAL135D, VAL138D
• E-F: ALA107E, ALA113E, ALA113F, ALA120E, ALA120F, ALA122E, ALA122F, ALA70E, ALA70F, ALA81E, ALA81F, ALA97E, ALA97F, ARG110E, ARG110F, ARG79E, ARG79F, ASN133E, ASN133F, ASN71E, ASN71F, ASP109E, ASP109F, ASP126E, ASP126F, ASP139E, ASP139F, ASP140E, ASP140F, GLN128E, GLN128F, GLN134E, GLN134F, GLN69F, GLN84E, GLN88F, GLU104E, GLU104F, GLU115E, GLU115F, GLU131E, GLU131F, GLU72E, GLU72F, GLU75E, GLU75F, GLU85E, GLU85F, GLU87E, GLU87F, GLU98E, GLU98F, GLY118E, GLY118F, GLY83E, GLY92E, GLY92F, GLY94E, GLY94F, GLY96E, GLY96F, HIS102E, HIS102F, HIS121E, HIS121F, HIS76E, HIS76F, ILE111E, ILE111F, ILE136E, ILE136F, ILE137E, ILE137F, ILE67F, ILE80F, ILE93E, ILE93F, LEU114E, LEU114F, LEU116E, LEU116F, LEU117E, LEU117F, LEU68F, LEU74E, LEU74F, LEU77E, LEU77F, LEU82E, LEU90E, LEU90F, LYS100E, LYS100F, LYS108E, LYS108F, LYS112E, LYS112F, LYS119E, LYS119F, LYS127E, LYS127F, LYS129E, LYS129F, LYS66F, LYS86E, LYS86F, LYS95E, LYS95F, MET91E, MET91F, PHE124E, PHE124F, SER106E, SER106F, THR101E, THR101F, THR125E, THR125F, THR132E, THR132F, THR78E, THR78F, THR99E, THR99F, VAL103E, VAL103F, VAL105E, VAL105F, VAL123E, VAL123F, VAL130E, VAL130F, VAL135E, VAL135F, VAL138E, VAL138F, VAL73E, VAL73F, VAL89E, VAL89F
• E-G: ALA120G, ALA122G, ASN133E, ASN133G, ASP126E, ASP126G, ASP139E, GLN128E, GLN128G, GLN134E, GLN134G, GLU131E, GLU131G, HIS121G, ILE136E, ILE136G, ILE137E, ILE67G, LYS108E, LYS108G, LYS119G, LYS127E, LYS127G, LYS129E, PHE124G, THR125G, THR132E, THR132G, VAL123E, VAL130E, VAL130G, VAL135E, VAL138E
• F-G: ALA107F, ALA113F, ALA113G, ALA120F, ALA120G, ALA122F, ALA122G, ALA70F, ALA70G, ALA81F, ALA81G, ALA97F, ALA97G, ARG110F, ARG110G, ARG79F, ARG79G, ASN133F, ASN133G, ASN71F, ASN71G, ASP109F, ASP109G, ASP126F, ASP126G, ASP139F, ASP140F, GLN128F, GLN128G, GLN134F, GLN134G, GLN69G, GLN84F, GLN88G, GLU104F, GLU104G, GLU115F, GLU115G, GLU131F, GLU131G, GLU72F, GLU72G, GLU75F, GLU75G, GLU85F, GLU85G, GLU87F, GLU87G, GLU98F, GLU98G, GLY118F, GLY118G, GLY83F, GLY92F, GLY92G, GLY94F, GLY94G, GLY96F, GLY96G, HIS102F, HIS102G, HIS121F, HIS121G, HIS76F, HIS76G, ILE111F, ILE111G, ILE136F, ILE136G, ILE137F, ILE137G, ILE67G, ILE80F, ILE80G, ILE93F, ILE93G, LEU114F, LEU114G, LEU116F, LEU116G, LEU117F, LEU117G, LEU68G, LEU74F, LEU74G, LEU77F, LEU77G, LEU82F, LEU90F, LEU90G, LYS100F, LYS100G, LYS108F, LYS108G, LYS112F, LYS112G, LYS119F, LYS119G, LYS127F, LYS127G, LYS129F, LYS129G, LYS66G, LYS86F, LYS86G, LYS95F, LYS95G, MET91F, MET91G, PHE124F, PHE124G, SER106F, SER106G, THR101F, THR101G, THR125F, THR125G, THR132F, THR132G, THR78F, THR78G, THR99F, THR99G, VAL103F, VAL103G, VAL105F, VAL105G, VAL123F, VAL123G, VAL130F, VAL130G, VAL135F, VAL135G, VAL138F, VAL138G, VAL73F, VAL73G, VAL89F, VAL89G
• F-H: ALA120H, ALA122H, ASN133F, ASN133H, ASP126F, ASP126H, GLN128F, GLN128H, GLN134F, GLN134H, GLU131F, GLU131H, HIS121H, ILE136F, ILE136H, ILE137F, ILE67H, LYS108F, LYS108H, LYS119H, LYS127F, LYS127H, LYS129F, PHE124H, THR125H, THR132F, THR132H, VAL123F, VAL130F, VAL130H, VAL135F, VAL138F
• G-H: ALA107G, ALA113G, ALA113H, ALA120G, ALA120H, ALA122G, ALA122H, ALA70G, ALA70H, ALA81G, ALA81H, ALA97G, ALA97H, ARG110G, ARG110H, ARG79G, ARG79H, ASN133G, ASN133H, ASN71G, ASN71H, ASP109G, ASP109H, ASP126G, ASP126H, ASP139G, ASP139H, ASP140G, ASP140H, GLN128G, GLN128H, GLN134G, GLN134H, GLN69H, GLN84G, GLN88H, GLU104G, GLU104H, GLU115G, GLU115H, GLU131G, GLU131H, GLU72G, GLU72H, GLU75G, GLU75H, GLU85G, GLU85H, GLU87G, GLU87H, GLU98G, GLU98H, GLY118G, GLY118H, GLY83G, GLY92G, GLY92H, GLY94G, GLY94H, GLY96G, GLY96H, HIS102G, HIS102H, HIS121G, HIS121H, HIS76G, HIS76H, ILE111G, ILE111H, ILE136G, ILE136H, ILE137G, ILE137H, ILE67H, ILE80G, ILE80H, ILE93G, ILE93H, LEU114G, LEU114H, LEU116G, LEU116H, LEU117G, LEU117H, LEU68H, LEU74G, LEU74H, LEU77G, LEU77H, LEU82G, LEU90G, LEU90H, LYS100G, LYS100H, LYS108G, LYS108H, LYS112G, LYS112H, LYS119G, LYS119H, LYS127G, LYS127H, LYS129G, LYS129H, LYS65H, LYS66H, LYS86G, LYS86H, LYS95G, LYS95H, MET91G, MET91H, PHE124G, PHE124H, SER106G, SER106H, SER141G, THR101G, THR101H, THR125G, THR125H, THR132G, THR132H, THR78G, THR78H, THR99G, THR99H, VAL103G, VAL103H, VAL105G, VAL105H, VAL123G, VAL123H, VAL130G, VAL130H, VAL135G, VAL135H, VAL138G, VAL138H, VAL73G, VAL73H, VAL89G, VAL89H
• G-I: ALA120I, ALA122I, ASN133G, ASP126G, ASP126I, ASP139G, GLN128G, GLN128I, GLN134G, GLN134I, GLU131G, HIS121I, ILE136G, ILE136I, ILE137G, ILE67I, LYS108G, LYS108I, LYS119I, LYS127G, LYS127I, LYS129G, PHE124I, SER141G, THR125I, THR132G, THR132I, VAL123G, VAL130G, VAL130I, VAL135G, VAL135I, VAL138G
• H-I: ALA107H, ALA113H, ALA113I, ALA120H, ALA120I, ALA122H, ALA122I, ALA70H, ALA70I, ALA81H, ALA81I, ALA97H, ALA97I, ARG110H, ARG110I, ARG79H, ARG79I, ASN133H, ASN133I, ASN71H, ASN71I, ASP109H, ASP109I, ASP126H, ASP126I, ASP139H, ASP139I, ASP140H, ASP140I, GLN128H, GLN128I, GLN134H, GLN134I, GLN69I, GLN84H, GLN88I, GLU104H, GLU104I, GLU115H, GLU115I, GLU131H, GLU131I, GLU72H, GLU72I, GLU75H, GLU75I, GLU85H, GLU85I, GLU87H, GLU87I, GLU98H, GLU98I, GLY118H, GLY118I, GLY83H, GLY92H, GLY92I, GLY94H, GLY94I, GLY96H, GLY96I, HIS102H, HIS102I, HIS121H, HIS121I, HIS76H, HIS76I, ILE111H, ILE111I, ILE136H, ILE136I, ILE137H, ILE137I, ILE67I, ILE80H, ILE80I, ILE93H, ILE93I, LEU114H, LEU114I, LEU116H, LEU116I, LEU117H, LEU117I, LEU68I, LEU74H, LEU74I, LEU77H, LEU77I, LEU82H, LEU90H, LEU90I, LYS100H, LYS100I, LYS108H, LYS108I, LYS112H, LYS112I, LYS119H, LYS119I, LYS127H, LYS127I, LYS129H, LYS129I, LYS65I, LYS66I, LYS86H, LYS86I, LYS95H, LYS95I, MET91H, MET91I, PHE124H, PHE124I, SER106H, SER106I, SER141H, THR101H, THR101I, THR125H, THR125I, THR132H, THR132I, THR78H, THR78I, THR99H, THR99I, VAL103H, VAL103I, VAL105H, VAL105I, VAL123H, VAL123I, VAL130H, VAL130I, VAL135H, VAL135I, VAL138H, VAL138I, VAL73H, VAL73I, VAL89H, VAL89I