3U33

crystal structure of the e. coli adaptive response protein aidb in the space group p3(2)

• Total interactions analyzed: 66
• Total true interactions: 28
• Strongest Interaction:
  • Chains: J-K
  • Int. Res.: 62
  • Norm. En. per Res.: -4.1841
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-160.4098	-60.0053	-919.123	-1139.5381	301	41	10	34515	18	108	99
A-C	0.0	-10.1698	-184.063	-194.2328	106	1	2	7286	0	30	35
A-D	-30.2929	2.1644	-189.878	-218.0065	59	7	0	6350	6	45	45
A-K	0.0	4.2547	-14.8871	-10.6324	37	0	0	1054	0	7	8
A-L	-12.533	0.0	-106.322	-118.855	70	4	0	4396	0	17	24
B-C	-29.7713	1.005	-172.812	-201.5783	58	5	0	6148	5	44	46
B-D	0.0	-38.9415	-195.713	-234.6545	106	1	2	7625	0	32	37
B-L	0.0	0.0	-10.6436	-10.6436	34	0	0	841	0	7	6
C-D	-153.0727	-74.6065	-928.299	-1155.9782	301	36	10	34514	19	107	97
C-E	0.0	0.0	-8.8446	-8.8446	19	0	0	586	0	6	7
C-F	0.0	0.0	-0.4687	-0.4687	8	0	0	98	0	0	0
D-E	0.0	0.0	-0.117	-0.117	3	0	0	17	0	5	6
D-F	0.0	0.0	-16.28	-16.28	24	1	0	961	0	6	7
E-F	-164.6618	-34.8941	-913.108	-1112.6639	296	38	10	34221	19	108	95
E-G	0.0	-24.6106	-174.148	-198.7586	107	2	2	7304	0	31	35
E-H	-28.2359	-26.7763	-181.607	-236.6192	58	6	0	6247	5	43	45
F-G	-26.3007	5.1389	-172.245	-193.4069	57	6	0	6039	5	42	46
F-H	0.0	-38.504	-192.233	-230.737	104	3	2	7777	0	32	35
G-H	-166.5681	-93.8667	-953.689	-1214.1238	303	35	10	35119	21	108	98
G-I	0.0	0.0	-1.6355	-1.6355	20	0	0	241	0	8	6
H-I	0.0	0.0	-18.9132	-18.9132	40	0	0	1240	0	12	12
H-J	0.0	0.0	-2.452	-2.452	25	0	0	305	0	7	6
I-J	-159.6349	-72.2489	-944.173	-1176.0568	301	41	10	34754	22	108	96
I-K	0.0	-11.8635	-212.562	-224.4255	105	1	2	7681	1	34	37
I-L	-38.1037	-7.9874	-181.891	-227.9822	58	7	0	6319	8	45	47
J-K	-45.0417	-17.1583	-197.213	-259.4131	62	8	0	6675	8	46	48
J-L	0.0	-40.416	-209.19	-249.606	105	2	2	7745	1	31	37
K-L	-144.1516	-28.1254	-895.284	-1067.561	295	37	10	33703	16	110	96

Interface residues

• A-B: ALA251A, ALA251B, ALA276A, ALA276B, ALA394A, ALA394B, ALA396A, ALA396B, ALA478A, ALA478B, ARG199A, ARG199B, ARG253A, ARG253B, ARG256A, ARG256B, ARG264A, ARG264B, ARG324A, ARG324B, ARG338A, ARG338B, ARG343A, ARG343B, ARG388A, ARG388B, ARG413A, ARG413B, ARG416A, ARG416B, ARG469A, ARG469B, ARG483A, ARG483B, ARG518A, ARG518B, ARG522A, ARG522B, ASN10A, ASN10B, ASN196A, ASN196B, ASN263A, ASN263B, ASN266A, ASN266B, ASN329A, ASN329B, ASN421A, ASN421B, ASN429A, ASN429B, ASP192A, ASP192B, ASP259A, ASP259B, ASP275A, ASP275B, ASP434A, ASP434B, ASP516A, ASP516B, CYS386A, CYS386B, CYS406A, CYS406B, CYS432A, CYS432B, GLN11A, GLN11B, GLN188A, GLN188B, GLN274A, GLN274B, GLN333A, GLN334A, GLN334B, GLN472A, GLN472B, GLN473A, GLN473B, GLN488A, GLN4A, GLN4B, GLN528A, GLN528B, GLU186A, GLU186B, GLU255A, GLU255B, GLU270A, GLU270B, GLU272A, GLU272B, GLU395A, GLU395B, GLU398A, GLU398B, GLU407A, GLU407B, GLU408A, GLU408B, GLU417A, GLU417B, GLU479A, GLU479B, GLU480A, GLU480B, GLU484A, GLU484B, GLU525A, GLU525B, GLY189A, GLY189B, GLY190A, GLY190B, GLY212A, GLY212B, GLY262A, GLY262B, GLY328A, GLY328B, GLY389A, GLY389B, GLY401A, GLY401B, GLY402A, GLY402B, GLY404A, GLY404B, GLY426A, GLY426B, GLY428A, GLY428B, GLY482A, GLY482B, GLY519A, GLY519B, GLY520A, GLY520B, HIS213A, HIS213B, HIS2A, HIS2B, HIS320A, HIS325A, HIS325B, HIS339A, HIS339B, HIS6A, HIS6B, ILE288A, ILE288B, ILE403A, ILE403B, ILE423A, ILE423B, ILE430A, ILE430B, ILE485A, ILE485B, LEU210A, LEU210B, LEU257A, LEU257B, LEU261A, LEU261B, LEU331A, LEU331B, LEU336A, LEU336B, LEU341A, LEU341B, LEU400A, LEU400B, LEU411A, LEU411B, LEU414A, LEU414B, LEU433A, LEU433B, LEU436A, LEU436B, LEU481A, LEU481B, LEU523A, LEU523B, LYS187A, LYS187B, LYS214A, LYS214B, LYS258A, LYS258B, LYS260A, LYS260B, LYS382A, LYS382B, LYS387A, LYS387B, LYS476A, MET194A, MET194B, MET1A, MET309A, MET337A, MET337B, MET344A, MET344B, MET390A, MET390B, MET397A, MET397B, MET418A, MET418B, MET431A, MET431B, PHE216A, PHE216B, PHE273A, PHE273B, PHE327A, PHE327B, PHE383A, PHE383B, PHE392A, PHE392B, PHE9A, PHE9B, PRO12A, PRO12B, PRO335A, PRO335B, PRO391A, PRO391B, PRO412A, PRO412B, PRO419A, PRO419B, PRO477A, SER191A, SER191B, SER195A, SER195B, SER268A, SER268B, SER342B, SER409A, SER409B, SER422A, SER422B, SER427A, SER427B, SER524A, SER524B, THR185A, THR185B, THR197A, THR197B, THR198A, THR198B, THR486A, THR486B, THR517A, THR517B, THR5A, THR5B, THR7A, THR7B, TRP215A, TRP215B, TRP3A, TRP3B, TRP424A, TRP424B, TYR405A, TYR405B, TYR415A, TYR415B, VAL193A, VAL193B, VAL211A, VAL211B, VAL271A, VAL271B, VAL326A, VAL326B, VAL340A, VAL340B, VAL393A, VAL393B, VAL399A, VAL399B, VAL420A, VAL420B, VAL513A, VAL521A, VAL521B, VAL64A, VAL64B, VAL8A, VAL8B
• A-C: ALA251A, ALA251C, ALA276A, ALA276C, ALA74A, ALA74C, ALA87A, ALA87C, ARG199A, ARG209A, ARG209C, ARG253A, ARG253C, ARG324A, ARG324C, ARG60A, ARG60C, ARG77A, ARG77C, ARG78A, ARG78C, ARG83A, ARG83C, ASN10A, ASN10C, ASN65A, ASN65C, ASP275A, ASP275C, ASP73A, ASP73C, CYS406A, CYS406C, GLN11A, GLN11C, GLN274A, GLN274C, GLN4A, GLN4C, GLN75A, GLN75C, GLU272A, GLU272C, GLU407A, GLU407C, GLU408A, GLU408C, GLU57A, GLU57C, GLU68A, GLU68C, GLY212A, GLY212C, GLY76A, GLY76C, HIS2A, HIS2C, HIS320A, HIS320C, HIS6A, HIS6C, HIS85A, HIS85C, ILE13A, ILE13C, ILE403A, ILE403C, LEU210A, LEU210C, LEU58A, LEU58C, LEU61A, LEU61C, LEU70A, LEU70C, LEU90A, LEU90C, MET1A, PHE273A, PHE273C, PHE84A, PHE84C, PHE9A, PHE9C, PRO12A, PRO12C, PRO14A, PRO14C, PRO86A, PRO86C, SER409A, SER409C, THR5A, THR5C, THR7A, THR7C, TRP3A, TRP3C, TYR72A, TYR72C, VAL211A, VAL211C, VAL64A, VAL64C, VAL8A, VAL8C
• A-D: ALA74A, ALA74D, ARG253A, ARG253D, ARG256A, ARG256D, ARG71A, ARG71D, ARG77A, ARG77D, ARG78A, ARG78D, ASP73A, ASP73D, GLN274A, GLN274D, GLN4A, GLN4D, GLN75A, GLN75D, GLU255A, GLU255D, GLU270A, GLU270D, GLU272A, GLU272D, GLY76A, GLY76D, HIS213A, HIS213D, HIS2A, HIS2D, HIS6A, HIS6D, LEU254A, LEU254D, LEU257A, LEU257D, LEU69A, LEU69D, LEU70A, LEU70D, LEU79A, LEU79D, LYS187A, LYS187D, LYS258A, LYS258D, MET1A, PHE216A, PHE216D, THR5A, THR5D, TRP215A, TRP215D, TRP3A, TRP3D, TYR72A, TYR72D
• A-K: ALA232A, ALA368A, ALA443A, ARG202A, ARG289A, ARG338K, ARG437A, ARG522K, ASN329K, ASN440A, ASN529K, ASP447A, GLN333K, GLN334K, GLN442A, GLN526K, GLN528K, GLU286A, GLU525K, GLY233A, GLY285A, GLY328K, GLY444A, HIS325K, LEU336K, LEU372A, LEU439A, LEU523K, LYS441A, PHE327K, PHE9K, PRO330K, PRO335K, SER524K, THR7K, TYR446A, VAL445A
• A-L: ALA232A, ALA232L, ALA443A, ALA443L, ALA478A, ALA478L, ARG199A, ARG199L, ARG437A, ARG437L, ARG475A, ARG475L, ASN196A, ASN196L, ASN440A, ASN440L, GLN188A, GLN188L, GLN230A, GLN230L, GLN442A, GLN442L, GLN471A, GLN471L, GLN472A, GLN472L, GLN473A, GLN473L, GLU479A, GLU479L, GLU480A, GLU480L, GLY233A, GLY233L, GLY234A, GLY234L, GLY444L, ILE485A, ILE485L, LEU235A, LEU235L, LEU433A, LEU433L, LEU436A, LEU436L, LEU439A, LEU439L, LEU470A, LEU474A, LEU474L, LEU481A, LEU481L, LYS441A, LYS441L, LYS476A, LYS476L, MET194A, MET194L, PRO477A, PRO477L, SER195A, SER195L, THR197A, THR197L, THR231A, THR231L, TYR446A, TYR446L, VAL438A, VAL445A
• B-C: ALA74B, ALA74C, ARG253B, ARG253C, ARG256B, ARG256C, ARG71B, ARG71C, ARG77B, ARG77C, ARG78B, ARG78C, ASP73B, ASP73C, GLN274B, GLN274C, GLN4B, GLN4C, GLN75B, GLN75C, GLU255B, GLU255C, GLU270B, GLU270C, GLU272B, GLU272C, GLY76B, GLY76C, HIS213B, HIS213C, HIS2B, HIS2C, HIS6B, HIS6C, LEU254B, LEU254C, LEU257B, LEU257C, LEU69B, LEU69C, LEU70B, LEU70C, LEU79B, LEU79C, LYS187B, LYS187C, LYS258B, LYS258C, PHE216B, PHE216C, THR5B, THR5C, TRP215B, TRP215C, TRP3B, TRP3C, TYR72B, TYR72C
• B-D: ALA251B, ALA251D, ALA276B, ALA276D, ALA74B, ALA74D, ALA87B, ALA87D, ARG199B, ARG199D, ARG209B, ARG209D, ARG253B, ARG253D, ARG324B, ARG324D, ARG60B, ARG60D, ARG77B, ARG77D, ARG78B, ARG78D, ARG83B, ARG83D, ASN10B, ASN10D, ASN16B, ASN16D, ASN65B, ASN65D, ASP275B, ASP275D, ASP73B, ASP73D, CYS406B, CYS406D, GLN11B, GLN11D, GLN274B, GLN274D, GLN4B, GLN4D, GLN75B, GLN75D, GLU272B, GLU272D, GLU408B, GLU408D, GLU57B, GLU57D, GLU68B, GLU68D, GLY212B, GLY212D, GLY76B, GLY76D, HIS2B, HIS2D, HIS320B, HIS320D, HIS6B, HIS6D, HIS85B, HIS85D, ILE13B, ILE13D, ILE403B, ILE403D, LEU210B, LEU210D, LEU58B, LEU58D, LEU61B, LEU61D, LEU70B, LEU70D, LEU90B, LEU90D, PHE273B, PHE273D, PHE84B, PHE84D, PHE9B, PHE9D, PRO12B, PRO12D, PRO14B, PRO14D, PRO86B, PRO86D, SER409B, SER409D, THR5B, THR5D, THR7B, THR7D, TRP3B, TRP3D, TYR72B, TYR72D, VAL211B, VAL211D, VAL64B, VAL64D, VAL8B, VAL8D
• B-L: ALA232L, ALA443L, ARG289L, ARG338B, ARG522B, ASN329B, ASN440L, ASN529B, ASP447L, GLN333B, GLN334B, GLN442L, GLN526B, GLN528B, GLU286L, GLU525B, GLY233L, GLY234L, GLY285L, GLY328B, GLY444L, HIS325B, ILE288L, LEU283L, LEU439L, LEU523B, LYS441L, PHE9B, PRO330B, PRO335B, SER524B, THR7B, TYR446L, VAL445L
• C-D: ALA251C, ALA251D, ALA276C, ALA276D, ALA394C, ALA394D, ALA396C, ALA396D, ALA478C, ALA478D, ARG199C, ARG199D, ARG253C, ARG253D, ARG256C, ARG256D, ARG264C, ARG264D, ARG324C, ARG324D, ARG338C, ARG338D, ARG343C, ARG343D, ARG388C, ARG388D, ARG413C, ARG413D, ARG416C, ARG416D, ARG437D, ARG469C, ARG469D, ARG483C, ARG483D, ARG518C, ARG518D, ARG522C, ARG522D, ASN10C, ASN10D, ASN196C, ASN196D, ASN263C, ASN263D, ASN266C, ASN266D, ASN329C, ASN329D, ASN421C, ASN421D, ASN429C, ASN429D, ASP192C, ASP192D, ASP259C, ASP259D, ASP275C, ASP275D, ASP434C, ASP434D, ASP516C, ASP516D, CYS386C, CYS386D, CYS406C, CYS406D, CYS432C, CYS432D, GLN11C, GLN11D, GLN188C, GLN188D, GLN274C, GLN274D, GLN334C, GLN334D, GLN473C, GLN473D, GLN488C, GLN488D, GLN4C, GLN4D, GLN528C, GLN528D, GLU186C, GLU186D, GLU255C, GLU255D, GLU270C, GLU270D, GLU272C, GLU272D, GLU395C, GLU395D, GLU398C, GLU398D, GLU407C, GLU407D, GLU408C, GLU408D, GLU417C, GLU417D, GLU479C, GLU479D, GLU480C, GLU480D, GLU484C, GLU484D, GLU525C, GLU525D, GLY189C, GLY189D, GLY190C, GLY190D, GLY212C, GLY212D, GLY262C, GLY262D, GLY328C, GLY328D, GLY389C, GLY389D, GLY401C, GLY401D, GLY402C, GLY402D, GLY404C, GLY404D, GLY426C, GLY426D, GLY428C, GLY428D, GLY482C, GLY482D, GLY519C, GLY519D, GLY520C, GLY520D, HIS213C, HIS213D, HIS2C, HIS2D, HIS320C, HIS320D, HIS325C, HIS325D, HIS339C, HIS339D, HIS6C, HIS6D, ILE288C, ILE288D, ILE403C, ILE403D, ILE423C, ILE423D, ILE430C, ILE430D, ILE485C, ILE485D, LEU210C, LEU210D, LEU257C, LEU257D, LEU261C, LEU261D, LEU331C, LEU331D, LEU336C, LEU336D, LEU341C, LEU341D, LEU400C, LEU400D, LEU411C, LEU411D, LEU414C, LEU414D, LEU433C, LEU433D, LEU436C, LEU436D, LEU481C, LEU481D, LEU523C, LEU523D, LYS187C, LYS187D, LYS214C, LYS214D, LYS258C, LYS258D, LYS260C, LYS260D, LYS382C, LYS382D, LYS387C, LYS387D, LYS476C, LYS476D, MET194C, MET194D, MET309C, MET337C, MET337D, MET344C, MET344D, MET390C, MET390D, MET397C, MET397D, MET418C, MET418D, MET431C, MET431D, PHE216C, PHE216D, PHE273C, PHE273D, PHE327C, PHE327D, PHE383C, PHE383D, PHE392C, PHE392D, PHE9C, PHE9D, PRO12C, PRO12D, PRO335C, PRO335D, PRO391C, PRO391D, PRO412C, PRO412D, PRO419C, PRO419D, PRO477D, SER191C, SER191D, SER195C, SER195D, SER268C, SER268D, SER342D, SER409C, SER409D, SER422C, SER422D, SER427C, SER427D, SER524C, SER524D, THR185C, THR185D, THR197C, THR197D, THR198C, THR198D, THR486C, THR486D, THR517C, THR517D, THR5C, THR5D, THR7C, THR7D, TRP215C, TRP215D, TRP3C, TRP3D, TRP424C, TRP424D, TYR405C, TYR405D, TYR415C, TYR415D, VAL193C, VAL193D, VAL211C, VAL211D, VAL271C, VAL271D, VAL326C, VAL326D, VAL340C, VAL340D, VAL393C, VAL393D, VAL399C, VAL399D, VAL420C, VAL420D, VAL513C, VAL521C, VAL521D, VAL64C, VAL64D, VAL8C, VAL8D
• C-E: ALA478E, ARG338C, ARG437E, ARG475E, ARG522C, ASN440E, ASN529C, GLN333C, GLN442E, GLN526C, GLU525C, LEU439E, LEU474E, LEU523C, LYS441E, LYS476E, PRO477E, SER524C, TYR446E
• C-F: ARG522C, ARG522F, ASN329C, ASN329F, GLY328C, GLY328F, PHE327C, PHE327F
• D-E: ALA478D, GLU480D, LYS476E
• D-F: ALA443D, ALA478D, ARG338F, ARG437D, ARG475D, ARG522F, ASN440D, ASN529F, ASP530F, GLN442D, GLN526F, GLU479D, GLU525F, GLY444D, ILE527F, LEU436D, LEU439D, LEU523F, LYS441D, LYS476D, PRO477D, SER524F, TYR446D, VAL438D
• E-F: ALA251E, ALA251F, ALA276E, ALA276F, ALA394E, ALA394F, ALA396E, ALA396F, ALA478E, ALA478F, ARG199E, ARG199F, ARG253E, ARG253F, ARG256E, ARG256F, ARG264E, ARG264F, ARG324E, ARG324F, ARG338E, ARG338F, ARG343E, ARG343F, ARG388E, ARG388F, ARG413E, ARG413F, ARG416E, ARG416F, ARG469E, ARG469F, ARG483E, ARG483F, ARG518E, ARG518F, ARG522E, ARG522F, ASN10E, ASN10F, ASN196E, ASN196F, ASN263E, ASN263F, ASN266E, ASN266F, ASN329E, ASN329F, ASN421E, ASN421F, ASN429E, ASN429F, ASP192E, ASP192F, ASP259E, ASP259F, ASP275E, ASP275F, ASP434E, ASP434F, ASP516E, ASP516F, CYS386E, CYS386F, CYS406E, CYS406F, CYS432E, CYS432F, GLN11E, GLN11F, GLN188E, GLN188F, GLN274E, GLN274F, GLN333E, GLN334E, GLN334F, GLN473E, GLN473F, GLN488E, GLN488F, GLN4E, GLN4F, GLN528E, GLN528F, GLU186E, GLU186F, GLU255E, GLU255F, GLU270E, GLU270F, GLU272E, GLU272F, GLU395E, GLU395F, GLU398E, GLU398F, GLU407E, GLU407F, GLU408E, GLU408F, GLU417E, GLU417F, GLU479E, GLU479F, GLU480E, GLU480F, GLU484E, GLU484F, GLY189E, GLY189F, GLY190E, GLY190F, GLY212E, GLY212F, GLY262E, GLY262F, GLY328E, GLY328F, GLY389E, GLY389F, GLY401E, GLY401F, GLY402E, GLY402F, GLY404E, GLY404F, GLY426E, GLY426F, GLY428E, GLY428F, GLY482E, GLY482F, GLY519E, GLY519F, GLY520E, GLY520F, HIS213E, HIS213F, HIS2E, HIS2F, HIS320E, HIS325E, HIS325F, HIS339E, HIS339F, HIS6E, HIS6F, ILE288E, ILE288F, ILE403E, ILE403F, ILE423E, ILE423F, ILE430E, ILE430F, ILE485E, ILE485F, LEU210E, LEU210F, LEU257E, LEU257F, LEU261E, LEU261F, LEU331E, LEU331F, LEU336E, LEU336F, LEU341E, LEU341F, LEU400E, LEU400F, LEU411E, LEU411F, LEU414E, LEU414F, LEU433E, LEU433F, LEU436E, LEU436F, LEU481E, LEU481F, LEU523E, LEU523F, LYS187E, LYS187F, LYS214E, LYS214F, LYS258E, LYS258F, LYS260E, LYS260F, LYS382E, LYS382F, LYS387E, LYS387F, LYS476E, LYS476F, MET194E, MET194F, MET309E, MET337E, MET337F, MET344E, MET344F, MET390E, MET390F, MET397E, MET397F, MET418E, MET418F, MET431E, MET431F, PHE216E, PHE216F, PHE273E, PHE273F, PHE327E, PHE327F, PHE383E, PHE383F, PHE392E, PHE392F, PHE9E, PHE9F, PRO12E, PRO12F, PRO335E, PRO335F, PRO391E, PRO391F, PRO412E, PRO412F, PRO419E, PRO419F, PRO477E, SER191E, SER191F, SER195E, SER195F, SER268E, SER268F, SER409E, SER409F, SER422E, SER422F, SER427E, SER427F, THR185E, THR185F, THR197E, THR197F, THR198E, THR198F, THR486E, THR486F, THR517E, THR517F, THR5E, THR5F, THR7E, THR7F, TRP215E, TRP215F, TRP3E, TRP3F, TRP424E, TRP424F, TYR405E, TYR405F, TYR415E, TYR415F, VAL193E, VAL193F, VAL211E, VAL211F, VAL271E, VAL271F, VAL326E, VAL326F, VAL340E, VAL340F, VAL393E, VAL393F, VAL399E, VAL399F, VAL420E, VAL420F, VAL513E, VAL513F, VAL521E, VAL521F, VAL64E, VAL64F, VAL8E, VAL8F
• E-G: ALA251E, ALA251G, ALA276E, ALA276G, ALA74E, ALA74G, ALA87E, ALA87G, ARG199E, ARG199G, ARG209E, ARG209G, ARG253E, ARG253G, ARG324E, ARG324G, ARG60E, ARG60G, ARG77E, ARG77G, ARG78E, ARG78G, ARG83E, ARG83G, ASN10E, ASN10G, ASN16E, ASN65E, ASN65G, ASP275E, ASP275G, ASP73E, ASP73G, CYS406E, CYS406G, GLN11E, GLN11G, GLN274E, GLN274G, GLN4E, GLN4G, GLN75E, GLN75G, GLU272E, GLU272G, GLU407E, GLU407G, GLU408E, GLU408G, GLU57E, GLU57G, GLU68E, GLU68G, GLY212E, GLY212G, GLY76E, GLY76G, HIS2E, HIS2G, HIS320E, HIS320G, HIS6E, HIS6G, HIS85E, HIS85G, ILE13E, ILE13G, ILE403E, ILE403G, LEU210E, LEU210G, LEU58E, LEU58G, LEU61E, LEU61G, LEU70E, LEU70G, LEU90E, LEU90G, PHE273E, PHE273G, PHE84E, PHE84G, PHE9E, PHE9G, PRO12E, PRO12G, PRO14E, PRO14G, PRO86E, PRO86G, SER409E, SER409G, THR5E, THR5G, THR7E, THR7G, TRP3E, TRP3G, TYR72E, TYR72G, VAL211E, VAL211G, VAL64E, VAL64G, VAL8E, VAL8G
• E-H: ALA74E, ALA74H, ARG253E, ARG253H, ARG256E, ARG256H, ARG71E, ARG71H, ARG77E, ARG77H, ARG78E, ARG78H, ASP73E, ASP73H, GLN274E, GLN274H, GLN4E, GLN4H, GLN75E, GLN75H, GLU255E, GLU255H, GLU270E, GLU270H, GLU272E, GLU272H, GLY76E, GLY76H, HIS213E, HIS213H, HIS2E, HIS2H, HIS6E, HIS6H, LEU254E, LEU254H, LEU257E, LEU257H, LEU69E, LEU69H, LEU70E, LEU70H, LEU79E, LEU79H, LYS187E, LYS187H, LYS258E, LYS258H, PHE216E, PHE216H, THR5E, THR5H, TRP215E, TRP215H, TRP3E, TRP3H, TYR72E, TYR72H
• F-G: ALA74F, ALA74G, ARG253F, ARG253G, ARG256F, ARG256G, ARG71F, ARG71G, ARG77F, ARG77G, ARG78F, ARG78G, ASP73F, ASP73G, GLN274F, GLN274G, GLN4F, GLN4G, GLN75F, GLN75G, GLU255F, GLU255G, GLU270F, GLU270G, GLU272F, GLU272G, GLY76F, GLY76G, HIS213F, HIS213G, HIS2F, HIS2G, HIS6F, HIS6G, LEU254F, LEU254G, LEU257F, LEU257G, LEU69F, LEU69G, LEU70F, LEU70G, LEU79F, LEU79G, LYS187F, LYS187G, LYS258F, LYS258G, PHE216G, THR5F, THR5G, TRP215F, TRP215G, TRP3F, TRP3G, TYR72F, TYR72G
• F-H: ALA251F, ALA251H, ALA276F, ALA276H, ALA74F, ALA74H, ALA87F, ALA87H, ARG209F, ARG209H, ARG253F, ARG253H, ARG324F, ARG324H, ARG60F, ARG60H, ARG77F, ARG77H, ARG78F, ARG78H, ARG83F, ARG83H, ASN10F, ASN10H, ASN16F, ASN16H, ASN65F, ASN65H, ASP275F, ASP275H, ASP73F, ASP73H, CYS406F, CYS406H, GLN11F, GLN11H, GLN274F, GLN274H, GLN4F, GLN4H, GLN75F, GLN75H, GLU272F, GLU272H, GLU408F, GLU408H, GLU57F, GLU57H, GLU68F, GLU68H, GLY212F, GLY212H, GLY76F, GLY76H, HIS2F, HIS2H, HIS320F, HIS320H, HIS6F, HIS6H, HIS85F, HIS85H, ILE13F, ILE13H, ILE403F, ILE403H, LEU210F, LEU210H, LEU58F, LEU58H, LEU61F, LEU61H, LEU70F, LEU70H, LEU90F, LEU90H, PHE273F, PHE273H, PHE84F, PHE84H, PHE9F, PHE9H, PRO12F, PRO12H, PRO14F, PRO14H, PRO86F, PRO86H, SER409F, SER409H, THR5F, THR5H, THR7F, THR7H, TRP3F, TRP3H, TYR72F, TYR72H, VAL211F, VAL211H, VAL64F, VAL64H, VAL8F, VAL8H
• G-H: ALA251G, ALA251H, ALA276H, ALA394G, ALA394H, ALA396G, ALA396H, ALA478G, ALA478H, ARG199G, ARG199H, ARG253G, ARG253H, ARG256G, ARG256H, ARG264G, ARG264H, ARG324G, ARG324H, ARG338G, ARG338H, ARG343G, ARG343H, ARG388G, ARG388H, ARG413G, ARG413H, ARG416G, ARG416H, ARG437H, ARG469G, ARG469H, ARG483G, ARG483H, ARG518G, ARG518H, ARG522G, ARG522H, ASN10G, ASN10H, ASN196G, ASN196H, ASN263G, ASN263H, ASN266G, ASN266H, ASN329G, ASN329H, ASN421G, ASN421H, ASN429G, ASN429H, ASP192G, ASP192H, ASP259G, ASP259H, ASP275G, ASP275H, ASP434G, ASP434H, ASP516G, ASP516H, CYS386G, CYS386H, CYS406G, CYS406H, CYS432G, CYS432H, GLN11G, GLN11H, GLN188G, GLN188H, GLN274G, GLN274H, GLN333H, GLN334G, GLN334H, GLN473G, GLN473H, GLN488G, GLN488H, GLN4G, GLN4H, GLN528G, GLN528H, GLU186G, GLU186H, GLU255G, GLU255H, GLU270G, GLU270H, GLU272G, GLU272H, GLU395G, GLU395H, GLU398G, GLU398H, GLU407G, GLU407H, GLU408G, GLU408H, GLU417G, GLU417H, GLU479G, GLU479H, GLU480G, GLU480H, GLU484G, GLU484H, GLU525G, GLU525H, GLY189G, GLY189H, GLY190G, GLY190H, GLY212G, GLY212H, GLY262G, GLY262H, GLY328G, GLY328H, GLY389G, GLY389H, GLY401G, GLY401H, GLY402G, GLY402H, GLY404G, GLY404H, GLY426G, GLY426H, GLY428G, GLY428H, GLY482G, GLY482H, GLY519G, GLY519H, GLY520G, GLY520H, HIS213G, HIS213H, HIS2G, HIS2H, HIS320G, HIS320H, HIS325G, HIS325H, HIS339G, HIS339H, HIS6G, HIS6H, ILE288G, ILE288H, ILE403G, ILE403H, ILE423G, ILE423H, ILE430G, ILE430H, ILE485G, ILE485H, LEU210G, LEU210H, LEU257G, LEU257H, LEU261G, LEU261H, LEU331G, LEU331H, LEU336G, LEU336H, LEU341G, LEU341H, LEU400G, LEU400H, LEU411G, LEU411H, LEU414G, LEU414H, LEU433G, LEU433H, LEU436G, LEU436H, LEU481G, LEU481H, LEU523G, LEU523H, LYS187G, LYS187H, LYS214G, LYS214H, LYS258G, LYS258H, LYS260G, LYS260H, LYS382G, LYS382H, LYS387G, LYS387H, LYS476G, LYS476H, MET194G, MET194H, MET309G, MET337G, MET337H, MET344G, MET344H, MET390G, MET390H, MET397G, MET397H, MET418G, MET418H, MET431G, MET431H, PHE216G, PHE216H, PHE273G, PHE273H, PHE327G, PHE327H, PHE383G, PHE383H, PHE392G, PHE392H, PHE9G, PHE9H, PRO12G, PRO12H, PRO335G, PRO335H, PRO391G, PRO391H, PRO412G, PRO412H, PRO419G, PRO419H, PRO477G, PRO477H, SER191G, SER191H, SER195G, SER195H, SER268G, SER268H, SER342H, SER409G, SER409H, SER422G, SER422H, SER427G, SER427H, SER524G, SER524H, THR185G, THR185H, THR197G, THR197H, THR198G, THR198H, THR486G, THR486H, THR517G, THR517H, THR5G, THR5H, THR7G, THR7H, TRP215G, TRP215H, TRP3G, TRP3H, TRP424G, TRP424H, TYR405G, TYR405H, TYR415G, TYR415H, VAL193G, VAL193H, VAL211G, VAL211H, VAL271G, VAL271H, VAL326G, VAL326H, VAL340G, VAL340H, VAL393G, VAL393H, VAL399G, VAL399H, VAL420G, VAL420H, VAL513G, VAL513H, VAL521G, VAL521H, VAL64G, VAL64H, VAL8G, VAL8H
• G-I: ALA232I, ALA443I, ARG437I, ARG522G, ASN329G, ASN440I, ASN529G, ASP447I, GLN334G, GLU525G, GLY233I, GLY328G, GLY444I, LEU439I, LYS441I, PHE327G, PHE9G, PRO335G, THR7G, TYR446I
• H-I: ALA232H, ALA232I, ALA443H, ALA478H, ALA478I, ARG199H, ARG199I, ARG475H, ARG475I, ASN196H, ASN196I, ASN440H, ASN440I, GLN188I, GLN230H, GLN230I, GLN471I, GLU479H, GLU479I, GLU480I, GLY233H, GLY233I, GLY234H, GLY234I, LEU474H, LEU474I, LYS441H, LYS441I, LYS476H, LYS476I, MET194H, MET194I, PRO477H, PRO477I, SER195I, THR197H, THR197I, THR231H, TYR446H, TYR446I
• H-J: ALA232H, ALA443H, ARG289H, ARG522J, ASN329J, ASN440H, ASN529J, GLN442H, GLN526J, GLU286H, GLU525J, GLY233H, GLY285H, GLY328J, GLY444H, HIS325J, LEU283H, LEU439H, LYS441H, PHE9J, PRO330J, PRO335J, SER524J, THR7J, TYR446H
• I-J: ALA251I, ALA251J, ALA276I, ALA276J, ALA394I, ALA394J, ALA396I, ALA396J, ALA478I, ALA478J, ARG199I, ARG199J, ARG253I, ARG253J, ARG256I, ARG256J, ARG264I, ARG264J, ARG324I, ARG324J, ARG338I, ARG338J, ARG343I, ARG343J, ARG388I, ARG388J, ARG413I, ARG413J, ARG416I, ARG416J, ARG437J, ARG469I, ARG469J, ARG483I, ARG483J, ARG518I, ARG518J, ARG522I, ARG522J, ASN10I, ASN10J, ASN196I, ASN196J, ASN263I, ASN263J, ASN266I, ASN266J, ASN329I, ASN329J, ASN421I, ASN421J, ASN429I, ASN429J, ASP192I, ASP192J, ASP259I, ASP259J, ASP275I, ASP275J, ASP434I, ASP434J, ASP516I, ASP516J, CYS386I, CYS386J, CYS406I, CYS406J, CYS432I, CYS432J, GLN11I, GLN11J, GLN188I, GLN188J, GLN274I, GLN274J, GLN334I, GLN334J, GLN473I, GLN473J, GLN488I, GLN488J, GLN4I, GLN4J, GLN528I, GLN528J, GLU186I, GLU186J, GLU255I, GLU255J, GLU270I, GLU270J, GLU272I, GLU272J, GLU395I, GLU395J, GLU398I, GLU398J, GLU407I, GLU407J, GLU408I, GLU408J, GLU417I, GLU417J, GLU479I, GLU479J, GLU480I, GLU480J, GLU484I, GLU484J, GLU525I, GLU525J, GLY189I, GLY189J, GLY190I, GLY190J, GLY212I, GLY212J, GLY262I, GLY262J, GLY328I, GLY328J, GLY389I, GLY389J, GLY401I, GLY401J, GLY402I, GLY402J, GLY404I, GLY404J, GLY426I, GLY426J, GLY428I, GLY428J, GLY482I, GLY482J, GLY519I, GLY519J, GLY520I, GLY520J, HIS213I, HIS213J, HIS2I, HIS2J, HIS320I, HIS325I, HIS325J, HIS339I, HIS339J, HIS6I, HIS6J, ILE288I, ILE288J, ILE403I, ILE403J, ILE423I, ILE423J, ILE430I, ILE430J, ILE485I, ILE485J, LEU210I, LEU210J, LEU257I, LEU257J, LEU261I, LEU261J, LEU331I, LEU331J, LEU336I, LEU336J, LEU341I, LEU341J, LEU400I, LEU400J, LEU411I, LEU411J, LEU414I, LEU414J, LEU433I, LEU433J, LEU436I, LEU436J, LEU481I, LEU481J, LEU523I, LEU523J, LYS187I, LYS187J, LYS214I, LYS214J, LYS258I, LYS258J, LYS260I, LYS260J, LYS382I, LYS382J, LYS387I, LYS387J, LYS476I, MET194I, MET194J, MET1J, MET309I, MET337I, MET337J, MET344I, MET344J, MET390I, MET390J, MET397I, MET397J, MET418I, MET418J, MET431I, MET431J, PHE216I, PHE216J, PHE273I, PHE273J, PHE327I, PHE327J, PHE383I, PHE383J, PHE392I, PHE392J, PHE9I, PHE9J, PRO12I, PRO12J, PRO335I, PRO335J, PRO391I, PRO391J, PRO412I, PRO412J, PRO419I, PRO419J, PRO477I, SER191I, SER191J, SER195I, SER195J, SER268I, SER268J, SER342J, SER409I, SER409J, SER422I, SER422J, SER427I, SER427J, SER524I, SER524J, THR185I, THR185J, THR197I, THR197J, THR198I, THR198J, THR486I, THR486J, THR517I, THR517J, THR5I, THR5J, THR7I, THR7J, TRP215I, TRP215J, TRP3I, TRP3J, TRP424I, TRP424J, TYR405I, TYR405J, TYR415I, TYR415J, VAL193I, VAL193J, VAL211I, VAL211J, VAL271I, VAL271J, VAL326I, VAL326J, VAL340I, VAL340J, VAL393I, VAL393J, VAL399I, VAL399J, VAL420I, VAL420J, VAL513I, VAL513J, VAL521I, VAL521J, VAL64I, VAL64J, VAL8I, VAL8J
• I-K: ALA251I, ALA251K, ALA276I, ALA276K, ALA74I, ALA74K, ALA87I, ALA87K, ARG199I, ARG209I, ARG209K, ARG253I, ARG253K, ARG324I, ARG324K, ARG60I, ARG60K, ARG77I, ARG77K, ARG78I, ARG78K, ARG83I, ARG83K, ASN10I, ASN10K, ASN65I, ASN65K, ASP275I, ASP275K, ASP73I, ASP73K, CYS406I, CYS406K, GLN11I, GLN11K, GLN274I, GLN274K, GLN4I, GLN4K, GLN75I, GLN75K, GLU272I, GLU272K, GLU407I, GLU408I, GLU408K, GLU57I, GLU57K, GLU68I, GLU68K, GLY212I, GLY212K, GLY76I, GLY76K, HIS2I, HIS2K, HIS320I, HIS320K, HIS6I, HIS6K, HIS85I, HIS85K, ILE13I, ILE13K, ILE403I, ILE403K, LEU210I, LEU210K, LEU58I, LEU58K, LEU61I, LEU61K, LEU70I, LEU70K, LEU90I, LEU90K, MET1K, PHE273I, PHE273K, PHE84I, PHE84K, PHE9I, PHE9K, PRO12I, PRO12K, PRO14I, PRO14K, PRO86I, PRO86K, SER409I, SER409K, THR5I, THR5K, THR7I, THR7K, TRP3I, TRP3K, TYR72I, TYR72K, VAL211I, VAL211K, VAL64I, VAL64K, VAL8I, VAL8K
• I-L: ALA74I, ALA74L, ARG253I, ARG253L, ARG256I, ARG256L, ARG71I, ARG71L, ARG77I, ARG77L, ARG78I, ARG78L, ASP73I, ASP73L, GLN274I, GLN274L, GLN4I, GLN4L, GLN75I, GLN75L, GLU255I, GLU255L, GLU270I, GLU270L, GLU272I, GLU272L, GLY76I, GLY76L, HIS213I, HIS213L, HIS2I, HIS2L, HIS6I, HIS6L, LEU254I, LEU254L, LEU257I, LEU257L, LEU69I, LEU69L, LEU70I, LEU70L, LEU79I, LEU79L, LYS187I, LYS187L, LYS258I, LYS258L, PHE216I, PHE216L, THR5I, THR5L, TRP215I, TRP215L, TRP3I, TRP3L, TYR72I, TYR72L
• J-K: ALA74J, ALA74K, ARG253J, ARG253K, ARG256J, ARG256K, ARG71J, ARG71K, ARG77J, ARG77K, ARG78J, ARG78K, ASP73J, ASP73K, GLN188J, GLN188K, GLN274J, GLN274K, GLN4J, GLN4K, GLN75J, GLN75K, GLU255J, GLU255K, GLU270J, GLU270K, GLU272J, GLU272K, GLY76J, GLY76K, HIS213J, HIS213K, HIS2J, HIS2K, HIS6J, HIS6K, LEU254J, LEU254K, LEU257J, LEU257K, LEU69J, LEU69K, LEU70J, LEU70K, LEU79J, LEU79K, LYS187J, LYS187K, LYS258J, LYS258K, MET1J, MET1K, PHE216J, PHE216K, THR5J, THR5K, TRP215J, TRP215K, TRP3J, TRP3K, TYR72J, TYR72K
• J-L: ALA251J, ALA251L, ALA276J, ALA276L, ALA74J, ALA74L, ALA87J, ALA87L, ARG209J, ARG209L, ARG253J, ARG253L, ARG324J, ARG324L, ARG60J, ARG60L, ARG77J, ARG77L, ARG78J, ARG78L, ARG83J, ARG83L, ASN10J, ASN10L, ASN16J, ASN16L, ASN65J, ASN65L, ASP275J, ASP275L, ASP73J, ASP73L, CYS406J, CYS406L, GLN11J, GLN11L, GLN274J, GLN274L, GLN4J, GLN4L, GLN75J, GLN75L, GLU272J, GLU272L, GLU408J, GLU408L, GLU57J, GLU57L, GLU68J, GLU68L, GLY212J, GLY212L, GLY76J, GLY76L, HIS2J, HIS2L, HIS320J, HIS320L, HIS6J, HIS6L, HIS85J, HIS85L, ILE13J, ILE13L, ILE403J, ILE403L, LEU210J, LEU210L, LEU58J, LEU58L, LEU61J, LEU61L, LEU70J, LEU70L, LEU90J, LEU90L, MET1J, PHE273J, PHE273L, PHE84J, PHE84L, PHE9J, PHE9L, PRO12J, PRO12L, PRO14J, PRO14L, PRO86J, PRO86L, SER409J, SER409L, THR5J, THR5L, THR7J, THR7L, TRP3J, TRP3L, TYR72J, TYR72L, VAL211J, VAL211L, VAL64J, VAL64L, VAL8J, VAL8L
• K-L: ALA251K, ALA251L, ALA276K, ALA276L, ALA394K, ALA394L, ALA396K, ALA396L, ALA478K, ALA478L, ARG199K, ARG199L, ARG253K, ARG253L, ARG256K, ARG256L, ARG264K, ARG264L, ARG324K, ARG324L, ARG338K, ARG338L, ARG343K, ARG343L, ARG388K, ARG388L, ARG413K, ARG413L, ARG416K, ARG416L, ARG469K, ARG469L, ARG483K, ARG483L, ARG518K, ARG518L, ARG522K, ARG522L, ASN10K, ASN10L, ASN196K, ASN196L, ASN263K, ASN263L, ASN266K, ASN266L, ASN329K, ASN329L, ASN421K, ASN421L, ASN429K, ASN429L, ASP192K, ASP192L, ASP259K, ASP259L, ASP275K, ASP275L, ASP434K, ASP434L, ASP516K, ASP516L, CYS386K, CYS386L, CYS406K, CYS406L, CYS432K, CYS432L, GLN11K, GLN11L, GLN188K, GLN188L, GLN274K, GLN274L, GLN334K, GLN334L, GLN473K, GLN473L, GLN488K, GLN488L, GLN4K, GLN4L, GLN528K, GLN528L, GLU186K, GLU186L, GLU255K, GLU255L, GLU270K, GLU270L, GLU272K, GLU272L, GLU395K, GLU395L, GLU398K, GLU398L, GLU407K, GLU407L, GLU408K, GLU408L, GLU417K, GLU417L, GLU479K, GLU479L, GLU480K, GLU480L, GLU484K, GLU484L, GLU525L, GLY189K, GLY189L, GLY190K, GLY190L, GLY212K, GLY212L, GLY262K, GLY262L, GLY328K, GLY328L, GLY389K, GLY389L, GLY401K, GLY401L, GLY402K, GLY402L, GLY404K, GLY404L, GLY426K, GLY426L, GLY428K, GLY428L, GLY482K, GLY482L, GLY519K, GLY519L, GLY520K, GLY520L, HIS213K, HIS213L, HIS2K, HIS2L, HIS320K, HIS325K, HIS325L, HIS339K, HIS339L, HIS6K, HIS6L, ILE288K, ILE288L, ILE403K, ILE403L, ILE423K, ILE423L, ILE430K, ILE430L, ILE485K, ILE485L, LEU210K, LEU210L, LEU257K, LEU257L, LEU261K, LEU261L, LEU331K, LEU331L, LEU336K, LEU336L, LEU341K, LEU341L, LEU400K, LEU400L, LEU411K, LEU411L, LEU414K, LEU414L, LEU433K, LEU433L, LEU436K, LEU436L, LEU481K, LEU481L, LEU523K, LEU523L, LYS187K, LYS187L, LYS214K, LYS214L, LYS258K, LYS258L, LYS260K, LYS260L, LYS382K, LYS382L, LYS387K, LYS387L, LYS476L, MET194K, MET194L, MET309K, MET337K, MET337L, MET344K, MET344L, MET390K, MET390L, MET397K, MET397L, MET418K, MET418L, MET431K, MET431L, PHE216K, PHE216L, PHE273K, PHE273L, PHE327K, PHE327L, PHE383K, PHE383L, PHE392K, PHE392L, PHE9K, PHE9L, PRO12K, PRO12L, PRO335K, PRO335L, PRO391K, PRO391L, PRO412K, PRO412L, PRO419K, PRO419L, PRO477L, SER191K, SER191L, SER195K, SER195L, SER268K, SER268L, SER342L, SER409K, SER409L, SER422K, SER422L, SER427K, SER427L, SER524L, THR185K, THR185L, THR197K, THR197L, THR198K, THR198L, THR486K, THR486L, THR517K, THR517L, THR5K, THR5L, THR7K, THR7L, TRP215K, TRP215L, TRP3K, TRP3L, TRP424K, TRP424L, TYR405K, TYR405L, TYR415K, TYR415L, VAL193K, VAL193L, VAL211K, VAL211L, VAL271K, VAL271L, VAL326K, VAL326L, VAL340K, VAL340L, VAL393K, VAL393L, VAL399K, VAL399L, VAL420K, VAL420L, VAL521K, VAL521L, VAL64K, VAL64L, VAL8K, VAL8L