3TDZ

n-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: structure of a human cul1whb- dcn1p-stapled acetylated ubc12n complex

• Total interactions analyzed: 15
• Total true interactions: 7
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 66
  • Norm. En. per Res.: -4.8879
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-79.2889	-79.4872	-163.825	-322.6011	66	12	0	6120	6	53	28
A-D	-2.2986	2.1004	-28.0445	-28.2427	33	3	0	1298	0	9	5
A-E	-34.7072	-73.2806	-98.1696	-206.1575	49	20	7	4737	3	14	1
C-B	0.0	0.0	-0.0606	-0.0606	3	0	0	9	0	2	3
C-D	0.0	0.0	-14.03	-14.03	18	0	0	709	0	4	6
B-D	-60.1133	-83.2582	-142.004	-285.3754	60	6	0	5820	6	52	27
B-F	-25.9541	-25.5323	-108.743	-160.2293	51	7	6	4562	2	14	2

Interface residues

• A-C: ALA235A, ARG745C, ARG764C, ASN214A, ASP156A, ASP211A, ASP218A, ASP231A, ASP241A, ASP242A, ASP754C, ASP766C, ASP770C, CYS752C, GLN159A, GLN728C, GLU232A, GLU233A, GLU758C, GLU760C, GLU763C, GLU768C, GLY172A, GLY234A, GLY767C, HIS727C, ILE208A, ILE240A, ILE749C, ILE753C, ILE755C, ILE757C, LEU215A, LEU216A, LEU217A, LEU239A, LEU730C, LEU731C, LEU735C, LEU756C, LYS155A, LYS171A, LYS210A, LYS726C, LYS750C, LYS751C, LYS759C, LYS769C, MET222A, PHE162A, PHE219A, PRO209A, PRO237A, PRO747C, SER207A, THR212A, THR221A, THR771C, TRP236A, TYR230A, TYR761C, TYR772C, VAL238A, VAL746C, VAL748C, VAL765C
• A-D: ALA224A, ALA235A, ARG248A, ARG722D, ASN229A, ASP218A, ASP225A, ASP226A, ASP231A, GLN728D, GLN729D, GLN737D, GLU232A, GLU233A, GLU733D, GLY234A, GLY732D, ILE223A, ILE718D, LEU725D, LEU735D, LYS726D, MET222A, MET227A, MET721D, PRO151A, SER228A, SER739D, SER740D, THR221A, THR736D, TRP236A, TYR230A
• A-E: ALA165A, ALA178A, ALA180A, ALA98A, ASN167A, ASN183A, ASP174A, ASP84A, ASP91A, ASP96A, CYS115A, CYS90A, GLN10E, GLN114A, GLN170A, GLN87A, GLN88A, GLU116A, GLU176A, GLY82A, GLY85A, ILE100A, ILE179A, ILE2E, ILE83A, ILE86A, LEU103A, LEU173A, LEU184A, LEU4E, LEU7E, LYS11E, LYS166A, LYS3E, LYS8E, MET177A, PHE164A, PHE89A, PRO168A, PRO75A, PRO97A, SER6E, SER99A, THR113A, THR161A, TRP182A, TYR181A, VAL102A, VAL185A
• C-B: GLU233B, GLU768C, LYS726C
• C-D: ARG741D, ASP770C, GLN728C, GLN729C, GLN729D, GLY732D, LEU725C, LEU735D, LEU738D, LYS726C, LYS743D, LYS769C, PHE742D, PRO744D, SER739D, SER740D, THR736D, VAL746D
• B-D: ALA235B, ARG764D, ASN214B, ASP156B, ASP211B, ASP218B, ASP231B, ASP241B, ASP242B, ASP754D, ASP766D, ASP770D, CYS752D, GLN159B, GLN728D, GLU232B, GLU233B, GLU758D, GLU760D, GLU763D, GLU768D, GLY172B, GLY234B, GLY767D, HIS727D, ILE208B, ILE240B, ILE749D, ILE753D, ILE755D, ILE757D, LEU215B, LEU217B, LEU239B, LEU731D, LYS155B, LYS171B, LYS210B, LYS708D, LYS726D, LYS750D, LYS751D, LYS759D, LYS769D, MET222B, PHE162B, PHE219B, PRO209B, PRO237B, PRO747D, THR212B, THR221B, THR771D, TRP236B, TYR230B, TYR772D, VAL238B, VAL746D, VAL748D, VAL765D
• B-F: ALA165B, ALA178B, ALA180B, ALA98B, ASN167B, ASN183B, ASP174B, ASP74B, ASP84B, ASP91B, ASP96B, CYS115B, CYS90B, GLN10F, GLN114B, GLN76B, GLN87B, GLN88B, GLU116B, GLU176B, GLY82B, GLY85B, ILE100B, ILE179B, ILE2F, ILE81B, ILE83B, ILE86B, LEU103B, LEU173B, LEU184B, LEU4F, LEU7F, LYS11F, LYS166B, LYS3F, LYS80B, LYS8F, MET177B, PHE164B, PHE89B, PRO168B, PRO75B, PRO97B, SER6F, SER99B, THR113B, THR161B, TRP182B, TYR181B, VAL102B