3U9S

crystal structure of p. aeruginosa 3-methylcrotonyl-coa carboxylase (mcc) 750 kd holoenzyme, coa complex

• Total interactions analyzed: 66
• Total true interactions: 32
• Strongest Interaction:
  • Chains: D-J
  • Int. Res.: 375
  • Norm. En. per Res.: -3.9326
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-78.8539	19.8317	-384.321	-443.3432	131	28	3	15528	4	66	62
A-C	-47.0724	-69.1393	-141.477	-257.6888	81	16	2	6494	8	32	42
A-E	-73.614	-32.3089	-111.351	-217.2739	80	16	1	5807	5	30	39
A-F	-32.9967	1.8098	-138.725	-169.912	76	12	0	5688	2	17	19
A-H	0.0	15.3084	-29.379	-14.0707	25	9	1	1768	0	3	4
B-C	0.0	0.0	-15.4384	-15.4384	16	3	0	452	0	7	9
B-D	-40.9276	-76.6335	-216.333	-333.8941	95	11	2	8776	6	32	31
B-F	-39.4532	-81.6188	-219.769	-340.841	95	16	2	8974	6	32	32
B-J	-28.271	20.1107	-159.779	-167.9393	67	13	3	6617	0	12	29
B-L	-146.0422	-279.2157	-1052.85	-1478.1079	381	84	70	44360	19	100	101
C-D	-66.742	27.694	-405.283	-444.331	136	29	4	15709	3	65	58
C-E	-47.5163	-58.8699	-151.268	-257.6542	86	14	2	6369	6	30	40
D-E	0.0	0.0	0.7411	0.7411	16	3	0	449	0	7	7
D-F	-56.4977	-102.378	-207.242	-366.1177	100	23	2	8956	6	32	32
D-H	-25.7426	24.4447	-148.547	-149.8448	65	11	3	6592	0	12	29
D-J	-166.1864	-280.4531	-1028.09	-1474.7295	375	87	69	44212	19	102	99
E-F	-48.5015	10.817	-392.857	-430.5415	132	22	3	15367	4	66	62
F-H	-161.6393	-256.175	-1049.0	-1466.8143	377	87	70	44395	17	102	99
F-I	0.0	0.0	-0.0325	-0.0325	4	0	0	14	0	0	1
F-L	-22.4119	25.3443	-159.283	-156.3505	68	20	3	6813	0	12	30
G-H	-64.3268	-18.8106	-355.425	-438.5624	136	39	3	15642	4	65	60
G-I	-42.6225	-30.954	-138.4	-211.9765	85	13	1	6353	5	32	42
G-K	-27.0344	-41.0194	-144.897	-212.9508	83	8	3	6094	3	32	43
G-L	0.0	0.0	-14.0962	-14.0962	15	1	0	464	0	7	9
H-I	0.0	-1.3579	-46.9208	-48.2787	42	14	0	1851	0	10	11
H-J	-46.2036	-78.8683	-200.192	-325.2639	98	20	2	8423	4	32	31
H-L	-45.9165	-83.4992	-217.945	-347.3607	98	18	2	9008	5	33	32
I-J	-77.252	-8.6318	-379.104	-464.9878	138	38	3	15862	3	66	62
I-K	-35.7266	-72.8905	-133.466	-242.0831	83	22	2	6378	6	32	40
J-K	0.0	0.0	-6.8835	-6.8835	17	4	0	438	0	7	9
J-L	-41.6088	-80.3199	-235.669	-357.5977	99	18	2	9220	5	32	32
K-L	-80.1671	8.6794	-387.547	-459.0347	130	29	4	15546	4	64	59

Interface residues

• A-B: ALA102B, ALA285B, ALA306B, ALA542B, ALA544B, ALA546A, ALA547B, ALA548A, ALA548B, ALA569A, ALA631A, ARG125B, ARG164B, ARG297B, ARG305B, ARG524A, ARG525A, ARG538B, ARG539A, ARG544A, ARG549A, ARG562A, ARG565A, ARG567A, ARG57B, ARG613A, ARG62B, ARG84B, ARG89B, ASN295B, ASN540A, ASN54B, ASN550B, ASN88B, ASP281B, ASP526A, ASP531A, ASP532A, ASP533B, ASP541A, ASP552A, ASP633A, ASP92B, CYS131B, CYS304B, CYS563A, GLN299B, GLN301B, GLN303B, GLN536B, GLU127B, GLU130B, GLU520A, GLU539B, GLU550A, GLU85B, GLU99B, GLY122B, GLY124B, GLY128B, GLY300B, GLY364B, GLY522A, GLY530B, GLY542A, GLY61B, GLY94B, HIS282B, HIS363B, HIS523A, HIS534A, HIS64B, ILE123B, ILE133B, ILE532B, ILE63B, ILE87B, LEU100B, LEU103B, LEU165B, LEU294B, LEU302B, LEU362B, LEU517A, LEU541B, LEU543B, LEU545B, LEU547A, LEU549B, LEU553A, LEU555A, LEU566A, LEU56B, LEU59B, LEU60B, LEU81B, LEU82B, LEU91B, LEU98B, LYS298B, MET554A, PHE461B, PHE97B, PRO166B, PRO307B, PRO521A, PRO533A, PRO536A, PRO93B, PRO96B, SER535A, SER538A, SER545A, SER546B, SER551A, SER95B, THR537B, THR58B, TRP296B, TRP463B, TRP516A, TRP537A, TRP543A, TYR365B, VAL126B, VAL129B, VAL531B, VAL53B, VAL540B, VAL564A, VAL632A
• A-C: ALA115C, ALA116C, ALA119C, ALA357C, ALA447A, ALA453A, ALA480A, ALA68C, ALA70C, ALA77C, ALA86C, ALA90C, ALA92C, ALA95C, ARG361C, ARG364C, ARG414A, ARG444A, ARG448A, ARG450A, ARG47C, ARG51C, ARG589A, ARG601A, ARG607A, ARG608A, ARG66C, ARG69C, ARG84C, ARG87C, ASP603A, ASP81C, ASP93C, ASP97C, GLN123C, GLN449A, GLN50C, GLU366C, GLU442A, GLU445A, GLU446A, GLU457A, GLU623A, GLU91C, GLY411A, GLY413A, GLY441A, GLY475A, GLY604A, GLY72C, GLY74C, HIS79C, HIS85C, ILE360C, ILE49C, ILE73C, ILE94C, LEU451A, LEU452A, LEU71C, LEU98C, MET454A, PRO369C, PRO412A, SER120C, SER48C, SER600A, SER609A, SER67C, SER80C, THR443A, THR606A, TRP440A, TYR46C, VAL599A, VAL602A, VAL605A, VAL76C, VAL78C, VAL89C, VAL96C
• A-E: ALA116A, ALA119A, ALA357A, ALA447E, ALA453E, ALA480E, ALA68A, ALA70A, ALA77A, ALA90A, ALA92A, ALA95A, ARG361A, ARG364A, ARG414E, ARG444E, ARG448E, ARG450E, ARG47A, ARG51A, ARG601E, ARG607E, ARG608E, ARG66A, ARG69A, ARG84A, ARG87A, ASP354A, ASP603E, ASP93A, ASP97A, GLN123A, GLN449E, GLN50A, GLU366A, GLU442E, GLU445E, GLU446E, GLU457E, GLU91A, GLY121A, GLY411E, GLY413E, GLY441E, GLY475E, GLY604E, GLY72A, GLY74A, HIS79A, HIS85A, HIS88A, ILE360A, ILE49A, ILE73A, ILE94A, LEU451E, LEU452E, LEU71A, LEU98A, MET454E, PRO369A, PRO412E, SER120A, SER48A, SER586E, SER600E, SER609E, SER67A, THR443E, THR606E, TRP358A, TRP440E, TYR46A, VAL599E, VAL602E, VAL605E, VAL76A, VAL78A, VAL89A, VAL96A
• A-F: ALA29F, ALA478F, ALA631A, ALA679A, ARG305F, ARG469F, ARG525A, ARG616A, ARG659A, ARG687A, ASN372F, ASN373F, ASN403F, ASN654A, ASP324F, ASP526A, ASP531A, ASP633A, CYS304F, GLN303F, GLN327F, GLN411F, GLN477F, GLU41F, GLU476F, GLU678A, GLU683A, GLU706A, GLU707A, GLY374F, GLY406F, GLY410F, GLY442F, GLY443F, GLY446F, GLY471F, GLY474F, GLY475F, GLY655A, HIS27F, HIS32F, HIS523A, HIS684A, ILE30F, ILE375F, ILE404F, ILE418F, LEU376F, LEU677A, LYS326F, LYS412F, LYS681A, MET28F, MET408F, MET473F, MET653A, MET680A, MET682A, PHE377F, PHE407F, PHE445F, PRO328F, PRO652A, SER26F, SER325F, SER444F, SER685A, THR354F, THR405F, TYR329F, TYR413F, TYR513F, VAL409F, VAL472F, VAL632A, VAL676A
• A-H: ALA242H, ALA249H, ALA250H, ALA651A, ALA679A, ASN654A, GLU253H, GLU678A, GLU706A, GLU707A, GLY252H, GLY655A, HIS684A, LEU246H, LEU677A, LEU704A, LYS248H, LYS681A, MET653A, MET680A, SER656A, THR251H, VAL247H, VAL254H, VAL705A
• B-C: ALA29B, ALA631C, ARG305B, ARG525C, ARG616C, ASP526C, ASP531C, ASP633C, GLN303B, HIS27B, HIS32B, HIS523C, ILE30B, MET28B, SER26B, VAL632C
• B-D: ALA203D, ALA225D, ALA263D, ALA273D, ALA277D, ALA285D, ALA292D, ALA29B, ALA349B, ALA360B, ALA368B, ALA391B, ARG164D, ARG204D, ARG234D, ARG288D, ARG289D, ARG297D, ARG305B, ARG308B, ARG394B, ASN293D, ASN295D, ASP228D, ASP264D, ASP274D, ASP345B, CYS267D, CYS290D, CYS304B, CYS357B, GLN208D, GLN301B, GLN303B, GLN382B, GLN393B, GLU127D, GLU229D, GLU278D, GLU343B, GLU346B, GLU379B, GLU389B, GLY205D, GLY271D, GLY352B, GLY358B, GLY395B, HIS266D, HIS275D, HIS27B, HIS282D, HIS361B, HIS386B, ILE206D, ILE209D, ILE286D, ILE30B, ILE367B, ILE396B, ILE553B, LEU294D, LEU302B, LEU350B, LEU390B, LYS268D, LYS298D, LYS348B, LYS383B, MET201D, MET226D, MET28B, PHE344B, PHE347B, PHE351B, PHE359B, PHE387B, PRO166D, PRO207D, PRO224D, PRO366B, PRO397B, SER202D, SER227D, SER26B, SER270D, THR230D, THR353B, TRP296D, TYR276D, TYR365B, VAL265D, VAL269D, VAL272D, VAL291D
• B-F: ALA203B, ALA225B, ALA263B, ALA273B, ALA277B, ALA283B, ALA285B, ALA292B, ALA29F, ALA349F, ALA360F, ALA368F, ALA391F, ARG164B, ARG204B, ARG288B, ARG289B, ARG297B, ARG305F, ARG308F, ARG394F, ASN293B, ASN295B, ASP228B, ASP264B, ASP274B, ASP281B, ASP345F, CYS267B, CYS290B, CYS304F, CYS357F, GLN208B, GLN301F, GLN303F, GLN382F, GLN393F, GLU127B, GLU229B, GLU278B, GLU343F, GLU346F, GLU379F, GLU389F, GLY205B, GLY271B, GLY352F, GLY358F, GLY395F, HIS266B, HIS275B, HIS27F, HIS282B, HIS361F, HIS386F, ILE206B, ILE209B, ILE286B, ILE30F, ILE367F, ILE396F, ILE553F, LEU294B, LEU302F, LEU350F, LEU390F, LYS268B, LYS298B, LYS348F, LYS383F, MET201B, MET226B, MET28F, PHE344F, PHE347F, PHE351F, PHE359F, PHE387F, PRO207B, PRO224B, PRO366F, PRO397F, SER202B, SER227B, SER26F, SER270B, THR230B, THR353F, TRP296B, TYR276B, TYR365F, VAL265B, VAL269B, VAL272B, VAL291B
• B-J: ALA378B, ALA378J, ALA381B, ALA381J, ALA385B, ALA385J, ALA391B, ALA391J, ALA415B, ALA415J, ALA423B, ALA428B, ALA428J, ALA557B, ALA557J, ARG394B, ARG394J, ARG562B, ARG562J, CYS392J, GLN382B, GLN382J, GLN393B, GLN393J, GLU379B, GLU379J, GLU389B, GLU389J, GLY384B, GLY384J, GLY417B, GLY559B, GLY559J, HIS386B, HIS386J, HIS421B, HIS421J, ILE388B, ILE388J, LEU390B, LEU390J, LEU425B, LEU425J, LYS348B, LYS348J, LYS383B, LYS383J, LYS420B, LYS420J, LYS424B, LYS424J, MET563B, MET563J, PHE347B, PHE347J, PHE351B, PHE351J, PHE387B, PHE387J, PHE558B, PHE558J, PHE561B, PHE561J, THR427B, THR427J, VAL560B, VAL560J
• B-L: ALA158B, ALA158L, ALA176B, ALA176L, ALA199B, ALA199L, ALA203B, ALA203L, ALA210B, ALA210L, ALA218B, ALA218L, ALA221B, ALA221L, ALA225B, ALA225L, ALA242B, ALA242L, ALA249B, ALA249L, ALA250B, ALA250L, ALA257B, ALA257L, ALA273B, ALA273L, ALA381B, ALA381L, ALA415B, ALA415L, ALA419B, ALA419L, ALA423B, ALA423L, ALA428B, ALA428L, ALA430B, ALA430L, ALA432B, ALA432L, ALA447B, ALA447L, ALA456B, ALA456L, ALA478B, ALA478L, ALA479B, ALA479L, ALA483B, ALA483L, ALA557B, ALA557L, ALA77B, ARG155B, ARG155L, ARG180B, ARG180L, ARG188B, ARG188L, ARG193B, ARG193L, ARG204B, ARG204L, ARG433B, ARG433L, ARG455B, ARG455L, ARG469B, ARG469L, ARG487B, ARG487L, ARG492B, ARG492L, ARG525B, ARG525L, ARG562B, ARG562L, ARG74B, ARG74L, ARG78B, ARG78L, ASN177B, ASN177L, ASN197B, ASN197L, ASN200B, ASN200L, ASN449B, ASN449L, ASP182B, ASP182L, ASP187B, ASP187L, ASP228B, ASP228L, ASP274B, ASP274L, ASP458B, ASP458L, ASP528B, ASP528L, CYS267B, CYS267L, CYS431B, CYS431L, CYS453L, GLN181B, GLN181L, GLN198B, GLN198L, GLN208B, GLN208L, GLN402B, GLN402L, GLN411B, GLN411L, GLN477B, GLN477L, GLN484B, GLN484L, GLN489B, GLN489L, GLN512B, GLN512L, GLN516B, GLN516L, GLU162B, GLU162L, GLU183B, GLU183L, GLU189B, GLU189L, GLU229B, GLU229L, GLU253B, GLU253L, GLU258B, GLU258L, GLU259B, GLU259L, GLU414B, GLU414L, GLU476B, GLU476L, GLU488B, GLU488L, GLU514B, GLU514L, GLY142B, GLY175B, GLY175L, GLY192B, GLY192L, GLY205B, GLY205L, GLY219B, GLY219L, GLY220L, GLY243B, GLY243L, GLY252B, GLY252L, GLY261B, GLY261L, GLY262B, GLY262L, GLY271B, GLY271L, GLY406B, GLY406L, GLY410B, GLY410L, GLY416B, GLY416L, GLY417B, GLY417L, GLY422B, GLY422L, GLY446B, GLY446L, GLY448B, GLY448L, GLY451B, GLY451L, GLY454B, GLY454L, GLY471B, GLY471L, GLY474B, GLY474L, GLY475B, GLY475L, GLY480B, GLY480L, GLY517B, GLY517L, GLY559B, GLY559L, HIS190B, HIS190L, HIS266B, HIS266L, HIS275B, HIS275L, HIS421B, HIS421L, HIS515B, HIS515L, ILE159B, ILE194B, ILE194L, ILE206B, ILE209B, ILE209L, ILE239B, ILE239L, ILE404B, ILE404L, ILE418B, ILE418L, ILE470B, ILE470L, ILE509B, ILE509L, LEU148B, LEU148L, LEU154B, LEU154L, LEU178B, LEU178L, LEU241B, LEU241L, LEU246B, LEU246L, LEU260B, LEU260L, LEU376B, LEU376L, LEU425B, LEU425L, LEU440B, LEU462B, LEU462L, LEU482B, LEU482L, LEU526B, LEU526L, LYS141B, LYS141L, LYS151B, LYS151L, LYS248B, LYS248L, LYS412B, LYS412L, LYS420B, LYS420L, LYS424B, LYS424L, LYS436B, LYS436L, LYS506L, MET201B, MET201L, MET226B, MET226L, MET408B, MET408L, MET464B, MET464L, MET473B, MET473L, MET563B, MET563L, PHE185B, PHE185L, PHE191B, PHE191L, PHE195B, PHE195L, PHE196B, PHE196L, PHE240B, PHE240L, PHE377L, PHE407B, PHE407L, PHE445B, PHE445L, PHE558B, PHE558L, PHE561B, PHE561L, PRO179B, PRO179L, PRO186B, PRO186L, PRO207B, PRO207L, PRO224B, PRO224L, PRO244B, PRO244L, PRO245B, PRO245L, PRO459B, PRO459L, PRO508B, PRO508L, SER202B, SER202L, SER227B, SER227L, SER256B, SER256L, SER270B, SER270L, SER444B, SER444L, SER522B, SER522L, THR144B, THR144L, THR217B, THR217L, THR230B, THR230L, THR251B, THR251L, THR427B, THR427L, THR556B, THR556L, TRP527B, TRP527L, TYR222B, TYR222L, TYR413B, TYR413L, TYR450B, TYR450L, TYR457B, TYR457L, TYR513B, TYR513L, TYR521B, TYR521L, VAL150B, VAL150L, VAL184B, VAL184L, VAL223B, VAL223L, VAL231B, VAL231L, VAL247B, VAL247L, VAL254B, VAL254L, VAL255B, VAL255L, VAL265B, VAL265L, VAL269B, VAL269L, VAL272B, VAL272L, VAL409B, VAL409L, VAL426B, VAL426L, VAL429B, VAL429L, VAL472B, VAL472L, VAL481B, VAL481L, VAL485B, VAL485L, VAL560B, VAL560L
• C-D: ALA102D, ALA285D, ALA306D, ALA542D, ALA544D, ALA546C, ALA547D, ALA548C, ALA548D, ALA569C, ALA631C, ARG125D, ARG164D, ARG288D, ARG297D, ARG305D, ARG524C, ARG525C, ARG538D, ARG539C, ARG544C, ARG549C, ARG561C, ARG562C, ARG565C, ARG567C, ARG57D, ARG613C, ARG62D, ARG84D, ARG86D, ARG89D, ASN295D, ASN540C, ASN54D, ASN550D, ASN88D, ASP281D, ASP526C, ASP531C, ASP532C, ASP533D, ASP541C, ASP552C, ASP633C, ASP92D, CYS131D, CYS304D, CYS563C, GLN299D, GLN301D, GLN303D, GLN536D, GLU127D, GLU130D, GLU520C, GLU539D, GLU550C, GLU85D, GLU99D, GLY122D, GLY124D, GLY128D, GLY300D, GLY364D, GLY522C, GLY530D, GLY542C, GLY61D, GLY94D, HIS282D, HIS363D, HIS523C, HIS534C, HIS568C, HIS64D, ILE123D, ILE532D, ILE63D, ILE87D, LEU100D, LEU165D, LEU294D, LEU302D, LEU362D, LEU517C, LEU541D, LEU543D, LEU545D, LEU547C, LEU549D, LEU553C, LEU555C, LEU566C, LEU56D, LEU59D, LEU60D, LEU81D, LEU82D, LEU90D, LEU91D, LEU98D, LYS298D, MET554C, PHE461D, PHE97D, PRO166D, PRO307D, PRO521C, PRO533C, PRO536C, PRO571C, PRO93D, PRO96D, SER519C, SER535C, SER538C, SER545C, SER546D, SER551C, SER95D, THR537D, THR58D, TRP296D, TRP463D, TRP516C, TRP537C, TRP543C, TYR365D, VAL126D, VAL129D, VAL531D, VAL53D, VAL540D, VAL564C, VAL632C
• C-E: ALA116E, ALA119E, ALA357E, ALA447C, ALA453C, ALA480C, ALA68E, ALA70E, ALA77E, ALA86E, ALA90E, ALA92E, ALA95E, ARG361E, ARG364E, ARG414C, ARG444C, ARG448C, ARG450C, ARG47E, ARG51E, ARG589C, ARG601C, ARG607C, ARG608C, ARG66E, ARG69E, ARG84E, ARG87E, ASP354E, ASP603C, ASP81E, ASP83E, ASP93E, ASP97E, GLN123E, GLN449C, GLN50E, GLU366E, GLU442C, GLU445C, GLU446C, GLU457C, GLU91E, GLY121E, GLY411C, GLY413C, GLY441C, GLY475C, GLY604C, GLY72E, GLY74E, HIS79E, HIS85E, HIS88E, ILE360E, ILE49E, ILE73E, ILE94E, LEU451C, LEU452C, LEU71E, LEU98E, MET454C, MET65E, PRO369E, PRO412C, SER120E, SER48E, SER600C, SER609C, SER67E, SER75E, SER80E, THR443C, THR606C, TRP358E, TRP440C, TYR46E, VAL599C, VAL602C, VAL605C, VAL76E, VAL78E, VAL89E, VAL96E
• D-E: ALA29D, ALA631E, ARG305D, ARG525E, ARG616E, ASP526E, ASP531E, ASP633E, GLN303D, HIS27D, HIS32D, HIS523E, ILE30D, MET28D, SER26D, VAL632E
• D-F: ALA203F, ALA225F, ALA263F, ALA273F, ALA277F, ALA285F, ALA292F, ALA29D, ALA349D, ALA360D, ALA368D, ALA391D, ARG164F, ARG204F, ARG234F, ARG288F, ARG289F, ARG297F, ARG305D, ARG308D, ARG394D, ASN293F, ASN295F, ASP228F, ASP264F, ASP274F, ASP281F, ASP345D, CYS267F, CYS290F, CYS304D, CYS357D, GLN208F, GLN299F, GLN301D, GLN303D, GLN382D, GLN393D, GLU127F, GLU229F, GLU343D, GLU346D, GLU379D, GLU389D, GLY205F, GLY271F, GLY352D, GLY358D, GLY395D, HIS266F, HIS275F, HIS27D, HIS282F, HIS361D, HIS386D, ILE206F, ILE209F, ILE286F, ILE30D, ILE367D, ILE396D, ILE553D, LEU294F, LEU302D, LEU350D, LEU390D, LYS268F, LYS298F, LYS348D, LYS383D, MET201F, MET226F, MET232F, MET28D, PHE344D, PHE347D, PHE351D, PHE359D, PHE387D, PRO166F, PRO207F, PRO224F, PRO366D, PRO397D, SER202F, SER227F, SER26D, SER270F, THR230F, THR353D, TRP296F, TYR276F, TYR365D, VAL129F, VAL231F, VAL265F, VAL269F, VAL272F, VAL291F, VAL434D
• D-H: ALA378D, ALA381D, ALA381H, ALA385D, ALA385H, ALA391D, ALA391H, ALA423H, ALA428D, ALA428H, ALA557D, ALA557H, ARG394D, ARG394H, ARG562D, ARG562H, CYS392D, CYS392H, GLN382D, GLN382H, GLN393D, GLN393H, GLU379D, GLU379H, GLU389D, GLU389H, GLY384D, GLY384H, GLY417D, GLY417H, GLY559D, GLY559H, HIS386D, HIS386H, HIS421D, HIS421H, ILE388D, ILE388H, LEU390D, LEU390H, LEU425D, LEU425H, LYS348D, LYS348H, LYS383D, LYS383H, LYS420D, LYS420H, LYS424D, LYS424H, MET563D, MET563H, PHE347D, PHE347H, PHE351D, PHE351H, PHE387D, PHE387H, PHE558D, PHE558H, PHE561D, PHE561H, THR427H, VAL560D, VAL560H
• D-J: ALA158D, ALA158J, ALA176D, ALA176J, ALA199D, ALA199J, ALA203D, ALA203J, ALA210D, ALA210J, ALA218D, ALA218J, ALA221D, ALA221J, ALA225D, ALA225J, ALA242D, ALA242J, ALA249D, ALA249J, ALA250D, ALA250J, ALA257D, ALA257J, ALA273D, ALA273J, ALA378D, ALA381D, ALA381J, ALA415D, ALA415J, ALA419D, ALA419J, ALA423D, ALA423J, ALA428D, ALA428J, ALA430D, ALA430J, ALA432D, ALA432J, ALA447D, ALA447J, ALA456D, ALA456J, ALA478D, ALA478J, ALA479D, ALA479J, ALA483D, ALA483J, ALA557D, ALA557J, ALA71J, ARG155D, ARG155J, ARG180D, ARG180J, ARG188D, ARG188J, ARG193D, ARG193J, ARG204D, ARG204J, ARG433D, ARG433J, ARG455D, ARG455J, ARG469D, ARG469J, ARG487D, ARG492D, ARG492J, ARG525D, ARG525J, ARG562D, ARG562J, ARG74D, ARG74J, ARG78D, ARG78J, ASN177D, ASN177J, ASN197D, ASN197J, ASN200D, ASN200J, ASN449D, ASN449J, ASP182D, ASP182J, ASP187D, ASP187J, ASP228D, ASP228J, ASP274D, ASP274J, ASP458D, ASP458J, ASP528D, ASP528J, CYS431D, CYS431J, CYS453D, CYS453J, GLN181D, GLN181J, GLN198D, GLN198J, GLN208D, GLN208J, GLN402D, GLN402J, GLN411D, GLN411J, GLN477D, GLN477J, GLN484D, GLN484J, GLN489D, GLN489J, GLN512D, GLN512J, GLN516D, GLN516J, GLU162D, GLU162J, GLU183D, GLU183J, GLU189D, GLU189J, GLU229D, GLU229J, GLU253D, GLU253J, GLU258J, GLU259D, GLU259J, GLU414D, GLU414J, GLU476D, GLU476J, GLU488D, GLU488J, GLY175D, GLY175J, GLY192D, GLY192J, GLY205D, GLY205J, GLY219D, GLY219J, GLY243D, GLY243J, GLY252D, GLY252J, GLY261D, GLY261J, GLY262D, GLY262J, GLY271D, GLY271J, GLY406D, GLY406J, GLY410D, GLY410J, GLY416D, GLY416J, GLY417D, GLY417J, GLY422D, GLY422J, GLY446D, GLY446J, GLY448D, GLY448J, GLY451D, GLY451J, GLY454D, GLY454J, GLY471D, GLY471J, GLY474D, GLY474J, GLY475J, GLY480D, GLY480J, GLY517D, GLY517J, GLY559D, GLY559J, HIS190D, HIS190J, HIS266D, HIS266J, HIS275D, HIS275J, HIS421D, HIS421J, HIS515D, HIS515J, ILE194D, ILE194J, ILE206D, ILE206J, ILE209D, ILE209J, ILE239D, ILE239J, ILE404D, ILE404J, ILE418D, ILE418J, ILE470D, ILE470J, ILE505J, ILE509D, ILE509J, LEU148D, LEU148J, LEU154D, LEU154J, LEU178D, LEU178J, LEU241D, LEU241J, LEU246D, LEU246J, LEU260D, LEU260J, LEU376D, LEU376J, LEU425D, LEU425J, LEU440D, LEU462D, LEU462J, LEU482D, LEU482J, LEU526D, LEU526J, LYS141D, LYS141J, LYS151D, LYS151J, LYS248D, LYS248J, LYS412D, LYS412J, LYS420D, LYS420J, LYS424D, LYS424J, LYS436D, LYS436J, LYS486D, LYS506D, LYS506J, MET201D, MET201J, MET226D, MET226J, MET408D, MET408J, MET473D, MET473J, MET563D, MET563J, PHE185D, PHE185J, PHE191D, PHE191J, PHE195D, PHE195J, PHE196D, PHE196J, PHE240D, PHE240J, PHE377J, PHE407D, PHE407J, PHE445D, PHE445J, PHE558D, PHE558J, PHE561D, PHE561J, PRO179D, PRO179J, PRO186D, PRO186J, PRO207D, PRO207J, PRO224D, PRO224J, PRO244D, PRO244J, PRO245D, PRO245J, PRO459D, PRO459J, PRO508D, SER202D, SER202J, SER227D, SER227J, SER256D, SER256J, SER270D, SER270J, SER444D, SER444J, SER522D, SER522J, THR144D, THR144J, THR217D, THR217J, THR230D, THR230J, THR238J, THR251D, THR251J, THR427D, THR427J, THR556D, THR556J, TRP527D, TRP527J, TYR222D, TYR222J, TYR413D, TYR413J, TYR450D, TYR450J, TYR457D, TYR457J, TYR513D, TYR513J, TYR521D, TYR521J, VAL150D, VAL150J, VAL184D, VAL184J, VAL223D, VAL223J, VAL231D, VAL231J, VAL247D, VAL247J, VAL254D, VAL254J, VAL255D, VAL255J, VAL265D, VAL265J, VAL269D, VAL269J, VAL272D, VAL272J, VAL409D, VAL409J, VAL426D, VAL426J, VAL429D, VAL429J, VAL472D, VAL472J, VAL481D, VAL481J, VAL485D, VAL485J, VAL560D, VAL560J
• E-F: ALA102F, ALA285F, ALA306F, ALA542F, ALA544F, ALA546E, ALA547F, ALA548E, ALA548F, ALA569E, ALA631E, ARG125F, ARG164F, ARG297F, ARG305F, ARG524E, ARG525E, ARG538F, ARG539E, ARG544E, ARG549E, ARG565E, ARG567E, ARG57F, ARG613E, ARG62F, ARG84F, ARG89F, ASN295F, ASN540E, ASN54F, ASN550F, ASN88F, ASP281F, ASP526E, ASP529F, ASP531E, ASP532E, ASP533F, ASP541E, ASP552E, ASP633E, ASP92F, CYS131F, CYS304F, CYS563E, GLN299F, GLN301F, GLN303F, GLN536F, GLU127F, GLU130F, GLU520E, GLU539F, GLU550E, GLU85F, GLU99F, GLY122F, GLY124F, GLY128F, GLY300F, GLY364F, GLY522E, GLY530F, GLY542E, GLY61F, GLY94F, HIS282F, HIS361F, HIS363F, HIS523E, HIS534E, HIS64F, ILE123F, ILE133F, ILE532F, ILE63F, ILE87F, LEU100F, LEU165F, LEU294F, LEU302F, LEU362F, LEU517E, LEU541F, LEU543F, LEU545F, LEU547E, LEU549F, LEU553E, LEU566E, LEU56F, LEU59F, LEU60F, LEU81F, LEU91F, LEU98F, LYS298F, MET554E, PHE461F, PHE97F, PRO166F, PRO307F, PRO366F, PRO521E, PRO533E, PRO536E, PRO93F, PRO96F, SER519E, SER535E, SER538E, SER545E, SER546F, SER551E, SER95F, THR537F, THR58F, TRP296F, TRP463F, TRP516E, TRP537E, TRP543E, TYR365F, VAL126F, VAL129F, VAL291F, VAL531F, VAL53F, VAL540F, VAL564E, VAL632E
• F-H: ALA158F, ALA158H, ALA176F, ALA176H, ALA199F, ALA199H, ALA203F, ALA203H, ALA210F, ALA210H, ALA218F, ALA218H, ALA221F, ALA221H, ALA225F, ALA225H, ALA242F, ALA242H, ALA249F, ALA249H, ALA250F, ALA250H, ALA257F, ALA257H, ALA273F, ALA273H, ALA378H, ALA381H, ALA415F, ALA415H, ALA419F, ALA419H, ALA423F, ALA423H, ALA428F, ALA428H, ALA430F, ALA430H, ALA432F, ALA432H, ALA447F, ALA447H, ALA456F, ALA456H, ALA478F, ALA478H, ALA479F, ALA479H, ALA483F, ALA483H, ALA557F, ALA557H, ALA77H, ARG155F, ARG155H, ARG180F, ARG180H, ARG188F, ARG188H, ARG193F, ARG193H, ARG204F, ARG204H, ARG433F, ARG433H, ARG455F, ARG455H, ARG469F, ARG487F, ARG487H, ARG492F, ARG492H, ARG525F, ARG525H, ARG562F, ARG562H, ARG74F, ARG74H, ARG78F, ARG78H, ASN177F, ASN177H, ASN197F, ASN197H, ASN200F, ASN200H, ASN449F, ASN449H, ASP182F, ASP182H, ASP187F, ASP187H, ASP228F, ASP228H, ASP274F, ASP274H, ASP458F, ASP458H, ASP528F, ASP528H, CYS267H, CYS431F, CYS431H, GLN181F, GLN181H, GLN198F, GLN198H, GLN208F, GLN208H, GLN402F, GLN402H, GLN411F, GLN411H, GLN477F, GLN477H, GLN484F, GLN484H, GLN489F, GLN489H, GLN512F, GLN512H, GLN516F, GLN516H, GLU162F, GLU162H, GLU183F, GLU183H, GLU189F, GLU189H, GLU229F, GLU229H, GLU253F, GLU253H, GLU258F, GLU258H, GLU259F, GLU259H, GLU414F, GLU414H, GLU476F, GLU476H, GLU488F, GLU488H, GLU514F, GLU554H, GLY175F, GLY175H, GLY192F, GLY192H, GLY205F, GLY205H, GLY219F, GLY219H, GLY243F, GLY243H, GLY252F, GLY252H, GLY261F, GLY261H, GLY262F, GLY262H, GLY271F, GLY271H, GLY406F, GLY406H, GLY410F, GLY410H, GLY416F, GLY416H, GLY417F, GLY417H, GLY422F, GLY422H, GLY446F, GLY446H, GLY448F, GLY448H, GLY451F, GLY451H, GLY454F, GLY454H, GLY471F, GLY471H, GLY474F, GLY474H, GLY475F, GLY475H, GLY480F, GLY480H, GLY517F, GLY517H, GLY559F, GLY559H, HIS190F, HIS190H, HIS266F, HIS266H, HIS275F, HIS275H, HIS421F, HIS421H, HIS515F, HIS515H, ILE194F, ILE194H, ILE206F, ILE206H, ILE209F, ILE209H, ILE239F, ILE239H, ILE404F, ILE404H, ILE418F, ILE418H, ILE470F, ILE470H, ILE505F, ILE509F, ILE509H, LEU148H, LEU154F, LEU154H, LEU178F, LEU178H, LEU241F, LEU241H, LEU246F, LEU246H, LEU260F, LEU260H, LEU376F, LEU376H, LEU425F, LEU425H, LEU440F, LEU440H, LEU462F, LEU462H, LEU482F, LEU482H, LEU526F, LEU526H, LYS141F, LYS141H, LYS151F, LYS151H, LYS248F, LYS248H, LYS412F, LYS412H, LYS420F, LYS420H, LYS424F, LYS424H, LYS436F, LYS436H, LYS486F, MET201F, MET201H, MET226F, MET226H, MET408F, MET408H, MET464F, MET464H, MET473F, MET473H, MET563F, MET563H, PHE185F, PHE185H, PHE191F, PHE191H, PHE195F, PHE195H, PHE196F, PHE196H, PHE240F, PHE240H, PHE377F, PHE407F, PHE407H, PHE445F, PHE445H, PHE558F, PHE558H, PHE561F, PHE561H, PRO179F, PRO179H, PRO186F, PRO186H, PRO207F, PRO207H, PRO224F, PRO224H, PRO244F, PRO244H, PRO245F, PRO245H, PRO459F, PRO459H, PRO508F, PRO508H, SER202F, SER202H, SER227F, SER227H, SER256F, SER256H, SER270F, SER270H, SER444F, SER444H, SER522F, SER522H, THR144F, THR144H, THR217F, THR217H, THR230F, THR230H, THR251F, THR251H, THR427F, THR427H, THR556F, THR556H, TRP527F, TRP527H, TYR222F, TYR222H, TYR413F, TYR413H, TYR450F, TYR450H, TYR457F, TYR457H, TYR513F, TYR513H, TYR521F, TYR521H, VAL150F, VAL150H, VAL184F, VAL184H, VAL223F, VAL223H, VAL231F, VAL231H, VAL247F, VAL247H, VAL254F, VAL254H, VAL255F, VAL255H, VAL265F, VAL265H, VAL269F, VAL269H, VAL272F, VAL272H, VAL409F, VAL409H, VAL426F, VAL426H, VAL429F, VAL429H, VAL472F, VAL472H, VAL481F, VAL481H, VAL485F, VAL485H, VAL560F, VAL560H
• F-I: ALA249F, ALA250F, LEU246F, LYS681I
• F-L: ALA378F, ALA378L, ALA381F, ALA381L, ALA385F, ALA385L, ALA391F, ALA391L, ALA415L, ALA423F, ALA428F, ALA428L, ALA557F, ALA557L, ARG394F, ARG394L, ARG562F, ARG562L, CYS392F, CYS392L, GLN382F, GLN382L, GLN393F, GLN393L, GLU379F, GLU379L, GLU389F, GLU389L, GLY384F, GLY384L, GLY417L, GLY559F, GLY559L, HIS386F, HIS386L, HIS421F, HIS421L, ILE388F, ILE388L, LEU390F, LEU390L, LEU425F, LEU425L, LYS348F, LYS348L, LYS383F, LYS383L, LYS420F, LYS420L, LYS424F, LYS424L, MET563F, MET563L, PHE347F, PHE347L, PHE351F, PHE351L, PHE387F, PHE387L, PHE558F, PHE558L, PHE561F, PHE561L, THR427F, THR427L, THR556F, VAL560F, VAL560L
• G-H: ALA102H, ALA285H, ALA306H, ALA542H, ALA544H, ALA546G, ALA547H, ALA548G, ALA548H, ALA569G, ALA631G, ARG125H, ARG164H, ARG288H, ARG289H, ARG297H, ARG305H, ARG308H, ARG524G, ARG525G, ARG538H, ARG539G, ARG544G, ARG549G, ARG562G, ARG565G, ARG567G, ARG57H, ARG613G, ARG62H, ARG84H, ARG89H, ASN295H, ASN540G, ASN54H, ASN550H, ASN88H, ASP281H, ASP526G, ASP529H, ASP531G, ASP532G, ASP533H, ASP541G, ASP552G, ASP633G, ASP92H, CYS131H, CYS304H, CYS563G, GLN299H, GLN301H, GLN303H, GLN536H, GLU127H, GLU130H, GLU520G, GLU539H, GLU550G, GLU85H, GLU99H, GLY122H, GLY124H, GLY128H, GLY300H, GLY364H, GLY522G, GLY530H, GLY542G, GLY61H, GLY94H, HIS282H, HIS363H, HIS523G, HIS534G, HIS568G, HIS64H, ILE123H, ILE532H, ILE63H, ILE87H, LEU100H, LEU165H, LEU294H, LEU302H, LEU362H, LEU517G, LEU541H, LEU543H, LEU545H, LEU547G, LEU549H, LEU553G, LEU555G, LEU566G, LEU56H, LEU59H, LEU60H, LEU81H, LEU82H, LEU90H, LEU91H, LEU98H, LYS298H, MET554G, PHE461H, PHE97H, PRO166H, PRO307H, PRO521G, PRO533G, PRO536G, PRO93H, PRO96H, SER535G, SER538G, SER545G, SER546H, SER551G, SER95H, THR537H, THR58H, TRP296H, TRP463H, TRP516G, TRP537G, TRP543G, TYR365H, VAL126H, VAL129H, VAL291H, VAL531H, VAL53H, VAL540H, VAL564G, VAL632G
• G-I: ALA116I, ALA119I, ALA357I, ALA409G, ALA447G, ALA453G, ALA480G, ALA68I, ALA70I, ALA77I, ALA86I, ALA90I, ALA92I, ALA95I, ARG361I, ARG364I, ARG414G, ARG448G, ARG450G, ARG47I, ARG51I, ARG589G, ARG601G, ARG607G, ARG608G, ARG66I, ARG69I, ARG84I, ARG87I, ASP603G, ASP81I, ASP83I, ASP93I, ASP97I, GLN123I, GLN449G, GLN50I, GLU366I, GLU442G, GLU445G, GLU446G, GLU457G, GLU91I, GLY121I, GLY411G, GLY413G, GLY441G, GLY475G, GLY604G, GLY72I, GLY74I, HIS79I, HIS85I, HIS88I, ILE360I, ILE49I, ILE73I, ILE94I, LEU451G, LEU452G, LEU71I, LEU98I, MET454G, MET65I, PRO369I, PRO412G, PRO477G, SER120I, SER48I, SER600G, SER609G, SER67I, SER80I, THR443G, THR606G, TRP358I, TRP440G, TYR46I, VAL599G, VAL602G, VAL605G, VAL76I, VAL78I, VAL89I, VAL96I
• G-K: ALA116G, ALA119G, ALA357G, ALA447K, ALA453K, ALA480K, ALA68G, ALA70G, ALA77G, ALA86G, ALA90G, ALA92G, ALA95G, ARG361G, ARG364G, ARG414K, ARG421G, ARG444K, ARG448K, ARG450K, ARG47G, ARG51G, ARG589K, ARG601K, ARG607K, ARG608K, ARG66G, ARG69G, ARG84G, ARG87G, ASP603K, ASP81G, ASP83G, ASP93G, ASP97G, GLN123G, GLN449K, GLN50G, GLU366G, GLU442K, GLU445K, GLU446K, GLU457K, GLU91G, GLY121G, GLY411K, GLY413K, GLY441K, GLY475K, GLY604K, GLY72G, GLY74G, HIS79G, HIS85G, ILE360G, ILE49G, ILE73G, ILE94G, LEU451K, LEU452K, LEU71G, LEU98G, MET454K, PRO369G, PRO412K, SER120G, SER48G, SER600K, SER609K, SER67G, SER80G, THR443K, THR606K, TRP358G, TRP440K, TYR46G, VAL599K, VAL602K, VAL605K, VAL76G, VAL78G, VAL89G, VAL96G
• G-L: ALA29L, ALA631G, ARG305L, ARG525G, ARG616G, ASP526G, ASP531G, ASP633G, GLN303L, HIS27L, HIS523G, ILE30L, MET28L, SER26L, VAL632G
• H-I: ALA29H, ALA478H, ALA631I, ARG305H, ARG525I, ARG616I, ASN403H, ASP526I, ASP531I, ASP633I, GLN303H, GLN477H, GLU476H, GLY374H, GLY406H, GLY443H, GLY446H, GLY471H, GLY474H, GLY475H, HIS27H, HIS32H, HIS523I, ILE30H, ILE375H, ILE404H, LYS326H, LYS681I, MET28H, MET408H, MET473H, PHE407H, PHE445H, PRO328H, SER26H, SER325H, SER444H, THR405H, TYR513H, VAL409H, VAL472H, VAL632I
• H-J: ALA203J, ALA225J, ALA263J, ALA273J, ALA277J, ALA285J, ALA292J, ALA29H, ALA349H, ALA360H, ALA368H, ALA391H, ARG164J, ARG204J, ARG234J, ARG288J, ARG289J, ARG297J, ARG305H, ARG308H, ARG394H, ASN293J, ASN295J, ASP228J, ASP264J, ASP274J, ASP281J, ASP345H, CYS267J, CYS290J, CYS304H, CYS357H, GLN208J, GLN301H, GLN303H, GLN382H, GLN393H, GLU127J, GLU229J, GLU278J, GLU343H, GLU346H, GLU379H, GLU389H, GLY205J, GLY271J, GLY352H, GLY358H, GLY395H, HIS266J, HIS275J, HIS27H, HIS282J, HIS361H, HIS386H, ILE206J, ILE209J, ILE286J, ILE30H, ILE367H, ILE396H, ILE553H, LEU294J, LEU302H, LEU350H, LEU390H, LYS268J, LYS298J, LYS348H, LYS383H, MET201J, MET226J, MET28H, PHE344H, PHE347H, PHE351H, PHE359H, PHE387H, PRO207J, PRO224J, PRO366H, PRO397H, SER202J, SER227J, SER26H, SER270J, THR230J, THR353H, TRP296J, TYR276J, TYR365H, VAL129J, VAL231J, VAL265J, VAL269J, VAL272J, VAL291J, VAL434H
• H-L: ALA203H, ALA225H, ALA263H, ALA273H, ALA277H, ALA285H, ALA287H, ALA292H, ALA29L, ALA349L, ALA360L, ALA368L, ALA391L, ARG164H, ARG204H, ARG234H, ARG288H, ARG289H, ARG297H, ARG297L, ARG305L, ARG308L, ARG394L, ASN293H, ASN295H, ASP228H, ASP264H, ASP274H, ASP281H, ASP345L, CYS267H, CYS290H, CYS304L, CYS357L, GLN208H, GLN301L, GLN303L, GLN382L, GLN393L, GLU127H, GLU229H, GLU343L, GLU346L, GLU379L, GLU389L, GLY205H, GLY271H, GLY352L, GLY358L, GLY395L, HIS266H, HIS275H, HIS27L, HIS282H, HIS361L, HIS386L, ILE206H, ILE209H, ILE286H, ILE367L, ILE396L, ILE553L, LEU284H, LEU294H, LEU302L, LEU350L, LEU390L, LYS268H, LYS298H, LYS348L, LYS383L, MET201H, MET226H, MET28L, PHE344L, PHE347L, PHE351L, PHE359L, PHE387L, PRO166H, PRO207H, PRO224H, PRO366L, PRO397L, SER202H, SER227H, SER26L, SER270H, THR230H, THR353L, TRP296H, TYR276H, TYR365L, VAL231H, VAL265H, VAL269H, VAL272H, VAL291H
• I-J: ALA102J, ALA285J, ALA306J, ALA542J, ALA544J, ALA546I, ALA547J, ALA548I, ALA548J, ALA569I, ALA631I, ARG125J, ARG164J, ARG288J, ARG297J, ARG305J, ARG524I, ARG525I, ARG538J, ARG539I, ARG544I, ARG549I, ARG562I, ARG565I, ARG567I, ARG57J, ARG613I, ARG62J, ARG84J, ARG89J, ASN295J, ASN540I, ASN54J, ASN550J, ASN88J, ASP281J, ASP526I, ASP529J, ASP531I, ASP532I, ASP533J, ASP541I, ASP552I, ASP633I, ASP92J, CYS131J, CYS304J, CYS563I, GLN299J, GLN301J, GLN303J, GLN536J, GLU127J, GLU130J, GLU520I, GLU539J, GLU550I, GLU85J, GLU99J, GLY122J, GLY124J, GLY128J, GLY300J, GLY364J, GLY522I, GLY530J, GLY542I, GLY61J, GLY94J, HIS282J, HIS363J, HIS523I, HIS534I, HIS568I, HIS64J, ILE123J, ILE133J, ILE532J, ILE63J, ILE87J, LEU100J, LEU103J, LEU165J, LEU294J, LEU302J, LEU362J, LEU517I, LEU541J, LEU543J, LEU545J, LEU547I, LEU549J, LEU553I, LEU555I, LEU566I, LEU56J, LEU59J, LEU60J, LEU81J, LEU82J, LEU90J, LEU91J, LEU98J, LYS298J, MET554I, PHE461J, PHE97J, PRO166J, PRO307J, PRO466J, PRO521I, PRO533I, PRO536I, PRO93J, PRO96J, SER101J, SER535I, SER538I, SER545I, SER546J, SER551I, SER95J, THR537J, THR58J, TRP296J, TRP463J, TRP516I, TRP537I, TRP543I, TYR365J, VAL126J, VAL129J, VAL291J, VAL531J, VAL53J, VAL540J, VAL564I, VAL632I
• I-K: ALA116K, ALA119K, ALA357K, ALA447I, ALA453I, ALA480I, ALA68K, ALA70K, ALA77K, ALA86K, ALA90K, ALA92K, ALA95K, ARG361K, ARG364K, ARG414I, ARG421K, ARG444I, ARG448I, ARG450I, ARG47K, ARG51K, ARG589I, ARG601I, ARG607I, ARG608I, ARG66K, ARG69K, ARG84K, ARG87K, ASP603I, ASP81K, ASP83K, ASP93K, ASP97K, GLN123K, GLN449I, GLN50K, GLU366K, GLU442I, GLU445I, GLU446I, GLU457I, GLU91K, GLY121K, GLY411I, GLY413I, GLY441I, GLY475I, GLY604I, GLY72K, GLY74K, HIS79K, HIS85K, HIS88K, ILE360K, ILE49K, ILE73K, ILE94K, LEU451I, LEU452I, LEU71K, LEU98K, MET454I, PRO369K, PRO412I, SER120K, SER48K, SER600I, SER609I, SER67K, SER80K, THR443I, THR606I, TRP440I, TYR46K, VAL599I, VAL602I, VAL605I, VAL76K, VAL78K, VAL89K, VAL96K
• J-K: ALA29J, ALA631K, ARG305J, ARG525K, ARG616K, ASP526K, ASP531K, ASP633K, GLN303J, GLU630K, HIS27J, HIS32J, HIS523K, ILE30J, MET28J, SER26J, VAL632K
• J-L: ALA203L, ALA225L, ALA263L, ALA273L, ALA277L, ALA283L, ALA285L, ALA292L, ALA29J, ALA349J, ALA360J, ALA368J, ALA391J, ARG164L, ARG204L, ARG234L, ARG288L, ARG289L, ARG297L, ARG305J, ARG308J, ARG394J, ASN293L, ASN295L, ASP228L, ASP264L, ASP274L, ASP281L, ASP345J, CYS267L, CYS290L, CYS304J, CYS357J, GLN208L, GLN301J, GLN303J, GLN382J, GLN393J, GLU127L, GLU229L, GLU278L, GLU343J, GLU346J, GLU379J, GLU389J, GLY205L, GLY271L, GLY352J, GLY358J, GLY395J, HIS266L, HIS275L, HIS27J, HIS282L, HIS361J, HIS386J, ILE206L, ILE209L, ILE286L, ILE30J, ILE367J, ILE396J, ILE553J, LEU284L, LEU294L, LEU302J, LEU350J, LEU390J, LYS268L, LYS298L, LYS348J, LYS383J, MET201L, MET226L, MET28J, PHE344J, PHE347J, PHE351J, PHE359J, PHE387J, PRO166L, PRO207L, PRO224L, PRO366J, PRO397J, SER202L, SER227L, SER26J, SER270L, THR230L, THR353J, TRP296L, TYR276L, TYR365J, VAL265L, VAL269L, VAL272L, VAL291L, VAL434J
• K-L: ALA102L, ALA285L, ALA306L, ALA542L, ALA544L, ALA546K, ALA547L, ALA548K, ALA548L, ALA569K, ALA631K, ARG125L, ARG164L, ARG297L, ARG305L, ARG524K, ARG525K, ARG538L, ARG539K, ARG544K, ARG549K, ARG565K, ARG567K, ARG57L, ARG613K, ARG62L, ARG84L, ARG89L, ASN295L, ASN540K, ASN54L, ASN550L, ASN88L, ASP281L, ASP526K, ASP531K, ASP532K, ASP533L, ASP541K, ASP552K, ASP633K, ASP92L, CYS131L, CYS304L, CYS563K, GLN299L, GLN301L, GLN303L, GLN536L, GLU127L, GLU130L, GLU520K, GLU539L, GLU550K, GLU85L, GLU99L, GLY122L, GLY124L, GLY128L, GLY300L, GLY364L, GLY522K, GLY530L, GLY542K, GLY61L, GLY94L, HIS282L, HIS363L, HIS523K, HIS534K, HIS568K, HIS64L, ILE123L, ILE532L, ILE63L, ILE87L, LEU100L, LEU165L, LEU294L, LEU302L, LEU362L, LEU517K, LEU541L, LEU543L, LEU545L, LEU547K, LEU549L, LEU553K, LEU566K, LEU56L, LEU59L, LEU60L, LEU81L, LEU82L, LEU90L, LEU91L, LEU98L, LYS298L, MET554K, PHE461L, PHE97L, PRO166L, PRO307L, PRO521K, PRO533K, PRO536K, PRO93L, PRO96L, SER535K, SER538K, SER545K, SER546L, SER551K, SER95L, THR537L, THR58L, TRP296L, TRP463L, TRP516K, TRP537K, TRP543K, TYR365L, VAL126L, VAL129L, VAL291L, VAL531L, VAL53L, VAL540L, VAL564K, VAL632K