3TVI

crystal structure of clostridium acetobutylicum aspartate kinase (caak): an important allosteric enzyme for industrial amino acids production

• Total interactions analyzed: 66
• Total true interactions: 27
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 202
  • Norm. En. per Res.: -2.9747
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-61.5038	-1.2222	-454.611	-517.3371	192	31	10	19221	2	69	82
A-C	0.0	0.0	-24.8625	-24.8625	26	1	0	1409	0	16	16
A-D	0.0	33.0453	-108.569	-75.5237	75	8	8	5240	2	26	31
A-I	0.0	-23.4016	-27.1383	-50.5399	38	1	0	1383	2	24	26
A-L	-7.7826	6.6123	-67.0759	-68.2462	59	3	0	3085	0	36	34
B-C	-2.6305	20.1404	-120.279	-102.7692	76	13	6	5958	0	31	31
B-D	0.0	0.6288	-3.4652	-2.8364	18	0	0	462	0	17	14
B-F	-10.1413	-33.3607	-39.5109	-83.0129	44	3	0	1978	3	25	28
B-G	-31.3763	-20.7056	-91.6997	-143.7816	60	6	0	3904	3	31	30
C-D	-73.3837	-92.4752	-435.021	-600.8799	202	37	10	18906	5	68	85
C-E	0.0	0.0	-9.6881	-9.6881	29	1	0	529	0	14	14
C-G	0.0	-4.7934	-0.5096	-5.303	4	0	0	81	0	2	6
C-J	-16.5641	19.799	-75.4552	-72.2204	69	4	2	3975	1	29	23
D-E	-6.8093	11.4366	-45.2634	-40.6361	60	1	2	3241	0	20	19
D-J	0.0	2.159	-9.5914	-7.4323	37	0	0	790	0	16	15
E-F	-47.2548	-74.1416	-346.79	-468.1864	181	26	10	15134	8	56	77
E-G	0.0	-9.5194	-47.5504	-57.0698	38	0	0	2499	1	16	20
E-H	0.0	29.9615	-100.821	-70.8595	86	6	8	5228	0	29	36
F-G	0.0	29.9093	-106.434	-76.5247	88	13	8	6341	1	32	35
F-H	-7.8324	-11.4147	-49.0647	-68.3118	35	0	0	2492	1	15	19
G-H	-60.0182	-72.9195	-401.731	-534.6686	184	28	10	16308	11	55	73
I-J	-78.2537	-41.4595	-434.196	-553.9092	202	32	13	18257	3	68	82
I-K	-5.0565	0.9684	-29.3011	-33.3891	26	1	0	1187	0	17	16
I-L	0.0	34.8622	-108.305	-73.4428	72	6	9	5293	1	31	32
J-K	-11.7857	34.1896	-104.255	-81.8511	75	5	9	5022	1	32	34
J-L	-3.7715	1.0516	-19.1285	-21.8484	24	1	0	911	0	15	13
K-L	-92.7217	-38.5883	-420.013	-551.323	201	35	11	17731	7	70	88

Interface residues

• A-B: ALA249A, ALA249B, ALA292A, ALA301A, ALA301B, ALA305A, ALA305B, ALA377A, ALA384A, ALA390A, ALA390B, ALA396A, ALA396B, ARG184A, ARG184B, ARG235A, ARG235B, ARG315A, ARG315B, ARG405A, ARG405B, ASN308A, ASN308B, ASN391A, ASN391B, ASN401A, ASN401B, ASN403A, ASN403B, ASN415A, ASN415B, ASP278B, ASP336A, ASP336B, ASP365A, ASP365B, ASP408A, ASP408B, CYS314A, CYS314B, GLN409A, GLN409B, GLU233A, GLU236A, GLU236B, GLU247A, GLU247B, GLU248A, GLU248B, GLU303A, GLU303B, GLU310A, GLU310B, GLU322A, GLU322B, GLU329A, GLU329B, GLU343A, GLU368A, GLU368B, GLU400B, GLU413A, GLU413B, GLU421B, GLY293A, GLY312A, GLY312B, GLY325A, GLY334A, GLY334B, GLY388A, GLY388B, GLY410A, GLY410B, GLY419A, GLY419B, HIS246A, HIS246B, HIS330A, HIS330B, HIS370A, HIS370B, ILE300B, ILE302A, ILE302B, ILE317A, ILE317B, ILE320A, ILE320B, ILE367B, ILE389A, ILE389B, ILE393A, ILE393B, ILE404A, ILE404B, ILE407A, ILE407B, ILE414A, ILE417A, ILE417B, LEU234A, LEU237A, LEU245A, LEU306A, LEU306B, LEU307A, LEU307B, LEU318A, LEU318B, LEU321A, LEU321B, LEU340B, LEU375A, LEU397A, LEU397B, LYS232A, LYS232B, LYS294A, LYS304A, LYS304B, LYS316A, LYS316B, LYS346A, LYS350A, LYS385A, LYS385B, LYS387A, LYS387B, LYS392A, LYS392B, LYS399A, LYS399B, PHE251A, PHE251B, PHE297A, PHE313A, PHE313B, PHE328A, PHE328B, PHE394A, PHE394B, PRO332A, PRO332B, SER238A, SER309A, SER309B, SER319A, SER319B, SER327A, SER327B, SER333A, SER333B, SER337A, SER337B, SER339A, SER339B, SER366A, SER366B, SER398A, SER398B, SER411A, SER411B, SER412A, SER412B, THR378A, THR386A, THR386B, THR395A, THR395B, TYR239A, TYR239B, TYR324A, VAL299A, VAL299B, VAL311A, VAL311B, VAL326A, VAL335A, VAL335B, VAL338A, VAL338B, VAL341A, VAL341B, VAL376A, VAL379A, VAL402A, VAL402B, VAL416A, VAL416B, VAL418A, VAL418B
• A-C: ARG315A, ARG315C, ASN363A, ASN363C, CYS362A, CYS362C, GLN361A, GLN361C, GLU310C, GLU322C, GLU357A, GLU357C, GLY312A, ILE320A, ILE320C, ILE358C, LYS316A, LYS316C, LYS359A, LYS359C, LYS360A, LYS360C, SER319A, SER319C, TYR324C, VAL311A
• A-D: ALA59A, ALA59D, ASN45A, ASN58A, ASN58D, ASN63A, ASN63D, ASP141D, ASP348A, ASP352A, ASP47A, ASP47D, ASP52A, ASP52D, ASP68A, ASP68D, ASP69A, ASP69D, CYS145D, CYS351A, CYS57A, CYS57D, GLU322A, GLU322D, GLY144D, GLY349A, GLY64A, GLY64D, HIS60A, HIS60D, ILE354A, ILE50A, ILE65A, ILE65D, ILE74A, LEU53A, LEU53D, LEU54A, LEU54D, LEU56A, LEU56D, LEU73A, LEU73D, LYS142D, LYS180D, LYS350A, LYS353A, LYS42A, LYS42D, LYS46A, LYS46D, LYS49A, LYS49D, LYS62A, LYS62D, PHE146D, PHE67A, PHE67D, PHE71A, PHE71D, PRO66A, PRO66D, SER143D, SER319A, THR51A, THR51D, TYR324A, TYR48A, TYR48D, TYR55A, TYR55D, VAL61A, VAL61D, VAL70A, VAL70D
• A-I: ALA165A, ARG218I, ASN163A, ASN176A, ASN296I, ASN372I, ASN45I, ASP141A, ASP216I, ASP344I, ASP348I, CYS162A, GLU130A, GLU153A, GLU157A, GLU426I, ILE132A, ILE219I, LEU160A, LYS142A, LYS149A, LYS150A, LYS156A, LYS158A, LYS164A, LYS295I, LYS46I, PHE175A, PHE297I, PHE425I, PRO371I, SER161A, THR298I, THR422I, THR44I, TYR34A, VAL159A, VAL423I
• A-L: ALA106A, ALA106L, ALA124A, ALA134L, ALA135L, ALA92A, ARG114L, ASN101A, ASN101L, ASN104A, ASN104L, ASN176L, ASP133L, ASP141L, ASP178L, ASP68A, ASP88A, ASP90A, GLU103A, GLU136L, GLU96A, GLU96L, GLY105A, GLY105L, GLY172L, GLY177L, ILE102A, ILE102L, ILE138L, ILE87A, ILE91A, LYS100A, LYS100L, LYS125A, LYS142L, LYS150L, LYS158L, LYS97A, LYS97L, LYS99A, PHE131A, PHE139L, PHE140L, PHE175L, SER107L, SER173L, SER174L, TYR110A, TYR110L, TYR117L, TYR171L, TYR93A, TYR93L, TYR94A, VAL121A, VAL137L, VAL179L, VAL98A, VAL98L
• B-C: ALA59B, ALA59C, ARG315C, ASN58B, ASN58C, ASN63B, ASN63C, ASP141B, ASP348C, ASP352C, ASP47B, ASP47C, ASP52B, ASP52C, ASP68B, ASP68C, ASP69B, ASP69C, CYS145B, CYS351C, CYS57B, CYS57C, GLU322B, GLU322C, GLY144B, GLY349C, GLY64B, GLY64C, HIS60B, HIS60C, ILE354C, ILE50B, ILE50C, ILE65B, ILE65C, ILE74B, ILE74C, LEU53B, LEU53C, LEU54B, LEU54C, LEU56B, LEU56C, LEU73B, LEU73C, LYS142B, LYS350C, LYS353B, LYS353C, LYS42B, LYS42C, LYS46B, LYS46C, LYS49B, LYS49C, LYS62B, LYS62C, PHE67B, PHE67C, PHE71B, PHE71C, PRO66B, PRO66C, SER143B, SER143C, THR51B, THR51C, TYR324C, TYR48B, TYR48C, TYR55B, TYR55C, VAL61B, VAL61C, VAL70B, VAL70C
• B-D: GLN361B, GLN361D, GLU356B, GLU356D, GLU357B, GLU357D, ILE320B, ILE320D, ILE354B, ILE358B, LYS353B, LYS353D, LYS360B, LYS360D, SER319B, SER319D, TYR324B, TYR324D
• B-F: ALA129B, ALA165B, ARG218F, ARG405F, ASN128B, ASN163B, ASN199B, ASN296F, ASN372F, ASN45F, ASP141B, ASP147B, ASP424F, CYS162B, GLU130B, GLU153B, GLU157B, GLU421F, GLU426F, HIS370F, ILE132B, ILE219F, LEU160B, LYS142B, LYS149B, LYS150B, LYS154B, LYS156B, LYS158B, LYS164B, LYS295F, LYS33B, LYS427F, LYS46F, PHE175B, PHE425F, PRO371F, SER161B, THR422F, THR44F, TYR152B, TYR34B, VAL159B, VAL423F
• B-G: ALA106B, ALA106G, ALA124B, ALA129B, ALA135G, ALA92B, ARG114G, ASN101B, ASN101G, ASN104B, ASN104G, ASN176G, ASN86B, ASP133G, ASP178B, ASP178G, ASP88B, ASP90B, GLU103B, GLU103G, GLU136G, GLU96B, GLU96G, GLY105B, GLY105G, GLY177G, ILE102B, ILE102G, ILE122B, ILE87B, ILE91B, LEU95B, LYS100B, LYS100G, LYS125B, LYS150G, LYS154G, LYS158G, LYS97B, LYS97G, LYS99B, LYS99G, PHE131B, PHE139G, PHE175G, SER107G, SER173G, SER174G, THR79B, TYR110B, TYR110G, TYR117B, TYR93B, TYR93G, TYR94B, VAL121B, VAL179G, VAL82B, VAL98B, VAL98G
• C-D: ALA249C, ALA292C, ALA301C, ALA301D, ALA305C, ALA305D, ALA377C, ALA377D, ALA384C, ALA390C, ALA390D, ALA396C, ALA396D, ARG184C, ARG184D, ARG235C, ARG235D, ARG315C, ARG315D, ARG405C, ARG405D, ASN308C, ASN308D, ASN363D, ASN391C, ASN391D, ASN401C, ASN401D, ASN403C, ASN403D, ASN415C, ASN415D, ASP278C, ASP336C, ASP336D, ASP365C, ASP365D, ASP408C, ASP408D, ASP424D, CYS314C, CYS314D, GLN409C, GLN409D, GLU233C, GLU233D, GLU236C, GLU236D, GLU247C, GLU247D, GLU248C, GLU248D, GLU303C, GLU303D, GLU310C, GLU310D, GLU322C, GLU322D, GLU329C, GLU329D, GLU343C, GLU368C, GLU368D, GLU400D, GLU413C, GLU413D, GLU421D, GLY185C, GLY293C, GLY312C, GLY312D, GLY325C, GLY325D, GLY334C, GLY334D, GLY388C, GLY388D, GLY410C, GLY410D, GLY419C, GLY419D, HIS246C, HIS246D, HIS330C, HIS330D, HIS370C, HIS370D, ILE300D, ILE302C, ILE302D, ILE317C, ILE317D, ILE320C, ILE320D, ILE389C, ILE389D, ILE393C, ILE393D, ILE404C, ILE404D, ILE407C, ILE407D, ILE414D, ILE417C, ILE417D, LEU234C, LEU234D, LEU237C, LEU237D, LEU306C, LEU306D, LEU307C, LEU307D, LEU318C, LEU318D, LEU321C, LEU321D, LEU340D, LEU375C, LEU397C, LEU397D, LYS232C, LYS232D, LYS254C, LYS254D, LYS294C, LYS304C, LYS304D, LYS316C, LYS316D, LYS346C, LYS346D, LYS385C, LYS385D, LYS387C, LYS387D, LYS392C, LYS392D, LYS399C, LYS399D, PHE251C, PHE251D, PHE313C, PHE313D, PHE328C, PHE328D, PHE394C, PHE394D, PRO332C, PRO332D, SER238C, SER238D, SER309C, SER309D, SER319C, SER319D, SER327C, SER327D, SER333C, SER333D, SER337C, SER337D, SER339C, SER339D, SER366D, SER398C, SER398D, SER411C, SER411D, SER412C, SER412D, THR378C, THR386C, THR395C, THR395D, TYR231C, TYR239C, TYR239D, TYR324C, TYR324D, VAL299C, VAL299D, VAL311C, VAL311D, VAL326C, VAL326D, VAL335C, VAL335D, VAL338C, VAL338D, VAL341C, VAL341D, VAL379C, VAL379D, VAL402C, VAL402D, VAL416C, VAL416D, VAL418C, VAL418D, VAL420D, VAL423D
• C-E: ALA196E, ALA200E, ARG405C, ASN199E, ASN401C, ASN403C, ASP201E, ASP365C, GLU303C, GLU368C, GLU400C, GLU421C, GLY257E, HIS280E, HIS370C, ILE258E, ILE283E, ILE367C, LEU285E, LEU397C, LYS156E, LYS399C, LYS427C, SER256E, SER277E, SER366C, SER398C, THR279E, VAL402C
• C-G: GLU153G, LYS149G, LYS150G, LYS46C
• C-J: ALA384C, ASN199C, ASN199J, ASN261J, ASN284C, ASN284J, ASN437J, ASP201J, ASP255C, ASP270J, ASP278C, GLU204J, GLU282C, GLU282J, GLU413C, GLY257C, GLY257J, GLY272J, GLY286C, GLY286J, GLY382C, HIS280C, HIS280J, ILE226J, ILE258C, ILE258J, ILE260J, ILE275J, ILE283C, ILE283J, ILE288J, ILE414C, LEU202J, LEU274J, LEU276J, LEU285C, LEU285J, LYS224J, LYS228C, LYS228J, LYS232C, LYS263J, LYS281C, LYS281J, LYS385C, LYS387C, LYS392J, PHE436J, PRO259C, PRO259J, PRO271J, SER227J, SER230C, SER256C, SER269J, SER277C, SER277J, THR225J, THR273J, THR279C, THR279J, THR287J, THR289J, THR381C, THR386C, TYR203J, TYR231C, TYR433J, VAL4J
• D-E: ALA200E, ALA384D, ALA435D, ASN199E, ASN261E, ASN284D, ASN284E, ASP201E, ASP278D, GLU204E, GLU282D, GLU282E, GLU413D, GLU438E, GLY257E, GLY286D, GLY286E, GLY382D, GLY388D, HIS280D, HIS280E, ILE229E, ILE258E, ILE260E, ILE275E, ILE283D, ILE283E, ILE389D, ILE414D, LEU1E, LEU202E, LEU274E, LEU276E, LEU285D, LEU285E, LYS224E, LYS228E, LYS232D, LYS281D, LYS281E, LYS2E, LYS385D, LYS387D, LYS392D, PHE436D, PRO259E, PRO271E, SER227E, SER230D, SER277D, SER277E, THR279D, THR279E, THR287D, THR287E, THR381D, THR386D, THR395D, TYR203E, VAL4E
• D-J: ALA196J, ALA200J, ARG405D, ASN199J, ASN284J, ASN372D, ASN401D, ASN403D, ASP201J, ASP255J, ASP352D, ASP424D, GLU282J, GLU368D, GLU421D, GLY197J, GLY257J, HIS280J, HIS370D, ILE258J, ILE283J, ILE367D, ILE369D, ILE3J, LEU285J, LYS156J, LYS281J, LYS359D, LYS385J, LYS427D, PRO371D, SER195J, SER256J, THR279J, VAL198J, VAL402D, VAL423D
• E-F: ALA249E, ALA249F, ALA301E, ALA301F, ALA305E, ALA305F, ALA377E, ALA377F, ALA390E, ALA390F, ALA396E, ALA396F, ARG184E, ARG184F, ARG235E, ARG235F, ARG315E, ARG315F, ARG405E, ARG405F, ASN308E, ASN308F, ASN391E, ASN391F, ASN401E, ASN401F, ASN403E, ASN403F, ASN415E, ASN415F, ASP278E, ASP278F, ASP336E, ASP336F, ASP365E, ASP408E, ASP408F, CYS314E, CYS314F, GLN409E, GLN409F, GLU233E, GLU233F, GLU236E, GLU236F, GLU247E, GLU247F, GLU248E, GLU248F, GLU303E, GLU303F, GLU310E, GLU310F, GLU322E, GLU322F, GLU329E, GLU329F, GLU368E, GLU368F, GLU413E, GLU413F, GLY312E, GLY312F, GLY334E, GLY334F, GLY388E, GLY388F, GLY410E, GLY410F, GLY419E, GLY419F, HIS246E, HIS330E, HIS330F, HIS370E, HIS370F, ILE250E, ILE250F, ILE300F, ILE302E, ILE302F, ILE317E, ILE317F, ILE320E, ILE320F, ILE389E, ILE389F, ILE393E, ILE393F, ILE404E, ILE404F, ILE407E, ILE407F, ILE414E, ILE414F, ILE417E, ILE417F, LEU234E, LEU234F, LEU237E, LEU237F, LEU306E, LEU306F, LEU307E, LEU307F, LEU318E, LEU318F, LEU321E, LEU321F, LEU340E, LEU340F, LEU397E, LEU397F, LYS232E, LYS232F, LYS304E, LYS304F, LYS316E, LYS316F, LYS346F, LYS385E, LYS385F, LYS387E, LYS387F, LYS392E, LYS392F, LYS399E, LYS399F, PHE251E, PHE251F, PHE313E, PHE313F, PHE328E, PHE328F, PHE394E, PHE394F, PRO332E, PRO332F, SER238E, SER238F, SER309E, SER309F, SER319E, SER319F, SER327E, SER327F, SER333E, SER333F, SER337E, SER337F, SER339E, SER339F, SER398E, SER398F, SER411E, SER411F, SER412E, SER412F, THR386F, THR395E, THR395F, TYR239E, TYR239F, VAL299E, VAL299F, VAL311E, VAL311F, VAL335E, VAL335F, VAL338E, VAL338F, VAL341E, VAL341F, VAL379E, VAL379F, VAL402E, VAL402F, VAL416E, VAL416F, VAL418E, VAL418F
• E-G: ARG315E, ARG315G, ASN363E, ASN363G, CYS362E, CYS362G, GLN361E, GLN361G, GLU310G, GLU322E, GLU322G, GLU356E, GLU357E, GLU357G, GLY312E, GLY312G, GLY325G, ILE320E, ILE320G, ILE358E, ILE358G, LEU318E, LEU321G, LYS316E, LYS316G, LYS353E, LYS359E, LYS359G, LYS360E, LYS360G, PHE313G, PRO364E, SER319E, SER319G, TYR324E, TYR324G, VAL311E, VAL311G
• E-H: ALA59E, ALA59H, ARG315E, ARG315H, ASN45E, ASN58E, ASN58H, ASN63E, ASN63H, ASP352E, ASP352H, ASP47E, ASP47H, ASP52E, ASP52H, ASP68E, ASP68H, ASP69E, ASP69H, CYS57E, CYS57H, GLN361H, GLU322E, GLU322H, GLY144E, GLY144H, GLY312E, GLY312H, GLY349E, GLY349H, GLY64E, GLY64H, HIS60E, HIS60H, ILE320E, ILE320H, ILE50E, ILE50H, ILE65E, ILE65H, ILE74E, LEU53E, LEU53H, LEU54E, LEU54H, LEU56E, LEU56H, LEU73E, LEU73H, LYS142E, LYS316E, LYS316H, LYS353E, LYS353H, LYS42E, LYS42H, LYS46E, LYS46H, LYS49E, LYS49H, LYS62E, LYS62H, PHE67E, PHE67H, PHE71E, PHE71H, PRO66E, PRO66H, SER143E, SER143H, SER319E, SER319H, THR51E, THR51H, TYR324E, TYR324H, TYR48E, TYR48H, TYR55E, TYR55H, VAL311E, VAL311H, VAL61E, VAL61H, VAL70E, VAL70H
• F-G: ALA59F, ALA59G, ARG315F, ARG315G, ASN58F, ASN58G, ASN63F, ASN63G, ASP141F, ASP141G, ASP147F, ASP348G, ASP352F, ASP352G, ASP47F, ASP47G, ASP52F, ASP52G, ASP68F, ASP68G, ASP69F, ASP69G, CYS145F, CYS145G, CYS351G, CYS57F, CYS57G, GLU322F, GLU322G, GLU356G, GLY144F, GLY144G, GLY349F, GLY349G, GLY64F, GLY64G, HIS60F, HIS60G, ILE354G, ILE50F, ILE50G, ILE65F, ILE65G, ILE74F, ILE74G, LEU53F, LEU53G, LEU54F, LEU54G, LEU56F, LEU56G, LEU73F, LEU73G, LYS142F, LYS142G, LYS350F, LYS350G, LYS353F, LYS353G, LYS42F, LYS42G, LYS46F, LYS46G, LYS49F, LYS49G, LYS62F, LYS62G, PHE140F, PHE146F, PHE175F, PHE67F, PHE67G, PHE71G, PRO66F, PRO66G, SER143F, SER143G, THR51F, THR51G, TYR324G, TYR48F, TYR48G, TYR55F, TYR55G, VAL61F, VAL61G, VAL70F, VAL70G
• F-H: ARG315F, ARG315H, ASN363F, ASN363H, CYS362F, CYS362H, GLN361F, GLN361H, GLU310F, GLU322F, GLU322H, GLU356H, GLU357F, GLU357H, GLY312F, GLY312H, ILE317F, ILE320F, ILE320H, ILE358F, ILE358H, LYS316F, LYS316H, LYS353H, LYS359F, LYS359H, LYS360F, LYS360H, PHE313F, PRO364H, SER319F, SER319H, TYR324H, VAL311F, VAL311H
• G-H: ALA249H, ALA301G, ALA301H, ALA305G, ALA305H, ALA377G, ALA377H, ALA384G, ALA390G, ALA390H, ALA396G, ALA396H, ARG235G, ARG235H, ARG315G, ARG315H, ARG405G, ARG405H, ASN308G, ASN308H, ASN391G, ASN391H, ASN401G, ASN401H, ASN403G, ASN403H, ASN415G, ASN415H, ASP278G, ASP336G, ASP336H, ASP365H, ASP408G, ASP408H, CYS314G, CYS314H, GLN409G, GLN409H, GLU233G, GLU233H, GLU236G, GLU236H, GLU247G, GLU247H, GLU248G, GLU248H, GLU303G, GLU303H, GLU310G, GLU310H, GLU322G, GLU322H, GLU329G, GLU329H, GLU368G, GLU368H, GLU400H, GLU413G, GLU413H, GLY312G, GLY312H, GLY325G, GLY334G, GLY334H, GLY388G, GLY388H, GLY410G, GLY410H, GLY419G, GLY419H, HIS246G, HIS246H, HIS330G, HIS330H, HIS370G, HIS370H, ILE250H, ILE300G, ILE302G, ILE302H, ILE317G, ILE317H, ILE320G, ILE320H, ILE389G, ILE389H, ILE393G, ILE393H, ILE404G, ILE404H, ILE407G, ILE407H, ILE414G, ILE414H, ILE417G, ILE417H, LEU234G, LEU234H, LEU237G, LEU237H, LEU306G, LEU306H, LEU307G, LEU307H, LEU318G, LEU318H, LEU321G, LEU321H, LEU340G, LEU340H, LEU397G, LEU397H, LYS232G, LYS232H, LYS304G, LYS304H, LYS316G, LYS316H, LYS346G, LYS346H, LYS385G, LYS385H, LYS387G, LYS387H, LYS392G, LYS392H, LYS399G, LYS399H, PHE251G, PHE251H, PHE313G, PHE313H, PHE328G, PHE328H, PHE394G, PHE394H, PRO332G, PRO332H, SER238G, SER238H, SER309G, SER309H, SER319G, SER319H, SER327G, SER327H, SER333G, SER333H, SER337G, SER337H, SER339G, SER339H, SER398G, SER398H, SER411G, SER411H, SER412G, SER412H, THR386G, THR386H, THR395G, THR395H, TYR231G, TYR239G, TYR239H, VAL299G, VAL299H, VAL311G, VAL311H, VAL326G, VAL335G, VAL335H, VAL338G, VAL338H, VAL341G, VAL341H, VAL379G, VAL379H, VAL402G, VAL402H, VAL416G, VAL416H, VAL418G, VAL418H
• I-J: ALA249I, ALA249J, ALA292I, ALA301I, ALA301J, ALA305I, ALA305J, ALA377I, ALA377J, ALA384I, ALA384J, ALA390I, ALA390J, ALA396I, ALA396J, ARG184I, ARG184J, ARG235I, ARG235J, ARG315I, ARG315J, ARG405I, ARG405J, ASN308I, ASN308J, ASN363J, ASN391I, ASN391J, ASN401I, ASN401J, ASN403I, ASN403J, ASN415I, ASN415J, ASP278I, ASP336I, ASP336J, ASP365J, ASP408I, ASP408J, CYS314I, CYS314J, GLN409I, GLN409J, GLU233J, GLU236I, GLU236J, GLU247I, GLU247J, GLU248I, GLU248J, GLU303I, GLU303J, GLU310I, GLU310J, GLU322I, GLU322J, GLU329I, GLU329J, GLU343I, GLU368I, GLU368J, GLU400J, GLU413I, GLU413J, GLU421J, GLY185I, GLY293I, GLY312I, GLY312J, GLY325I, GLY334I, GLY334J, GLY388I, GLY388J, GLY410I, GLY410J, GLY419I, GLY419J, HIS246I, HIS246J, HIS330I, HIS330J, HIS370I, HIS370J, ILE250I, ILE250J, ILE300I, ILE300J, ILE302I, ILE302J, ILE317I, ILE317J, ILE320I, ILE389I, ILE389J, ILE393I, ILE393J, ILE404I, ILE404J, ILE407I, ILE407J, ILE414I, ILE417I, ILE417J, LEU234I, LEU234J, LEU237I, LEU237J, LEU245I, LEU306I, LEU306J, LEU307I, LEU307J, LEU318I, LEU318J, LEU321I, LEU321J, LEU340J, LEU375I, LEU375J, LEU397I, LEU397J, LYS232I, LYS232J, LYS254I, LYS294I, LYS304I, LYS304J, LYS316I, LYS316J, LYS346I, LYS346J, LYS385I, LYS385J, LYS387I, LYS387J, LYS392I, LYS392J, LYS399I, LYS399J, PHE251I, PHE251J, PHE297I, PHE313I, PHE313J, PHE328I, PHE328J, PHE394I, PHE394J, PRO332I, PRO332J, SER238I, SER238J, SER309I, SER309J, SER319I, SER319J, SER327I, SER327J, SER333I, SER333J, SER337I, SER337J, SER339I, SER339J, SER366J, SER398I, SER398J, SER411I, SER411J, SER412I, SER412J, THR386I, THR386J, THR395I, THR395J, TYR231I, TYR231J, TYR239I, TYR239J, TYR324I, VAL299I, VAL299J, VAL311I, VAL311J, VAL326I, VAL326J, VAL335I, VAL335J, VAL338I, VAL338J, VAL341I, VAL341J, VAL379I, VAL379J, VAL402I, VAL402J, VAL416I, VAL416J, VAL418I, VAL418J
• I-K: ASN363K, CYS362I, CYS362K, GLN361I, GLN361K, GLU322I, GLU322K, GLU356I, GLU356K, GLU357I, GLU357K, ILE320I, ILE320K, ILE358I, LYS316I, LYS316K, LYS359I, LYS359K, LYS360I, LYS360K, SER319I, SER319K, TYR324I, TYR324K, VAL311I, VAL311K
• I-L: ALA59I, ALA59L, ASN58I, ASN58L, ASN63I, ASN63L, ASP141I, ASP141L, ASP352L, ASP47I, ASP47L, ASP52I, ASP52L, ASP68I, ASP68L, ASP69I, ASP69L, CYS145I, CYS145L, CYS57I, CYS57L, GLU322I, GLU322L, GLY349L, GLY64I, GLY64L, HIS60I, HIS60L, ILE50I, ILE50L, ILE65I, ILE65L, ILE74I, LEU53I, LEU53L, LEU54I, LEU54L, LEU56I, LEU56L, LEU73I, LEU73L, LYS142I, LYS142L, LYS180I, LYS353I, LYS353L, LYS42I, LYS42L, LYS46I, LYS46L, LYS49I, LYS49L, LYS62I, LYS62L, PHE140I, PHE146I, PHE67I, PHE67L, PHE71I, PHE71L, PRO66I, PRO66L, THR51I, THR51L, TYR48I, TYR48L, TYR55I, TYR55L, VAL61I, VAL61L, VAL70I, VAL70L
• J-K: ALA59J, ALA59K, ASN58J, ASN58K, ASN63J, ASN63K, ASP141J, ASP141K, ASP352J, ASP47J, ASP47K, ASP52J, ASP52K, ASP68J, ASP68K, ASP69J, ASP69K, CYS145J, CYS145K, CYS351J, CYS57J, CYS57K, GLU322J, GLU322K, GLY349J, GLY349K, GLY64J, GLY64K, HIS60J, HIS60K, ILE50J, ILE50K, ILE65J, ILE65K, ILE74J, LEU53J, LEU53K, LEU54J, LEU54K, LEU56J, LEU56K, LEU73J, LEU73K, LYS142J, LYS142K, LYS350J, LYS353J, LYS353K, LYS42J, LYS42K, LYS46J, LYS46K, LYS49J, LYS49K, LYS62J, LYS62K, PHE140K, PHE146K, PHE67J, PHE67K, PHE71J, PHE71K, PRO66J, PRO66K, SER319J, THR51J, THR51K, TYR48J, TYR48K, TYR55J, TYR55K, VAL61J, VAL61K, VAL70J, VAL70K
• J-L: CYS362L, GLN361J, GLN361L, GLU322J, GLU322L, GLU356J, GLU356L, GLU357J, GLU357L, ILE320J, ILE320L, ILE358L, LYS316J, LYS316L, LYS359J, LYS359L, LYS360J, LYS360L, SER319J, SER319L, TYR324J, TYR324L, VAL311J, VAL311L
• K-L: ALA249K, ALA249L, ALA292K, ALA301K, ALA301L, ALA305K, ALA305L, ALA377K, ALA377L, ALA384K, ALA390K, ALA390L, ALA396K, ALA396L, ARG184K, ARG184L, ARG235K, ARG235L, ARG315K, ARG315L, ARG405K, ARG405L, ASN308K, ASN308L, ASN363L, ASN391K, ASN391L, ASN401K, ASN401L, ASN403K, ASN403L, ASN415K, ASN415L, ASP255K, ASP278K, ASP336K, ASP336L, ASP365K, ASP365L, ASP408K, ASP408L, CYS314K, CYS314L, GLN409K, GLN409L, GLU233K, GLU236K, GLU236L, GLU247K, GLU247L, GLU248K, GLU248L, GLU303K, GLU303L, GLU310L, GLU322K, GLU322L, GLU329K, GLU329L, GLU343K, GLU368L, GLU400K, GLU400L, GLU413K, GLU413L, GLU421L, GLY293K, GLY312K, GLY312L, GLY325K, GLY334K, GLY334L, GLY388K, GLY388L, GLY410K, GLY410L, GLY419K, GLY419L, HIS246K, HIS246L, HIS330K, HIS330L, HIS370K, HIS370L, ILE250K, ILE250L, ILE300L, ILE302K, ILE302L, ILE317K, ILE317L, ILE320K, ILE320L, ILE389K, ILE389L, ILE393K, ILE393L, ILE404K, ILE404L, ILE407K, ILE407L, ILE414K, ILE417K, ILE417L, LEU234K, LEU234L, LEU237K, LEU237L, LEU245K, LEU306K, LEU306L, LEU307K, LEU307L, LEU318K, LEU318L, LEU321K, LEU321L, LEU340K, LEU340L, LEU375K, LEU397K, LEU397L, LYS232K, LYS232L, LYS254K, LYS254L, LYS294K, LYS304K, LYS304L, LYS316K, LYS316L, LYS346K, LYS385K, LYS385L, LYS387K, LYS387L, LYS392K, LYS392L, LYS399K, LYS399L, PHE251K, PHE251L, PHE297K, PHE313K, PHE313L, PHE328K, PHE328L, PHE394K, PHE394L, PRO332K, PRO332L, PRO364L, SER238K, SER238L, SER309K, SER309L, SER319K, SER319L, SER327K, SER327L, SER333K, SER333L, SER337K, SER337L, SER339K, SER339L, SER366L, SER398K, SER398L, SER411K, SER411L, SER412K, SER412L, THR386K, THR386L, THR395K, THR395L, TYR231K, TYR231L, TYR239K, TYR239L, TYR324K, VAL299K, VAL299L, VAL311K, VAL311L, VAL326K, VAL326L, VAL335K, VAL335L, VAL338K, VAL338L, VAL341L, VAL379K, VAL379L, VAL402K, VAL402L, VAL416K, VAL416L, VAL418K, VAL418L