3U8K

crystal structure of the acetylcholine binding protein (achbp) from lymnaea stagnalis in complex with ns3573 (1-(5-ethoxypyridin-3-yl)-1, 4-diazepane)

• Total interactions analyzed: 190
• Total true interactions: 27
• Strongest Interaction:
  • Chains: P-Q
  • Int. Res.: 127
  • Norm. En. per Res.: -2.8438
• Hub Node: C(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-23.726	-1.6207	-283.891	-309.2377	127	11	6	12194	6	31	28
A-E	-30.3187	6.5247	-308.234	-332.028	135	15	6	13341	6	34	31
B-C	-30.4428	-3.7345	-288.509	-322.6863	128	5	5	12413	5	31	28
B-M	-6.8804	9.2219	-63.048	-60.7064	36	3	1	2760	0	11	12
B-N	0.0	6.0238	-0.2432	5.7806	12	0	0	60	0	9	4
C-D	-31.0941	-1.0704	-279.592	-311.7565	128	7	5	12158	5	32	29
C-M	0.0	5.1441	-0.0685	5.0756	10	0	0	13	0	12	4
C-N	0.0	5.7369	-4.2855	1.4513	7	0	0	161	0	4	1
D-E	-30.992	-14.6523	-289.656	-335.3002	131	14	6	12677	6	32	30
D-G	0.0	11.1332	-27.9825	-16.8493	38	1	0	1867	0	21	19
D-H	-5.5238	-6.5776	-12.3373	-24.4387	17	0	0	662	0	9	6
F-G	-22.2905	-6.2123	-277.016	-305.5188	130	13	5	12101	5	32	28
F-J	-35.0953	6.4355	-295.255	-323.9149	127	14	6	12782	6	35	30
G-H	-36.5814	-17.4823	-295.061	-349.1248	129	9	6	12444	6	32	27
H-I	-23.2751	5.4129	-293.73	-311.5922	124	6	5	12478	4	32	27
I-J	-27.4113	-30.2408	-271.674	-329.3261	130	10	5	12077	4	31	28
J-S	0.0	15.0518	-55.0919	-40.0401	50	5	0	3028	0	30	27
K-L	-22.5253	-6.4436	-285.155	-314.124	128	8	6	12184	4	31	27
K-O	-27.8445	-1.9949	-289.671	-319.5104	127	9	6	12453	4	35	27
L-M	-33.347	-1.0576	-276.654	-311.0586	131	8	7	12376	4	32	29
M-N	-28.4455	-5.3472	-278.518	-312.3107	127	6	5	12206	4	34	29
N-O	-23.152	-1.5009	-278.809	-303.4618	126	6	5	12080	6	31	28
P-Q	-31.1641	-42.065	-287.938	-361.1671	127	9	6	12226	9	32	30
P-T	-25.7607	3.4837	-278.128	-300.405	127	5	5	12131	5	32	28
Q-R	-24.3314	-5.87	-281.865	-312.0663	123	10	6	12162	5	28	23
R-S	-23.8507	-14.7614	-296.523	-335.1351	129	6	6	12348	4	32	29
S-T	-26.2321	-12.2737	-280.373	-318.8788	125	11	6	12240	5	29	25

Interface residues

• A-B: ALA103B, ALA4B, ALA87A, ALA88A, ALA91A, ARG104B, ARG118B, ARG11B, ARG120A, ARG137A, ARG148A, ARG15A, ARG170B, ARG23A, ARG25A, ARG3B, ASN37B, ASN42A, ASN46A, ASN90A, ASN9B, ASP124A, ASP161B, ASP17A, ASP24A, ASP2B, ASP49B, ASP5B, ASP72B, ASP85A, CYS123A, CYS136A, CYS187A, CYS188A, GLN101B, GLN119A, GLN12B, GLN167B, GLN22A, GLN54B, GLN55B, GLN73B, GLU149A, GLU163B, GLU190A, GLU40B, GLU43A, GLU47A, GLU96B, GLY141A, HIS145A, HIS146A, ILE10B, ILE117B, ILE150A, ILE19A, ILE36B, ILE38B, ILE44A, ILE6B, ILE78B, ILE92A, LEU102B, LEU112B, LEU39B, LEU7B, LEU86A, LEU98B, LYS139A, LYS203B, LYS204B, LYS34B, LYS94A, MET114B, PHE121A, PHE171B, PHE52B, PRO100B, PRO115B, PRO16A, PRO189A, PRO20A, PRO26A, PRO71B, PRO77B, PRO84A, PRO95A, PRO95B, SER116B, SER122A, SER126A, SER142A, SER166B, SER169B, SER186A, SER32B, SER75B, SER80B, SER93A, THR135A, THR144A, THR155B, THR184A, THR21A, THR45A, THR62A, THR99B, TRP143A, TRP53B, TRP82A, TYR113B, TYR164B, TYR168B, TYR185A, TYR192A, TYR89A, TYR8B, VAL105B, VAL125A, VAL183A, VAL18A, VAL27A, VAL51B, VAL74B, VAL76B, VAL83A, VAL97B
• A-E: ALA103A, ALA4A, ALA87E, ALA88E, ALA91E, ARG104A, ARG118A, ARG11A, ARG120E, ARG137E, ARG148E, ARG15E, ARG170A, ARG206A, ARG23E, ARG25E, ARG3A, ASN158A, ASN37A, ASN42E, ASN46E, ASN90E, ASN9A, ASP124E, ASP160A, ASP17E, ASP24E, ASP2A, ASP49A, ASP5A, ASP72A, ASP85E, CYS123E, CYS136E, CYS187E, CYS188E, GLN101A, GLN119E, GLN12A, GLN167A, GLN22E, GLN54A, GLN55A, GLN73A, GLU149E, GLU157A, GLU163A, GLU190E, GLU208A, GLU40A, GLU43E, GLU47E, GLU96A, GLY141E, HIS145E, HIS146E, HIS69A, ILE10A, ILE117A, ILE150E, ILE19E, ILE209A, ILE36A, ILE38A, ILE44E, ILE6A, ILE78A, ILE92E, LEU102A, LEU112A, LEU1A, LEU39A, LEU7A, LEU86E, LEU98A, LYS139E, LYS203A, LYS204A, LYS34A, LYS94E, MET114A, PHE121E, PHE171A, PHE52A, PRO100A, PRO115A, PRO16E, PRO189E, PRO20E, PRO26E, PRO71A, PRO77A, PRO84E, PRO95A, PRO95E, SER116A, SER122E, SER126E, SER142E, SER159A, SER166A, SER169A, SER186E, SER70A, SER75A, SER80A, SER93E, THR135E, THR144E, THR184E, THR21E, THR45E, THR57A, THR62E, THR99A, TRP143E, TRP53A, TRP82E, TYR113A, TYR164A, TYR168A, TYR185E, TYR192E, TYR89E, TYR8A, VAL105A, VAL125E, VAL183E, VAL18E, VAL27E, VAL51A, VAL74A, VAL76A, VAL83E, VAL97A
• B-C: ALA103C, ALA4C, ALA87B, ALA88B, ALA91B, ARG104C, ARG118C, ARG11C, ARG120B, ARG137B, ARG148B, ARG15B, ARG170C, ARG23B, ARG25B, ARG3C, ASN37C, ASN42B, ASN46B, ASN90B, ASN9C, ASP124B, ASP160C, ASP17B, ASP24B, ASP2C, ASP49C, ASP5C, ASP72C, ASP85B, CYS123B, CYS136B, CYS187B, CYS188B, GLN101C, GLN119B, GLN12C, GLN167C, GLN22B, GLN54C, GLN55C, GLN73C, GLU149B, GLU157C, GLU163C, GLU190B, GLU40C, GLU43B, GLU47B, GLU96C, GLY141B, HIS145B, HIS146B, ILE10C, ILE117C, ILE150B, ILE19B, ILE36C, ILE38C, ILE44B, ILE6C, ILE78C, ILE92B, LEU102C, LEU112C, LEU39C, LEU7C, LEU86B, LEU98C, LYS139B, LYS203C, LYS204C, LYS34C, LYS94B, MET114C, PHE121B, PHE171C, PHE52C, PRO100C, PRO115C, PRO16B, PRO189B, PRO20B, PRO26B, PRO71C, PRO77C, PRO84B, PRO95B, PRO95C, SER116C, SER122B, SER126B, SER142B, SER166C, SER169C, SER186B, SER32C, SER75C, SER80C, SER93B, THR135B, THR144B, THR155C, THR184B, THR21B, THR45B, THR62B, THR99C, TRP143B, TRP53C, TRP82B, TYR113C, TYR164C, TYR168C, TYR185B, TYR192B, TYR89B, TYR8C, VAL105C, VAL125B, VAL183B, VAL18B, VAL27B, VAL51C, VAL74C, VAL76C, VAL83B, VAL97C
• B-M: ALA191B, ALA191M, ARG148B, ARG148M, ASN181B, ASN181M, CYS188B, CYS188M, GLU190B, GLU190M, GLU193B, GLU193M, HIS146B, HIS146M, LYS179B, LYS180B, LYS180M, PRO189B, PRO189M, PRO26B, PRO26M, SER147B, SER147M, SER151B, SER182B, SER182M, SER186B, SER186M, THR184B, THR184M, TYR185B, TYR185M, TYR192B, TYR192M, VAL183B, VAL183M
• B-N: ARG148B, ARG23B, ARG25B, ASP108N, ASP24B, ASP72N, GLN73N, GLU163N, HIS69N, LYS179B, SER67N, SER68N
• C-D: ALA103D, ALA4D, ALA87C, ALA88C, ALA91C, ARG104D, ARG118D, ARG11D, ARG120C, ARG137C, ARG148C, ARG15C, ARG170D, ARG206D, ARG23C, ARG25C, ARG3D, ASN37D, ASN42C, ASN46C, ASN90C, ASN9D, ASP124C, ASP161D, ASP17C, ASP24C, ASP2D, ASP49D, ASP5D, ASP72D, ASP85C, CYS123C, CYS136C, CYS187C, CYS188C, GLN101D, GLN119C, GLN12D, GLN167D, GLN22C, GLN54D, GLN55D, GLN73D, GLU149C, GLU163D, GLU190C, GLU40D, GLU43C, GLU47C, GLU96D, GLY141C, HIS145C, HIS146C, ILE10D, ILE117D, ILE150C, ILE19C, ILE36D, ILE38D, ILE44C, ILE6D, ILE78D, ILE92C, LEU102D, LEU112D, LEU39D, LEU7D, LEU86C, LEU98D, LYS139C, LYS203D, LYS204D, LYS34D, LYS94C, MET114D, PHE121C, PHE171D, PHE52D, PRO100D, PRO115D, PRO16C, PRO189C, PRO20C, PRO26C, PRO71D, PRO77D, PRO84C, PRO95C, PRO95D, SER116D, SER122C, SER126C, SER142C, SER166D, SER169D, SER186C, SER32D, SER75D, SER80D, SER93C, THR135C, THR144C, THR155D, THR184C, THR21C, THR45C, THR62C, THR99D, TRP143C, TRP53D, TRP82C, TYR113D, TYR164D, TYR168D, TYR185C, TYR192C, TYR89C, TYR8D, VAL105D, VAL125C, VAL183C, VAL18C, VAL27C, VAL51D, VAL74D, VAL76D, VAL83C, VAL97D
• C-M: ARG148M, ARG23M, ASP160C, ASP24M, ASP72C, GLN73C, HIS69C, LYS179M, SER67C, SER68C
• C-N: HIS69C, HIS69N, LEU1C, SER68C, SER68N, SER70C, SER70N
• D-E: ALA103E, ALA4E, ALA87D, ALA88D, ALA91D, ARG104E, ARG118E, ARG11E, ARG120D, ARG137D, ARG148D, ARG15D, ARG170E, ARG23D, ARG25D, ARG3E, ASN37E, ASN42D, ASN46D, ASN90D, ASN9E, ASP124D, ASP160E, ASP17D, ASP24D, ASP2E, ASP49E, ASP5E, ASP72E, ASP85D, CYS123D, CYS136D, CYS187D, CYS188D, GLN101E, GLN119D, GLN12E, GLN167E, GLN22D, GLN54E, GLN55E, GLN73E, GLU149D, GLU163E, GLU190D, GLU40E, GLU43D, GLU47D, GLU96E, GLY141D, HIS145D, HIS146D, ILE10E, ILE117E, ILE150D, ILE19D, ILE36E, ILE38E, ILE44D, ILE6E, ILE78E, ILE92D, LEU102E, LEU112E, LEU39E, LEU7E, LEU86D, LEU98E, LYS139D, LYS203E, LYS204E, LYS34E, LYS94D, MET114E, PHE121D, PHE171E, PHE52E, PRO100E, PRO115E, PRO16D, PRO189D, PRO20D, PRO26D, PRO71E, PRO77E, PRO84D, PRO95D, PRO95E, SER116E, SER122D, SER126D, SER142D, SER159E, SER166E, SER169E, SER186D, SER70E, SER75E, SER80E, SER93D, THR135D, THR144D, THR155E, THR184D, THR21D, THR45D, THR57E, THR62D, THR99E, TRP143D, TRP53E, TRP82D, TYR113E, TYR164E, TYR168E, TYR185D, TYR192D, TYR89D, TYR8E, VAL105E, VAL125D, VAL183D, VAL18D, VAL27D, VAL41E, VAL50E, VAL51E, VAL74E, VAL76E, VAL83D, VAL97E
• D-G: ALA191D, ALA191G, ARG148D, ARG148G, ARG23G, ARG25D, ARG25G, ASN181D, ASP153D, ASP194D, ASP24D, ASP24G, CYS188G, GLN178D, GLU190D, GLU190G, GLU193D, GLU193G, LYS179D, LYS180D, LYS180G, PRO154D, PRO189G, PRO26D, PRO26G, SER147D, SER147G, SER151D, SER182D, SER182G, SER186G, THR184D, THR184G, TYR185G, TYR192G, VAL152D, VAL183D, VAL183G
• D-H: ARG23D, ARG25D, ASN66H, ASP160H, ASP72H, GLN178D, GLN73H, GLU163H, HIS69H, LYS179D, PRO71H, SER107H, SER67H, SER68H, SER70H, THR177D, TRP65H
• F-G: ALA103G, ALA4G, ALA87F, ALA88F, ALA91F, ARG104G, ARG118G, ARG11G, ARG120F, ARG137F, ARG148F, ARG15F, ARG170G, ARG23F, ARG25F, ARG3G, ASN37G, ASN42F, ASN46F, ASN90F, ASN9G, ASP124F, ASP160G, ASP161G, ASP17F, ASP24F, ASP2G, ASP49G, ASP5G, ASP72G, ASP85F, CYS123F, CYS136F, CYS187F, CYS188F, GLN101G, GLN119F, GLN12G, GLN167G, GLN22F, GLN54G, GLN55G, GLN73G, GLU149F, GLU163G, GLU190F, GLU40G, GLU43F, GLU47F, GLU96G, GLY141F, HIS145F, HIS146F, ILE10G, ILE117G, ILE150F, ILE19F, ILE36G, ILE38G, ILE44F, ILE6G, ILE78G, ILE92F, LEU102G, LEU112G, LEU39G, LEU7G, LEU86F, LEU98G, LYS139F, LYS203G, LYS204G, LYS34G, LYS94F, MET114G, PHE121F, PHE165G, PHE171G, PHE52G, PRO100G, PRO115G, PRO16F, PRO189F, PRO20F, PRO26F, PRO71G, PRO77G, PRO84F, PRO95F, PRO95G, SER116G, SER122F, SER126F, SER142F, SER166G, SER169G, SER186F, SER32G, SER75G, SER80G, SER93F, THR135F, THR144F, THR155G, THR184F, THR21F, THR45F, THR57G, THR62F, THR99G, TRP143F, TRP53G, TRP82F, TYR113G, TYR164G, TYR168G, TYR185F, TYR192F, TYR89F, TYR8G, VAL105G, VAL125F, VAL183F, VAL18F, VAL27F, VAL51G, VAL74G, VAL76G, VAL83F, VAL97G
• F-J: ALA103F, ALA4F, ALA87J, ALA88J, ALA91J, ARG104F, ARG118F, ARG11F, ARG120J, ARG137J, ARG148J, ARG15J, ARG170F, ARG23J, ARG25J, ARG3F, ASN37F, ASN42J, ASN46J, ASN90J, ASN9F, ASP124J, ASP160F, ASP17J, ASP24J, ASP2F, ASP49F, ASP5F, ASP72F, ASP85J, CYS123J, CYS136J, CYS187J, CYS188J, GLN101F, GLN119J, GLN12F, GLN167F, GLN22J, GLN54F, GLN55F, GLN73F, GLU149J, GLU163F, GLU190J, GLU40F, GLU43J, GLU47J, GLU96F, GLY141J, HIS145J, HIS146J, ILE10F, ILE117F, ILE150J, ILE19J, ILE36F, ILE38F, ILE44J, ILE6F, ILE78F, ILE92J, LEU102F, LEU112F, LEU39F, LEU7F, LEU86J, LEU98F, LYS139J, LYS203F, LYS204F, LYS34F, LYS94J, MET114F, PHE121J, PHE171F, PHE52F, PRO100F, PRO115F, PRO16J, PRO189J, PRO20J, PRO26J, PRO71F, PRO77F, PRO84J, PRO95F, PRO95J, SER116F, SER122J, SER126J, SER142J, SER166F, SER169F, SER186J, SER75F, SER80F, SER93J, THR135J, THR144J, THR184J, THR21J, THR45J, THR62J, THR99F, TRP143J, TRP53F, TRP82J, TYR113F, TYR164F, TYR168F, TYR185J, TYR192J, TYR89J, TYR8F, VAL105F, VAL125J, VAL183J, VAL18J, VAL27J, VAL41F, VAL50F, VAL51F, VAL74F, VAL76F, VAL83J, VAL97F
• G-H: ALA103H, ALA4H, ALA87G, ALA88G, ALA91G, ARG104H, ARG118H, ARG11H, ARG120G, ARG137G, ARG148G, ARG15G, ARG170H, ARG23G, ARG25G, ARG3H, ASN158H, ASN37H, ASN42G, ASN46G, ASN90G, ASN9H, ASP124G, ASP160H, ASP17G, ASP24G, ASP2H, ASP49H, ASP5H, ASP72H, ASP85G, CYS123G, CYS136G, CYS187G, CYS188G, GLN101H, GLN119G, GLN12H, GLN167H, GLN22G, GLN54H, GLN55H, GLN73H, GLU149G, GLU163H, GLU190G, GLU40H, GLU43G, GLU47G, GLU96H, GLY141G, HIS145G, HIS146G, ILE10H, ILE117H, ILE150G, ILE19G, ILE36H, ILE38H, ILE44G, ILE6H, ILE78H, ILE92G, LEU102H, LEU112H, LEU39H, LEU7H, LEU86G, LEU98H, LYS139G, LYS203H, LYS204H, LYS34H, LYS94G, MET114H, PHE121G, PHE171H, PHE52H, PRO100H, PRO115H, PRO16G, PRO189G, PRO20G, PRO26G, PRO71H, PRO77H, PRO84G, PRO95G, PRO95H, SER116H, SER122G, SER126G, SER142G, SER159H, SER166H, SER169H, SER186G, SER75H, SER80H, SER93G, THR135G, THR144G, THR155H, THR184G, THR21G, THR45G, THR62G, THR99H, TRP143G, TRP53H, TRP82G, TYR113H, TYR164H, TYR168H, TYR185G, TYR192G, TYR89G, TYR8H, VAL105H, VAL125G, VAL183G, VAL18G, VAL27G, VAL41H, VAL51H, VAL74H, VAL76H, VAL83G, VAL97H
• H-I: ALA103I, ALA4I, ALA87H, ALA88H, ALA91H, ARG104I, ARG118I, ARG11I, ARG120H, ARG137H, ARG148H, ARG15H, ARG170I, ARG23H, ARG25H, ARG3I, ASN37I, ASN42H, ASN46H, ASN90H, ASN9I, ASP124H, ASP17H, ASP24H, ASP2I, ASP49I, ASP5I, ASP72I, ASP85H, CYS123H, CYS136H, CYS187H, CYS188H, GLN101I, GLN119H, GLN12I, GLN167I, GLN22H, GLN54I, GLN55I, GLN73I, GLU149H, GLU163I, GLU190H, GLU40I, GLU43H, GLU47H, GLU96I, GLY141H, HIS145H, HIS146H, ILE10I, ILE117I, ILE150H, ILE19H, ILE36I, ILE38I, ILE44H, ILE6I, ILE92H, LEU102I, LEU112I, LEU39I, LEU7I, LEU86H, LEU98I, LYS139H, LYS203I, LYS204I, LYS34I, LYS94H, MET114I, PHE121H, PHE171I, PHE52I, PRO100I, PRO115I, PRO16H, PRO189H, PRO20H, PRO26H, PRO71I, PRO77I, PRO84H, PRO95H, PRO95I, SER116I, SER122H, SER126H, SER142H, SER166I, SER169I, SER186H, SER32I, SER75I, SER80I, SER93H, THR135H, THR144H, THR184H, THR21H, THR45H, THR62H, THR99I, TRP143H, TRP53I, TRP82H, TYR113I, TYR164I, TYR168I, TYR185H, TYR192H, TYR89H, TYR8I, VAL105I, VAL125H, VAL183H, VAL18H, VAL27H, VAL51I, VAL74I, VAL76I, VAL83H, VAL97I
• I-J: ALA103J, ALA4J, ALA87I, ALA88I, ALA91I, ARG104J, ARG118J, ARG11J, ARG120I, ARG137I, ARG148I, ARG15I, ARG170J, ARG23I, ARG25I, ARG3J, ASN37J, ASN42I, ASN46I, ASN90I, ASN9J, ASP124I, ASP160J, ASP17I, ASP24I, ASP2J, ASP49J, ASP5J, ASP72J, ASP85I, CYS123I, CYS136I, CYS187I, CYS188I, GLN101J, GLN119I, GLN12J, GLN167J, GLN22I, GLN54J, GLN55J, GLN73J, GLU149I, GLU157J, GLU163J, GLU190I, GLU40J, GLU43I, GLU47I, GLU96J, GLY141I, HIS145I, HIS146I, ILE10J, ILE117J, ILE150I, ILE19I, ILE36J, ILE38J, ILE44I, ILE6J, ILE78J, ILE92I, LEU102J, LEU112J, LEU39J, LEU7J, LEU86I, LEU98J, LYS139I, LYS203J, LYS204J, LYS34J, LYS94I, MET114J, PHE121I, PHE171J, PHE52J, PRO100J, PRO115J, PRO16I, PRO189I, PRO20I, PRO26I, PRO71J, PRO77J, PRO84I, PRO95I, PRO95J, SER116J, SER122I, SER126I, SER142I, SER159J, SER166J, SER169J, SER186I, SER32J, SER70J, SER75J, SER80J, SER93I, THR135I, THR144I, THR155J, THR184I, THR21I, THR45I, THR62I, THR99J, TRP143I, TRP53J, TRP82I, TYR113J, TYR164J, TYR168J, TYR185I, TYR192I, TYR89I, TYR8J, VAL105J, VAL125I, VAL183I, VAL18I, VAL27I, VAL51J, VAL74J, VAL76J, VAL83I, VAL97J
• J-S: ALA191S, ALA28J, ALA28S, ARG148J, ARG23J, ARG25J, ARG25S, ASN181J, ASN181S, ASP153J, ASP153S, ASP24J, GLN178J, GLN178S, GLN22J, GLU157J, GLU190S, GLU193J, GLU193S, GLU196J, GLU196S, LYS179J, LYS179S, LYS180J, LYS180S, PRO154J, PRO154S, PRO189S, PRO26J, PRO26S, SER147J, SER147S, SER151J, SER151S, SER182J, SER182S, SER198J, THR155J, THR155S, THR156J, THR177J, THR177S, THR184S, TYR185S, TYR192S, VAL152J, VAL152S, VAL183S, VAL195J, VAL27J
• K-L: ALA103L, ALA4L, ALA87K, ALA88K, ALA91K, ARG104L, ARG118L, ARG11L, ARG120K, ARG137K, ARG148K, ARG15K, ARG170L, ARG23K, ARG25K, ARG3L, ASN37L, ASN42K, ASN46K, ASN90K, ASN9L, ASP124K, ASP160L, ASP17K, ASP24K, ASP2L, ASP49L, ASP5L, ASP72L, ASP85K, CYS123K, CYS136K, CYS187K, CYS188K, GLN101L, GLN119K, GLN12L, GLN167L, GLN22K, GLN54L, GLN55L, GLN73L, GLU149K, GLU163L, GLU190K, GLU40L, GLU43K, GLU47K, GLU96L, GLY141K, HIS145K, HIS146K, ILE10L, ILE117L, ILE150K, ILE19K, ILE36L, ILE38L, ILE44K, ILE6L, ILE92K, LEU102L, LEU112L, LEU39L, LEU7L, LEU86K, LEU98L, LYS139K, LYS203L, LYS204L, LYS34L, LYS94K, MET114L, PHE121K, PHE171L, PHE52L, PRO100L, PRO115L, PRO16K, PRO189K, PRO20K, PRO26K, PRO71L, PRO77L, PRO84K, PRO95K, PRO95L, SER116L, SER122K, SER126K, SER142K, SER166L, SER169L, SER186K, SER32L, SER75L, SER80L, SER93K, THR135K, THR144K, THR155L, THR156L, THR184K, THR21K, THR45K, THR62K, THR99L, TRP143K, TRP53L, TRP82K, TYR113L, TYR164L, TYR168L, TYR185K, TYR192K, TYR89K, TYR8L, VAL105L, VAL125K, VAL183K, VAL18K, VAL27K, VAL41L, VAL51L, VAL74L, VAL76L, VAL83K, VAL97L
• K-O: ALA103K, ALA4K, ALA87O, ALA88O, ALA91O, ARG104K, ARG118K, ARG11K, ARG120O, ARG137O, ARG148O, ARG15O, ARG170K, ARG23O, ARG25O, ARG3K, ASN37K, ASN42O, ASN46O, ASN90O, ASN9K, ASP124O, ASP160K, ASP17O, ASP24O, ASP2K, ASP49K, ASP5K, ASP72K, ASP85O, CYS123O, CYS136O, CYS187O, CYS188O, GLN101K, GLN119O, GLN12K, GLN167K, GLN22O, GLN54K, GLN55K, GLN73K, GLU149O, GLU163K, GLU190O, GLU40K, GLU43O, GLU47O, GLU96K, GLY141O, HIS145O, HIS146O, ILE10K, ILE117K, ILE150O, ILE19O, ILE36K, ILE38K, ILE44O, ILE6K, ILE78K, ILE92O, LEU102K, LEU112K, LEU39K, LEU7K, LEU86O, LEU98K, LYS139O, LYS203K, LYS204K, LYS34K, LYS94O, MET114K, PHE121O, PHE171K, PHE52K, PRO100K, PRO115K, PRO16O, PRO189O, PRO20O, PRO26O, PRO71K, PRO77K, PRO84O, PRO95K, PRO95O, SER116K, SER122O, SER126O, SER142O, SER159K, SER166K, SER169K, SER186O, SER75K, SER80K, SER93O, THR135O, THR144O, THR155K, THR184O, THR21O, THR45O, THR62O, THR99K, TRP143O, TRP53K, TRP82O, TYR113K, TYR164K, TYR168K, TYR185O, TYR192O, TYR89O, TYR8K, VAL105K, VAL125O, VAL183O, VAL18O, VAL27O, VAL51K, VAL74K, VAL76K, VAL83O, VAL97K
• L-M: ALA103M, ALA4M, ALA87L, ALA88L, ALA91L, ARG104M, ARG118M, ARG11M, ARG120L, ARG137L, ARG148L, ARG15L, ARG170M, ARG206M, ARG23L, ARG25L, ARG3M, ASN37M, ASN42L, ASN46L, ASN90L, ASN9M, ASP124L, ASP160M, ASP17L, ASP24L, ASP2M, ASP49M, ASP5M, ASP72M, ASP85L, CYS123L, CYS136L, CYS187L, CYS188L, GLN101M, GLN119L, GLN12M, GLN167M, GLN22L, GLN54M, GLN55M, GLN73M, GLU149L, GLU163M, GLU190L, GLU208M, GLU40M, GLU43L, GLU47L, GLU96M, GLY127L, GLY141L, HIS145L, HIS146L, ILE10M, ILE117M, ILE150L, ILE19L, ILE209M, ILE36M, ILE38M, ILE44L, ILE6M, ILE78M, ILE92L, LEU102M, LEU112M, LEU210M, LEU39M, LEU7M, LEU86L, LEU98M, LYS139L, LYS203M, LYS204M, LYS34M, LYS94L, MET114M, PHE121L, PHE171M, PHE52M, PRO100M, PRO115M, PRO16L, PRO189L, PRO20L, PRO26L, PRO71M, PRO77M, PRO84L, PRO95L, PRO95M, SER116M, SER122L, SER126L, SER142L, SER166M, SER169M, SER186L, SER75M, SER80M, SER93L, THR135L, THR144L, THR155M, THR184L, THR21L, THR45L, THR62L, THR99M, TRP143L, TRP53M, TRP82L, TYR113M, TYR164M, TYR168M, TYR185L, TYR192L, TYR89L, TYR8M, VAL105M, VAL125L, VAL183L, VAL18L, VAL27L, VAL51M, VAL74M, VAL76M, VAL83L, VAL97M
• M-N: ALA103N, ALA4N, ALA87M, ALA88M, ALA91M, ARG104N, ARG118N, ARG11N, ARG120M, ARG137M, ARG148M, ARG15M, ARG170N, ARG23M, ARG25M, ARG3N, ASN37N, ASN42M, ASN46M, ASN90M, ASN9N, ASP124M, ASP17M, ASP24M, ASP2N, ASP49N, ASP5N, ASP72N, ASP85M, CYS123M, CYS136M, CYS187M, CYS188M, GLN101N, GLN119M, GLN12N, GLN167N, GLN22M, GLN54N, GLN55N, GLN73N, GLU149M, GLU163N, GLU190M, GLU40N, GLU43M, GLU47M, GLU96N, GLY141M, HIS145M, HIS146M, ILE10N, ILE117N, ILE150M, ILE19M, ILE209N, ILE36N, ILE38N, ILE44M, ILE6N, ILE78N, ILE92M, LEU102N, LEU112N, LEU39N, LEU7N, LEU86M, LEU98N, LYS139M, LYS203N, LYS204N, LYS34N, LYS94M, MET114N, PHE121M, PHE171N, PHE52N, PRO100N, PRO115N, PRO16M, PRO189M, PRO20M, PRO26M, PRO71N, PRO77N, PRO84M, PRO95M, PRO95N, SER116N, SER122M, SER126M, SER142M, SER166N, SER169N, SER186M, SER75N, SER80N, SER93M, THR135M, THR144M, THR155N, THR184M, THR21M, THR45M, THR57N, THR62M, THR99N, TRP143M, TRP53N, TRP82M, TYR113N, TYR164N, TYR168N, TYR185M, TYR192M, TYR89M, TYR8N, VAL105N, VAL125M, VAL183M, VAL18M, VAL27M, VAL51N, VAL74N, VAL76N, VAL83M, VAL97N
• N-O: ALA103O, ALA4O, ALA87N, ALA88N, ALA91N, ARG104O, ARG118O, ARG11O, ARG120N, ARG137N, ARG148N, ARG15N, ARG170O, ARG23N, ARG25N, ARG3O, ASN37O, ASN42N, ASN46N, ASN90N, ASN9O, ASP124N, ASP17N, ASP24N, ASP2O, ASP49O, ASP5O, ASP72O, ASP85N, CYS123N, CYS136N, CYS187N, CYS188N, GLN101O, GLN119N, GLN12O, GLN167O, GLN22N, GLN54O, GLN55O, GLN73O, GLU149N, GLU163O, GLU190N, GLU40O, GLU43N, GLU47N, GLU96O, GLY141N, HIS145N, HIS146N, ILE10O, ILE117O, ILE150N, ILE19N, ILE36O, ILE38O, ILE44N, ILE6O, ILE78O, ILE92N, LEU102O, LEU112O, LEU39O, LEU7O, LEU86N, LEU98O, LYS139N, LYS203O, LYS204O, LYS34O, LYS94N, MET114O, PHE121N, PHE171O, PHE52O, PRO100O, PRO115O, PRO16N, PRO189N, PRO20N, PRO26N, PRO71O, PRO77O, PRO84N, PRO95N, PRO95O, SER116O, SER122N, SER126N, SER142N, SER166O, SER169O, SER186N, SER75O, SER80O, SER93N, THR135N, THR144N, THR155O, THR184N, THR21N, THR45N, THR57O, THR62N, THR99O, TRP143N, TRP53O, TRP82N, TYR113O, TYR164O, TYR168O, TYR185N, TYR192N, TYR89N, TYR8O, VAL105O, VAL125N, VAL183N, VAL18N, VAL27N, VAL51O, VAL74O, VAL76O, VAL83N, VAL97O
• P-Q: ALA103Q, ALA4Q, ALA87P, ALA88P, ALA91P, ARG104Q, ARG118Q, ARG11Q, ARG120P, ARG137P, ARG148P, ARG15P, ARG170Q, ARG23P, ARG25P, ARG3Q, ASN37Q, ASN42P, ASN46P, ASN90P, ASN9Q, ASP124P, ASP161Q, ASP17P, ASP24P, ASP2Q, ASP49Q, ASP5Q, ASP72Q, ASP85P, CYS123P, CYS136P, CYS187P, CYS188P, GLN101Q, GLN119P, GLN12Q, GLN167Q, GLN22P, GLN54Q, GLN55Q, GLN73Q, GLU149P, GLU163Q, GLU190P, GLU40Q, GLU43P, GLU47P, GLU96Q, GLY141P, HIS145P, HIS146P, ILE10Q, ILE117Q, ILE150P, ILE19P, ILE36Q, ILE38Q, ILE44P, ILE6Q, ILE78Q, ILE92P, LEU102Q, LEU112Q, LEU39Q, LEU7Q, LEU86P, LEU98Q, LYS139P, LYS203Q, LYS204Q, LYS34Q, LYS94P, MET114Q, PHE121P, PHE171Q, PHE52Q, PRO100Q, PRO115Q, PRO16P, PRO189P, PRO20P, PRO26P, PRO71Q, PRO77Q, PRO84P, PRO95P, PRO95Q, SER116Q, SER122P, SER126P, SER142P, SER166Q, SER169Q, SER186P, SER75Q, SER80Q, SER93P, THR135P, THR144P, THR155Q, THR184P, THR21P, THR45P, THR57Q, THR62P, THR99Q, TRP143P, TRP53Q, TRP82P, TYR113Q, TYR164Q, TYR168Q, TYR185P, TYR192P, TYR89P, TYR8Q, VAL105Q, VAL125P, VAL183P, VAL18P, VAL27P, VAL51Q, VAL74Q, VAL76Q, VAL83P, VAL97Q
• P-T: ALA103P, ALA4P, ALA87T, ALA88T, ALA91T, ARG104P, ARG118P, ARG11P, ARG120T, ARG137T, ARG148T, ARG15T, ARG170P, ARG23T, ARG25T, ARG3P, ASN37P, ASN42T, ASN46T, ASN90T, ASN9P, ASP124T, ASP161P, ASP17T, ASP24T, ASP2P, ASP49P, ASP5P, ASP72P, ASP85T, CYS123T, CYS136T, CYS187T, CYS188T, GLN101P, GLN119T, GLN12P, GLN167P, GLN22T, GLN54P, GLN55P, GLN73P, GLU149T, GLU163P, GLU190T, GLU40P, GLU43T, GLU47T, GLU96P, GLY141T, HIS145T, HIS146T, ILE10P, ILE117P, ILE150T, ILE19T, ILE36P, ILE38P, ILE44T, ILE6P, ILE78P, ILE92T, LEU102P, LEU112P, LEU39P, LEU7P, LEU86T, LEU98P, LYS139T, LYS203P, LYS204P, LYS34P, LYS94T, MET114P, PHE121T, PHE171P, PHE52P, PRO100P, PRO115P, PRO16T, PRO189T, PRO20T, PRO26T, PRO71P, PRO77P, PRO84T, PRO95P, PRO95T, SER116P, SER122T, SER126T, SER142T, SER14T, SER166P, SER169P, SER186T, SER75P, SER80P, SER93T, THR135T, THR144T, THR184T, THR21T, THR45T, THR62T, THR99P, TRP143T, TRP53P, TRP82T, TYR113P, TYR164P, TYR168P, TYR185T, TYR192T, TYR89T, TYR8P, VAL105P, VAL125T, VAL183T, VAL18T, VAL27T, VAL41P, VAL51P, VAL74P, VAL76P, VAL83T, VAL97P
• Q-R: ALA103R, ALA4R, ALA87Q, ALA88Q, ALA91Q, ARG104R, ARG118R, ARG11R, ARG120Q, ARG137Q, ARG148Q, ARG15Q, ARG170R, ARG25Q, ARG3R, ASN37R, ASN42Q, ASN46Q, ASN90Q, ASN9R, ASP124Q, ASP160R, ASP17Q, ASP2R, ASP49R, ASP5R, ASP72R, ASP85Q, CYS123Q, CYS136Q, CYS187Q, CYS188Q, GLN101R, GLN119Q, GLN12R, GLN167R, GLN22Q, GLN54R, GLN55R, GLN73R, GLU149Q, GLU163R, GLU190Q, GLU40R, GLU43Q, GLU47Q, GLU96R, GLY141Q, HIS145Q, HIS146Q, ILE10R, ILE117R, ILE150Q, ILE19Q, ILE36R, ILE38R, ILE44Q, ILE6R, ILE78R, ILE92Q, LEU102R, LEU112R, LEU39R, LEU7R, LEU86Q, LEU98R, LYS139Q, LYS203R, LYS204R, LYS34R, LYS94Q, MET114R, PHE121Q, PHE171R, PHE52R, PRO100R, PRO115R, PRO16Q, PRO189Q, PRO20Q, PRO26Q, PRO71R, PRO77R, PRO84Q, PRO95Q, PRO95R, SER116R, SER122Q, SER126Q, SER142Q, SER166R, SER169R, SER186Q, SER75R, SER80R, SER93Q, THR135Q, THR144Q, THR184Q, THR21Q, THR45Q, THR62Q, THR99R, TRP143Q, TRP53R, TRP82Q, TYR113R, TYR164R, TYR168R, TYR185Q, TYR192Q, TYR89Q, TYR8R, VAL105R, VAL125Q, VAL183Q, VAL18Q, VAL27Q, VAL51R, VAL74R, VAL76R, VAL83Q, VAL97R
• R-S: ALA103S, ALA4S, ALA87R, ALA88R, ALA91R, ARG104S, ARG118S, ARG11S, ARG120R, ARG137R, ARG148R, ARG15R, ARG170S, ARG23R, ARG25R, ARG3S, ASN37S, ASN42R, ASN46R, ASN90R, ASN9S, ASP124R, ASP160S, ASP17R, ASP24R, ASP2S, ASP49S, ASP5S, ASP72S, ASP85R, CYS123R, CYS136R, CYS187R, CYS188R, GLN101S, GLN119R, GLN12S, GLN167S, GLN22R, GLN54S, GLN55S, GLN73S, GLU149R, GLU163S, GLU190R, GLU40S, GLU43R, GLU47R, GLU96S, GLY141R, HIS145R, HIS146R, ILE10S, ILE117S, ILE150R, ILE19R, ILE36S, ILE38S, ILE44R, ILE6S, ILE78S, ILE92R, LEU102S, LEU112S, LEU39S, LEU7S, LEU86R, LEU98S, LYS139R, LYS203S, LYS204S, LYS34S, LYS94R, MET114S, PHE121R, PHE165S, PHE171S, PHE52S, PRO100S, PRO115S, PRO16R, PRO189R, PRO20R, PRO26R, PRO71S, PRO77S, PRO84R, PRO95R, PRO95S, SER116S, SER122R, SER126R, SER142R, SER166S, SER169S, SER186R, SER70S, SER75S, SER80S, SER93R, THR135R, THR144R, THR155S, THR184R, THR21R, THR45R, THR62R, THR99S, TRP143R, TRP53S, TRP82R, TYR113S, TYR164S, TYR168S, TYR185R, TYR192R, TYR89R, TYR8S, VAL105S, VAL125R, VAL183R, VAL18R, VAL27R, VAL41S, VAL51S, VAL74S, VAL76S, VAL83R, VAL97S
• S-T: ALA103T, ALA4T, ALA87S, ALA88S, ALA91S, ARG104T, ARG118T, ARG11T, ARG120S, ARG137S, ARG148S, ARG15S, ARG170T, ARG206T, ARG25S, ARG3T, ASN37T, ASN42S, ASN46S, ASN90S, ASN9T, ASP124S, ASP160T, ASP17S, ASP2T, ASP49T, ASP5T, ASP72T, ASP85S, CYS123S, CYS136S, CYS187S, CYS188S, GLN101T, GLN119S, GLN12T, GLN167T, GLN54T, GLN55T, GLN73T, GLU149S, GLU163T, GLU190S, GLU208T, GLU40T, GLU43S, GLU47S, GLU96T, GLY141S, HIS145S, HIS146S, ILE10T, ILE117T, ILE150S, ILE19S, ILE36T, ILE38T, ILE44S, ILE6T, ILE78T, ILE92S, LEU102T, LEU112T, LEU39T, LEU7T, LEU86S, LEU98T, LYS139S, LYS203T, LYS204T, LYS34T, LYS94S, MET114T, PHE121S, PHE171T, PHE52T, PRO100T, PRO115T, PRO16S, PRO189S, PRO20S, PRO26S, PRO71T, PRO77T, PRO84S, PRO95S, PRO95T, SER116T, SER122S, SER126S, SER142S, SER166T, SER169T, SER186S, SER75T, SER80T, SER93S, THR135S, THR144S, THR155T, THR184S, THR21S, THR45S, THR62S, THR99T, TRP143S, TRP53T, TRP82S, TYR113T, TYR164T, TYR168T, TYR185S, TYR192S, TYR89S, TYR8T, VAL105T, VAL125S, VAL183S, VAL18S, VAL27S, VAL51T, VAL74T, VAL76T, VAL83S, VAL97T