3U8L

crystal structure of the acetylcholine binding protein (achbp) from lymnaea stagnalis in complex with ns3570 (1-(5-phenylpyridin-3-yl)-1, 4-diazepane)

• Total interactions analyzed: 45
• Total true interactions: 25
• Strongest Interaction:
  • Chains: F-G
  • Int. Res.: 129
  • Norm. En. per Res.: -2.6553
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-29.0732	5.8923	-300.896	-324.0769	136	15	5	12934	5	34	29
A-E	-24.9446	0.6726	-265.75	-290.022	126	7	6	12024	5	34	26
A-G	0.0	0.0	-0.0103	-0.0103	2	0	0	8	0	0	1
A-H	0.0	-1.3265	-50.3861	-51.7126	41	1	0	2307	0	14	15
A-I	0.0	65.7498	-4.6545	61.0953	14	0	0	272	0	6	4
B-C	-17.3205	-3.221	-273.797	-294.3384	128	4	5	11998	5	34	27
B-F	0.0	0.0	-0.0012	-0.0012	2	0	0	3	0	0	1
B-G	0.0	-2.8519	-49.5448	-52.3967	45	5	0	2807	0	14	14
B-H	0.0	65.3958	-4.2394	61.1565	13	0	0	244	0	6	4
C-D	-18.8117	2.882	-271.958	-287.8877	129	8	6	11906	5	33	28
C-F	0.0	12.6661	-69.8265	-57.1604	48	1	0	3005	0	14	15
C-G	0.0	70.7768	-6.4676	64.3092	14	0	0	331	0	6	4
C-J	0.0	0.0	-0.0087	-0.0087	2	0	0	7	0	0	0
D-E	-21.5266	-26.8512	-274.383	-322.7608	131	10	6	12081	6	34	28
D-F	0.0	78.1103	-7.7493	70.361	12	0	0	335	0	6	4
D-I	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
D-J	-4.6052	-4.035	-84.0084	-92.6486	52	2	0	3437	1	14	15
E-H	0.0	0.0	-0.0579	-0.0579	2	0	0	18	0	0	1
E-I	-8.7449	-27.9349	-78.45	-115.1298	53	8	0	3467	2	14	14
E-J	0.0	73.2504	-7.3884	65.862	14	0	0	362	0	7	4
F-G	-35.3525	-9.7101	-297.469	-342.5316	129	10	6	12614	6	33	28
F-J	-20.5959	-12.2524	-266.437	-299.2853	127	9	6	11661	6	34	28
G-H	-28.1836	10.7724	-276.982	-294.3932	128	9	6	12270	6	34	25
H-I	-23.4751	7.5739	-272.951	-288.8522	130	5	6	11738	5	33	28
I-J	-14.667	-32.069	-266.773	-313.509	129	5	5	11760	6	34	27

Interface residues

• A-B: ALA103B, ALA4B, ALA87A, ALA88A, ALA91A, ARG104B, ARG118B, ARG11B, ARG120A, ARG120B, ARG137A, ARG148A, ARG15A, ARG170B, ARG23A, ARG25A, ARG3B, ASN158B, ASN37B, ASN42A, ASN46A, ASN90A, ASN9B, ASP124A, ASP160B, ASP161B, ASP17A, ASP24A, ASP2B, ASP49B, ASP5B, ASP72B, ASP85A, CYS123A, CYS136A, CYS187A, CYS188A, GLN101B, GLN119A, GLN12B, GLN167B, GLN22A, GLN54B, GLN55B, GLN73B, GLU149A, GLU157B, GLU163B, GLU190A, GLU40B, GLU43A, GLU47A, GLU96B, GLY141A, HIS145A, HIS146A, ILE10B, ILE117B, ILE150A, ILE19A, ILE36B, ILE38B, ILE44A, ILE6B, ILE78B, ILE92A, LEU102B, LEU112B, LEU39B, LEU7B, LEU86A, LEU98B, LYS203B, LYS204B, LYS34B, LYS94A, LYS94B, MET114B, PHE121A, PHE165B, PHE171B, PHE52B, PRO100B, PRO115B, PRO16A, PRO189A, PRO20A, PRO26A, PRO71B, PRO77B, PRO84A, PRO95A, PRO95B, SER116B, SER122A, SER126A, SER142A, SER159B, SER166B, SER169B, SER186A, SER70B, SER75B, SER79B, SER80B, SER93A, THR135A, THR144A, THR155B, THR156B, THR184A, THR21A, THR45A, THR62A, THR99B, TRP143A, TRP53B, TRP82A, TYR113B, TYR164B, TYR168B, TYR185A, TYR192A, TYR89A, TYR8B, VAL105B, VAL125A, VAL183A, VAL18A, VAL27A, VAL50B, VAL51B, VAL74B, VAL76B, VAL83A, VAL97B
• A-E: ALA103A, ALA4A, ALA87E, ALA88E, ALA91E, ARG104A, ARG118A, ARG11A, ARG120E, ARG137E, ARG148E, ARG15E, ARG170A, ARG23E, ARG25E, ARG3A, ASN37A, ASN42E, ASN46E, ASN90E, ASP124E, ASP160A, ASP17E, ASP24E, ASP2A, ASP49A, ASP5A, ASP72A, ASP85E, CYS123E, CYS136E, CYS187E, CYS188E, GLN101A, GLN119E, GLN167A, GLN22E, GLN54A, GLN55A, GLN73A, GLU149E, GLU163A, GLU190E, GLU40A, GLU43E, GLU47E, GLU96A, GLY141E, HIS145E, HIS146E, ILE117A, ILE150E, ILE19E, ILE36A, ILE38A, ILE44E, ILE6A, ILE78A, ILE92E, LEU102A, LEU112A, LEU39A, LEU7A, LEU86E, LEU98A, LYS139E, LYS203A, LYS204A, LYS34A, LYS94A, LYS94E, MET114A, PHE121E, PHE171A, PHE52A, PRO100A, PRO115A, PRO16E, PRO189E, PRO20E, PRO26E, PRO71A, PRO77A, PRO84E, PRO95A, PRO95E, SER116A, SER122E, SER126E, SER142E, SER166A, SER169A, SER186E, SER75A, SER79A, SER80A, SER93E, THR135E, THR144E, THR184E, THR21E, THR45E, THR57A, THR62E, THR99A, TRP143E, TRP53A, TRP82E, TYR113A, TYR164A, TYR168A, TYR185E, TYR192E, TYR89E, TYR8A, VAL105A, VAL125E, VAL183E, VAL18E, VAL27E, VAL50A, VAL51A, VAL74A, VAL76A, VAL83E, VAL97A
• A-G: ARG15A, ARG15G
• A-H: ALA64A, ALA64H, ARG11A, ARG11H, ARG15A, ARG15H, ARG23A, ARG23H, ARG61A, ARG61H, ASN66A, ASN66H, ASN9A, ASN9H, ASP5A, ASP5H, GLN12A, GLN12H, GLN22A, GLN22H, HIS69A, HIS69H, ILE10A, ILE10H, LEU1A, LEU1H, PRO16A, PRO16H, SER14A, SER14H, SER68A, SER68H, SER70A, THR13A, THR13H, THR62A, THR62H, TYR8A, TYR8H, VAL18A, VAL18H
• A-I: ALA4A, ALA4I, ARG11A, ARG11I, ASP2A, ASP2I, ASP5A, ASP5I, GLN12A, GLN12I, LEU1A, LEU1I, TYR8A, TYR8I
• B-C: ALA103C, ALA4C, ALA87B, ALA88B, ALA91B, ARG104C, ARG118C, ARG11C, ARG120B, ARG137B, ARG148B, ARG15B, ARG170C, ARG23B, ARG25B, ARG3C, ASN37C, ASN42B, ASN46B, ASN90B, ASP124B, ASP160C, ASP17B, ASP24B, ASP2C, ASP49C, ASP5C, ASP72C, ASP85B, CYS123B, CYS136B, CYS187B, CYS188B, GLN101C, GLN119B, GLN167C, GLN22B, GLN54C, GLN55C, GLN73C, GLU149B, GLU163C, GLU190B, GLU40C, GLU43B, GLU47B, GLU96C, GLY141B, HIS145B, HIS146B, ILE10C, ILE117C, ILE150B, ILE19B, ILE36C, ILE38C, ILE44B, ILE6C, ILE78C, ILE92B, LEU102C, LEU112C, LEU39C, LEU7C, LEU86B, LEU98C, LYS139B, LYS203C, LYS204C, LYS34C, LYS94B, LYS94C, MET114C, PHE121B, PHE171C, PHE52C, PRO100C, PRO115C, PRO16B, PRO189B, PRO20B, PRO26B, PRO71C, PRO77C, PRO84B, PRO95B, PRO95C, SER116C, SER122B, SER126B, SER142B, SER166C, SER169C, SER186B, SER75C, SER79C, SER80C, SER93B, THR135B, THR144B, THR155C, THR184B, THR21B, THR45B, THR62B, THR99C, TRP143B, TRP53C, TRP82B, TYR113C, TYR164C, TYR168C, TYR185B, TYR192B, TYR89B, TYR8C, VAL105C, VAL125B, VAL183B, VAL18B, VAL27B, VAL41C, VAL50C, VAL51C, VAL74C, VAL76C, VAL83B, VAL97C
• B-F: ARG15B, ARG15F
• B-G: ALA4G, ALA64B, ALA64G, ARG11B, ARG11G, ARG15B, ARG15G, ARG23B, ARG23G, ARG61B, ARG61G, ASN66B, ASN66G, ASN9B, ASN9G, ASP2B, ASP2G, ASP5B, ASP5G, GLN12B, GLN12G, GLN22B, GLN22G, HIS69B, HIS69G, ILE10B, ILE10G, ILE6G, LEU1B, LEU1G, PRO16B, PRO16G, SER14B, SER14G, SER68B, SER68G, SER70B, THR13B, THR13G, THR62B, THR62G, TYR8B, TYR8G, VAL18B, VAL18G
• B-H: ALA4B, ALA4H, ARG11B, ARG11H, ASP2B, ASP2H, ASP5B, ASP5H, GLN12H, LEU1B, LEU1H, TYR8B, TYR8H
• C-D: ALA103D, ALA4D, ALA87C, ALA88C, ALA91C, ARG104D, ARG118D, ARG11D, ARG120C, ARG137C, ARG148C, ARG15C, ARG170D, ARG23C, ARG25C, ARG3D, ASN37D, ASN42C, ASN46C, ASN90C, ASN9D, ASP124C, ASP17C, ASP24C, ASP2D, ASP49D, ASP5D, ASP72D, ASP85C, CYS123C, CYS136C, CYS187C, CYS188C, GLN101D, GLN119C, GLN12D, GLN167D, GLN22C, GLN54D, GLN55D, GLN73D, GLU149C, GLU163D, GLU190C, GLU40D, GLU43C, GLU47C, GLU96D, GLY141C, HIS145C, HIS146C, ILE117D, ILE150C, ILE19C, ILE36D, ILE38D, ILE44C, ILE6D, ILE78D, ILE92C, LEU102D, LEU112D, LEU39D, LEU7D, LEU86C, LEU98D, LYS139C, LYS203D, LYS204D, LYS34D, LYS94C, LYS94D, MET114D, PHE121C, PHE171D, PHE52D, PRO100D, PRO115D, PRO16C, PRO189C, PRO20C, PRO26C, PRO71D, PRO77D, PRO84C, PRO95C, PRO95D, SER116D, SER122C, SER126C, SER142C, SER14C, SER166D, SER169D, SER186C, SER75D, SER79D, SER80D, SER93C, THR135C, THR144C, THR155D, THR184C, THR21C, THR45C, THR62C, THR99D, TRP143C, TRP53D, TRP82C, TYR113D, TYR164D, TYR168D, TYR185C, TYR192C, TYR89C, TYR8D, VAL105D, VAL125C, VAL183C, VAL18C, VAL27C, VAL41D, VAL50D, VAL51D, VAL74D, VAL76D, VAL83C, VAL97D
• C-F: ALA4C, ALA64C, ALA64F, ARG11C, ARG11F, ARG15C, ARG15F, ARG23C, ARG23F, ARG25C, ARG61C, ARG61F, ASN66C, ASN66F, ASN9C, ASN9F, ASP5C, ASP5F, GLN12C, GLN12F, GLN22C, GLN22F, HIS69C, HIS69F, ILE10C, ILE10F, ILE6F, LEU1C, LEU1F, PRO16C, PRO16F, SER14C, SER14F, SER68C, SER68F, SER70C, SER70F, THR13C, THR13F, THR21C, THR62C, THR62F, TRP65C, TRP65F, TYR8C, TYR8F, VAL18C, VAL18F
• C-G: ALA4C, ALA4G, ARG11C, ARG11G, ASP2C, ASP2G, ASP5C, ASP5G, GLN12C, GLN12G, LEU1C, LEU1G, TYR8C, TYR8G
• C-J: ARG15C, ARG15J
• D-E: ALA103E, ALA4E, ALA87D, ALA88D, ALA91D, ARG104E, ARG118E, ARG11E, ARG120D, ARG137D, ARG148D, ARG15D, ARG170E, ARG23D, ARG25D, ARG3E, ASN158E, ASN37E, ASN42D, ASN46D, ASN90D, ASP124D, ASP160E, ASP17D, ASP24D, ASP2E, ASP49E, ASP5E, ASP72E, ASP85D, CYS123D, CYS136D, CYS187D, CYS188D, GLN101E, GLN119D, GLN167E, GLN22D, GLN54E, GLN55E, GLN73E, GLU149D, GLU157E, GLU163E, GLU190D, GLU40E, GLU43D, GLU47D, GLU96E, GLY141D, HIS145D, HIS146D, ILE10E, ILE117E, ILE150D, ILE19D, ILE36E, ILE38E, ILE44D, ILE6E, ILE78E, ILE92D, LEU102E, LEU112E, LEU39E, LEU7E, LEU86D, LEU98E, LYS139D, LYS203E, LYS204E, LYS34E, LYS94D, LYS94E, MET114E, PHE121D, PHE171E, PHE52E, PRO100E, PRO115E, PRO16D, PRO189D, PRO20D, PRO26D, PRO71E, PRO77E, PRO84D, PRO95D, PRO95E, SER116E, SER122D, SER126D, SER142D, SER159E, SER166E, SER169E, SER186D, SER32E, SER75E, SER79E, SER80E, SER93D, THR135D, THR144D, THR184D, THR21D, THR45D, THR62D, THR99E, TRP143D, TRP53E, TRP82D, TYR113E, TYR164E, TYR168E, TYR185D, TYR192D, TYR89D, TYR8E, VAL105E, VAL125D, VAL183D, VAL18D, VAL27D, VAL41E, VAL50E, VAL51E, VAL74E, VAL76E, VAL83D, VAL97E
• D-F: ALA4D, ALA4F, ASP2D, ASP2F, ASP5D, ASP5F, GLN12D, GLN12F, LEU1D, LEU1F, TYR8D, TYR8F
• D-I: ARG15D, ARG15I
• D-J: ALA4D, ALA4J, ALA64D, ALA64J, ARG11D, ARG11J, ARG15D, ARG15J, ARG23D, ARG23J, ARG25J, ARG61D, ARG61J, ASN66D, ASN66J, ASN9D, ASN9J, ASP2J, ASP5D, ASP5J, GLN12D, GLN12J, GLN22D, GLN22J, HIS69D, HIS69J, ILE10D, ILE10J, ILE6D, ILE6J, LEU1D, LEU1J, LEU63J, LEU7J, PRO16D, PRO16J, SER14D, SER14J, SER68D, SER68J, SER70J, THR13D, THR13J, THR21J, THR62D, THR62J, TRP65D, TRP65J, TYR8D, TYR8J, VAL18D, VAL18J
• E-H: ARG15E, ARG15H
• E-I: ALA4E, ALA4I, ALA64E, ALA64I, ARG11E, ARG11I, ARG15E, ARG15I, ARG23E, ARG23I, ARG25E, ARG25I, ARG3E, ARG61E, ARG61I, ASN66E, ASN66I, ASN9E, ASN9I, ASP2E, ASP2I, ASP5E, ASP5I, GLN12E, GLN12I, GLN22E, GLN22I, HIS69E, HIS69I, ILE10E, ILE10I, ILE6E, ILE6I, LEU1E, LEU1I, LEU7E, PRO16E, PRO16I, SER14E, SER14I, SER67E, SER68E, SER68I, SER70E, SER70I, THR13E, THR13I, THR62E, THR62I, TYR8E, TYR8I, VAL18E, VAL18I
• E-J: ALA4E, ALA4J, ARG11E, ARG11J, ASP2E, ASP2J, ASP5E, ASP5J, GLN12E, GLN12J, LEU1E, LEU1J, TYR8E, TYR8J
• F-G: ALA103G, ALA4G, ALA87F, ALA88F, ALA91F, ARG104G, ARG118G, ARG11G, ARG120F, ARG137F, ARG148F, ARG15F, ARG170G, ARG23F, ARG25F, ARG3G, ASN37G, ASN42F, ASN46F, ASN90F, ASN9G, ASP124F, ASP160G, ASP17F, ASP24F, ASP2G, ASP49G, ASP5G, ASP72G, ASP85F, CYS123F, CYS136F, CYS187F, CYS188F, GLN101G, GLN119F, GLN12G, GLN167G, GLN22F, GLN54G, GLN55G, GLN73G, GLU149F, GLU163G, GLU190F, GLU40G, GLU43F, GLU47F, GLU96G, GLY141F, HIS145F, HIS146F, ILE10G, ILE117G, ILE150F, ILE19F, ILE36G, ILE38G, ILE44F, ILE6G, ILE78G, ILE92F, LEU102G, LEU112G, LEU39G, LEU7G, LEU86F, LEU98G, LYS139F, LYS203G, LYS204G, LYS34G, LYS94F, LYS94G, MET114G, PHE121F, PHE171G, PHE52G, PRO100G, PRO115G, PRO16F, PRO189F, PRO20F, PRO26F, PRO71G, PRO77G, PRO84F, PRO95F, PRO95G, SER116G, SER122F, SER126F, SER142F, SER166G, SER169G, SER186F, SER70G, SER75G, SER79G, SER80G, SER93F, THR135F, THR144F, THR184F, THR21F, THR45F, THR62F, THR99G, TRP143F, TRP53G, TRP82F, TYR113G, TYR164G, TYR168G, TYR185F, TYR192F, TYR89F, TYR8G, VAL105G, VAL125F, VAL183F, VAL18F, VAL27F, VAL50G, VAL51G, VAL74G, VAL76G, VAL83F, VAL97G
• F-J: ALA103F, ALA4F, ALA87J, ALA88J, ALA91J, ARG104F, ARG118F, ARG11F, ARG120F, ARG120J, ARG137J, ARG148J, ARG15J, ARG170F, ARG23J, ARG25J, ARG3F, ASN37F, ASN42J, ASN46J, ASN90J, ASN9F, ASP124J, ASP17J, ASP24J, ASP2F, ASP49F, ASP5F, ASP72F, ASP85J, CYS123J, CYS136J, CYS188J, GLN101F, GLN119J, GLN12F, GLN167F, GLN22J, GLN54F, GLN73F, GLU149J, GLU163F, GLU190J, GLU40F, GLU43J, GLU47J, GLU96F, GLY141J, HIS145J, HIS146J, ILE10F, ILE117F, ILE150J, ILE19J, ILE36F, ILE38F, ILE44J, ILE6F, ILE78F, ILE92J, LEU102F, LEU112F, LEU39F, LEU7F, LEU86J, LEU98F, LYS139J, LYS203F, LYS204F, LYS34F, LYS94F, LYS94J, MET114F, PHE121J, PHE171F, PHE52F, PRO100F, PRO115F, PRO16J, PRO189J, PRO20J, PRO26J, PRO71F, PRO77F, PRO84J, PRO95F, PRO95J, SER116F, SER122J, SER126J, SER142J, SER166F, SER169F, SER70F, SER75F, SER79F, SER80F, SER93J, THR135J, THR144J, THR184J, THR21J, THR45J, THR62J, THR99F, TRP143J, TRP53F, TRP82J, TYR113F, TYR164F, TYR168F, TYR185J, TYR192J, TYR89J, TYR8F, VAL105F, VAL125J, VAL183J, VAL18J, VAL27J, VAL41F, VAL50F, VAL51F, VAL74F, VAL76F, VAL83J, VAL97F
• G-H: ALA103H, ALA4H, ALA87G, ALA88G, ALA91G, ARG104H, ARG118H, ARG11H, ARG120G, ARG137G, ARG148G, ARG15G, ARG170H, ARG23G, ARG25G, ARG3H, ASN37H, ASN42G, ASN46G, ASN90G, ASN9H, ASP124G, ASP17G, ASP24G, ASP2H, ASP49H, ASP5H, ASP72H, ASP85G, CYS123G, CYS136G, CYS187G, CYS188G, GLN101H, GLN119G, GLN12H, GLN167H, GLN22G, GLN54H, GLN55H, GLN73H, GLU149G, GLU163H, GLU190G, GLU40H, GLU43G, GLU47G, GLU96H, GLY141G, HIS145G, HIS146G, ILE10H, ILE117H, ILE150G, ILE19G, ILE36H, ILE38H, ILE44G, ILE6H, ILE78H, ILE92G, LEU102H, LEU112H, LEU39H, LEU7H, LEU86G, LEU98H, LYS139G, LYS203H, LYS204H, LYS34H, LYS94G, LYS94H, MET114H, PHE121G, PHE171H, PHE52H, PRO100H, PRO115H, PRO16G, PRO189G, PRO20G, PRO26G, PRO71H, PRO77H, PRO84G, PRO95G, PRO95H, SER116H, SER122G, SER126G, SER142G, SER166H, SER169H, SER186G, SER75H, SER79H, SER80H, SER93G, THR135G, THR144G, THR155H, THR184G, THR21G, THR45G, THR57H, THR62G, THR99H, TRP143G, TRP53H, TRP82G, TYR113H, TYR164H, TYR168H, TYR185G, TYR192G, TYR89G, TYR8H, VAL105H, VAL125G, VAL183G, VAL18G, VAL50H, VAL51H, VAL74H, VAL76H, VAL83G, VAL97H
• H-I: ALA103I, ALA4I, ALA87H, ALA88H, ALA91H, ARG104I, ARG118I, ARG11I, ARG120H, ARG120I, ARG137H, ARG148H, ARG15H, ARG170I, ARG23H, ARG25H, ARG3I, ASN158I, ASN37I, ASN42H, ASN46H, ASN90H, ASN9I, ASP124H, ASP17H, ASP24H, ASP2I, ASP49I, ASP5I, ASP72I, ASP85H, CYS123H, CYS136H, CYS187H, CYS188H, GLN101I, GLN119H, GLN12I, GLN167I, GLN22H, GLN54I, GLN55I, GLN73I, GLU149H, GLU163I, GLU190H, GLU40I, GLU43H, GLU47H, GLU96I, GLY141H, HIS145H, HIS146H, ILE10I, ILE117I, ILE150H, ILE19H, ILE36I, ILE38I, ILE44H, ILE6I, ILE78I, ILE92H, LEU102I, LEU112I, LEU39I, LEU7I, LEU86H, LEU98I, LYS139H, LYS203I, LYS204I, LYS34I, LYS94H, LYS94I, MET114I, PHE121H, PHE165I, PHE171I, PHE52I, PRO100I, PRO115I, PRO16H, PRO189H, PRO20H, PRO26H, PRO71I, PRO77I, PRO84H, PRO95H, PRO95I, SER116I, SER122H, SER126H, SER142H, SER166I, SER169I, SER186H, SER75I, SER79I, SER80I, SER93H, THR135H, THR144H, THR184H, THR21H, THR45H, THR62H, THR99I, TRP143H, TRP53I, TRP82H, TYR113I, TYR164I, TYR168I, TYR185H, TYR192H, TYR89H, TYR8I, VAL105I, VAL125H, VAL183H, VAL18H, VAL27H, VAL50I, VAL51I, VAL74I, VAL76I, VAL83H, VAL97I
• I-J: ALA103J, ALA4J, ALA87I, ALA88I, ALA91I, ARG104J, ARG118J, ARG11J, ARG120I, ARG137I, ARG148I, ARG15I, ARG170J, ARG23I, ARG25I, ARG3J, ASN37J, ASN42I, ASN46I, ASN90I, ASP124I, ASP160J, ASP17I, ASP24I, ASP2J, ASP49J, ASP5J, ASP72J, ASP85I, CYS123I, CYS136I, CYS187I, CYS188I, GLN101J, GLN119I, GLN167J, GLN22I, GLN54J, GLN55J, GLN73J, GLU149I, GLU163J, GLU190I, GLU40J, GLU43I, GLU47I, GLU96J, GLY141I, HIS145I, HIS146I, ILE10J, ILE117J, ILE150I, ILE19I, ILE36J, ILE38J, ILE44I, ILE6J, ILE78J, ILE92I, LEU102J, LEU112J, LEU39J, LEU7J, LEU86I, LEU98J, LYS139I, LYS203J, LYS204J, LYS34J, LYS94I, LYS94J, MET114J, PHE121I, PHE171J, PHE52J, PRO100J, PRO115J, PRO16I, PRO189I, PRO20I, PRO26I, PRO71J, PRO77J, PRO84I, PRO95I, PRO95J, SER116J, SER122I, SER126I, SER142I, SER166J, SER169J, SER186I, SER70J, SER75J, SER79J, SER80J, SER93I, THR135I, THR144I, THR155J, THR184I, THR21I, THR45I, THR62I, THR99J, TRP143I, TRP53J, TRP82I, TYR113J, TYR164J, TYR168J, TYR185I, TYR192I, TYR89I, TYR8J, VAL105J, VAL125I, VAL183I, VAL18I, VAL27I, VAL41J, VAL50J, VAL51J, VAL74J, VAL76J, VAL83I, VAL97J