3U5I

the structure of the eukaryotic ribosome at 3.0 a resolution. this entry contains proteins of the 60s subunit, ribosome b

• Total interactions analyzed: 990
• Total true interactions: 82
• Strongest Interaction:
  • Chains: L-N
  • Int. Res.: 36
  • Norm. En. per Res.: -6.2633
• Hub Node: C(13)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-G	-13.1552	0.0	-68.1436	-81.2988	37	6	4	2822	0	4	3
A-N	0.0	0.0	-2.9842	-2.9842	7	0	0	202	0	0	2
A-Z	0.0	0.0	-0.2247	-0.2247	2	0	0	29	0	0	0
A-g	0.0	-2.0505	-0.1587	-2.2092	8	0	0	71	0	2	2
A-p	-51.6227	-15.217			16
B-O	-9.458	-7.1908	-108.987	-125.6358	47	4	1	4169	1	8	15
B-P	0.0	0.0	-0.0006	-0.0006	2	0	0	1	0	0	1
B-V	-5.3164	-5.9358	-89.5709	-100.8231	51	1	2	4296	0	23	26
B-W	-7.6086	-27.1775	-122.983	-157.769	71	5	1	5579	1	16	19
C-E	0.0	0.0	-0.7315	-0.7315	10	0	0	198	0	0	5
C-F	-26.4834	-22.2774	-265.771	-314.5318	109	10	6	11607	2	21	31
C-L	0.0	3.9549	-47.804	-43.8491	24	2	1	1782	0	6	10
C-N	-10.5803	4.3107	-71.081	-77.3506	24	3	0	2659	0	0	14
C-Q	-53.643	23.5121	-262.39	-292.5209	89	21	15	12652	0	15	13
C-S	-11.2748	-9.5064	-65.7256	-86.5067	27	5	1	2640	0	11	12
C-T	0.0	0.0	-18.3452	-18.3452	19	0	1	991	0	0	1
C-Y	-2.254	33.6729	-22.874	8.545	23	4	0	1260	0	4	19
C-a	0.0	0.0	-0.067	-0.067	8	0	0	33	0	0	0
C-e	0.0	0.0	-0.0079	-0.0079	4	0	0	9	0	0	2
C-j	-26.0504	0.0	-7.0553	-33.1056	11	3	0	575	0	0	6
D-I	0.0	-4.1607	-55.7377	-59.8984	31	1	8	3029	0	2	7
D-J	-5.748	12.024	-44.0463	-37.7703	35	1	0	2262	0	11	25
D-T	-35.6467	4.7248	-207.96	-238.8819	76	8	6	8610	0	7	39
D-b	0.0	0.0	-0.4507	-0.4507	7	0	0	116	0	3	3
E-M	-2.3597	-42.239	-145.637	-190.2358	48	12	4	5564	2	14	14
E-O	0.0	0.0	-0.0119	-0.0119	5	0	0	11	0	0	0
E-S	0.0	0.0	-0.0291	-0.0291	4	0	0	23	0	0	1
E-e	-22.4977	-9.5069	-133.912	-165.9167	47	6	5	4844	0	11	5
E-f	-24.8492	-27.8709	-251.91	-304.6301	73	11	12	10025	2	11	25
F-Q	-16.2038	-45.3834	-62.117	-123.7042	24	2	1	2347	3	9	8
F-S	-7.6445	-2.2875	-88.0529	-97.9849	63	0	6	4045	1	11	18
F-T	-69.2995	-5.0769	-163.561	-237.9374	43	10	4	6049	0	6	9
F-b	0.0	0.0	-0.0027	-0.0027	3	0	0	3	0	0	7
G-N	-27.2751	-24.9297	-225.181	-277.3859	93	14	10	10443	6	32	28
G-X	-21.283	0.0	-104.724	-126.007	27	5	4	4094	0	1	8
G-Z	0.0	0.0	-36.9175	-36.9175	30	1	1	1906	0	0	9
G-g	0.0	0.0	-0.0212	-0.0212	4	0	0	17	0	0	0
G-i	-22.5016	-52.7039	-46.7868	-121.9924	37	5	6	2773	3	8	7
H-M	-30.7486	-3.0296	-114.901	-148.6792	57	12	4	5018	0	6	10
H-O	0.0	1.351	-3.5047	-2.1537	16	0	0	253	0	7	15
H-S	-15.9411	-4.5312	-67.1615	-87.6338	31	3	1	2670	0	4	11
H-m	-11.0574	-8.3506	-142.062	-161.47	56	9	12	5972	0	9	16
I-S	-10.7402	0.0	-7.7912	-18.5314	9	0	0	354	0	1	2
I-T	-18.0327	-3.4894	-40.6632	-62.1853	24	4	1	1953	0	3	1
I-b	0.0	0.0	-0.0717	-0.0717	4	0	0	43	0	0	1
L-N	-77.5787	-0.5378	-147.361	-225.4775	36	12	3	5477	0	4	22
L-Q	0.0	0.0	-45.7859	-45.7859	23	2	1	1995	0	1	4
L-Y	0.0	0.0	-0.0049	-0.0049	3	0	0	8	0	0	0
L-a	-85.5968	-35.7393	-398.242	-519.5781	124	23	12	15091	9	23	45
L-h	-56.7402	22.7654	-253.796	-287.7708	63	20	14	10378	0	5	11
L-i	-34.9649	9.8407	-166.429	-191.5532	65	12	4	6437	0	8	22
M-O	-11.3865	0.0	-167.293	-178.6795	62	3	13	8405	0	4	6
M-S	-35.8221	13.1745	-253.064	-275.7116	87	12	12	10494	2	26	30
M-f	0.0	0.0	-0.0331	-0.0331	4	0	0	13	0	2	0
N-a	0.0	2.6682	-0.1798	2.4884	3	0	0	38	0	0	3
N-h	-19.9944	-40.1924	-79.4197	-139.6065	40	3	1	3580	2	13	21
N-i	-5.3751	7.2292	-98.6901	-96.836	41	5	5	5125	2	20	17
O-S	-36.0577	-15.982	-151.019	-203.0586	63	6	5	6895	1	7	20
O-f	0.0	0.0	-29.8112	-29.8112	35	0	0	1862	0	3	12
P-d	0.0	-3.5539	-0.4639	-4.0178	5	0	0	67	0	4	4
Q-a	-63.5592	-61.2224	-219.478	-344.2596	83	16	2	9145	6	33	51
Q-b	0.0	0.0	-0.3634	-0.3634	3	0	0	58	0	2	7
R-X	0.0	0.0	-0.0176	-0.0176	3	0	0	13	0	1	1
S-T	-90.2877	-38.0423	-254.596	-382.9259	75	17	4	9544	2	10	8
S-f	0.0	0.0	-0.0475	-0.0475	6	0	0	17	0	2	1
T-b	-26.9167	3.3762	-112.748	-136.2885	50	2	1	4513	0	7	17
V-W	-40.2516	0.524	-116.061	-155.7886	48	6	6	4845	0	13	10
X-h	-23.9948	-14.4355	-179.278	-217.7083	83	5	7	7749	1	16	19
X-l	-18.4584	0.0	-39.3338	-57.7922	18	3	0	1962	0	0	7
Y-j	0.0	0.0	-0.0409	-0.0409	5	0	0	23	0	0	0
Y-l	-4.444	0.0	-12.8525	-17.2965	10	0	0	641	0	0	1
Z-c	-9.6338	-3.1757	-142.979	-155.7885	49	9	1	5434	0	10	18
Z-g	-13.5648	-3.5162	-157.273	-174.3541	53	4	13	7056	0	11	21
a-e	-2.9534	4.7622	-23.1698	-21.361	16	1	0	1030	0	1	15
a-i	0.0	3.2638	-49.7258	-46.462	24	3	5	2068	0	3	9
c-g	0.0	-4.3089	-62.664	-66.9729	30	4	2	2619	0	9	10
c-p	0.0	5.5486			2
e-f	0.0	6.7697	-5.8068	0.9629	6	0	0	321	0	0	3
g-l	0.0	0.0	-9.9951	-9.9951	7	0	0	370	0	0	1
h-j	-4.4598	5.4944	-25.5187	-24.4841	22	0	0	1424	0	0	11
j-l	0.0	0.0	-53.713	-53.713	23	7	1	2187	0	0	16
q-r	-4.9306	0.0			2

Interface residues

• A-G: ALA35A, ALA39G, ALA90A, ARG30A, ARG37A, ARG42A, ARG44G, ARG64A, ARG70A, ASN33G, ASP33A, ASP65A, GLN38G, GLN41G, GLU36A, GLY35G, GLY37G, GLY39A, GLY91A, HIS38A, ILE36G, ILE41A, LEU46G, LYS32G, LYS43G, LYS68A, LYS92A, LYS93A, PHE34G, PRO42G, PRO66A, TYR34A, TYR40A, TYR49G, TYR67A, TYR69A, VAL40G
• A-N: ARG3A, ARG9A, GLN8A, ILE5A, LYS77N, SER231A, VAL4A
• A-Z: ARG135Z, TYR69A
• A-g: ARG42A, ARG80g, ARG91g, ASP46g, GLY45g, ILE95g, LYS46A, PHE87A
• A-p: ALA65p, ARG17p, ARG80p, ASP176A, GLU30p, GLU80A, GLY171A, GLY66p, GLY81A, HIS83A, LYS177A, LYS181A, LYS28p, LYS62p, THR73p, VAL82A
• B-O: ALA154O, ALA258B, ALA63O, ALA75O, ARG163O, ARG68O, ARG97B, ASN65O, ASP151O, GLU106O, GLU150O, GLU157O, GLU94B, GLY107O, GLY98B, HIS259B, ILE108O, LEU14B, LEU156O, LEU99B, LYS148O, LYS153B, LYS155O, LYS159O, LYS66O, MET261B, PHE105O, PHE64O, PRO109O, PRO110O, PRO257B, PRO76O, PRO96B, SER156B, SER263B, THR62O, THR67O, THR95B, TRP147O, TRP262B, TYR149O, TYR154B, VAL152O, VAL153O, VAL260B, VAL264B, VAL93B
• B-P: ARG21B, ARG69P
• B-V: ALA75B, ALA8B, ARG10B, ARG45V, ARG48V, ARG4B, ARG58B, ARG62B, ARG70B, ARG86V, ARG87V, ARG88V, ASN47V, ASP124V, ASP89V, GLU121V, GLU71B, GLU74B, GLU7B, GLY12B, GLY234B, GLY64B, GLY8V, GLY90V, HIS11B, HIS68B, ILE56B, LEU125V, LEU46V, LEU60B, LYS10V, LYS120V, LYS236B, LYS237B, LYS5B, LYS66B, PHE11V, PHE67B, PHE92V, PRO9B, SER44V, SER65B, THR235B, THR55B, THR9V, TYR6B, VAL137V, VAL57B, VAL72B, VAL73B, VAL91V
• B-W: ALA11W, ALA362B, ALA378B, ALA37W, ARG17W, ARG369B, ARG56W, ARG58B, ASN33W, ASP299B, ASP360B, ASP59B, ASP6W, GLN32W, GLN371B, GLU375B, GLU65W, GLU71B, GLU74B, GLY10W, GLY16W, GLY18W, GLY366B, GLY368B, GLY381B, GLY62W, ILE13W, ILE359B, ILE56B, ILE5W, ILE63W, LEU383B, LYS12W, LYS2W, LYS303B, LYS357B, LYS35W, LYS364B, LYS367B, LYS376B, LYS57W, MET1W, MET308B, MET380B, PHE298B, PHE365B, PHE370B, PHE379B, PRO15W, SER34W, SER363B, SER36W, SER9W, THR19W, THR296B, THR301B, THR361B, THR372B, THR382B, THR52W, THR54B, THR55B, THR64W, TRP358B, TRP51W, TYR14W, VAL3W, VAL53W, VAL57B, VAL72B, VAL73B
• C-E: ARG22E, ARG309C, ARG326C, GLN322C, LEU313C, LYS19E, LYS23E, LYS308C, LYS315C, VAL312C
• C-F: ALA167F, ALA331C, ALA344C, ALA352C, ALA353C, ALA42F, ALA49F, ALA50F, ALA69F, ALA71F, ALA72F, ARG145F, ARG151F, ARG160F, ARG326C, ARG33F, ARG41F, ARG47F, ARG60F, ARG67F, ASN166F, ASN244F, ASN316C, ASN328C, ASN48F, ASP165F, ASP182F, ASP183F, ASP68F, GLN146F, GLN322C, GLN52F, GLN64F, GLU337C, GLU345C, GLU46F, GLU56F, GLU59F, GLY152F, GLY340C, GLY348C, GLY73F, HIS311C, ILE144F, ILE168F, ILE169F, ILE181F, ILE185F, ILE43F, ILE44F, ILE63F, LEU147F, LEU163F, LEU313C, LEU318C, LEU324C, LEU325C, LEU327C, LEU339C, LEU359C, LEU45F, LYS150F, LYS241F, LYS308C, LYS314C, LYS315C, LYS319C, LYS332C, LYS338C, LYS342C, LYS343C, LYS346C, LYS350C, LYS40F, LYS53F, LYS66F, LYS70F, PHE153F, PHE334C, PHE355C, PRO162F, PRO317C, PRO329C, PRO351C, SER142F, SER164F, SER180F, SER341C, SER74F, THR143F, THR310C, THR347C, THR349C, THR356C, THR358C, THR57F, TYR141F, TYR149F, TYR330C, TYR51F, TYR55F, TYR75F, TYR76F, VAL148F, VAL161F, VAL312C, VAL323C, VAL333C, VAL354C
• C-L: ALA29L, ALA49C, ALA51C, ARG107C, ARG21L, ARG47C, ASN110C, GLN19L, GLN28L, GLN48C, GLU20L, GLU54C, LYS104C, LYS108C, LYS23L, PHE26L, PRO102C, THR105C, TRP106C, TRP109C, TRP18L, TYR50C, VAL22L, VAL24L
• C-N: ALA49C, ARG107C, ARG201N, ARG203N, ARG47C, ASN110C, ASN45C, LEU197N, LEU199N, LYS108C, LYS112C, LYS118C, LYS204N, LYS44C, LYS46C, SER41C, THR105C, TRP106C, TRP109C, TRP200N, TYR202N, VAL111C, VAL113C, VAL42C
• C-Q: ALA103Q, ALA108Q, ALA127C, ALA128Q, ALA131Q, ALA28C, ALA298C, ALA302C, ALA305C, ALA37Q, ALA42Q, ARG105Q, ARG111Q, ARG130Q, ARG288C, ARG300C, ARG31C, ARG38Q, ARG39Q, ASN23Q, ASN291C, ASN45Q, ASP125Q, ASP22Q, ASP285C, ASP33C, ASP41Q, GLN126Q, GLN135Q, GLN296C, GLU265C, GLU294C, GLY303C, HIS279C, HIS36C, ILE122Q, ILE280C, ILE281C, ILE289C, ILE290C, ILE295C, ILE299C, ILE30C, ILE34C, LEU104Q, LEU124Q, LEU127Q, LEU244C, LEU26Q, LEU28Q, LEU29Q, LEU32Q, LEU36Q, LEU52Q, LYS133Q, LYS27Q, LYS31Q, LYS46Q, PHE106Q, PHE35Q, PRO132Q, PRO277C, PRO29C, PRO301C, PRO32C, SER124C, SER21Q, SER278C, SER27C, SER282C, SER284C, SER292C, SER293C, SER297C, THR123Q, THR275C, THR283C, THR287C, THR34Q, THR37C, THR40Q, THR86Q, TYR120C, TYR25Q, TYR33Q, VAL129Q, VAL24Q, VAL286C, VAL30Q
• C-S: ALA127S, ALA67S, ARG26S, ARG28S, ARG99S, ASN62S, ASN65S, ASP362C, GLN63S, GLN8S, GLU357C, GLU6S, HIS361C, ILE10S, ILE61S, ILE64S, LEU24S, LEU359C, LYS125S, LYS360C, MET27S, PHE355C, SER60S, THR356C, THR358C, TYR7S, VAL126S
• C-T: ALA152T, ALA352C, ASN146T, ASP362C, GLN149T, GLU144T, GLU357C, GLY145T, HIS361C, LEU151T, LEU359C, LYS360C, PHE355C, PRO148T, THR143T, THR150T, THR358C, VAL147T, VAL354C
• C-Y: ALA2Y, ARG12Y, ARG13Y, ARG16Y, ARG195C, ARG197C, ARG198C, ARG220C, ASN196C, ASN221C, ASP11Y, GLN4Y, GLY192C, LEU187C, LYS14Y, LYS193C, LYS217C, LYS3Y, SER10Y, SER9Y, TRP199C, TYR194C, VAL216C
• C-a: ARG107C, ARG4a, HIS36C, LYS44C, PHE5a, PRO2a, SER3a, THR40C
• C-e: ARG141C, ARG309C, LYS62e, LYS80e
• C-j: ALA51j, ARG55j, ARG56j, ARG84C, GLN59C, HIS58C, LYS52j, LYS55C, SER61C, THR60C, VAL77C
• D-I: ALA218I, ALA219I, ALA283D, ALA287D, ALA288D, ALA291D, ALA292D, ALA294D, ARG211I, ARG282D, ARG285D, ASN208I, ASN209I, GLN220I, GLN296D, GLN297D, GLU207I, GLU215I, GLY295D, ILE210I, ILE290D, LEU206I, LEU293D, LYS202I, LYS289D, PHE213I, PHE217I, PRO214I, SER205I, TYR216I, VAL286D
• D-J: ALA98J, ARG137J, ARG141J, ARG143J, ARG152D, ARG22D, ARG23D, ARG24D, ARG54D, ASN150J, ASN57D, ASP29D, CYS144J, GLN151D, GLN4D, GLU25D, GLY100J, GLY146J, GLY149D, GLY26D, ILE148D, ILE61D, LEU150D, LYS142J, LYS145J, LYS153J, LYS156J, LYS27D, PHE55D, SER97J, THR154J, THR155J, THR28D, THR56D, THR99J
• D-T: ALA11D, ALA24T, ALA42D, ARG15D, ARG17T, ARG20T, ARG23D, ARG33D, ARG35D, ARG50D, ARG92T, ASN45D, ASN66T, ASP18T, ASP29D, ASP38T, ASP72D, GLN17D, GLN32D, GLN39D, GLU94T, GLY23T, GLY71D, HIS22T, HIS26T, HIS40D, HIS98T, ILE48T, ILE69D, ILE96T, LEU27T, LEU31T, LEU36D, LEU91T, LYS21T, LYS32T, LYS34D, LYS35T, LYS41D, LYS43D, LYS48D, LYS69T, PHE16D, PHE19T, PHE20D, PRO19D, PRO47D, SER13D, SER14D, SER28T, SER66D, SER67D, SER70T, SER71T, THR18D, THR28D, THR29T, THR38D, THR46D, THR68D, THR68T, THR70D, TYR12D, TYR30D, TYR30T, TYR31D, TYR34T, TYR44D, VAL25T, VAL33T, VAL36T, VAL37D, VAL64T, VAL67T, VAL72T, VAL93T
• D-b: ALA42D, ASP36b, HIS40D, LYS38b, LYS43D, PHE39b, TYR44D
• E-M: ALA110M, ALA111M, ALA161E, ARG108M, ARG109M, ARG117M, ARG51E, ASP114M, ASP169E, GLN119M, GLN126M, GLN157E, GLU107M, GLU116M, ILE41E, ILE85E, LEU112M, LEU123M, LEU154E, LEU155E, LEU159E, LEU165E, LEU174E, LYS156E, LYS166E, LYS170E, LYS175E, LYS90E, MET121M, MET173E, PHE115M, PHE118M, PHE163E, PHE176E, PRO153E, PRO171E, SER160E, SER162E, SER164E, SER88E, THR113M, THR152E, THR87E, THR89E, TYR158E, VAL120M, VAL122M, VAL39E
• E-O: ASN167E, GLU4O, LEU154E, PHE197O, VAL3O
• E-S: GLY168E, LYS161S, LYS170E, THR160S
• E-e: ALA16E, ALA2e, ALA3E, ALA6E, ALA77e, ALA97e, ASN78e, ASN99e, ASP14E, ASP81e, GLN4E, GLU13E, GLU95e, HIS6e, HIS71e, HIS88e, HIS98e, ILE100e, ILE96e, LEU4e, LEU66e, LEU75e, LEU82e, LEU85e, LYS5E, LYS72e, LYS80e, LYS8E, LYS90e, MET87e, PHE74e, PRO11E, PRO5e, PRO7E, SER12E, SER2E, SER3e, THR73e, THR84e, THR86e, THR89e, THR91e, TRP9E, TYR10E, TYR92e, VAL15E, VAL76e
• E-f: ALA161E, ALA2f, ALA32E, ALA36f, ALA41f, ALA44E, ALA81E, ALA86E, ARG31E, ARG48E, ARG48f, ARG6f, ARG82E, ASN106f, ASN167E, ASN80E, ASP169E, ASP40f, GLN39f, GLN42f, GLU33f, GLU3f, GLY168E, GLY34f, GLY45E, GLY46f, GLY49E, HIS172E, HIS5f, ILE100f, ILE107f, ILE32f, ILE41E, ILE85E, LEU102f, LEU165E, LEU174E, LEU30E, LEU34E, LEU40E, LEU42E, LEU43E, LEU7f, LYS10f, LYS166E, LYS170E, LYS175E, LYS29E, LYS47f, LYS50E, MET173E, PHE101f, PHE163E, PHE176E, PHE43f, PHE47E, PRO104f, PRO171E, SER105f, SER162E, SER164E, SER33E, SER4f, THR37f, THR87E, TRP68f, TYR103f, TYR44f, TYR83E, TYR8f, VAL35f, VAL84E, VAL9f
• F-Q: ARG100F, ARG107F, ARG110F, ARG88F, ASN93F, ASP4Q, GLN104F, GLY2Q, GLY91F, HIS5Q, ILE111F, ILE3Q, ILE92F, ILE95F, LEU103F, LEU105F, LEU108F, LYS101F, LYS206F, PRO99F, SER113F, SER7Q, THR109F, THR6Q
• F-S: ALA2S, ALA31S, ALA37S, ALA54S, ARG119S, ARG12S, ARG232F, ARG26S, ARG40S, ASN231F, ASN33S, ASN62S, GLN225F, GLN80F, GLN8S, GLU233F, GLU234F, GLU34S, GLU57S, GLU78F, GLY11S, GLY226F, GLY227F, GLY230F, GLY56S, GLY73F, HIS222F, HIS81F, ILE10S, ILE224F, ILE236F, ILE36S, ILE58S, ILE61S, LEU124F, LEU14S, LEU24S, LYS121F, LYS128F, LYS221F, LYS38S, LYS52S, LYS53S, LYS5S, LYS66F, LYS70F, MET1S, PHE118S, PHE223F, PHE235F, SER32S, SER39S, SER60S, SER74F, TRP42S, TYR138F, TYR43S, TYR75F, TYR76F, TYR7S, VAL35S, VAL59S, VAL77F
• F-T: ALA122F, ALA133T, ALA65F, ALA69F, ALA72F, ALA79F, ARG136T, ARG139T, ASN146T, ASP68F, GLN131T, GLN134T, GLN80F, GLU137T, GLU144T, GLU78F, GLY73F, HIS81F, ILE140T, ILE62F, LEU124F, LEU83F, LYS118F, LYS121F, LYS66F, LYS70F, LYS82F, PRO132T, PRO135T, PRO148T, SER138T, SER142T, SER74F, THR120F, THR123F, THR143T, TYR75F, TYR76F, VAL119F, VAL141T, VAL147T, VAL191F, VAL77F
• F-b: ARG14b, PRO97F, THR13b
• G-N: ALA141G, ALA168G, ALA196G, ALA3N, ALA76G, ARG20N, ARG24N, ARG26N, ARG31N, ARG41N, ARG44N, ARG49N, ARG57G, ARG60G, ARG63N, ARG68G, ASN137G, ASN34N, ASP158G, ASP17N, ASP46N, GLN11N, GLN23N, GLN32N, GLN59G, GLN61G, GLU144G, GLU161G, GLU29N, GLU54G, GLU8N, GLY135G, GLY234G, GLY235G, GLY236G, GLY2N, HIS138G, ILE143G, ILE160G, ILE64G, ILE67G, ILE75G, LEU10N, LEU136G, LEU142G, LEU162G, LEU166G, LEU169G, LEU19N, LEU22N, LEU65G, LEU69G, LEU7N, LYS172G, LYS183G, LYS193G, LYS230G, LYS33N, LYS5N, LYS62G, LYS63G, LYS70G, MET173G, PHE165G, PHE21N, PRO159G, PRO42N, PRO45N, PRO72G, PRO73G, SER16N, SER66G, THR194G, THR43N, THR74G, TRP233G, TRP28N, TYR119N, TYR30N, TYR4N, TYR55G, TYR6N, VAL139G, VAL140G, VAL157G, VAL163G, VAL164G, VAL18N, VAL197G, VAL25N, VAL27N, VAL58G, VAL71G
• G-X: ALA30X, ARG27X, ARG33X, ARG44G, ARG48G, ARG60G, ASN45G, LEU24X, LEU34X, LEU46G, LYS25X, LYS43G, LYS51G, PHE32X, PRO35X, PRO42G, PRO53G, SER29X, SER47G, THR28X, THR31X, TRP52G, TYR49G, TYR55G, VAL26X, VAL50G, VAL56G
• G-Z: ALA124Z, ALA63Z, ARG121Z, ARG65Z, ASN24G, GLN123Z, GLN128Z, GLU119Z, GLY125Z, HIS122Z, HIS28G, HIS57Z, LEU26G, LEU51Z, LYS126Z, LYS52Z, LYS55Z, LYS56Z, PHE131Z, PRO25G, PRO50Z, SER132Z, SER29G, THR27G, THR30G, THR54Z, THR66Z, TRP129Z, VAL53Z, VAL62Z
• G-g: ASN33G, GLN38G, LYS103g, LYS99g
• G-i: ALA141G, ALA168G, ALA48i, ARG36i, ARG45i, ARG55i, ASN137G, ASN145G, CYS170G, GLN77G, GLU144G, GLU46i, GLY49i, ILE143G, ILE47i, ILE75G, LEU166G, LEU169G, LEU43i, LYS171G, LYS172G, LYS230G, MET173G, PHE165G, PHE39i, PRO167G, PRO72G, PRO73G, SER42i, THR74G, TRP233G, TYR226G, VAL140G, VAL163G, VAL164G, VAL40i, VAL44i
• H-M: ALA56H, ALA9M, ARG23H, ASN49H, ASN50H, ASN59H, ASP40M, ASP42H, ASP4M, GLN41M, GLN51H, GLN5H, GLY15H, GLY60H, HIS58H, ILE10H, ILE20H, ILE38M, ILE4H, ILE53H, ILE6M, ILE79H, LEU14M, LEU52H, LYS21H, LYS26H, LYS2H, LYS42M, LYS47H, LYS54H, LYS8M, MET1H, PHE45H, PRO13H, SER10M, SER19H, SER22H, SER2M, SER5M, THR17H, THR3M, THR44H, THR46H, TRP12M, TYR3H, VAL12H, VAL15M, VAL16H, VAL18H, VAL25H, VAL27H, VAL28H, VAL43H, VAL48H, VAL55H, VAL57H, VAL7M
• H-O: ARG133O, ARG23H, ASN59H, ASP42H, GLY132O, GLY60H, GLY61H, HIS40H, HIS64H, ILE41H, LYS130O, LYS134O, LYS2H, LYS63H, PRO131O, TYR135O
• H-S: ALA56H, ARG113S, ARG137S, ASN59H, ASP42H, GLN138S, GLN142S, GLN5H, GLY60H, HIS154S, HIS58H, HIS64H, ILE4H, LEU144S, LEU148S, LEU152S, LYS141S, LYS149S, LYS2H, MET1H, PHE143S, PHE150S, PRO151S, PRO153S, THR145S, THR44H, THR6H, TYR139S, TYR3H, VAL140S, VAL57H
• H-m: ALA158H, ALA159H, ALA84m, ALA86m, ALA95H, ARG166H, ARG173H, ARG91H, ASN90m, ASP142H, ASP171H, ASP177H, ASP92m, CYS165H, CYS91m, GLN162H, GLN163H, GLU143H, GLU79m, GLY178H, HIS183H, HIS96H, ILE172H, ILE179H, ILE77m, ILE78m, LEU176H, LEU82m, LEU85m, LYS124m, LYS125m, LYS126m, LYS128m, LYS141H, LYS174H, LYS184H, LYS83m, LYS88m, LYS89H, LYS93m, MET90H, PHE117H, PHE175H, PHE97H, PRO98H, SER182H, SER81m, SER87m, TYR180H, TYR89m, TYR92H, TYR94H, VAL140H, VAL167H, VAL181H, VAL93H
• I-S: ARG84S, ASN55I, GLN162I, GLY86S, HIS88S, LYS164I, SER83S, SER85S, THR87S
• I-T: ARG12T, ARG21I, ARG90I, ASN175I, ASP177I, CYS49I, GLN133I, GLU157T, GLY132I, HIS51I, ILE134I, ILE160T, ILE166I, LEU167I, LYS164I, LYS169I, LYS170I, PHE159T, SER168I, THR158T, TYR156T, TYR22I, VAL50I, VAL53I
• I-b: ARG116I, GLY117I, LYS3b, MET115I
• L-N: ALA29L, ARG100L, ARG193N, ARG201N, ARG203N, ARG21L, ARG35L, ASN195N, ASP27L, GLN194N, GLN19L, GLN28L, GLU20L, GLY30L, HIS13L, HIS17L, HIS25L, LEU197N, LEU199N, LYS16L, LYS176N, LYS192N, LYS204N, LYS23L, LYS31L, LYS32L, PHE14L, PHE26L, SER198N, THR196N, TRP18L, TRP191N, TRP200N, TYR202N, VAL22L, VAL24L
• L-Q: ALA162Q, ARG164Q, ASN12L, ASN6L, GLU173Q, GLY154Q, GLY156Q, HIS152Q, ILE165Q, ILE9L, LEU10L, LEU166Q, LEU7L, LYS11L, LYS161Q, LYS171Q, LYS5L, MET155Q, PHE153Q, PHE172Q, PRO163Q, PRO8L, SER167Q
• L-Y: ASN37L, LEU6Y, VAL33L
• L-a: ALA106a, ALA107a, ALA127a, ALA134a, ALA141a, ALA149a, ALA151L, ALA156L, ALA158L, ALA166L, ALA173L, ALA2L, ALA35a, ALA66a, ALA99a, ARG128a, ARG139a, ARG157L, ARG15L, ARG168L, ARG171L, ARG174L, ARG32a, ARG42a, ARG59L, ARG67L, ASN162L, ASN44a, ASN66L, ASN6L, ASP103a, ASP153L, ASP161L, ASP46a, GLN149L, GLN160L, GLN38a, GLN64a, GLN65a, GLN89a, GLU135a, GLU136a, GLU146a, GLU155L, GLU164L, GLU97a, GLY108a, GLY110a, GLY142a, GLY143a, GLY163L, GLY30a, GLY31a, GLY33a, GLY36a, GLY37a, HIS28a, HIS39a, HIS40a, HIS41a, HIS49a, HIS67a, ILE102a, ILE124a, ILE138a, ILE148a, ILE3L, ILE43a, ILE82a, ILE9L, LEU105a, LEU10L, LEU133a, LEU147a, LEU170L, LEU7L, LYS111a, LYS11L, LYS126a, LYS132a, LYS47a, LYS5L, LYS64L, LYS68L, LYS70a, LYS86a, LYS96a, MET34a, MET45a, PHE129a, PHE167L, PHE53a, PHE68a, PRO100a, PRO122a, PRO29a, PRO71a, PRO83a, PRO8L, SER131a, SER165L, SER4L, SER95a, THR104a, THR152L, THR169L, THR62L, THR98a, TRP69a, TYR109a, TYR48a, TYR52a, TYR65L, TYR90a, VAL101a, VAL121a, VAL123a, VAL125a, VAL130a, VAL144a, VAL145a, VAL154L, VAL159L, VAL63L
• L-h: ALA110h, ALA117h, ALA120h, ALA132L, ALA135L, ALA141L, ALA142L, ALA143L, ALA47L, ALA87L, ALA88L, ALA90L, ARG114h, ARG128L, ARG42L, ARG49L, ARG91L, ASN129L, ASP52L, GLN108h, GLN113h, GLN120L, GLN137L, GLU118L, GLU134L, GLU136L, GLY130L, GLY94L, ILE109h, ILE118h, ILE123L, ILE124L, ILE46L, ILE93L, ILE95L, LEU139L, LEU51L, LEU53L, LEU54L, LYS106h, LYS107h, LYS115h, LYS119h, LYS122L, LYS131L, LYS45L, PHE111h, PHE126L, PHE145L, PRO112h, PRO127L, PRO48L, PRO50L, SER121L, SER140L, THR144L, THR86L, THR92L, TYR116h, TYR119L, TYR89L, VAL125L, VAL138L
• L-i: ALA166L, ALA173L, ALA23i, ALA78L, ALA82L, ALA8i, ARG100L, ARG101L, ARG104L, ARG171L, ARG174L, ARG180L, ARG183L, ARG59L, ARG67L, ASN103L, ASN105L, ASN12i, ASN66L, ASP110L, GLN102L, GLN106L, GLU107L, GLU176L, GLU184L, GLU79L, GLY10i, GLY14i, GLY181L, GLY6i, HIS99L, ILE108L, ILE7i, ILE9i, LEU11i, LEU170L, LEU172L, LEU77L, LYS13i, LYS15i, LYS16i, LYS177L, LYS178L, LYS25i, LYS4i, LYS81L, MET20i, PHE109L, PHE179L, PRO22i, PRO24i, SER165L, SER175L, SER19i, THR152L, THR169L, THR18i, THR21i, THR2i, THR5i, THR76L, TYR28i, VAL113L, VAL17i, VAL63L
• M-O: ALA104M, ALA110M, ALA111M, ALA134M, ALA136M, ALA138M, ALA181O, ALA183O, ALA184O, ALA185O, ALA186O, ALA191O, ALA195O, ALA196O, ARG106M, ARG108M, ARG109M, ARG117M, ARG124M, ARG128M, ASN182O, ASP189O, GLN105M, GLN119M, GLN126M, GLN193O, GLU107M, GLU116M, GLU187O, GLY198O, LEU112M, LEU123M, LEU135M, LEU194O, LEU197O, LYS125M, LYS127M, LYS132M, LYS133M, LYS137M, LYS176O, LYS177O, LYS192O, MET121M, PHE115M, PHE118M, PHE174O, PHE197O, SER179O, SER180O, SER188O, THR113M, THR130M, THR175O, THR184O, TYR129M, TYR199O, VAL120M, VAL122M, VAL131M, VAL178O, VAL190O
• M-S: ALA101S, ALA102S, ALA57M, ALA76M, ARG13M, ARG155S, ARG19M, ARG55M, ARG74M, ARG77M, ARG95S, ASN11M, ASN74S, ASP147S, ASP40M, ASP47M, ASP96S, GLN108S, GLN142S, GLN157S, GLN41M, GLN56M, GLU104S, GLU16M, GLU37M, GLY61M, GLY75M, HIS154S, HIS68S, ILE35M, ILE38M, ILE39M, ILE46M, ILE58M, ILE94S, LEU144S, LEU148S, LEU14M, LEU152S, LEU22M, LEU45M, LEU60M, LEU65M, LYS146S, LYS149S, LYS158S, LYS24M, LYS25M, LYS42M, LYS43M, LYS71S, LYS73S, PHE143S, PHE150S, PHE171S, PRO151S, PRO153S, PRO54M, PRO67M, PRO69S, PRO73M, SER10M, SER98S, THR105S, THR132S, THR145S, THR160S, THR170S, THR66M, THR69M, THR70S, THR78M, TRP12M, TRP99M, TYR139S, TYR172S, VAL140S, VAL156S, VAL15M, VAL17M, VAL21M, VAL36M, VAL44M, VAL63M, VAL64M, VAL72S, VAL97S
• M-f: ALA2f, GLU3f, LYS125M, MET121M
• N-a: ASN181N, HIS178N, HIS62a
• N-h: ALA146N, ALA87h, ALA91h, ALA97h, ARG105h, ARG114N, ARG143N, ARG144N, ARG147N, ARG86h, ARG89h, ARG90h, ASN149N, ASP145N, ASP153N, CYS152N, GLN104h, GLN138N, GLN99h, GLU102h, GLU96h, HIS139N, ILE142N, ILE151N, LEU88h, LEU92h, LYS103h, LYS140N, LYS157N, LYS74h, PHE95h, PRO137N, PRO154N, SER98h, THR101h, THR93h, TRP150N, TYR148N, TYR75h, VAL100h
• N-i: ALA3N, ALA48i, ARG12N, ARG20N, ARG36i, ARG41i, ARG45i, ARG55i, ARG56i, ARG76i, ASP17N, GLN11N, GLN15N, GLU54i, GLU89i, GLU8N, GLU9N, GLY2N, GLY49i, ILE47i, LEU10N, LEU19N, LEU43i, LEU50i, LEU7N, LYS13N, LYS14N, LYS5N, LYS86i, PHE39i, PRO52i, SER16N, SER42i, SER51i, THR37i, TYR4N, TYR53i, TYR6N, VAL18N, VAL40i, VAL44i
• O-S: ALA11O, ALA123O, ARG117O, ARG125O, ARG128O, ARG155S, ARG167S, ARG37O, ASN42O, ASP10O, ASP13O, GLN122O, GLN157S, GLN26O, GLN31O, GLN4O, GLU40O, GLU4O, GLY11O, GLY13O, HIS14O, HIS154S, ILE23O, ILE33O, ILE9O, LEU124O, LEU127O, LEU129O, LEU15O, LEU19O, LEU27O, LEU41O, LYS116O, LYS12O, LYS130O, LYS158S, LYS161S, LYS166S, LYS25O, LYS32O, PHE163S, PRO121O, PRO131O, PRO153S, PRO168S, SER159S, SER164S, SER169S, THR160S, THR162S, THR170S, TYR165S, VAL118O, VAL119O, VAL120O, VAL126O, VAL156S, VAL22O, VAL23O, VAL35O, VAL3O, VAL7O, VAL8O
• O-f: ALA91f, ALA93O, ALA96f, ALA97O, ALA98O, ARG101O, ARG18f, ARG94O, ASN29O, GLN26O, GLN31O, GLU33f, GLU4O, GLY30O, GLY34f, GLY95O, GLY95f, HIS13f, LEU14f, LEU27O, LEU28O, LYS10f, LYS12f, LYS25O, LYS31f, LYS32O, LYS92f, PHE94f, PRO5O, SER15f, SER97f, THR93f, TYR16f, VAL3O, VAL80f
• P-d: ASP47d, ASP53P, GLU49P, LEU52P, LYS86d
• Q-a: ALA112Q, ALA162Q, ALA175Q, ALA91Q, ARG117a, ARG164Q, ARG170Q, ARG174Q, ARG176Q, ARG178Q, ARG179Q, ARG42a, ARG59a, ARG69Q, ARG87a, ARG92Q, ASN74a, ASP46a, ASP76a, ASP85a, ASP88a, ASP89Q, ASP90Q, GLN38a, GLU173Q, GLU84a, GLU95Q, GLY109Q, GLY116a, GLY154Q, GLY156Q, GLY160Q, GLY169Q, GLY177Q, GLY183Q, GLY37a, GLY51a, GLY54a, GLY57a, HIS152Q, HIS158Q, HIS49a, ILE118a, ILE165Q, ILE43a, ILE93Q, LEU166Q, LEU75a, LEU78a, LEU91a, LYS113Q, LYS115a, LYS116Q, LYS159Q, LYS161Q, LYS171Q, LYS182Q, LYS185Q, LYS47a, LYS55a, LYS63a, LYS77a, MET155Q, MET45a, MET58a, PHE172Q, PHE184Q, PHE53a, PHE61a, PHE94Q, PRO119a, PRO157Q, PRO163Q, PRO50a, SER181Q, THR80a, TRP79a, TYR48a, TYR52a, TYR60a, VAL121a, VAL186Q, VAL56a
• Q-b: ARG18b, ASN19b, LYS8Q
• R-X: ASN39R, LYS74X, SER37R
• S-T: ALA152T, ALA54S, ARG12S, ARG136T, ARG139T, ARG26S, ARG28S, ARG40S, ARG80S, ASN146T, ASN89S, ASP82S, GLN149T, GLN8S, GLU137T, GLU144T, GLU157T, GLU21S, GLU57S, GLY11S, GLY145T, GLY56S, GLY86S, HIS122S, HIS49S, HIS88S, ILE10S, ILE121S, ILE123S, ILE140T, ILE29S, ILE58S, LEU124S, LEU14S, LEU151T, LEU24S, LEU45S, LEU48S, LYS125S, LYS23S, LYS47S, LYS53S, MET27S, MET90S, PHE159T, PHE25S, PHE44S, PRO148T, PRO153T, PRO155T, PRO15S, PRO20S, PRO22S, SER142T, SER55S, SER60S, THR143T, THR150T, THR158T, THR87S, TRP42S, TRP78S, TYR156T, TYR41S, TYR43S, TYR81S, VAL126S, VAL141T, VAL147T, VAL154T, VAL19S, VAL51S, VAL59S, VAL79S, VAL9S
• S-f: ALA36f, GLY34f, LYS161S, LYS31f, THR160S, THR162S
• T-b: ALA16b, ARG18b, ARG40b, ARG83T, ARG88T, ASN19b, ASN66T, ASN77T, ASN82T, ASN90T, ASP36b, GLN12b, GLU86T, GLY20b, GLY34b, GLY73T, GLY81T, HIS17b, HIS7b, ILE21b, ILE75T, ILE76T, LEU32b, LEU85T, LYS15b, LYS22b, LYS23b, LYS25b, LYS33b, LYS3T, LYS69T, LYS78T, LYS87T, MET79T, PHE39b, PRO24b, PRO30b, PRO37b, SER31b, THR13b, THR26b, THR68T, TYR27b, TYR65T, TYR84T, VAL35b, VAL36T, VAL64T, VAL67T, VAL80T
• V-W: ALA37W, ALA82V, ARG17W, ARG23W, ARG30W, ARG43W, ARG80V, ARG86V, ARG87V, ASP25W, ASP89V, ASP97V, GLN81V, GLU4W, GLU96V, GLY116V, GLY119V, GLY134V, GLY16W, GLY18W, GLY24W, GLY90V, ILE13W, ILE28W, LEU20W, LEU93V, LYS27W, LYS41W, PHE21W, PHE29W, PHE31W, PHE40W, PHE92V, PHE95V, PRO117V, PRO15W, SER26W, SER84V, THR115V, THR19W, TRP85V, TYR94V, VAL118V, VAL135V, VAL136V, VAL137V, VAL22W, VAL91V
• X-h: ALA136X, ALA29h, ALA47X, ALA50X, ALA52h, ALA65h, ARG138X, ARG38h, ARG48h, ARG56X, ARG63h, ARG67h, ARG81h, ASN137X, ASN55X, ASN59h, ASP23h, ASP58X, ASP79h, GLN34h, GLN61h, GLN62h, GLN65X, GLN76h, GLN85X, GLU101X, GLU27h, GLU30h, GLU60h, GLU64X, GLU64h, GLY140X, HIS53X, ILE139X, ILE142X, ILE44h, ILE51h, ILE58h, ILE63X, ILE67X, LEU102X, LEU21h, LEU24h, LEU28h, LEU31h, LEU36h, LEU55h, LEU69h, LEU80h, LYS14h, LYS25h, LYS26h, LYS32h, LYS35h, LYS45X, LYS49X, LYS61X, LYS73h, LYS74h, LYS78h, PHE84X, PRO44X, PRO52X, PRO66X, PRO77h, SER37h, SER48X, SER59X, SER69X, THR56h, THR68X, TYR103X, TYR141X, TYR46X, TYR54X, TYR60X, TYR70h, TYR75h, VAL22h, VAL33h, VAL51X, VAL62X, VAL66h
• X-l: ALA14l, ARG115X, ASN117X, GLN11l, GLY118X, LEU113X, LYS10l, LYS120X, LYS15l, LYS17l, LYS18l, LYS5l, MET13l, MET88X, PHE7l, PRO116X, THR119X, VAL114X
• Y-j: ALA117Y, ALA88j, ARG121Y, ASP114Y, LYS113Y
• Y-l: ARG27Y, ARG30l, ASN32l, LEU29l, LEU76Y, LYS77Y, PHE20Y, PHE78Y, THR31l, TYR74Y
• Z-c: ALA11Z, ALA2Z, ALA41Z, ALA60c, ARG15Z, ARG35c, ARG84Z, ASN76Z, ASN78Z, ASP30Z, GLN36c, GLU31Z, GLU55c, GLY37c, GLY39Z, HIS40Z, HIS79Z, ILE25Z, LEU34c, LEU5Z, LEU62c, LEU80Z, LEU81Z, LYS28c, LYS32c, LYS38c, LYS3Z, LYS64c, LYS9Z, MET61c, PHE38Z, PHE4Z, PRO82Z, SER33c, SER39c, SER54c, SER63c, THR65c, THR83Z, TRP129Z, TYR27c, TYR58c, TYR59c, TYR77Z, TYR85Z, VAL10Z, VAL12Z, VAL14Z, VAL31c
• Z-g: ALA11Z, ALA19Z, ALA75g, ALA82g, ALA92g, ARG135Z, ARG15Z, ARG17Z, ARG74g, ARG80g, ARG84Z, ARG88g, ARG91g, ASN78Z, ASN83g, CYS81g, CYS84g, GLN98g, GLU87g, GLU96g, GLU97g, GLY16Z, GLY20Z, HIS79Z, ILE100g, ILE89g, ILE90g, ILE95g, LEU134Z, LEU80Z, LEU81Z, LEU94g, LYS133Z, LYS21Z, LYS22Z, LYS86g, PHE136Z, PHE93g, PRO82Z, SER73g, THR83Z, TRP129Z, TYR18Z, TYR76g, TYR85Z, VAL101g, VAL104g, VAL10Z, VAL12Z, VAL13Z, VAL14Z, VAL72g, VAL85g
• a-e: ARG12a, ARG19e, ARG21a, ARG33e, ARG43e, ASP39e, GLN35e, GLY13a, GLY37e, HIS11a, HIS14a, ILE38e, LYS34e, LYS36e, SER16a, VAL15a
• a-i: ALA127a, ALA149a, ALA8i, ARG128a, ASP103a, GLU146a, GLY10i, GLY110a, GLY14i, GLY6i, HIS67a, ILE148a, ILE7i, ILE9i, LEU105a, LEU147a, LYS126a, LYS13i, LYS15i, LYS16i, LYS4i, LYS70a, PHE129a, THR5i
• c-g: ALA92g, ARG52c, ARG88g, ARG91g, GLN98g, GLU55c, GLU57c, GLU87g, GLU97g, ILE100g, ILE89g, ILE90g, ILE95g, LEU51c, LEU56c, LEU62c, LEU94g, LYS102g, LYS28c, LYS53c, LYS86g, MET61c, PHE93g, PRO49c, SER54c, TYR27c, TYR58c, TYR59c, VAL101g, VAL50c
• c-p: ARG86c, LYS44p
• e-f: ARG21f, ARG47e, ASN23f, LYS20f, SER19f, VAL22f
• g-l: ALA2l, ALA3l, ARG10g, ARG9g, ASN11g, GLN4l, LYS5l
• h-j: ALA82h, ARG10h, ARG67h, ARG73j, ARG81h, ARG86h, ARG89h, GLN79j, GLY77j, GLY81j, LEU80h, LEU88h, LYS83h, LYS84h, LYS85j, PHE74j, PHE78j, THR80j, THR85h, TYR66j, TYR7h, VAL70j
• j-l: ALA2l, ARG21j, ARG24j, ARG25j, ARG8l, ASN20j, ASN50l, CYS19j, CYS22j, GLY23j, HIS16j, ILE51l, ILE9l, LEU18j, LYS12l, LYS14j, LYS48l, MET13l, MET49l, PHE27j, SER26j, SER6l, THR17j
• q-r: GLN195q, UNK35-4.9306142.916216