3TOS

crystal structure of cals11, calicheamicin methyltransferase

• Total interactions analyzed: 45
• Total true interactions: 25
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 111
  • Norm. En. per Res.: -4.734
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-0.0524	-0.0524	2	0	0	4	0	0	1
A-C	-71.8769	-35.2811	-418.314	-525.472	111	10	9	15197	0	35	34
A-D	-48.7541	-79.3157	-705.572	-833.6418	186	10	27	30509	2	80	64
A-H	-43.0682	-36.0722	-415.938	-495.0784	110	11	9	15287	0	32	34
A-J	-7.8802	0.0	-50.3426	-58.2228	31	1	1	1798	0	0	2
B-C	-49.694	-88.802	-705.813	-844.309	186	13	27	30558	3	80	64
B-D	-68.0265	-36.0061	-419.444	-523.4767	111	12	9	15416	0	32	36
B-F	-12.6441	0.0	-51.1103	-63.7544	30	1	1	1796	0	0	2
B-G	-50.6761	-35.7484	-413.56	-499.9844	110	11	9	15250	0	35	34
C-D	-10.6288	0.0	-52.6378	-63.2666	30	2	1	1821	0	0	2
C-F	-70.9225	-31.2101	-417.597	-519.7296	110	10	9	15200	0	33	34
C-G	0.0	0.0	-0.0283	-0.0283	2	0	0	5	0	0	1
D-H	0.0	0.0	-0.068	-0.068	2	0	0	5	0	0	1
D-J	-74.6463	-35.231	-409.068	-518.9453	110	11	8	14862	0	33	34
E-F	-58.9085	-36.0928	-426.703	-521.7044	111	11	9	15409	0	33	34
E-G	-5.943	0.0	-52.2595	-58.2025	31	2	1	1823	0	0	2
E-H	-59.8332	-35.7617	-419.469	-515.0639	112	10	8	15313	0	34	34
E-I	-22.9932	-82.8552	-700.138	-805.9864	187	11	27	30404	2	80	64
E-J	0.0	0.0	-0.0643	-0.0643	2	0	0	5	0	0	1
F-G	-46.8872	-81.9983	-706.399	-835.2845	186	11	27	30488	2	79	64
F-I	0.0	0.0	-0.0731	-0.0731	2	0	0	5	0	0	1
G-I	-46.9203	-35.9149	-419.986	-502.8212	111	10	8	15254	0	33	34
H-I	0.0	0.0	-50.7413	-50.7413	31	4	1	1827	0	0	2
H-J	-23.8848	-80.7383	-699.117	-803.74	187	9	27	30265	2	81	64
I-J	-44.3916	-36.1211	-423.863	-504.3757	111	10	9	15366	0	32	34

Interface residues

• A-B: GLU18A, GLU18B
• A-C: ALA11A, ALA176C, ALA184C, ALA229A, ALA239A, ALA249A, ALA251A, ARG101C, ARG102C, ARG10A, ARG159C, ARG204C, ARG231A, ARG242A, ARG247A, ARG254A, ARG254C, ARG50A, ARG64C, ASN178C, ASN220A, ASN227A, ASN98C, ASP119A, ASP15A, ASP216A, ASP219A, ASP237A, ASP257A, ASP257C, ASP68C, ASP8A, GLN158C, GLN180C, GLN65C, GLN7A, GLU177C, GLU18A, GLU19A, GLU217A, GLU226A, GLU95C, GLY154C, GLY210C, GLY225A, GLY235A, GLY246A, GLY256A, GLY256C, GLY71C, HIS14A, HIS155C, HIS238A, HIS238C, HIS51A, ILE183C, ILE203C, ILE212C, ILE228A, LEU100C, LEU175C, LEU207C, LEU218A, LEU236A, LEU241A, LEU243A, LEU244A, LEU253A, LEU67C, LEU9A, LYS209C, LYS222A, PHE12A, PHE152C, PHE153C, PHE215A, PRO179C, PRO17A, PRO205C, PRO221A, PRO224A, PRO240A, PRO245A, PRO248A, PRO250A, PRO70C, PRO96C, PRO99C, SER16A, SER211C, THR157C, THR181C, THR208C, THR54A, TRP223A, TRP255C, TYR174C, TYR206C, TYR252A, TYR63C, TYR94C, TYR97C, VAL118A, VAL121A, VAL13A, VAL156C, VAL161C, VAL182C, VAL66C, VAL69C, VAL72C
• A-D: ALA131A, ALA131D, ALA138A, ALA138D, ALA146A, ALA146D, ALA61A, ALA61D, ALA88A, ALA88D, ALA89A, ALA89D, ARG129A, ARG129D, ARG247A, ARG247D, ARG25A, ARG25D, ARG49A, ARG49D, ARG50A, ARG50D, ARG64A, ARG64D, ARG79A, ARG79D, ARG82A, ARG82D, ARG91A, ARG91D, ASN32A, ASN32D, ASN42A, ASN42D, ASN43A, ASN43D, ASP145A, ASP145D, ASP151A, ASP151D, ASP15A, ASP15D, ASP55A, ASP55D, ASP60A, ASP60D, CYS149A, CYS149D, GLN24A, GLN24D, GLN52A, GLN52D, GLU142A, GLU142D, GLU148A, GLU148D, GLU18A, GLU18D, GLU19A, GLU19D, GLU21A, GLU21D, GLU38A, GLU38D, GLU39A, GLU39D, GLU95A, GLU95D, GLY134A, GLY134D, GLY135A, GLY135D, GLY154A, GLY154D, GLY246A, GLY246D, GLY81A, GLY81D, GLY85A, GLY85D, GLY92A, GLY92D, HIS147A, HIS147D, HIS51A, HIS51D, HIS83A, HIS83D, ILE35A, ILE35D, LEU140A, LEU140D, LEU144A, LEU144D, LEU26A, LEU26D, LEU29A, LEU29D, LEU30A, LEU30D, LEU40A, LEU40D, LEU44A, LEU44D, LEU46A, LEU46D, LEU48A, LEU48D, LEU56A, LEU56D, LEU57A, LEU57D, LEU84A, LEU84D, LEU90A, LEU90D, LYS141A, LYS141D, LYS28A, LYS28D, PHE130A, PHE130D, PHE152A, PHE152D, PHE47A, PHE47D, PHE80A, PHE80D, PHE87A, PHE87D, PRO133A, PRO133D, PRO137A, PRO137D, PRO17A, PRO17D, PRO245A, PRO245D, PRO34A, PRO34D, PRO36A, PRO36D, PRO45A, PRO45D, PRO96A, PRO96D, SER150A, SER150D, SER16A, SER16D, SER33A, SER33D, SER58A, SER58D, THR20A, THR20D, THR22A, THR22D, THR23A, THR23D, THR27A, THR27D, THR31A, THR31D, THR37A, THR37D, THR54A, THR54D, THR86A, THR86D, TYR136A, TYR136D, TYR139A, TYR139D, TYR94A, TYR94D, VAL132A, VAL132D, VAL143A, VAL143D, VAL41A, VAL41D, VAL78A, VAL78D, VAL93A, VAL93D
• A-H: ALA11H, ALA176A, ALA184A, ALA229H, ALA239H, ALA249H, ALA251H, ARG101A, ARG102A, ARG10H, ARG159A, ARG204A, ARG231H, ARG242H, ARG247H, ARG254A, ARG254H, ARG50H, ARG64A, ASN178A, ASN220H, ASN227H, ASN98A, ASP119H, ASP15H, ASP216H, ASP219H, ASP237H, ASP257A, ASP257H, ASP68A, ASP8H, GLN158A, GLN180A, GLN65A, GLN7H, GLU177A, GLU18H, GLU19H, GLU217H, GLU226H, GLU95A, GLY154A, GLY210A, GLY225H, GLY235H, GLY246H, GLY256A, GLY256H, GLY71A, HIS14H, HIS155A, HIS238A, HIS238H, HIS51H, ILE183A, ILE203A, ILE228H, LEU100A, LEU175A, LEU207A, LEU218H, LEU236H, LEU241H, LEU243H, LEU244H, LEU253H, LEU67A, LEU9H, LYS209A, LYS222H, PHE12H, PHE152A, PHE153A, PHE215H, PRO179A, PRO17H, PRO205A, PRO221H, PRO224H, PRO240H, PRO245H, PRO248H, PRO250H, PRO70A, PRO96A, PRO99A, SER16H, SER211A, THR157A, THR181A, THR208A, THR54H, TRP223H, TRP255A, TYR174A, TYR206A, TYR252H, TYR63A, TYR94A, TYR97A, VAL118H, VAL121H, VAL13H, VAL156A, VAL161A, VAL182A, VAL66A, VAL69A, VAL72A
• A-J: ALA89A, ARG159J, ARG91A, ARG91J, ASN98A, ASP151A, ASP151J, CYS149A, CYS149J, GLU95A, GLU95J, GLY154A, GLY154J, GLY92A, GLY92J, LEU90A, LEU90J, PHE152A, PHE152J, PHE153A, PHE153J, PRO96A, PRO96J, SER150A, SER150J, TYR94A, TYR94J, TYR97A, TYR97J, VAL93A, VAL93J
• B-C: ALA131B, ALA131C, ALA138B, ALA138C, ALA146B, ALA146C, ALA61B, ALA61C, ALA88B, ALA88C, ALA89B, ALA89C, ARG129B, ARG129C, ARG247B, ARG247C, ARG25B, ARG25C, ARG49B, ARG49C, ARG50B, ARG50C, ARG64B, ARG64C, ARG79B, ARG79C, ARG82B, ARG82C, ARG91B, ARG91C, ASN32B, ASN32C, ASN42B, ASN42C, ASN43B, ASN43C, ASP145B, ASP145C, ASP151B, ASP151C, ASP15B, ASP15C, ASP55B, ASP55C, ASP60B, ASP60C, CYS149B, CYS149C, GLN24B, GLN24C, GLN52B, GLN52C, GLU142B, GLU142C, GLU148B, GLU148C, GLU18B, GLU18C, GLU19B, GLU19C, GLU21B, GLU21C, GLU38B, GLU38C, GLU39B, GLU39C, GLU95B, GLU95C, GLY134B, GLY134C, GLY135B, GLY135C, GLY154B, GLY154C, GLY246B, GLY246C, GLY81B, GLY81C, GLY85B, GLY85C, GLY92B, GLY92C, HIS147B, HIS147C, HIS51B, HIS51C, HIS83B, HIS83C, ILE35B, ILE35C, LEU140B, LEU140C, LEU144B, LEU144C, LEU26B, LEU26C, LEU29B, LEU29C, LEU30B, LEU30C, LEU40B, LEU40C, LEU44B, LEU44C, LEU46B, LEU46C, LEU48B, LEU48C, LEU56B, LEU56C, LEU57B, LEU57C, LEU84B, LEU84C, LEU90B, LEU90C, LYS141B, LYS141C, LYS28B, LYS28C, PHE130B, PHE130C, PHE152B, PHE152C, PHE47B, PHE47C, PHE80B, PHE80C, PHE87B, PHE87C, PRO133B, PRO133C, PRO137B, PRO137C, PRO17B, PRO17C, PRO245B, PRO245C, PRO34B, PRO34C, PRO36B, PRO36C, PRO45B, PRO45C, PRO96B, PRO96C, SER150B, SER150C, SER16B, SER16C, SER33B, SER33C, SER58B, SER58C, THR20B, THR20C, THR22B, THR22C, THR23B, THR23C, THR27B, THR27C, THR31B, THR31C, THR37B, THR37C, THR54B, THR54C, THR86B, THR86C, TYR136B, TYR136C, TYR139B, TYR139C, TYR94B, TYR94C, VAL132B, VAL132C, VAL143B, VAL143C, VAL41B, VAL41C, VAL78B, VAL78C, VAL93B, VAL93C
• B-D: ALA11B, ALA176D, ALA184D, ALA229B, ALA239B, ALA249B, ALA251B, ARG101D, ARG102D, ARG10B, ARG159D, ARG204D, ARG231B, ARG242B, ARG247B, ARG254B, ARG254D, ARG50B, ARG64D, ASN178D, ASN220B, ASN227B, ASN98D, ASP119B, ASP15B, ASP216B, ASP219B, ASP237B, ASP257B, ASP257D, ASP68D, ASP8B, GLN158D, GLN180D, GLN65D, GLN7B, GLU177D, GLU18B, GLU19B, GLU217B, GLU226B, GLU95D, GLY154D, GLY210D, GLY225B, GLY235B, GLY246B, GLY256B, GLY256D, GLY6B, GLY71D, HIS14B, HIS155D, HIS238B, HIS238D, HIS51B, ILE183D, ILE203D, ILE228B, LEU100D, LEU175D, LEU207D, LEU218B, LEU236B, LEU241B, LEU243B, LEU244B, LEU253B, LEU67D, LEU9B, LYS209D, LYS222B, PHE12B, PHE152D, PHE153D, PHE215B, PRO179D, PRO17B, PRO205D, PRO221B, PRO224B, PRO240B, PRO245B, PRO248B, PRO250B, PRO70D, PRO96D, PRO99D, SER16B, SER211D, THR157D, THR181D, THR208D, THR54B, TRP223B, TRP255D, TYR174D, TYR206D, TYR252B, TYR63D, TYR94D, TYR97D, VAL118B, VAL121B, VAL13B, VAL156D, VAL161D, VAL182D, VAL66D, VAL69D, VAL72D
• B-F: ALA89B, ALA89F, ARG91B, ARG91F, ASP151B, ASP151F, CYS149B, CYS149F, GLU95B, GLU95F, GLY154B, GLY154F, GLY92B, GLY92F, LEU90B, LEU90F, PHE152B, PHE152F, PHE153B, PHE153F, PRO96B, PRO96F, SER150B, SER150F, TYR94B, TYR94F, TYR97B, TYR97F, VAL93B, VAL93F
• B-G: ALA11G, ALA176B, ALA184B, ALA229G, ALA239G, ALA249G, ALA251G, ARG101B, ARG102B, ARG10G, ARG159B, ARG204B, ARG231G, ARG242G, ARG247G, ARG254B, ARG254G, ARG50G, ARG64B, ASN178B, ASN220G, ASN227G, ASN98B, ASP119G, ASP15G, ASP216G, ASP219G, ASP237G, ASP257B, ASP257G, ASP68B, ASP8G, GLN158B, GLN180B, GLN65B, GLU177B, GLU18G, GLU19G, GLU217G, GLU226G, GLU95B, GLY154B, GLY210B, GLY225G, GLY235G, GLY246G, GLY256B, GLY256G, GLY71B, HIS14G, HIS155B, HIS238B, HIS238G, HIS51G, ILE183B, ILE203B, ILE228G, LEU100B, LEU175B, LEU207B, LEU218G, LEU236G, LEU241G, LEU243G, LEU244G, LEU253G, LEU67B, LEU9G, LYS209B, LYS222G, PHE12G, PHE152B, PHE153B, PHE215G, PRO179B, PRO17G, PRO205B, PRO221G, PRO224G, PRO240G, PRO245G, PRO248G, PRO250G, PRO70B, PRO96B, PRO99B, SER16G, SER211B, THR157B, THR181B, THR208B, THR20G, THR54G, TRP223G, TRP255B, TYR174B, TYR206B, TYR252G, TYR63B, TYR94B, TYR97B, VAL118G, VAL121G, VAL13G, VAL156B, VAL161B, VAL182B, VAL66B, VAL69B, VAL72B
• C-D: ALA89C, ALA89D, ARG91C, ARG91D, ASP151C, ASP151D, CYS149C, CYS149D, GLU95C, GLU95D, GLY154C, GLY154D, GLY92C, GLY92D, LEU90C, LEU90D, PHE152C, PHE152D, PHE153C, PHE153D, PRO96C, PRO96D, SER150C, SER150D, TYR94C, TYR94D, TYR97C, TYR97D, VAL93C, VAL93D
• C-F: ALA11C, ALA176F, ALA184F, ALA229C, ALA239C, ALA249C, ALA251C, ARG101F, ARG102F, ARG10C, ARG159F, ARG204F, ARG231C, ARG242C, ARG247C, ARG254C, ARG254F, ARG50C, ARG64F, ASN178F, ASN220C, ASN227C, ASN98F, ASP119C, ASP15C, ASP216C, ASP219C, ASP237C, ASP257C, ASP257F, ASP68F, ASP8C, GLN158F, GLN180F, GLN65F, GLN7C, GLU177F, GLU18C, GLU19C, GLU217C, GLU226C, GLU95F, GLY154F, GLY210F, GLY225C, GLY235C, GLY246C, GLY256C, GLY256F, GLY71F, HIS14C, HIS155F, HIS238C, HIS238F, HIS51C, ILE183F, ILE203F, ILE228C, LEU100F, LEU175F, LEU207F, LEU218C, LEU236C, LEU241C, LEU243C, LEU244C, LEU253C, LEU67F, LEU9C, LYS209F, LYS222C, PHE12C, PHE152F, PHE153F, PHE215C, PRO179F, PRO17C, PRO205F, PRO221C, PRO224C, PRO240C, PRO245C, PRO248C, PRO250C, PRO70F, PRO96F, PRO99F, SER16C, SER211F, THR157F, THR181F, THR208F, THR54C, TRP223C, TRP255F, TYR174F, TYR206F, TYR252C, TYR63F, TYR94F, TYR97F, VAL118C, VAL121C, VAL13C, VAL156F, VAL161F, VAL182F, VAL66F, VAL69F, VAL72F
• C-G: GLU18C, GLU18G
• D-H: GLU18D, GLU18H
• D-J: ALA11D, ALA176J, ALA184J, ALA229D, ALA239D, ALA249D, ALA251D, ARG101J, ARG102J, ARG10D, ARG159J, ARG204J, ARG231D, ARG242D, ARG247D, ARG254D, ARG254J, ARG50D, ARG64J, ASN178J, ASN220D, ASN227D, ASN98J, ASP119D, ASP15D, ASP216D, ASP219D, ASP237D, ASP257D, ASP257J, ASP68J, ASP8D, GLN158J, GLN180J, GLN65J, GLN7D, GLU177J, GLU18D, GLU19D, GLU217D, GLU226D, GLU95J, GLY154J, GLY210J, GLY225D, GLY235D, GLY246D, GLY256D, GLY256J, GLY71J, HIS14D, HIS155J, HIS238D, HIS238J, HIS51D, ILE183J, ILE203J, ILE228D, LEU100J, LEU175J, LEU207J, LEU218D, LEU236D, LEU241D, LEU243D, LEU244D, LEU253D, LEU67J, LEU9D, LYS209J, LYS222D, PHE12D, PHE152J, PHE153J, PHE215D, PRO179J, PRO17D, PRO205J, PRO221D, PRO224D, PRO240D, PRO245D, PRO248D, PRO250D, PRO70J, PRO96J, PRO99J, SER16D, SER211J, THR157J, THR181J, THR208J, THR22D, THR54D, TRP223D, TRP255J, TYR174J, TYR206J, TYR252D, TYR94J, TYR97J, VAL118D, VAL121D, VAL13D, VAL156J, VAL161J, VAL182J, VAL66J, VAL69J, VAL72J
• E-F: ALA11F, ALA176E, ALA184E, ALA229F, ALA239F, ALA249F, ALA251F, ARG101E, ARG102E, ARG10F, ARG159E, ARG204E, ARG231F, ARG242F, ARG247F, ARG254E, ARG254F, ARG50F, ARG64E, ASN178E, ASN220F, ASN227F, ASN98E, ASP119F, ASP15F, ASP216F, ASP219F, ASP237F, ASP257E, ASP257F, ASP68E, ASP8F, GLN158E, GLN180E, GLN65E, GLN7F, GLU177E, GLU18F, GLU19F, GLU217F, GLU226F, GLU95E, GLY154E, GLY210E, GLY225F, GLY235F, GLY246F, GLY256E, GLY256F, GLY71E, HIS14F, HIS155E, HIS238E, HIS238F, HIS51F, ILE183E, ILE203E, ILE228F, LEU100E, LEU175E, LEU207E, LEU218F, LEU236F, LEU241F, LEU243F, LEU244F, LEU253F, LEU67E, LEU9F, LYS209E, LYS222F, PHE12F, PHE152E, PHE153E, PHE215F, PRO179E, PRO17F, PRO205E, PRO221F, PRO224F, PRO240F, PRO245F, PRO248F, PRO250F, PRO70E, PRO96E, PRO99E, SER16F, SER211E, THR157E, THR181E, THR208E, THR22F, THR54F, TRP223F, TRP255E, TYR174E, TYR206E, TYR252F, TYR63E, TYR94E, TYR97E, VAL118F, VAL121F, VAL13F, VAL156E, VAL161E, VAL182E, VAL66E, VAL69E, VAL72E
• E-G: ALA89E, ALA89G, ARG91E, ARG91G, ASN98G, ASP151E, ASP151G, CYS149E, CYS149G, GLU95E, GLU95G, GLY154E, GLY154G, GLY92E, GLY92G, LEU90E, LEU90G, PHE152E, PHE152G, PHE153E, PHE153G, PRO96E, PRO96G, SER150E, SER150G, TYR94E, TYR94G, TYR97E, TYR97G, VAL93E, VAL93G
• E-H: ALA11E, ALA176H, ALA184H, ALA229E, ALA239E, ALA249E, ALA251E, ARG101H, ARG102H, ARG10E, ARG159H, ARG204H, ARG231E, ARG242E, ARG247E, ARG254E, ARG254H, ARG50E, ARG64H, ASN178H, ASN220E, ASN227E, ASN98H, ASP119E, ASP15E, ASP216E, ASP219E, ASP237E, ASP257E, ASP257H, ASP68H, ASP8E, GLN158H, GLN180H, GLN65H, GLN7E, GLU177H, GLU18E, GLU19E, GLU217E, GLU226E, GLU95H, GLY154H, GLY210H, GLY225E, GLY235E, GLY246E, GLY256E, GLY256H, GLY71H, HIS14E, HIS155H, HIS238E, HIS238H, HIS51E, ILE183H, ILE203H, ILE212H, ILE228E, LEU100H, LEU175H, LEU207H, LEU218E, LEU236E, LEU241E, LEU243E, LEU244E, LEU253E, LEU67H, LEU9E, LYS209H, LYS222E, PHE12E, PHE152H, PHE153H, PHE215E, PRO179H, PRO17E, PRO205H, PRO221E, PRO224E, PRO240E, PRO245E, PRO248E, PRO250E, PRO70H, PRO96H, PRO99H, SER16E, SER211H, THR157H, THR181H, THR208H, THR22E, THR54E, TRP223E, TRP255H, TYR174H, TYR206H, TYR252E, TYR63H, TYR94H, TYR97H, VAL118E, VAL121E, VAL13E, VAL156H, VAL161H, VAL182H, VAL66H, VAL69H, VAL72H
• E-I: ALA131E, ALA131I, ALA138E, ALA138I, ALA146E, ALA146I, ALA61E, ALA61I, ALA88E, ALA88I, ALA89E, ALA89I, ARG129E, ARG129I, ARG247E, ARG247I, ARG25E, ARG25I, ARG49E, ARG49I, ARG50E, ARG50I, ARG64E, ARG64I, ARG79E, ARG79I, ARG82E, ARG82I, ARG91E, ARG91I, ASN32E, ASN32I, ASN42E, ASN42I, ASN43E, ASN43I, ASP145E, ASP145I, ASP151E, ASP151I, ASP15E, ASP15I, ASP55E, ASP55I, ASP60E, ASP60I, CYS149E, CYS149I, GLN24E, GLN24I, GLN52E, GLN52I, GLU142E, GLU142I, GLU148E, GLU148I, GLU18E, GLU18I, GLU19E, GLU19I, GLU21E, GLU21I, GLU38E, GLU38I, GLU39E, GLU39I, GLU95E, GLU95I, GLY134E, GLY134I, GLY135E, GLY135I, GLY154E, GLY154I, GLY246E, GLY246I, GLY81E, GLY81I, GLY85E, GLY85I, GLY92E, GLY92I, HIS147E, HIS147I, HIS51E, HIS51I, HIS83E, HIS83I, ILE35E, ILE35I, LEU140E, LEU140I, LEU144E, LEU144I, LEU26E, LEU26I, LEU29E, LEU29I, LEU30E, LEU30I, LEU40E, LEU40I, LEU44E, LEU44I, LEU46E, LEU46I, LEU48E, LEU48I, LEU56E, LEU56I, LEU57E, LEU57I, LEU84E, LEU84I, LEU90E, LEU90I, LYS141E, LYS141I, LYS28E, LYS28I, PHE130E, PHE130I, PHE152E, PHE152I, PHE47E, PHE47I, PHE80E, PHE80I, PHE87E, PHE87I, PRO133E, PRO133I, PRO137E, PRO137I, PRO17E, PRO17I, PRO245E, PRO245I, PRO34E, PRO34I, PRO36E, PRO36I, PRO45E, PRO45I, PRO96E, PRO96I, SER150E, SER150I, SER16E, SER16I, SER33E, SER33I, SER58E, SER58I, THR20E, THR20I, THR22E, THR22I, THR23E, THR23I, THR27E, THR27I, THR31E, THR31I, THR37E, THR37I, THR54E, THR54I, THR86E, THR86I, TYR136E, TYR136I, TYR139E, TYR139I, TYR63I, TYR94E, TYR94I, VAL132E, VAL132I, VAL143E, VAL143I, VAL41E, VAL41I, VAL78E, VAL78I, VAL93E, VAL93I
• E-J: GLU18E, GLU18J
• F-G: ALA131F, ALA131G, ALA138F, ALA138G, ALA146F, ALA146G, ALA61F, ALA61G, ALA88F, ALA88G, ALA89F, ALA89G, ARG129F, ARG129G, ARG247F, ARG247G, ARG25F, ARG25G, ARG49F, ARG49G, ARG50F, ARG50G, ARG64F, ARG64G, ARG79F, ARG79G, ARG82F, ARG82G, ARG91F, ARG91G, ASN32F, ASN32G, ASN42F, ASN42G, ASN43F, ASN43G, ASP145F, ASP145G, ASP151F, ASP151G, ASP15F, ASP15G, ASP55F, ASP55G, ASP60F, ASP60G, CYS149F, CYS149G, GLN24F, GLN24G, GLN52F, GLN52G, GLU142F, GLU142G, GLU148F, GLU148G, GLU18F, GLU18G, GLU19F, GLU19G, GLU21F, GLU21G, GLU38F, GLU38G, GLU39F, GLU39G, GLU95F, GLU95G, GLY134F, GLY134G, GLY135F, GLY135G, GLY154F, GLY154G, GLY246F, GLY246G, GLY81F, GLY81G, GLY85F, GLY85G, GLY92F, GLY92G, HIS147F, HIS147G, HIS51F, HIS51G, HIS83F, HIS83G, ILE35F, ILE35G, LEU140F, LEU140G, LEU144F, LEU144G, LEU26F, LEU26G, LEU29F, LEU29G, LEU30F, LEU30G, LEU40F, LEU40G, LEU44F, LEU44G, LEU46F, LEU46G, LEU48F, LEU48G, LEU56F, LEU56G, LEU57F, LEU57G, LEU84F, LEU84G, LEU90F, LEU90G, LYS141F, LYS141G, LYS28F, LYS28G, PHE130F, PHE130G, PHE152F, PHE152G, PHE47F, PHE47G, PHE80F, PHE80G, PHE87F, PHE87G, PRO133F, PRO133G, PRO137F, PRO137G, PRO17F, PRO17G, PRO245F, PRO245G, PRO34F, PRO34G, PRO36F, PRO36G, PRO45F, PRO45G, PRO96F, PRO96G, SER150F, SER150G, SER16F, SER16G, SER33F, SER33G, SER58F, SER58G, THR20F, THR20G, THR22F, THR22G, THR23F, THR23G, THR27F, THR27G, THR31F, THR31G, THR37F, THR37G, THR54F, THR54G, THR86F, THR86G, TYR136F, TYR136G, TYR139F, TYR139G, TYR94F, TYR94G, VAL132F, VAL132G, VAL143F, VAL143G, VAL41F, VAL41G, VAL78F, VAL78G, VAL93F, VAL93G
• F-I: GLU18F, GLU18I
• G-I: ALA11I, ALA176G, ALA184G, ALA229I, ALA239I, ALA249I, ALA251I, ARG101G, ARG102G, ARG10I, ARG159G, ARG204G, ARG231I, ARG242I, ARG247I, ARG254G, ARG254I, ARG50I, ARG64G, ASN178G, ASN220I, ASN227I, ASN98G, ASP119I, ASP15I, ASP216I, ASP219I, ASP237I, ASP257G, ASP257I, ASP68G, ASP8I, GLN158G, GLN180G, GLN65G, GLN7I, GLU177G, GLU18I, GLU19I, GLU217I, GLU226I, GLU95G, GLY154G, GLY210G, GLY225I, GLY235I, GLY246I, GLY256G, GLY256I, GLY71G, HIS14I, HIS155G, HIS238G, HIS238I, HIS51I, ILE183G, ILE203G, ILE212G, ILE228I, LEU100G, LEU175G, LEU207G, LEU218I, LEU236I, LEU241I, LEU243I, LEU244I, LEU253I, LEU67G, LEU9I, LYS209G, LYS222I, PHE12I, PHE152G, PHE153G, PHE215I, PRO179G, PRO17I, PRO205G, PRO221I, PRO224I, PRO240I, PRO245I, PRO248I, PRO250I, PRO70G, PRO96G, PRO99G, SER16I, SER211G, THR157G, THR181G, THR208G, THR54I, TRP223I, TRP255G, TYR174G, TYR206G, TYR252I, TYR63G, TYR94G, TYR97G, VAL118I, VAL121I, VAL13I, VAL156G, VAL161G, VAL182G, VAL66G, VAL69G, VAL72G
• H-I: ALA89I, ARG159I, ARG91H, ARG91I, ASN98H, ASN98I, ASP151H, ASP151I, CYS149I, GLU95H, GLU95I, GLY154H, GLY154I, GLY92H, GLY92I, LEU90H, LEU90I, PHE152H, PHE152I, PHE153H, PHE153I, PRO96H, PRO96I, SER150H, SER150I, TYR94H, TYR94I, TYR97H, TYR97I, VAL93H, VAL93I
• H-J: ALA131H, ALA131J, ALA138H, ALA138J, ALA146H, ALA146J, ALA61H, ALA61J, ALA88H, ALA88J, ALA89H, ALA89J, ARG129H, ARG129J, ARG247H, ARG247J, ARG25H, ARG25J, ARG49H, ARG49J, ARG50H, ARG50J, ARG64H, ARG64J, ARG79H, ARG79J, ARG82H, ARG82J, ARG91H, ARG91J, ASN32H, ASN32J, ASN42H, ASN42J, ASN43H, ASN43J, ASP145H, ASP145J, ASP151H, ASP151J, ASP15H, ASP15J, ASP55H, ASP55J, ASP60H, ASP60J, CYS149H, CYS149J, GLN24H, GLN24J, GLN52H, GLN52J, GLU142H, GLU142J, GLU148H, GLU148J, GLU18H, GLU18J, GLU19H, GLU19J, GLU21H, GLU21J, GLU38H, GLU38J, GLU39H, GLU39J, GLU95H, GLU95J, GLY134H, GLY134J, GLY135H, GLY135J, GLY154H, GLY154J, GLY246H, GLY246J, GLY81H, GLY81J, GLY85H, GLY85J, GLY92H, GLY92J, HIS147H, HIS147J, HIS51H, HIS51J, HIS83H, HIS83J, ILE35H, ILE35J, LEU140H, LEU140J, LEU144H, LEU144J, LEU26H, LEU26J, LEU29H, LEU29J, LEU30H, LEU30J, LEU40H, LEU40J, LEU44H, LEU44J, LEU46H, LEU46J, LEU48H, LEU48J, LEU56H, LEU56J, LEU57H, LEU57J, LEU84H, LEU84J, LEU90H, LEU90J, LYS141H, LYS141J, LYS28H, LYS28J, PHE130H, PHE130J, PHE152H, PHE152J, PHE47H, PHE47J, PHE80H, PHE80J, PHE87H, PHE87J, PRO133H, PRO133J, PRO137H, PRO137J, PRO17H, PRO17J, PRO245H, PRO245J, PRO34H, PRO34J, PRO36H, PRO36J, PRO45H, PRO45J, PRO96H, PRO96J, SER150H, SER150J, SER16H, SER16J, SER33H, SER33J, SER58H, SER58J, THR20H, THR20J, THR22H, THR22J, THR23H, THR23J, THR27H, THR27J, THR31H, THR31J, THR37H, THR37J, THR54H, THR54J, THR86H, THR86J, TYR136H, TYR136J, TYR139H, TYR139J, TYR63J, TYR94H, TYR94J, VAL132H, VAL132J, VAL143H, VAL143J, VAL41H, VAL41J, VAL78H, VAL78J, VAL93H, VAL93J
• I-J: ALA11J, ALA176I, ALA184I, ALA229J, ALA239J, ALA249J, ALA251J, ARG101I, ARG102I, ARG10J, ARG159I, ARG204I, ARG231J, ARG242J, ARG247J, ARG254I, ARG254J, ARG50J, ARG64I, ASN178I, ASN220J, ASN227J, ASN98I, ASP119J, ASP15J, ASP216J, ASP219J, ASP237J, ASP257I, ASP257J, ASP68I, ASP8J, GLN158I, GLN180I, GLN65I, GLN7J, GLU177I, GLU18J, GLU19J, GLU217J, GLU226J, GLU95I, GLY154I, GLY210I, GLY225J, GLY235J, GLY246J, GLY256I, GLY256J, GLY71I, HIS14J, HIS155I, HIS238I, HIS238J, HIS51J, ILE183I, ILE203I, ILE228J, LEU100I, LEU175I, LEU207I, LEU218J, LEU236J, LEU241J, LEU243J, LEU244J, LEU253J, LEU67I, LEU9J, LYS209I, LYS222J, PHE12J, PHE152I, PHE153I, PHE215J, PRO179I, PRO17J, PRO205I, PRO221J, PRO224J, PRO240J, PRO245J, PRO248J, PRO250J, PRO70I, PRO96I, PRO99I, SER16J, SER211I, THR157I, THR181I, THR208I, THR22J, THR54J, TRP223J, TRP255I, TYR174I, TYR206I, TYR252J, TYR63I, TYR94I, TYR97I, VAL118J, VAL121J, VAL13J, VAL156I, VAL161I, VAL182I, VAL66I, VAL69I, VAL72I