3UVJ

crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1.

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 140
  • Norm. En. per Res.: -2.5207
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-35.1596	0.0	-309.036	-344.1956	140	11	15	13055	0	19	17
A-D	-12.0507	1.7232	-87.3399	-97.6674	48	2	0	3541	0	25	28
B-D	-4.8063	0.0	-3.6218	-8.4281	9	0	0	159	0	8	12
C-D	-34.594	0.0	-318.298	-352.892	140	9	15	13288	0	22	19

Interface residues

• A-B: ALA414B, ALA432B, ALA438B, ALA443B, ALA474A, ALA492A, ALA508A, ALA531A, ALA584A, ARG416B, ARG536B, ARG539B, ARG552B, ARG574A, ARG593A, ASN431B, ASN448B, ASN451B, ASN507A, ASN545B, ASN548B, ASN599A, ASN600A, ASN605A, ASP452B, ASP458B, ASP477B, ASP486A, ASP514A, ASP530A, CYS434B, CYS476B, CYS494A, CYS497A, CYS595A, CYS610A, GLN470A, GLN473A, GLN496A, GLN501A, GLN535B, GLU473B, GLU526A, GLU527B, GLU554B, GLU608A, GLY440B, GLY442B, GLY529A, GLY531B, GLY534B, GLY544B, GLY585A, GLY594B, GLY598A, HIS437B, ILE422B, ILE446B, ILE487A, ILE493A, ILE503A, ILE528A, ILE533B, LEU450B, LEU500A, LEU506A, LEU509A, LEU542B, LEU549B, LEU596A, LEU603A, LYS415B, LYS436B, LYS445B, LYS471B, LYS475A, LYS476A, LYS478B, LYS524A, LYS593B, LYS606A, MET444B, MET480B, MET505A, MET537B, MET591A, PHE424B, PHE430B, PHE433B, PHE477A, PHE484A, PHE490A, PHE543B, PHE583A, PHE597A, PRO413B, PRO499A, PRO538B, SER425B, SER435B, SER439B, SER495A, SER498A, SER541B, SER551B, SER609A, SER611A, THR455B, THR474B, THR491A, THR504A, THR511A, THR527A, THR530B, THR546B, THR550B, THR555B, THR602A, TYR417B, TYR454B, TYR479B, TYR510A, TYR532A, TYR540B, TYR594A, VAL447B, VAL471A, VAL472A, VAL472B, VAL475B, VAL502A, VAL525A, VAL528B, VAL529B, VAL532B, VAL547B, VAL582A, VAL586A, VAL587A, VAL601A
• A-D: ARG574A, ARG587D, ARG606D, ARG637A, ARG639A, ASN577D, ASN645A, ASP579D, CYS610A, GLN581D, GLN600D, GLU585D, GLU640A, GLU641A, GLY588D, HIS583D, HIS586D, ILE653A, LEU572D, LEU584D, LEU604D, LEU642A, LYS606A, LYS607D, LYS615A, MET573D, PHE582D, PHE603D, PHE646A, PHE656A, PRO575D, PRO580D, PRO589D, PRO613A, PRO636A, PRO643A, PRO644A, SER574D, SER578D, SER605D, SER609A, SER611A, SER638A, SER648A, THR635A, TRP602D, TYR569D, VAL612A
• B-D: GLN518D, GLU558D, GLU597B, GLY560D, LYS559D, LYS561D, LYS596B, PRO598B, VAL428D
• C-D: ALA414D, ALA432D, ALA438D, ALA443D, ALA474C, ALA492C, ALA508C, ALA531C, ALA584C, ARG416D, ARG536D, ARG539D, ARG552D, ARG593C, ASN431D, ASN448D, ASN451D, ASN507C, ASN545D, ASN548D, ASN599C, ASN600C, ASN605C, ASP452D, ASP458D, ASP477D, ASP486C, ASP514C, ASP530C, CYS434D, CYS476D, CYS494C, CYS497C, CYS533C, CYS595C, GLN470C, GLN473C, GLN496C, GLN501C, GLN515C, GLN535D, GLU473D, GLU526C, GLU527D, GLU554D, GLU608C, GLY440D, GLY442D, GLY529C, GLY531D, GLY534D, GLY544D, GLY585C, GLY594D, GLY598C, HIS437D, ILE422D, ILE446D, ILE487C, ILE493C, ILE503C, ILE528C, ILE533D, LEU449D, LEU450D, LEU500C, LEU506C, LEU509C, LEU542D, LEU549D, LEU596C, LEU603C, LYS415D, LYS436D, LYS445D, LYS471D, LYS475C, LYS476C, LYS478D, LYS524C, LYS593D, MET444D, MET480D, MET505C, MET537D, MET591C, PHE424D, PHE430D, PHE433D, PHE477C, PHE484C, PHE490C, PHE543D, PHE583C, PHE597C, PRO413D, PRO499C, PRO538D, SER425D, SER435D, SER439D, SER495C, SER498C, SER541D, SER551D, SER609C, THR455D, THR474D, THR491C, THR504C, THR511C, THR527C, THR530D, THR546D, THR550D, THR555D, THR602C, TYR417D, TYR454D, TYR479D, TYR510C, TYR532C, TYR540D, TYR594C, VAL412D, VAL447D, VAL471C, VAL472C, VAL472D, VAL475D, VAL502C, VAL525C, VAL528D, VAL529D, VAL532D, VAL547D, VAL582C, VAL586C, VAL587C, VAL601C