3TSX

structure-function analysis of receptor-binding in adeno-associated virus serotype 6 (aav-6)

• Total interactions analyzed: 190
• Total true interactions: 39
• Strongest Interaction:
  • Chains: A-F
  • Int. Res.: 139
  • Norm. En. per Res.: -5.9382
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-73.4482	-3.3989	-672.014	-748.8611	215	47	13	26749	1	19	18
A-C	0.0	0.0	-0.0267	-0.0267	5	0	0	16	0	0	1
A-D	0.0	0.0	-0.0286	-0.0286	5	0	0	16	0	0	1
A-E	-79.5474	-3.1362	-657.783	-740.4667	213	52	14	26424	1	19	18
A-F	-184.5928	-238.6296	-402.189	-825.4113	139	36	2	15751	16	32	36
A-I	0.0	0.0	-6.0539	-6.0539	12	0	1	444	0	0	1
A-J	-298.4086	-24.6767	-1505.02	-1828.1053	343	143	26	58543	7	61	65
B-C	-90.5964	-3.4631	-658.873	-752.9325	215	53	13	26439	1	19	18
B-D	0.0	0.0	-0.0261	-0.0261	5	0	0	15	0	0	1
B-E	0.0	0.0	-0.0262	-0.0262	5	0	0	15	0	0	1
C-D	-82.8329	-3.3308	-661.051	-747.2147	213	41	13	26229	1	19	16
C-E	0.0	0.0	-0.0279	-0.0279	5	0	0	16	0	0	1
D-E	-92.9823	-2.3805	-684.936	-780.2988	214	44	13	26702	1	19	16
D-F	0.0	0.0	-7.6424	-7.6424	12	0	2	501	0	0	1
E-F	-316.0789	-24.8153	-1546.17	-1887.0641	342	134	27	58796	6	62	65
F-G	-64.8522	-2.6247	-661.022	-728.4989	212	44	13	26305	1	19	18
F-H	0.0	0.0	-0.0173	-0.0173	5	0	0	13	0	0	1
F-I	0.0	0.0	-0.0308	-0.0308	5	0	0	17	0	0	1
F-J	-89.1436	-4.7043	-707.953	-801.8009	216	56	13	27425	1	19	18
G-H	-74.1777	-3.5381	-663.071	-740.7868	213	43	13	26268	1	19	17
G-I	0.0	0.0	-0.032	-0.032	5	0	0	17	0	0	1
G-J	0.0	0.0	-0.0315	-0.0315	5	0	0	16	0	0	1
H-I	-79.3301	-2.8123	-678.746	-760.8884	216	53	13	26831	1	19	18
H-J	0.0	0.0	-0.0252	-0.0252	5	0	0	15	0	0	1
I-J	-68.1486	-2.576	-629.008	-699.7326	214	36	13	25578	1	19	16
K-L	-92.3918	-2.7466	-671.406	-766.5444	214	48	13	26461	1	19	18
K-M	0.0	0.0	-0.0257	-0.0257	5	0	0	15	0	0	1
K-O	-79.8013	-2.1643			25
K-P	-163.1955	-238.0415			29
K-T	-328.5054	-25.0525			84
L-M	-79.8794	-3.6631	-444.509	-528.0515	169	27	9	18004	1	14	13
M-N	-78.9205	-3.5919			23
N-O	-66.3824	-3.2172			21
O-P	-329.1718	-31.5013			82
P-Q	-74.9512	-3.689			22
P-T	-75.6093	-2.5939			24
Q-R	-83.6991	-4.3899			25
R-S	-68.9174	-3.3003			21
S-T	-82.5357	-3.0062			23

Interface residues

• A-B: ALA218A, ALA224B, ALA248B, ALA263A, ALA334A, ALA334B, ALA368B, ALA387A, ALA548B, ALA656A, ALA660A, ALA664A, ALA668A, ALA706B, ALA709B, ARG245B, ARG287B, ARG295B, ARG299B, ARG390A, ARG405A, ARG405B, ASN223A, ASN223B, ASN227B, ASN253A, ASN253B, ASN254B, ASN318B, ASN327A, ASN335A, ASN335B, ASN336A, ASN336B, ASN382A, ASN383A, ASN408A, ASN408B, ASN409A, ASN409B, ASN651B, ASN657A, ASN704B, ASN710B, ASN717B, ASN718B, ASP219A, ASP219B, ASP231B, ASP296B, ASP328A, ASP369B, ASP712B, ASP716B, CYS230B, CYS290B, CYS362B, CYS395A, GLN259A, GLN320B, GLN342A, GLN350A, GLN360B, GLN375B, GLN386A, GLN402A, GLN673A, GLN673B, GLN678B, GLU323A, GLU323B, GLU348A, GLU397A, GLU546B, GLU661A, GLY217A, GLY220A, GLY220B, GLY222A, GLY222B, GLY226B, GLY275A, GLY281B, GLY329B, GLY361B, GLY384A, GLY389A, GLY407A, GLY407B, GLY677B, GLY719B, HIS229B, HIS255A, HIS291B, HIS359B, ILE240B, ILE260A, ILE319A, ILE319B, ILE333B, ILE373B, ILE671A, LEU249B, LEU256A, LEU337A, LEU337B, LEU381A, LEU396A, LEU404A, LEU720B, LYS258A, LYS258B, LYS322B, LYS650A, LYS666A, LYS707B, MET372B, MET403A, PHE274A, PHE292B, PHE317B, PHE344A, PHE366B, PHE371B, PHE393A, PHE399A, PHE410A, PHE662A, PHE667A, PHE670A, PHE713B, PRO250B, PRO279A, PRO294B, PRO364B, PRO367B, PRO374B, PRO400A, PRO653A, PRO655A, PRO658A, PRO659A, SER225B, SER232B, SER243B, SER261A, SER277A, SER293B, SER339A, SER385A, SER391A, SER392A, SER401A, SER663A, SER669A, SER675B, SER703B, SER708B, THR233B, THR241B, THR242B, THR244B, THR246B, THR251B, THR278A, THR325A, THR325B, THR326A, THR326B, THR331B, THR332A, THR332B, THR338A, THR340A, THR380A, THR406A, THR406B, THR652A, THR665A, THR672A, THR672B, THR676B, THR702B, THR714B, THR722B, TRP228B, TRP234B, TRP247B, TRP280A, TRP297B, TYR252B, TYR257A, TYR276A, TYR282B, TYR376B, TYR378A, TYR394A, TYR398A, TYR674B, TYR705B, TYR721B, VAL221A, VAL221B, VAL239B, VAL321A, VAL321B, VAL324B, VAL330B, VAL341A, VAL343A, VAL370B, VAL388A, VAL654A, VAL711B, VAL715B
• A-C: ARG405A, GLY222C, LEU337A, LEU337C, THR338A
• A-D: ARG405D, GLY222A, LEU337A, LEU337D, THR338D
• A-E: ALA218E, ALA224A, ALA248A, ALA263E, ALA334A, ALA334E, ALA368A, ALA387E, ALA548A, ALA656E, ALA660E, ALA664E, ALA668E, ALA706A, ALA709A, ARG245A, ARG287A, ARG295A, ARG299A, ARG390E, ARG405A, ARG405E, ASN223A, ASN223E, ASN227A, ASN253A, ASN253E, ASN254A, ASN318A, ASN327E, ASN335A, ASN335E, ASN336A, ASN336E, ASN382E, ASN383E, ASN408A, ASN408E, ASN409E, ASN651A, ASN657E, ASN704A, ASN710A, ASN717A, ASN718A, ASP219A, ASP219E, ASP231A, ASP296A, ASP328E, ASP369A, ASP712A, ASP716A, CYS230A, CYS290A, CYS362A, CYS395E, GLN259E, GLN320A, GLN342E, GLN350E, GLN360A, GLN375A, GLN386E, GLN402E, GLN673A, GLN673E, GLN678A, GLU323A, GLU323E, GLU348E, GLU397E, GLU546A, GLU661E, GLY217E, GLY220A, GLY220E, GLY222A, GLY222E, GLY226A, GLY275E, GLY281A, GLY329A, GLY361A, GLY384E, GLY389E, GLY407A, GLY407E, GLY677A, GLY719A, HIS229A, HIS255E, HIS291A, HIS359A, ILE240A, ILE260E, ILE319A, ILE319E, ILE333A, ILE373A, ILE671E, LEU249A, LEU256E, LEU337A, LEU337E, LEU381E, LEU396E, LEU404E, LEU720A, LYS258A, LYS258E, LYS322A, LYS650E, LYS666E, LYS707A, MET372A, MET403E, PHE274E, PHE292A, PHE317A, PHE344E, PHE366A, PHE371A, PHE393E, PHE399E, PHE410E, PHE662E, PHE667E, PHE670E, PHE713A, PRO250A, PRO279E, PRO294A, PRO364A, PRO367A, PRO374A, PRO400E, PRO653E, PRO655E, PRO658E, PRO659E, SER225A, SER232A, SER243A, SER261E, SER277E, SER293A, SER339E, SER385E, SER391E, SER392E, SER401E, SER663E, SER669E, SER675A, SER703A, SER708A, THR233A, THR241A, THR242A, THR244A, THR246A, THR251A, THR278E, THR325A, THR325E, THR326A, THR326E, THR331A, THR332A, THR332E, THR338E, THR340E, THR380E, THR406A, THR406E, THR652E, THR665E, THR672A, THR672E, THR676A, THR702A, THR714A, THR722A, TRP228A, TRP234A, TRP247A, TRP280E, TRP297A, TYR252A, TYR257E, TYR276E, TYR282A, TYR376A, TYR378E, TYR394E, TYR398E, TYR674A, TYR705A, TYR721A, VAL221A, VAL221E, VAL321A, VAL321E, VAL324A, VAL330A, VAL341E, VAL343E, VAL370A, VAL388E, VAL654E, VAL711A, VAL715A
• A-F: ALA368A, ALA368F, ALA706A, ALA706F, ARG245A, ARG245F, ARG295A, ARG295F, ARG299A, ARG299F, ARG694A, ARG694F, ARG725A, ARG725F, ASN302A, ASN302F, ASN303A, ASN303F, ASN304A, ASN304F, ASN691A, ASN691F, ASN696A, ASN696F, ASN704A, ASN704F, ASP231A, ASP231F, ASP296A, ASP296F, ASP529A, ASP529F, ASP530A, ASP530F, ASP532A, ASP532F, ASP712A, ASP712F, CYS230A, CYS230F, CYS290A, CYS290F, GLN298A, GLN298F, GLN700A, GLN700F, GLU564A, GLU564F, GLU565A, GLU565F, GLU690A, GLU690F, GLU698A, GLU698F, GLU723A, GLU723F, GLY236A, GLY236F, HIS289A, HIS289F, HIS291A, HIS291F, HIS527A, HIS527F, ILE301A, ILE301F, ILE727A, ILE727F, LEU614A, LEU614F, LEU732A, LEU732F, LYS567A, LYS567F, LYS689A, LYS689F, LYS693A, LYS693F, LYS707A, LYS707F, PHE292A, PHE292F, PHE366A, PHE366F, PHE713A, PHE713F, PRO294A, PRO294F, PRO364A, PRO364F, PRO365A, PRO365F, PRO367A, PRO367F, PRO697A, PRO697F, PRO724A, PRO724F, SER232A, SER232F, SER243A, SER243F, SER293A, SER293F, SER692A, SER692F, SER703A, SER703F, THR233A, THR233F, THR242F, THR702A, THR702F, THR714A, THR714F, THR733A, THR733F, TRP234A, TRP234F, TRP297A, TRP297F, TRP305A, TRP305F, TRP695A, TRP695F, TYR701A, TYR701F, TYR705A, TYR705F, TYR721A, TYR721F, TYR731A, TYR731F, VAL699A, VAL699F, VAL711A, VAL711F, VAL715A, VAL715F
• A-I: ALA664I, ARG465A, ASN436A, ASP440A, GLN441A, GLU661I, ILE439A, LEU438A, PHE662I, SER663I, THR665I, TYR442A
• A-J: ALA267J, ALA358J, ALA426A, ALA456A, ALA469A, ALA506J, ALA523J, ALA525A, ALA548J, ALA550J, ALA554J, ALA568A, ALA573J, ALA581A, ALA592A, ALA601A, ALA601J, ALA620J, ARG287J, ARG390J, ARG433A, ARG448A, ARG465A, ARG485A, ARG485J, ARG488J, ARG514J, ARG576A, ARG576J, ARG610A, ARG610J, ARG694A, ARG730A, ARG734A, ASN253J, ASN269J, ASN271J, ASN286J, ASN302A, ASN382J, ASN383J, ASN436A, ASN447A, ASN451A, ASN458A, ASN477A, ASN496J, ASN497J, ASN498J, ASN500J, ASN510A, ASN510J, ASN512J, ASN519J, ASN552J, ASN557J, ASN570A, ASN570J, ASN583A, ASN691A, ASN696A, ASP270J, ASP284J, ASP346J, ASP432A, ASP440A, ASP460A, ASP495J, ASP529A, ASP530A, ASP556J, ASP590A, ASP595A, ASP595J, ASP609A, ASP609J, ASP611A, ASP626J, CYS290J, CYS362J, CYS395J, CYS483J, GLN350J, GLN360J, GLN375J, GLN386J, GLN429A, GLN441A, GLN450A, GLN452A, GLN457A, GLN474A, GLN486J, GLN487J, GLN585A, GLN608A, GLN608J, GLN615J, GLN646J, GLN688A, GLN700A, GLU348J, GLU397J, GLU515J, GLU546J, GLU564A, GLU565A, GLU575A, GLU575J, GLU698A, GLY266J, GLY275J, GLY281J, GLY306A, GLY356J, GLY361J, GLY377J, GLY384J, GLY389J, GLY466A, GLY470A, GLY481A, GLY481J, GLY505J, GLY513J, GLY521J, GLY539J, GLY544J, GLY549J, GLY578A, GLY594A, GLY600A, GLY600J, GLY604A, GLY616J, GLY627A, GLY627J, GLY636J, GLY637A, GLY637J, GLY639J, HIS272J, HIS289J, HIS359J, HIS422A, HIS427A, HIS527A, HIS597A, HIS597J, HIS624J, HIS628A, HIS628J, HIS630A, HIS630J, ILE260J, ILE301A, ILE373J, ILE439A, ILE517J, ILE518J, ILE542J, ILE560J, ILE566A, ILE618J, ILE622J, LEU351J, LEU355J, LEU379J, LEU381J, LEU396J, LEU431A, LEU434A, LEU438A, LEU443A, LEU446A, LEU461A, LEU462A, LEU479A, LEU511J, LEU555J, LEU584A, LEU584J, LEU602A, LEU602J, LEU634J, LEU640J, LEU732A, LEU736A, LYS258J, LYS459A, LYS476A, LYS491J, LYS493J, LYS508J, LYS528A, LYS528J, LYS531A, LYS531J, LYS533J, LYS545J, LYS567A, LYS621J, LYS693A, MET435A, MET471A, MET524J, MET537J, MET541J, MET559J, MET599A, MET599J, MET605A, MET605J, MET635J, PHE274J, PHE288J, PHE344J, PHE393J, PHE399J, PHE421A, PHE463A, PHE501J, PHE534J, PHE535J, PHE543J, PHE577A, PHE629A, PHE629J, PHE638J, PRO279J, PRO352J, PRO374J, PRO400J, PRO420A, PRO437A, PRO468A, PRO475A, PRO480A, PRO482A, PRO482J, PRO520J, PRO536J, PRO571A, PRO591A, PRO603A, PRO603J, PRO617J, PRO623J, PRO631J, PRO633J, PRO697A, PRO735A, SER261J, SER262J, SER268J, SER277J, SER357J, SER385J, SER391J, SER392J, SER423A, SER424A, SER428A, SER430A, SER464A, SER467A, SER472A, SER490J, SER499J, SER507J, SER516J, SER538J, SER547J, SER551J, SER586A, SER587A, SER588A, SER632A, SER632J, SER692A, THR265J, THR278J, THR380J, THR449A, THR492J, THR494J, THR502J, THR504J, THR522J, THR553J, THR561J, THR569A, THR574A, THR574J, THR579A, THR589A, THR593A, THR625J, THR729A, THR733A, TRP280J, TRP305A, TRP478A, TRP503J, TRP607A, TRP607J, TRP619J, TRP695A, TYR252J, TYR273J, TYR276J, TYR282J, TYR349J, TYR353J, TYR376J, TYR378J, TYR394J, TYR398J, TYR425A, TYR442A, TYR444A, TYR445A, TYR484J, TYR509J, TYR613J, TYR701A, TYR731A, VAL354J, VAL388J, VAL473A, VAL489J, VAL540J, VAL558J, VAL572A, VAL572J, VAL580A, VAL582A, VAL596A, VAL596J, VAL598A, VAL598J, VAL606A, VAL699A
• B-C: ALA218B, ALA224C, ALA248C, ALA263B, ALA334B, ALA334C, ALA368C, ALA387B, ALA548C, ALA656B, ALA660B, ALA664B, ALA668B, ALA706C, ALA709C, ARG245C, ARG287C, ARG295C, ARG299C, ARG390B, ARG405B, ARG405C, ASN223B, ASN223C, ASN227C, ASN253B, ASN253C, ASN254C, ASN318C, ASN327B, ASN335B, ASN335C, ASN336B, ASN336C, ASN382B, ASN383B, ASN408B, ASN408C, ASN409B, ASN409C, ASN651C, ASN657B, ASN704C, ASN710C, ASN717C, ASN718C, ASP219B, ASP219C, ASP231C, ASP296C, ASP328B, ASP369C, ASP712C, ASP716C, CYS230C, CYS290C, CYS362C, CYS395B, GLN259B, GLN320C, GLN342B, GLN350B, GLN360C, GLN375C, GLN386B, GLN402B, GLN673B, GLN673C, GLN678C, GLU323B, GLU323C, GLU348B, GLU397B, GLU546C, GLU661B, GLY217B, GLY220B, GLY220C, GLY222B, GLY222C, GLY226C, GLY275B, GLY281C, GLY329C, GLY361C, GLY384B, GLY389B, GLY407B, GLY407C, GLY677C, GLY719C, HIS229C, HIS255B, HIS291C, HIS359C, ILE240C, ILE260B, ILE319C, ILE333C, ILE373C, ILE671B, LEU249C, LEU256B, LEU337B, LEU337C, LEU381B, LEU396B, LEU404B, LEU720C, LYS258B, LYS258C, LYS322C, LYS650B, LYS666B, LYS707C, MET372C, MET403B, PHE274B, PHE292C, PHE317C, PHE344B, PHE366C, PHE371C, PHE393B, PHE399B, PHE410B, PHE662B, PHE667B, PHE670B, PHE713C, PRO250C, PRO279B, PRO294C, PRO364C, PRO365C, PRO367C, PRO374C, PRO400B, PRO653B, PRO655B, PRO658B, PRO659B, SER225C, SER232C, SER243C, SER261B, SER277B, SER293C, SER339B, SER385B, SER391B, SER392B, SER401B, SER663B, SER669B, SER675C, SER703C, SER708C, THR233C, THR241C, THR242C, THR244C, THR246C, THR251C, THR278B, THR325B, THR325C, THR326B, THR326C, THR331C, THR332B, THR332C, THR338B, THR340B, THR380B, THR406B, THR406C, THR652B, THR665B, THR672B, THR672C, THR676C, THR702C, THR714C, THR722C, TRP228C, TRP234C, TRP247C, TRP280B, TRP297C, TYR252C, TYR257B, TYR276B, TYR282C, TYR376C, TYR378B, TYR394B, TYR398B, TYR674C, TYR705C, TYR721C, VAL221B, VAL221C, VAL239C, VAL321B, VAL321C, VAL324C, VAL330C, VAL341B, VAL343B, VAL370C, VAL388B, VAL654B, VAL711C, VAL715C
• B-D: ARG405B, GLY222D, LEU337B, LEU337D, THR338B
• B-E: ARG405E, GLY222B, LEU337B, LEU337E, THR338E
• C-D: ALA218C, ALA224D, ALA248D, ALA263C, ALA334C, ALA334D, ALA368D, ALA387C, ALA548D, ALA656C, ALA660C, ALA664C, ALA668C, ALA706D, ALA709D, ARG245D, ARG287D, ARG295D, ARG299D, ARG390C, ARG405C, ARG405D, ASN223C, ASN223D, ASN227D, ASN253C, ASN253D, ASN254D, ASN318D, ASN327C, ASN335C, ASN335D, ASN336C, ASN336D, ASN382C, ASN383C, ASN408C, ASN408D, ASN409C, ASN409D, ASN651D, ASN657C, ASN704D, ASN710D, ASN717D, ASN718D, ASP219C, ASP219D, ASP231D, ASP296D, ASP328C, ASP369D, ASP712D, ASP716D, CYS230D, CYS290D, CYS362D, CYS395C, GLN259C, GLN320D, GLN342C, GLN350C, GLN360D, GLN375D, GLN386C, GLN402C, GLN673C, GLN673D, GLN678D, GLU323C, GLU323D, GLU348C, GLU397C, GLU546D, GLU661C, GLY217C, GLY220C, GLY220D, GLY222C, GLY222D, GLY226D, GLY275C, GLY281D, GLY329D, GLY361D, GLY384C, GLY389C, GLY407C, GLY407D, GLY677D, GLY719D, HIS229D, HIS255C, HIS291D, HIS359D, ILE240D, ILE260C, ILE319D, ILE333D, ILE373D, ILE671C, LEU249D, LEU256C, LEU337C, LEU337D, LEU381C, LEU396C, LEU404C, LEU720D, LYS258C, LYS258D, LYS322D, LYS650C, LYS666C, LYS707D, MET372D, MET403C, PHE274C, PHE292D, PHE317D, PHE344C, PHE366D, PHE371D, PHE393C, PHE399C, PHE410C, PHE662C, PHE667C, PHE670C, PHE713D, PRO250D, PRO279C, PRO294D, PRO364D, PRO367D, PRO374D, PRO400C, PRO653C, PRO655C, PRO658C, PRO659C, SER225D, SER232D, SER243D, SER261C, SER277C, SER293D, SER339C, SER385C, SER391C, SER392C, SER401C, SER663C, SER669C, SER675D, SER703D, SER708D, THR233D, THR241D, THR242D, THR244D, THR246D, THR251D, THR278C, THR325C, THR325D, THR326C, THR326D, THR331D, THR332C, THR332D, THR338C, THR340C, THR380C, THR406C, THR406D, THR652C, THR665C, THR672C, THR672D, THR676D, THR702D, THR714D, THR722D, TRP228D, TRP234D, TRP247D, TRP280C, TRP297D, TYR252D, TYR257C, TYR276C, TYR282D, TYR376D, TYR378C, TYR394C, TYR398C, TYR674D, TYR705D, TYR721D, VAL221C, VAL221D, VAL321C, VAL321D, VAL324D, VAL330D, VAL341C, VAL343C, VAL370D, VAL388C, VAL654C, VAL711D, VAL715D
• C-E: ARG405C, GLY222E, LEU337C, LEU337E, THR338C
• D-E: ALA218D, ALA224E, ALA248E, ALA263D, ALA334D, ALA334E, ALA368E, ALA387D, ALA548E, ALA656D, ALA660D, ALA664D, ALA668D, ALA706E, ALA709E, ARG245E, ARG287E, ARG295E, ARG299E, ARG390D, ARG405D, ARG405E, ASN223D, ASN223E, ASN227E, ASN253D, ASN253E, ASN254E, ASN318E, ASN327D, ASN335D, ASN335E, ASN336D, ASN336E, ASN382D, ASN383D, ASN408D, ASN408E, ASN409D, ASN651E, ASN657D, ASN704E, ASN710E, ASN717E, ASN718E, ASP219D, ASP219E, ASP231E, ASP296E, ASP328D, ASP369E, ASP712E, ASP716E, CYS230E, CYS290E, CYS362E, CYS395D, GLN259D, GLN320E, GLN342D, GLN350D, GLN360E, GLN375E, GLN386D, GLN402D, GLN673D, GLN673E, GLN678E, GLU323D, GLU323E, GLU348D, GLU397D, GLU546E, GLU661D, GLY217D, GLY220D, GLY220E, GLY222D, GLY222E, GLY226E, GLY275D, GLY281E, GLY329E, GLY361E, GLY384D, GLY389D, GLY407D, GLY407E, GLY677E, GLY719E, HIS229E, HIS255D, HIS291E, HIS359E, ILE240E, ILE260D, ILE319D, ILE319E, ILE333E, ILE373E, ILE671D, LEU249E, LEU256D, LEU337D, LEU337E, LEU381D, LEU396D, LEU404D, LEU720E, LYS258D, LYS258E, LYS322E, LYS650D, LYS666D, LYS707E, MET372E, MET403D, PHE274D, PHE292E, PHE317E, PHE344D, PHE366E, PHE371E, PHE393D, PHE399D, PHE410D, PHE662D, PHE667D, PHE670D, PHE713E, PRO250E, PRO279D, PRO294E, PRO364E, PRO365E, PRO367E, PRO374E, PRO400D, PRO653D, PRO655D, PRO658D, PRO659D, SER225E, SER232E, SER243E, SER261D, SER277D, SER293E, SER339D, SER385D, SER391D, SER392D, SER401D, SER663D, SER669D, SER675E, SER703E, SER708E, THR233E, THR241E, THR242E, THR244E, THR246E, THR251E, THR278D, THR325D, THR325E, THR326D, THR326E, THR331E, THR332D, THR332E, THR338D, THR340D, THR380D, THR406D, THR406E, THR652D, THR665D, THR672D, THR672E, THR676E, THR702E, THR714E, THR722E, TRP228E, TRP234E, TRP247E, TRP280D, TRP297E, TYR252E, TYR257D, TYR276D, TYR282E, TYR376E, TYR378D, TYR394D, TYR398D, TYR674E, TYR705E, TYR721E, VAL221D, VAL221E, VAL321D, VAL321E, VAL324E, VAL330E, VAL341D, VAL343D, VAL370E, VAL388D, VAL654D, VAL711E, VAL715E
• D-F: ALA664D, ARG465F, ASN436F, ASP440F, GLN441F, GLU661D, ILE439F, LEU438F, PHE662D, SER663D, THR665D, TYR442F
• E-F: ALA267E, ALA358E, ALA426F, ALA456F, ALA469F, ALA506E, ALA523E, ALA525F, ALA548E, ALA550E, ALA554E, ALA568F, ALA573E, ALA581F, ALA592F, ALA601E, ALA601F, ALA620E, ARG287E, ARG390E, ARG433F, ARG448F, ARG465F, ARG485E, ARG485F, ARG488E, ARG514E, ARG576E, ARG576F, ARG610E, ARG610F, ARG694F, ARG730F, ARG734F, ASN253E, ASN269E, ASN271E, ASN286E, ASN302F, ASN382E, ASN383E, ASN436F, ASN447F, ASN451F, ASN458F, ASN477F, ASN496E, ASN497E, ASN498E, ASN500E, ASN510E, ASN510F, ASN512E, ASN519E, ASN552E, ASN557E, ASN570E, ASN570F, ASN583F, ASN691F, ASN696F, ASP270E, ASP284E, ASP346E, ASP432F, ASP440F, ASP460F, ASP495E, ASP529F, ASP530F, ASP556E, ASP590F, ASP595E, ASP595F, ASP609E, ASP609F, ASP611F, ASP626E, CYS362E, CYS395E, CYS483E, CYS483F, GLN350E, GLN360E, GLN375E, GLN386E, GLN429F, GLN441F, GLN450F, GLN452F, GLN457F, GLN474F, GLN486E, GLN487E, GLN585F, GLN608E, GLN608F, GLN615E, GLN646E, GLN688F, GLN700F, GLU348E, GLU397E, GLU515E, GLU546E, GLU564F, GLU565F, GLU575E, GLU575F, GLU698F, GLY266E, GLY275E, GLY281E, GLY306F, GLY356E, GLY361E, GLY377E, GLY384E, GLY389E, GLY466F, GLY470F, GLY481E, GLY481F, GLY505E, GLY513E, GLY521E, GLY539E, GLY544E, GLY549E, GLY578F, GLY594F, GLY600E, GLY600F, GLY604F, GLY616E, GLY627E, GLY627F, GLY636E, GLY637E, GLY637F, GLY639E, HIS272E, HIS289E, HIS359E, HIS422F, HIS427F, HIS527F, HIS597E, HIS597F, HIS624E, HIS628E, HIS628F, HIS630E, HIS630F, ILE260E, ILE373E, ILE439F, ILE517E, ILE518E, ILE542E, ILE560E, ILE566F, ILE618E, ILE622E, LEU351E, LEU355E, LEU379E, LEU381E, LEU396E, LEU431F, LEU434F, LEU438F, LEU443F, LEU446F, LEU461F, LEU462F, LEU479F, LEU511E, LEU555E, LEU584E, LEU584F, LEU602E, LEU602F, LEU634E, LEU640E, LEU732F, LEU736F, LYS258E, LYS459F, LYS476F, LYS491E, LYS493E, LYS508E, LYS528E, LYS528F, LYS531E, LYS531F, LYS533E, LYS545E, LYS567F, LYS621E, LYS693F, MET435F, MET471F, MET524E, MET537E, MET541E, MET559E, MET599E, MET599F, MET605E, MET605F, MET635E, PHE274E, PHE288E, PHE344E, PHE393E, PHE399E, PHE421F, PHE463F, PHE501E, PHE534E, PHE535E, PHE543E, PHE577F, PHE629E, PHE629F, PHE638E, PRO279E, PRO352E, PRO374E, PRO400E, PRO420F, PRO437F, PRO468F, PRO475F, PRO480F, PRO482E, PRO482F, PRO520E, PRO536E, PRO571F, PRO591F, PRO603E, PRO603F, PRO617E, PRO623E, PRO631E, PRO633E, PRO697F, PRO735F, SER261E, SER262E, SER268E, SER277E, SER357E, SER385E, SER391E, SER392E, SER423F, SER424F, SER428F, SER430F, SER464F, SER467F, SER472F, SER490E, SER499E, SER507E, SER516E, SER538E, SER547E, SER551E, SER586F, SER587F, SER588F, SER632E, SER632F, SER692F, THR265E, THR278E, THR380E, THR449F, THR492E, THR494E, THR502E, THR504E, THR522E, THR553E, THR561E, THR569F, THR574E, THR574F, THR579F, THR589F, THR593F, THR625E, THR729F, THR733F, TRP280E, TRP305F, TRP478F, TRP503E, TRP607E, TRP607F, TRP619E, TRP695F, TYR252E, TYR273E, TYR276E, TYR282E, TYR349E, TYR353E, TYR376E, TYR378E, TYR394E, TYR398E, TYR425F, TYR442F, TYR444F, TYR445F, TYR484E, TYR509E, TYR613E, TYR701F, TYR731F, VAL354E, VAL388E, VAL473F, VAL489E, VAL540E, VAL558E, VAL572E, VAL572F, VAL580F, VAL582F, VAL596E, VAL596F, VAL598E, VAL598F, VAL606F, VAL699F
• F-G: ALA218F, ALA224G, ALA248G, ALA263F, ALA334F, ALA334G, ALA368G, ALA387F, ALA548G, ALA656F, ALA660F, ALA664F, ALA668F, ALA706G, ALA709G, ARG245G, ARG287G, ARG295G, ARG299G, ARG390F, ARG405F, ARG405G, ASN223F, ASN223G, ASN227G, ASN253F, ASN253G, ASN254G, ASN318G, ASN327F, ASN335F, ASN335G, ASN336F, ASN336G, ASN382F, ASN383F, ASN408F, ASN408G, ASN409F, ASN651G, ASN657F, ASN704G, ASN710G, ASN717G, ASN718G, ASP219F, ASP219G, ASP231G, ASP296G, ASP328F, ASP369G, ASP712G, ASP716G, CYS230G, CYS290G, CYS362G, CYS395F, GLN259F, GLN320G, GLN342F, GLN350F, GLN360G, GLN375G, GLN386F, GLN402F, GLN673F, GLN673G, GLN678G, GLU323F, GLU323G, GLU348F, GLU397F, GLU546G, GLU661F, GLY217F, GLY220F, GLY220G, GLY222F, GLY222G, GLY226G, GLY275F, GLY281G, GLY329G, GLY361G, GLY384F, GLY389F, GLY407F, GLY407G, GLY677G, GLY719G, HIS229G, HIS255F, HIS291G, HIS359G, ILE240G, ILE260F, ILE319F, ILE319G, ILE333G, ILE373G, ILE671F, LEU249G, LEU256F, LEU337F, LEU337G, LEU381F, LEU396F, LEU404F, LEU720G, LYS258F, LYS258G, LYS322G, LYS650F, LYS666F, LYS707G, MET372G, MET403F, PHE274F, PHE292G, PHE317G, PHE344F, PHE366G, PHE371G, PHE393F, PHE399F, PHE410F, PHE662F, PHE667F, PHE670F, PHE713G, PRO250G, PRO279F, PRO294G, PRO364G, PRO367G, PRO374G, PRO400F, PRO653F, PRO655F, PRO658F, PRO659F, SER225G, SER232G, SER243G, SER261F, SER277F, SER293G, SER339F, SER385F, SER391F, SER392F, SER401F, SER663F, SER669F, SER675G, SER703G, SER708G, THR233G, THR241G, THR242G, THR244G, THR246G, THR251G, THR278F, THR325F, THR325G, THR326F, THR326G, THR331G, THR332G, THR338F, THR340F, THR380F, THR406F, THR406G, THR652F, THR665F, THR672F, THR672G, THR676G, THR702G, THR714G, THR722G, TRP228G, TRP234G, TRP247G, TRP280F, TRP297G, TYR252G, TYR257F, TYR276F, TYR282G, TYR376G, TYR378F, TYR394F, TYR398F, TYR674G, TYR705G, TYR721G, VAL221F, VAL221G, VAL321F, VAL321G, VAL324G, VAL330G, VAL341F, VAL343F, VAL370G, VAL388F, VAL654F, VAL711G, VAL715G
• F-H: ARG405F, GLY222H, LEU337F, LEU337H, THR338F
• F-I: ARG405I, GLY222F, LEU337F, LEU337I, THR338I
• F-J: ALA218J, ALA224F, ALA248F, ALA263J, ALA334F, ALA334J, ALA368F, ALA387J, ALA548F, ALA656J, ALA660J, ALA664J, ALA668J, ALA706F, ALA709F, ARG245F, ARG287F, ARG295F, ARG299F, ARG390J, ARG405F, ARG405J, ASN223F, ASN223J, ASN227F, ASN253F, ASN253J, ASN254F, ASN318F, ASN327F, ASN327J, ASN335F, ASN335J, ASN336F, ASN336J, ASN382J, ASN383J, ASN408F, ASN408J, ASN409F, ASN409J, ASN651F, ASN657J, ASN704F, ASN710F, ASN717F, ASN718F, ASP219F, ASP219J, ASP231F, ASP296F, ASP328J, ASP369F, ASP712F, ASP716F, CYS230F, CYS290F, CYS362F, CYS395J, GLN259J, GLN320F, GLN342J, GLN350J, GLN360F, GLN375F, GLN386J, GLN402J, GLN673F, GLN673J, GLN678F, GLU323F, GLU323J, GLU348J, GLU397J, GLU546F, GLU661J, GLY217J, GLY220F, GLY220J, GLY222F, GLY222J, GLY226F, GLY275J, GLY281F, GLY329F, GLY361F, GLY384J, GLY389J, GLY407F, GLY407J, GLY677F, GLY719F, HIS229F, HIS255J, HIS291F, HIS359F, ILE240F, ILE260J, ILE319F, ILE319J, ILE333F, ILE373F, ILE671J, LEU249F, LEU256J, LEU337F, LEU337J, LEU381J, LEU396J, LEU404J, LEU720F, LYS258F, LYS258J, LYS322F, LYS650J, LYS666J, LYS707F, MET372F, MET403J, PHE274J, PHE292F, PHE317F, PHE344J, PHE366F, PHE371F, PHE393J, PHE399J, PHE410J, PHE662J, PHE667J, PHE670J, PHE713F, PRO250F, PRO279J, PRO294F, PRO364F, PRO367F, PRO374F, PRO400J, PRO653J, PRO655J, PRO658J, PRO659J, SER225F, SER232F, SER243F, SER261J, SER277J, SER293F, SER339J, SER385J, SER391J, SER392J, SER401J, SER663J, SER669J, SER675F, SER703F, SER708F, THR233F, THR241F, THR242F, THR244F, THR246F, THR251F, THR278J, THR325F, THR325J, THR326F, THR326J, THR331F, THR332F, THR332J, THR338J, THR340J, THR380J, THR406F, THR406J, THR652J, THR665J, THR672F, THR672J, THR676F, THR702F, THR714F, THR722F, TRP228F, TRP234F, TRP247F, TRP280J, TRP297F, TYR252F, TYR257J, TYR276J, TYR282F, TYR376F, TYR378J, TYR394J, TYR398J, TYR674F, TYR705F, TYR721F, VAL221F, VAL221J, VAL239F, VAL321F, VAL321J, VAL324F, VAL330F, VAL341J, VAL343J, VAL370F, VAL388J, VAL654J, VAL711F, VAL715F
• G-H: ALA218G, ALA224H, ALA248H, ALA263G, ALA334G, ALA334H, ALA368H, ALA387G, ALA548H, ALA656G, ALA660G, ALA664G, ALA668G, ALA706H, ALA709H, ARG245H, ARG287H, ARG295H, ARG299H, ARG390G, ARG405G, ARG405H, ASN223G, ASN223H, ASN227H, ASN253G, ASN253H, ASN254H, ASN318H, ASN327G, ASN335G, ASN335H, ASN336G, ASN336H, ASN382G, ASN383G, ASN408G, ASN408H, ASN409G, ASN409H, ASN651H, ASN657G, ASN704H, ASN710H, ASN717H, ASN718H, ASP219G, ASP219H, ASP231H, ASP296H, ASP328G, ASP369H, ASP712H, ASP716H, CYS230H, CYS290H, CYS362H, CYS395G, GLN259G, GLN320H, GLN342G, GLN350G, GLN360H, GLN375H, GLN386G, GLN402G, GLN673G, GLN673H, GLN678H, GLU323G, GLU323H, GLU348G, GLU397G, GLU546H, GLU661G, GLY217G, GLY220G, GLY220H, GLY222G, GLY222H, GLY226H, GLY275G, GLY281H, GLY329H, GLY361H, GLY384G, GLY389G, GLY407G, GLY407H, GLY677H, GLY719H, HIS229H, HIS255G, HIS291H, HIS359H, ILE240H, ILE260G, ILE319G, ILE319H, ILE333H, ILE373H, ILE671G, LEU249H, LEU256G, LEU337G, LEU337H, LEU381G, LEU396G, LEU404G, LEU720H, LYS258G, LYS258H, LYS322H, LYS650G, LYS666G, LYS707H, MET372H, MET403G, PHE274G, PHE292H, PHE317H, PHE344G, PHE366H, PHE371H, PHE393G, PHE399G, PHE410G, PHE662G, PHE667G, PHE670G, PHE713H, PRO250H, PRO279G, PRO294H, PRO364H, PRO367H, PRO374H, PRO400G, PRO653G, PRO655G, PRO658G, PRO659G, SER225H, SER232H, SER243H, SER261G, SER277G, SER293H, SER339G, SER385G, SER391G, SER392G, SER401G, SER663G, SER669G, SER675H, SER703H, SER708H, THR233H, THR241H, THR242H, THR244H, THR246H, THR251H, THR278G, THR325G, THR325H, THR326G, THR326H, THR331H, THR332H, THR338G, THR340G, THR380G, THR406G, THR406H, THR652G, THR665G, THR672G, THR672H, THR676H, THR702H, THR714H, THR722H, TRP228H, TRP234H, TRP247H, TRP280G, TRP297H, TYR252H, TYR257G, TYR276G, TYR282H, TYR376H, TYR378G, TYR394G, TYR398G, TYR674H, TYR705H, TYR721H, VAL221G, VAL221H, VAL321G, VAL321H, VAL324H, VAL330H, VAL341G, VAL343G, VAL370H, VAL388G, VAL654G, VAL711H, VAL715H
• G-I: ARG405G, GLY222I, LEU337G, LEU337I, THR338G
• G-J: ARG405J, GLY222G, LEU337G, LEU337J, THR338J
• H-I: ALA218H, ALA224I, ALA248I, ALA263H, ALA334H, ALA334I, ALA368I, ALA387H, ALA548I, ALA656H, ALA660H, ALA664H, ALA668H, ALA706I, ALA709I, ARG245I, ARG287I, ARG295I, ARG299I, ARG390H, ARG405H, ARG405I, ASN223H, ASN223I, ASN227I, ASN253H, ASN253I, ASN254I, ASN318I, ASN327H, ASN335H, ASN335I, ASN336H, ASN336I, ASN382H, ASN383H, ASN408H, ASN408I, ASN409H, ASN409I, ASN651I, ASN657H, ASN704I, ASN710I, ASN717I, ASN718I, ASP219H, ASP219I, ASP231I, ASP296I, ASP328H, ASP369I, ASP712I, ASP716I, CYS230I, CYS290I, CYS362I, CYS395H, GLN259H, GLN320I, GLN342H, GLN350H, GLN360I, GLN375I, GLN386H, GLN402H, GLN673H, GLN673I, GLN678I, GLU323H, GLU323I, GLU348H, GLU397H, GLU546I, GLU661H, GLY217H, GLY220H, GLY220I, GLY222H, GLY222I, GLY226I, GLY275H, GLY281I, GLY329I, GLY361I, GLY384H, GLY389H, GLY407H, GLY407I, GLY677I, GLY719I, HIS229I, HIS255H, HIS291I, HIS359I, ILE240I, ILE260H, ILE319H, ILE319I, ILE333I, ILE373I, ILE671H, LEU249I, LEU256H, LEU337H, LEU337I, LEU381H, LEU396H, LEU404H, LEU720I, LYS258H, LYS258I, LYS322I, LYS650H, LYS666H, LYS707I, MET372I, MET403H, PHE274H, PHE292I, PHE317I, PHE344H, PHE366I, PHE371I, PHE393H, PHE399H, PHE410H, PHE662H, PHE667H, PHE670H, PHE713I, PRO250I, PRO279H, PRO294I, PRO364I, PRO365I, PRO367I, PRO374I, PRO400H, PRO653H, PRO655H, PRO658H, PRO659H, SER225I, SER232I, SER243I, SER261H, SER277H, SER293I, SER339H, SER385H, SER391H, SER392H, SER401H, SER663H, SER669H, SER675I, SER703I, SER708I, THR233I, THR241I, THR242I, THR244I, THR246I, THR251I, THR278H, THR325H, THR325I, THR326H, THR326I, THR331I, THR332H, THR332I, THR338H, THR340H, THR380H, THR406H, THR406I, THR652H, THR665H, THR672H, THR672I, THR676I, THR702I, THR714I, THR722I, TRP228I, TRP234I, TRP247I, TRP280H, TRP297I, TYR252I, TYR257H, TYR276H, TYR282I, TYR376I, TYR378H, TYR394H, TYR398H, TYR674I, TYR705I, TYR721I, VAL221H, VAL221I, VAL239I, VAL321H, VAL321I, VAL324I, VAL330I, VAL341H, VAL343H, VAL370I, VAL388H, VAL654H, VAL711I, VAL715I
• H-J: ARG405H, GLY222J, LEU337H, LEU337J, THR338H
• I-J: ALA218I, ALA224J, ALA248J, ALA263I, ALA334I, ALA334J, ALA368J, ALA387I, ALA548J, ALA656I, ALA660I, ALA664I, ALA668I, ALA706J, ALA709J, ARG245J, ARG287J, ARG295J, ARG299J, ARG390I, ARG405I, ARG405J, ASN223I, ASN223J, ASN227J, ASN253I, ASN253J, ASN254J, ASN318J, ASN327I, ASN335I, ASN335J, ASN336I, ASN336J, ASN382I, ASN383I, ASN408I, ASN408J, ASN409I, ASN651J, ASN657I, ASN704J, ASN710J, ASN717J, ASN718J, ASP219I, ASP219J, ASP231J, ASP296J, ASP328I, ASP369J, ASP712J, ASP716J, CYS230J, CYS290J, CYS362J, CYS395I, GLN259I, GLN320J, GLN342I, GLN350I, GLN360J, GLN375J, GLN386I, GLN402I, GLN673I, GLN673J, GLN678J, GLU323I, GLU323J, GLU348I, GLU397I, GLU546J, GLU661I, GLY217I, GLY220I, GLY220J, GLY222I, GLY222J, GLY226J, GLY275I, GLY281J, GLY329J, GLY361J, GLY384I, GLY389I, GLY407I, GLY407J, GLY677J, GLY719J, HIS229J, HIS255I, HIS291J, HIS359J, ILE240J, ILE260I, ILE319I, ILE319J, ILE333J, ILE373J, ILE671I, LEU249J, LEU256I, LEU337I, LEU337J, LEU381I, LEU396I, LEU404I, LEU720J, LYS258I, LYS258J, LYS322J, LYS650I, LYS666I, LYS707J, MET372J, MET403I, PHE274I, PHE292J, PHE317J, PHE344I, PHE366J, PHE371J, PHE393I, PHE399I, PHE410I, PHE662I, PHE667I, PHE670I, PHE713J, PRO250J, PRO279I, PRO294J, PRO364J, PRO365J, PRO367J, PRO374J, PRO400I, PRO653I, PRO655I, PRO658I, PRO659I, SER225J, SER232J, SER243J, SER261I, SER277I, SER293J, SER339I, SER385I, SER391I, SER392I, SER401I, SER663I, SER669I, SER675J, SER703J, SER708J, THR233J, THR241J, THR242J, THR244J, THR246J, THR251J, THR278I, THR325I, THR325J, THR326I, THR326J, THR331J, THR332J, THR338I, THR340I, THR380I, THR406I, THR406J, THR652I, THR665I, THR672I, THR672J, THR676J, THR702J, THR714J, THR722J, TRP228J, TRP234J, TRP247J, TRP280I, TRP297J, TYR252J, TYR257I, TYR276I, TYR282J, TYR376J, TYR378I, TYR394I, TYR398I, TYR674J, TYR705J, TYR721J, VAL221I, VAL221J, VAL239J, VAL321I, VAL321J, VAL324J, VAL330J, VAL341I, VAL343I, VAL370J, VAL388I, VAL654I, VAL711J, VAL715J
• K-L: ALA218K, ALA224L, ALA248L, ALA263K, ALA334K, ALA334L, ALA368L, ALA387K, ALA548L, ALA656K, ALA660K, ALA664K, ALA668K, ALA706L, ALA709L, ARG245L, ARG287L, ARG295L, ARG299L, ARG390K, ARG405K, ARG405L, ASN223K, ASN223L, ASN227L, ASN253K, ASN253L, ASN254L, ASN318L, ASN327K, ASN335K, ASN335L, ASN336K, ASN336L, ASN382K, ASN383K, ASN408K, ASN408L, ASN409K, ASN409L, ASN651L, ASN657K, ASN704L, ASN710L, ASN717L, ASN718L, ASP219K, ASP219L, ASP231L, ASP296L, ASP328K, ASP369L, ASP712L, ASP716L, CYS230L, CYS290L, CYS362L, CYS395K, GLN259K, GLN320L, GLN342K, GLN350K, GLN360L, GLN375L, GLN386K, GLN402K, GLN673K, GLN673L, GLN678L, GLU323K, GLU323L, GLU348K, GLU397K, GLU546L, GLU661K, GLY217K, GLY220K, GLY220L, GLY222K, GLY222L, GLY226L, GLY275K, GLY281L, GLY329L, GLY361L, GLY384K, GLY389K, GLY407K, GLY407L, GLY677L, GLY719L, HIS229L, HIS255K, HIS291L, HIS359L, ILE240L, ILE260K, ILE319L, ILE333L, ILE373L, ILE671K, LEU249L, LEU256K, LEU337K, LEU337L, LEU381K, LEU396K, LEU404K, LEU720L, LYS258K, LYS258L, LYS322L, LYS650K, LYS666K, LYS707L, MET372L, MET403K, PHE274K, PHE292L, PHE317L, PHE344K, PHE366L, PHE371L, PHE393K, PHE399K, PHE410K, PHE662K, PHE667K, PHE670K, PHE713L, PRO250L, PRO279K, PRO294L, PRO364L, PRO367L, PRO374L, PRO400K, PRO653K, PRO655K, PRO658K, PRO659K, SER225L, SER232L, SER243L, SER261K, SER277K, SER293L, SER339K, SER385K, SER391K, SER392K, SER401K, SER663K, SER669K, SER675L, SER703L, SER708L, THR233L, THR241L, THR242L, THR244L, THR246L, THR251L, THR278K, THR325K, THR325L, THR326K, THR326L, THR331L, THR332K, THR332L, THR338K, THR340K, THR380K, THR406K, THR406L, THR652K, THR665K, THR672K, THR672L, THR676L, THR702L, THR714L, THR722L, TRP228L, TRP234L, TRP247L, TRP280K, TRP297L, TYR252L, TYR257K, TYR276K, TYR282L, TYR376L, TYR378K, TYR394K, TYR398K, TYR674L, TYR705L, TYR721L, VAL221K, VAL221L, VAL239L, VAL321K, VAL321L, VAL324L, VAL330L, VAL341K, VAL343K, VAL370L, VAL388K, VAL654K, VAL711L, VAL715L
• K-M: ARG405K, GLY222M, LEU337K, LEU337M, THR338K
• K-O: ALA387O, ARG245K, ARG405O, ASN227K, ASN335K, ASP219K, ASP219O, ASP369K, ASP716K, GLN259O, GLU397O, GLY222K, GLY389O, GLY407O, GLY719K, ILE319K, LYS258O, LYS666O, MET403O, SER401O, SER708K, THR338O, THR406K, TRP228K, TYR705K
• K-P: ARG295K, ARG295P, ARG299K, ARG299P, ARG694K, ARG694P, ASN303K, ASN303P, ASP231K, ASP231P, ASP529K, ASP529P, ASP530K, ASP530P, GLN298K, GLN298P, GLN700K, GLU690K, GLU690P, GLU698K, GLU698P, LYS693K, LYS693P, LYS707K, LYS707P, SER703K, THR702P, TRP695K, TRP695P
• K-T: ALA358T, ALA550T, ALA601K, ALA601T, ARG390T, ARG433K, ARG465K, ARG514T, ARG576K, ARG694K, ARG734K, ASN271T, ASN436K, ASN447K, ASN477K, ASN496T, ASN497T, ASN498T, ASN500T, ASN510T, ASN583K, ASP270T, ASP346T, ASP432K, ASP440K, ASP460K, ASP495T, ASP529K, ASP609K, ASP611K, ASP626T, GLN360T, GLN375T, GLN450K, GLN487T, GLN585K, GLU348T, GLU515T, GLU564K, GLU565K, GLU575K, GLU698K, GLY356T, GLY389T, GLY604K, GLY627T, HIS272T, HIS359T, HIS422K, HIS427K, HIS624T, HIS628T, HIS630K, ILE517T, ILE542T, LEU634T, LEU736K, LYS459K, LYS493T, LYS508T, LYS528K, LYS693K, MET605K, MET635T, PHE393T, PHE463K, PHE577K, PHE629T, SER391T, SER392T, SER472K, SER499T, SER587K, THR449K, THR494T, THR502T, THR553T, THR579K, TRP607K, TRP695K, TYR398T, TYR442K, TYR444K, TYR484T
• L-M: ALA218L, ALA224M, ALA248M, ALA334L, ALA334M, ALA368M, ALA387L, ALA656L, ALA660L, ALA664L, ALA668L, ARG245M, ARG287M, ARG295M, ARG299M, ARG405L, ARG405M, ASN223L, ASN223M, ASN227M, ASN253M, ASN254M, ASN318M, ASN327L, ASN335L, ASN335M, ASN336L, ASN336M, ASN408L, ASN408M, ASN409L, ASN657L, ASP219L, ASP219M, ASP231M, ASP296M, ASP328L, ASP369M, ASP716M, CYS230M, CYS290M, CYS362M, CYS395L, GLN259L, GLN320M, GLN342L, GLN350L, GLN360M, GLN375M, GLN402L, GLN673L, GLU323L, GLU323M, GLU348L, GLU397L, GLU661L, GLY217L, GLY220L, GLY220M, GLY222L, GLY222M, GLY226M, GLY281M, GLY329M, GLY361M, GLY389L, GLY407L, GLY407M, GLY719M, HIS229M, HIS255L, HIS291M, HIS359M, ILE240M, ILE319L, ILE319M, ILE333M, ILE373M, ILE671L, LEU249M, LEU256L, LEU337L, LEU337M, LEU396L, LEU404L, LYS258L, LYS258M, LYS322M, LYS650L, LYS666L, MET372M, MET403L, PHE292M, PHE317M, PHE344L, PHE366M, PHE371M, PHE393L, PHE399L, PHE410L, PHE662L, PHE667L, PHE670L, PRO250M, PRO279L, PRO294M, PRO364M, PRO367M, PRO374M, PRO400L, PRO653L, PRO655L, PRO658L, PRO659L, SER225M, SER232M, SER243M, SER293M, SER339L, SER392L, SER401L, SER663L, SER669L, SER708M, THR233M, THR241M, THR242M, THR244M, THR246M, THR251M, THR278L, THR325L, THR325M, THR326L, THR326M, THR331M, THR332L, THR332M, THR338L, THR340L, THR406L, THR406M, THR652L, THR665L, THR672L, TRP228M, TRP234M, TRP247M, TRP280L, TRP297M, TYR252M, TYR257L, TYR282M, TYR376M, TYR378L, TYR394L, TYR398L, TYR674M, TYR705M, VAL221L, VAL221M, VAL321L, VAL321M, VAL324M, VAL330M, VAL341L, VAL343L, VAL370M, VAL654L
• M-N: ALA387M, ARG245N, ARG405M, ASP219M, ASP219N, ASP369N, ASP716N, GLN259M, GLU397M, GLU546N, GLY222N, GLY389M, GLY407M, GLY719N, ILE319N, LYS258M, LYS666M, SER401M, SER708N, THR406N, TRP228N, TYR705N, VAL221N
• N-O: ALA387N, ARG245O, ARG405N, ASP219N, ASP219O, ASP369O, ASP716O, GLU397N, GLU546O, GLY222O, GLY389N, GLY407N, GLY719O, LYS258N, LYS666N, SER401N, SER708O, THR406O, TRP228O, TYR705O, VAL221O
• O-P: ALA358O, ALA550O, ALA601O, ALA601P, ARG390O, ARG433P, ARG465P, ARG514O, ARG576P, ARG694P, ARG734P, ASN271O, ASN436P, ASN477P, ASN497O, ASN498O, ASN500O, ASN510O, ASN583P, ASP270O, ASP346O, ASP432P, ASP440P, ASP460P, ASP495O, ASP529P, ASP609P, ASP626O, GLN360O, GLN375O, GLN450P, GLN487O, GLN585P, GLU348O, GLU515O, GLU564P, GLU565P, GLU575P, GLU698P, GLY356O, GLY389O, GLY549O, GLY604P, GLY627O, HIS272O, HIS359O, HIS422P, HIS427P, HIS624O, HIS628O, HIS630P, ILE517O, ILE542O, LEU634O, LEU736P, LYS459P, LYS493O, LYS508O, LYS528P, LYS693P, MET605P, MET635O, PHE393O, PHE463P, PHE577P, PHE629O, SER391O, SER428P, SER430P, SER472P, SER499O, SER587P, THR380O, THR449P, THR494O, THR553O, THR579P, TRP607P, TRP695P, TYR398O, TYR442P, TYR444P
• P-Q: ALA387P, ARG245Q, ARG405P, ASP219P, ASP219Q, ASP369Q, ASP716Q, GLN259P, GLU397P, GLU546Q, GLY222Q, GLY389P, GLY407P, GLY719Q, ILE319Q, LYS258P, LYS666P, SER401P, SER708Q, THR406Q, TRP228Q, TYR705Q
• P-T: ALA387T, ARG245P, ARG405T, ASN335P, ASP219P, ASP219T, ASP369P, ASP716P, GLN259T, GLU397T, GLY222P, GLY389T, GLY407T, GLY719P, ILE319P, LYS258T, LYS666T, SER401T, SER708P, THR338T, THR406P, TRP228P, TYR705P, VAL221P
• Q-R: ALA387Q, ARG245R, ARG405Q, ASN227R, ASP219Q, ASP219R, ASP369R, ASP716R, GLN259Q, GLU397Q, GLU546R, GLY222R, GLY389Q, GLY407Q, GLY719R, ILE319R, LYS258Q, LYS666Q, MET403Q, SER401Q, SER708R, THR406R, TRP228R, TYR705R, VAL221R
• R-S: ALA387R, ARG245S, ARG405R, ASP219R, ASP219S, ASP369S, ASP716S, GLU397R, GLU546S, GLY222S, GLY389R, GLY407R, GLY719S, LYS258R, LYS666R, SER401R, SER708S, THR406S, TRP228S, TYR705S, VAL221S
• S-T: ALA387S, ARG245T, ARG405S, ASP219S, ASP219T, ASP369T, ASP716T, GLN259S, GLU397S, GLU546T, GLY222T, GLY389S, GLY407S, GLY719T, ILE319T, LYS258S, LYS666S, SER401S, SER708T, THR406T, TRP228T, TYR705T, VAL221T